• 수면정신생리
• /
• 제11권1호
• /
• pp.44-49
• /
• 2004

목 적 : 만성 정신분열병 환자에서 양성증상과 음성증상의 호전이 인지기능에 어떤 영향을 끼치는 지를 알아보기 위함이다. 방 법：증상의 호전이 예상되는 활성기 정신분열병 환자 68명을 대상으로 입원 직후에 증상과 인지기능을 측정하고 6개월 약물치료 후 증상과 인지기능을 재차 측정하여 두 영역에서의 변화간의 연관성을 조사하였다. 또 약물치료에 의해 인지기능이 어느 수준까지 호전되는지를 알아보기 위하여 나이와 교육수준이 비슷한 정상 대조군 20명의 인지기능과도 비교하였다. 증상은 PANSS로 평가하였고, 인지기능은 고난도 지속수행검사를 이용한 지속적 주의력, 위스콘신 카드분류검사를 이용한 실행능력, 숫자 주의력을 이용한 주의 집중력, 그리고 레이 청각 언어성 학습검사를 이용한 언어성 기억과 학습 등을 측정하였다. 결 과：양성증상과 음성증상에서의 호전은 각 인지검사 점수의 변화에 유의한 영향을 미치지 않았고, 인지검사 점수의 변화에서 증상의 호전으로 설명될 수 있는 정도는 미미하였다. 또 정신분열병의 활성기에 비하여 6개월 약물치료 때의 관해기때 주의력, 실행능력, 기억력 모두 유의한 호전을 보였지만, 나이와 교육수준이 비슷한 정상대조군과 비교 시는 여전히 유의한 결손을 보였다. 결 론：이러한 결과는 정신분열병에서 증상과 인지기능이 서로 다른 영역일 가능성을 시사하며, 나아가 정신분열병 치료에 있어 증상의 호전뿐 아니라 인지기능의 호전에도 초점을 두어야 할 필요성을 부각시킨다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2004년도 춘계학술대회 논문요약집
• /
• pp.300-300
• /
• 2004

본 연구에서는 언어과제 수행 시 일반 공기 중의 산소 농도 (21%) 환경에 비해 외부에서 고 농도 (30%)의 산소 공급이 혈중 산소 포화도(SPO$_2$), 심박동율(Heart Rate), 정답률(Accuracy), 반응속도(Reaction Time)에 어떠한 영향을 미치는지를 검증하고자 한다. 30%와 21%의 산소를 8L/min의 양으로 일정하게 공급할 수 있는 산소 공급 장치를 이용하였고, 10명의 대학생(오른손잡이, 평균나이 23.4세)을 대상으로 실험을 수행하였다. 난이도가 비슷한 두 가지 언어과제를 28문제씩 피험자에게 풀게하여 정답률과 반응속도를 계산하였다.(중략)

• 생물정신의학
• /
• 제20권3호
• /
• pp.104-110
• /
• 2013

Objectives : The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) ${\varepsilon}4$ on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD). Methods : The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE ${\varepsilon}4$. Results : The impact of ${\varepsilon}4$ allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033). Conclusions : The APOE ${\varepsilon}4$ allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.

• 대한불안의학회지
• /
• 제16권1호
• /
• pp.32-40
• /
• 2020

Objective : The purpose of this study was to investigate the cognitive performance of major depressive disorder (MDD) in military service/conscription personnel who visited the psychiatric clinic for a medical certificate to consider the situation from the perspective of Korea's unique compulsory military system. We used the Korean Wechsler Adult Intelligence Scale-IV (K-WAIS-IV) as the test for verifying the suitable level of cognitive functioning for military service and as the embedded measure with reflecting suboptimal effort. Methods : The study was conducted on 56 (28 males, age 19-34) in/out-patients admitted to the psychiatry department and diagnosed with MDD (DSM-IV). All participants completed a structured clinical interview (MINI-Plus), as well as self-report questionnaires related to demographics and severity of clinical symptoms. K-WAIS-IV was administered to each subject to assess cognitive characteristics. Results : Military group showed significantly lower processing speed index (PSI) score including subtests of symbol search (SS) and coding (CD) score, compared to the control group. There was no other significant differences in the Full Scale IQ (FSIQ), Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI) scores including sub-tests comprised of the above indices, and Reliable Digit Span (RDS), Enhanced-RDS-Revised (E-RDS-R) between the study and control groups. Conclusion : This study was the first effort to verify the characteristics of Korea's military group with MDD and suggest the applicability of PSI and processing speed of K-WAIS-IV as an embedded performance index to test sub-optimal effort or low motivation beyond the purpose of testing cognitive deficits.

• ETRI Journal
• /
• 제44권4호
• /
• pp.613-623
• /
• 2022

Autism spectrum disorder (ASD) is a developmental disorder associated with cognitive and neurobehavioral disorders. It affects the person's behavior and performance. Autism affects verbal and non-verbal communication in social interactions. Early screening and diagnosis of ASD are essential and helpful for early educational planning and treatment, the provision of family support, and for providing appropriate medical support for the child on time. Thus, developing automated methods for diagnosing ASD is becoming an essential need. Herein, we investigate using various machine learning methods to build predictive models for diagnosing ASD in children using facial images. To achieve this, we used an autistic children dataset containing 2936 facial images of children with autism and typical children. In application, we used classical machine learning methods, such as support vector machine and random forest. In addition to using deep-learning methods, we used a state-of-the-art method, that is, automated machine learning (AutoML). We compared the results obtained from the existing techniques. Consequently, we obtained that AutoML achieved the highest performance of approximately 96% accuracy via the Hyperpot and tree-based pipeline optimization tool optimization. Furthermore, AutoML methods enabled us to easily find the best parameter settings without any human efforts for feature engineering.

