• Journal of Genetic Medicine
• /
• v.18 no.2
• /
• pp.142-146
• /
• 2021

Alagille syndrome (AGS) is a rare autosomal dominant inherited disorder, with major clinical manifestations of bile duct paucity, cholestasis, cardiovascular anomaly, ophthalmic abnormalities, butterfly vertebrae, and dysmorphic facial appearance. It is caused by heterozygous mutations in JAG1 or NOTCH of the Notch signaling pathway presenting with variable phenotypic penetrance and involving multiple organ systems. The following case report describes a unique case of a 16-year-old female with AGS who presented with the primary complaint of renovascular hypertension. She had a medical history of ventricular septal defect and polycystic ovary syndrome. The patient had a dysmorphic facial appearance including frontal bossing, bulbous tip of the nose, a pointed chin with prognathism, and deeply set eyes with mild hypertelorism. Stenoocclusive changes of both renal arteries, celiac artery, lower part of the abdominal aorta, and left intracranial artery, along with absence of the left internal carotid artery were found on examination. Whole exome sequencing was performed and revealed a pathologic mutation of JAG1, leading to the diagnosis of AGS. Reverse phenotyping detected butterfly vertebrae and normal structure and function of the liver and gallbladder. While the representative symptom of AGS in most scenarios is a hepatic problem, in this case, the presenting clinical features were the vascular anomalies. Clinical manifestations of AGS are diverse, and this case demonstrates that renovascular hypertension might be in some cases a presenting symptom of AGS.

• Journal of radiological science and technology
• /
• v.45 no.5
• /
• pp.391-396
• /
• 2022

The purpose of this study was to investigate the effect of cross arms and palms facing forward on spinopelvic parameters during the whole spine lateral radiography. In addition, we would like to present the usefulness of a posture with the palm facing forward during whole spine lateral radiography of the spine using EOS. The subjects of this study were images of a total of 50 patients (18 males, 32 females) who whole spine lateral radiography using the conventional method and the EOS method from October 2020 to March 2021. The posture used in this study was set as 'CAP' for cross arms and 'PUSH' for posture with palms facing forward. In this study, among the spinal stability factors, thoracic kyphosis (thoracic vertebrae 4 to 12), lumbar lordosis (lumbar vertebrae 1 to sacrum 1), sagittal vertical axis, sacral slope, and shoulder flexion angle were compared on average. The mean thoracic kyphosis was 34.52±12.46° for CAP and 28.46±10.81° for PUSH (p<0.01). The lumbar lordosis of CAP was 42.45±17.45°and that of PUSH was 40.56±16.14°(p>0.57). The sagittal vertical axis was 26.59±34.34 mm in CAP and 21.21±35.41 mm in PUSH (p>0.44). In CAP, the sacral slope was 30.96±10.29°, and in PUSH, it was 31.01±10.19° (p>0.98). shoulder flexion angle was 38.31±8.24° for CAP and 26,08±6.71° for PUSH(p<0.01). As a result of this study, the PUSH posture is considered to be a posture that can minimize the shoulder flexion angle and can perform a stable examination while minimizing changes in spino-pelvic parameter.

• Journal of Veterinary Clinics
• /
• v.39 no.5
• /
• pp.235-239
• /
• 2022

A 10-year-old neutered male Siberian Husky presented with paraparesis and severe lethargy. On physical examination, the patient was unable to weight-bear and walk and exhibited significant muscle mass loss in both hindlimbs and generalized truncal alopecia with a dull coat of hair. On neurological examination, cranial lumbar vertebral pain, hind limb cross-extensor reflex, delayed hindlimb postural reaction, upper motor neuron bladder dysfunction, and total absence of cutaneous trunci reflex were identified. Computed tomography revealed diffuse idiopathic skeletal hyperostosis and spondylosis deformans of the cervical and thoracolumbar vertebrae. In addition, a generalized decrease in bone mineral density of the vertebrae was identified. Magnetic resonance imaging showed hyperplasia of the epidural fat compressing the spinal cord in the thoracolumbar region and concurrent mild multiple intervertebral disc herniations. No specific findings were observed in cerebrospinal fluid analysis. Blood analysis of thyroid function revealed decreased total T4 and free T4 levels, and increased TSH levels. The patient was tentatively diagnosed with spinal epidural lipomatosis (SEL) secondary to hypothyroidism. The patient was treated with levothyroxine, firocoxib, and gabapentin. Clinical signs gradually improved, and the patient showed normal ambulation 40 days after treatment initiation. SEL is extremely rare in dogs. To the best of our knowledge, this is the first case report of SEL secondary to hypothyroidism that was treated conservatively. Secondary SEL can be sufficiently managed by treating the underlying cause, if possible.

• Journal of Veterinary Clinics
• /
• v.40 no.2
• /
• pp.119-123
• /
• 2023

Although various imaging evaluation methods have been developed and utilized, thoracic radiography remains essential and is the top priority for diagnosing and managing cardiac diseases. Thoracic radiographic measurements associated with the vertebral heart scale (VHS) and caudal vena cava (CVC) can objectively diagnose cardiac disease in many animals. In particular, VHS measurement is primarily used to evaluate the dimensions of the heart size on thoracic radiographs and can measure cardiomegaly more objectively. Additionally, the value of the CVC compared with the aorta (Ao) and the length of vertebrae (VL) can be used as valuable parameters in right congestive heart failure. To describe the CVC/Ao and CVC/VL ratios in 10 long-tailed gorals (Naemorhedus caudatus) without subjective radiographic evidence of cardiac diseases. The VHS, CVC, Ao, and VL of gorals were measured in the right lateral (RL) view of the thoracic radiographs. In the RL view of 10 gorals, the VHS was 9.31 ± 0.55 vertebrae (v), the CVC/Ao ratio was 0.84 ± 0.13, and the CVC/VL ratio was 0.67 ± 0.09. Additionally, the thoracic morphology of gorals was determined to be intermediate (thoracic depth-to-width ratio, 1.04 ± 0.09, 0.75-1.25). This study confirmed that VHS was significantly correlated with CVC and Ao, and measuring and comparing each value would help diagnose cardiac diseases in gorals. The radiographic measurements in this study will allow veterinarians to diagnose several cardiac diseases in gorals.

• Journal of the Korean Society of Radiology
• /
• v.17 no.3
• /
• pp.351-357
• /
• 2023

This Study Rreceived Subjective Evaluation ROC Evaluation from five projection. of projection. at a University Hospital to Obtain and Diagnose Sharp images of apophyseal joints and Vertral arch of Thoracic vertebrae from thoracic X-ray projection. In the Subjective evaluation, the highest Score was obtained by raising the phantom from Supine to LAO by 70° and scoring 20 points at 5° with the X-ray Tube facing the head. In addition, he scored the highest score of 19 points at 8° with the Prone Phantom standing 60° with RAO and the X-ray Tube facing the head. For Objective Evaluation, the Signal-to-noise ratio, was calculated. ROI was set at 1,564 mm2 to obtain the image signal average value (Mean value) and the Standard deviation (SD value). Objective Evaluation The signal-to-noise ratio, was the highest at 5° toward the head in the LPO 70° position of the phantom in the lying position of the Thoracic spine projection, and the Thoracic Spine was the highest at 8° toward the head of the RAO posture of 5,645.

• Korean Journal of Ichthyology
• /
• v.35 no.4
• /
• pp.244-252
• /
• 2023

This study compared the morphological and molecular characteristics of the two Pampus spp. in Korea, Japan and China to clarify the long-confused taxonomic status of the two Korean pomfrets named as "Byeong-eo" and "Deok-dae". Among them "Byeong-eo" was identified as Pampus punctatissimus in having the following morphological traits: patch of wavy ridges extending beyond the anterior tip of the pectoral fin, the groove on the lower ridge of gill cover absent, and the number of vertebrae 34. On the other hand, "Deok-dae" was identified as Pampus argenteus in having the following morphological traits: patch of wavy ridges not reaching to the anterior tip of the pectoral fin, the groove on the lower ridge of gill cover reaching to the lower jaw, and the number of vertebrae 38~42. In addition, "Byeong-eo" almost corresponded to P. punctatissimus from Japan in the mitochondrial DNA cytochrome c oxidase subunit I sequences (genetic distance=0.1%), while "Deokdae" showed genetic distance of 0.3% when compared to P. argenteus from China. Our comprehensive results suggest the validify of P. punctatissimus for "Byeong-eo", and P. argenteus for "Deok-dae".

• Korean Journal of Ichthyology
• /
• v.35 no.4
• /
• pp.378-383
• /
• 2023

A re-examination of Luciogobius guttatus was conducted using 84 samples, which lives on all coastal waters of Korea. As a result, 41 specimens (31.3~54.4 mm SL) collected from the west and south coasts were classified as L. martellii. The morphological features of L. martellii as follows: number of abdominal vertebrae 16; total number of vertebrae 35~37; dorsal fin base length longer than upper caudal peduncle length or equal; one free ray on its upper pectoral fin; and edge of tail fin white. Among these, the most prominent morphological difference in L. guttatus is comparing the dorsal fin base length and upper caudal peduncle length, which is also well observed in syntypes of L. martellii. We proposed a new Korean name, "Geom-jeong-mi-kken-mang-duk" referring to their color.

• Korean Journal of Ichthyology
• /
• v.36 no.2
• /
• pp.129-138
• /
• 2024

This study examines the osteological development of the Pike gudgeon, Pseudogobio esocinus in the cranial, vertebral, caudal, pelvic and pectoral girdle for the purpose of taxonomic and aquacultural studies. Adult Pike gudgeon collected from the Boseonggang River were reared at 18.5~19.5℃ (average 19.0℃). At 5 days after hatching (total length (TL) 4.25 mm), the parasphenoid, dentary, centrum of vertebrae and clavicle began to ossify. At 22 days after hatching (TL 6.33 mm), 36 to 38 vertebrae had ossified. At 42 days after hatching (TL 16.71 mm), the majority of the skeleton had ossified. Pike gudgeon exhibited comparable characteristics to other fishes of Gobionidae throughout its development, although it displayed differences in some areas, such as the caudal skeleton and fin supports.

• Korean Journal of Veterinary Research
• /
• v.28 no.2
• /
• pp.213-219
• /
• 1988

The measurement was investigated with 18 heads of fetus(60, 90, 120 days of gestation) and neonate in Korean native goats. The results were summerized as follows: 1. The crown-rump length of fetuses at 60, 90, 120 days of gestation and neonate was 8.71, 20.83, 31.10 and 34.93 cm, respectively. 2. The length of small intestine at 60, 90, 120 days of gestation and neonate was 32.28, 157.10, 303.52 and 457.06 cm, respectively. 3. The length of large intestine at 60, 90, 120 days of gestation and neonate was 9.20, 37.70, 82.06 and 94.46 cm, respectively. 4. The ratio of intestinal length to crown-rump length at 60, 90, 120 days of gestation and neonate was 4.76, 9.45, 12.40 and 15.79 times, respectively. 5. At 60 days of gestation, the total length of the vertebral column was $7.40{\pm}0.72cm$, The mean length of each segment of the vertebral column was $1.55{\pm}0.20cm$ in cervical, $2.29{\pm}0.21cm$ in thoracic, $1.46{\pm}0.10cm$ in lumbar, $0.51{\pm}0.04cm$ in sacral and $1.59{\pm}0.17cm$ in coccygeal vertebrae. 6. At 90 days of gestation, the total length of the vertebral column was $16.52{\pm}0.80cm$. The mean length of each segment of the vertebral column was $3.72{\pm}0.12cm$ in cervical, $5.09{\pm}0.26cm$ in thoracic, $3.22{\pm}0.04cm$ in lumbar, $1.97{\pm}0.03cm$ in sacral and $2.64{\pm}0.35cm$ in coccygeal vertebrae. 7. At 120 days of gestation, the total length of the vertebral column was $26.35{\pm}0.34cm$. The mean length of each segment of the vertebral column was $6.09{\pm}0.16cm$ in cervical, $7.81{\pm}0.07cm$ in thoracic, $5.08{\pm}0.07cm$ in lumbar, $3.07{\pm}0.02cm$ in and $4.31{\pm}0.02cm$ in coccygeal vertebrae. 8. In the neonate, the total length of the vertebral column was $32.41{\pm}1.57cm$. The mean length of each segment of vertebral was $7.70{\pm}0.25cm$ in cervical, $9.97{\pm}0.68cm$ in thoracic, $5.58{\pm}0.44cm$ in lumbar, $3.85{\pm}0.15cm$ in sacral and $5.05{\pm}0.06cm$ coccygeal vertebrae. 9. The chest girth at 60, 90, 120 days of gestation and neonate was $6.13{\pm}0.51$, $13.45{\pm}0.84$, $20.28{\pm}1.53$ and $22.94{\pm}1.75cm$, respectively. 10. The head length at 60, 90, 120 days of gestation and neonate was $2.93{\pm}0.07$, $6.67{\pm}0.13$, $8.84{\pm}0.51$ and $9.76{\pm}0.44cm$, respectively. 11. The width of the head at 60, 90, 120 days of gestation and neonate was $2.20{\pm}0.13$, $4.45{\pm}0.11$, $5.33{\pm}0.20$ and $5.51{\pm}0.32cm$, respectively.

• Journal of the Korean Orthopaedic Association
• /
• v.56 no.5
• /
• pp.419-426
• /
• 2021

Purpose: In the surgical treatment of pyogenic lumbar spondylodiscitis, screw insertion at the affected vertebra has been avoided because of biofilm formation, and the risk of infection recurrence. The authors analyzed the success rate of infection treatment while minimizing the number of instrumented segments by inserting pedicle screws into the affected vertebrae. Therefore, this study examined the usefulness of this technique. Materials and Methods: From January 2000 to June 2018, among patients with pyogenic lumbar spondylodiscitis treated surgically, group A consisted of patients with pedicle screws inserted directly at the affected vertebrae (28 cases), and group B underwent fusion by inserting screws at the adjacent normal vertebrae due to bone destruction of the affected vertebral pedicle (20 cases). The classified clinical results were analyzed retrospectively. All patients were treated via the posterior-only approach, so the affected disc and sequestrum were removed. Posterior interbody fusion was performed with an autogenous strut bone graft, and the segments were then stabilized with pedicle screw systems. The hospitalization period, operation time, amount of blood loss, EQ-5D index, duration of intravenous antibiotics, and the clinical and radiological results were analyzed. Results: In group A, the number of instrumented segments, operation time, blood loss, and EQ-5D index at one month postoperatively showed significant improvement compared to group B. There were no significant differences in the duration of antibiotic use, hospitalization, radiological bone union time, sagittal angle correction rate, and recurrence rate. Conclusion: Minimal segmental fixation, in which pedicle screws were inserted directly into the affected vertebrae through the posterior approach, reduced the surgery time and blood loss, preserved the lumbar motion by minimizing fixed segments and showed rapid recovery without spreading or recurrence of infection. Therefore, this procedure recommended for the surgical treatment of lumbar pyogenic spondyodiscitis.