• 정신신체의학
• /
• 제11권1호
• /
• pp.36-43
• /
• 2003

연구목적: 본 연구의 목적은 외상후 스트레스 장애에서 증상의 정도에 따른 인지기능의 차이가 어떠한지에 대하여 연구한 것이다. 방 법: 교통사고 관련 외상후 스트레스 장애로 진단된 90명의 외래, 입원환자를 대상으로 외상후 스트레스 장애 증상의 심각도(MMPI 우울증 척도, 강박 척도, 정신분열증 척도)와 인지기능(K-WAIS)을 측정하였다. 그들을 MMPI 우울증 척도, 강박증 척도, 정신분열증 척도 점수에 따라 상위 30%에 해당하는 집단과 하위 30%에 해당하는 집단으로 구분하여 두 군간의 지능과 소검사 점수 차이에 대하여 각각 검증하였다. 결 과: 우울증 척도의 상위군과 하위군 사이에 유의한 차이는 없었다. 그리고 강박 척도에서 하위군이 상위군보다 기본지식, 어휘문제, 공통성문제, 빠진곳 찾기, 차례맞추기가 유의하게 높았다. 그리고 정신분열증 척도에서 하위군이 상위군보다 전체지능, 언어성지능, 동작성지능, 기본지식, 어휘문제, 이해문제, 산수문제, 빠진곳 찾기, 차례맞추기, 토막짜기, 모양맞추기, 바꿔쓰기가 유의하게 높았다. 결 론: 본 연구 결과, 외상후 스트레스 장애에서 증상의 정도에 따른 인지기능의 차이가 있었다. 따라서 증상의 정도가 심한 집단에서 인지기능 장애가 더 심하다는 것을 알 수 있었다. 그러므로 외상후 스트레스 장애는 불안장애이기도 하지만 인지기능 또한 증상에 의해 많은 영향을 받는다는 것을 알 수 있었다. 향후 외상후 스트레스 장애를 치료함에 있어서 약물치료 뿐만이 아니라 다양한 인지적 치료 접근이 필요할 것으로 생각된다.

• The Journal of Korean Physical Therapy
• /
• 제14권3호
• /
• pp.334-344
• /
• 2002

This study was to investigate the effects of the sensory-motor training program childhood body concept and to investigate the difference between the control group and experimental group. Subjects of the study were compared with children whose age varied from three to four years old, where I.Q was over 100. The major things of this study was as follows, First, sensory-motor training program was effective with regards to body concept improvement among the three-, four-year-old children. Second, both the experimental group trained by sensory-motor program and the control group trained by cognitive-perceptual training program were revealed a meaningful performance. But, sensory-motor program offering subcognitive sensory body experiences yielded higher mean gains in scores than a cognitive-perceptual program. Sensory-motor learning is more effective than verbal learning is promoting body concept reflected in the ability to draw human figures.

• 생물정신의학
• /
• 제12권2호
• /
• pp.173-180
• /
• 2005

Purpose:We investigated the effect of menopausal duration on cognitive function using adjunctive hormone replacement therapy(HRT) in postmenopausal women with depression. Method:Twelve postmenopausal women with depressive disorder were enrolled. Six patients having menopausal duration of less than 3 years was assigned to the short duration group and six patients of more than 3 years to the long duration group. Each patient was treated with conjugated equine estrogen(1.25mg) plus medroxyprogesterone(5mg) for 8 weeks. Cognitive performance was measured by the Verbal Memory Test, Visual Memory Test, Trail Making Test, Digit Symbol Test, and Attention Shift Test. The Beck Depression Inventory was used for evaluation of depressed mood. The reproductive hormone levels were also measured. Results:The long duration group showed the lower performance only in Trail Making Test B compared with the short duration group at baseline. After 8 weeks, the long duration group performed significantly better in the Trail Making Test B compared with the short duration group. The differences in change of depressive mood and gonadal hormone level between two groups were not significant. Conclusion:Menopausal duration before HRT may influence the effect of estrogen on cognition in some cognitive domains. This might be related with estrogen receptor hypersensitivity which induced by the longer estrogen deficiency.

• 한국정밀공학회지
• /
• 제22권1호
• /
• pp.183-192
• /
• 2005

This study compared cerebral lateralization index based on the area of neural activation with that based on the intensity of neural activation. For this purpose, 8 right-handed male college students (the mean age - 23.5 years) and 10 right-handed male college students (the mean age - 25.1 years) participated respectively in researches on visuospatial and verbal task brain function. Functional brain images were taken from 3T MRI using the single-shot EPI method. The result of measuring cerebral lateralization index based on the area of neural activation suggested that the right hemisphere is dominant in visuospatial tasks and the left one is in verbal tasks. However, the dominance is not sufficient to locate the exact part of the brain for these tasks. When cerebral lateralization index was computed based on the intensity of neural activation, it was derived that the area of cerebral lateralization closely related to visuospatial tasks is the superior parietal lobe, and the area of cerebral lateralization closely related to verbal tasks is the inferior and middle frontal lobes. Thus, cerebral lateralization index by area based on the intensity of neural activation as proposed by this study can determine the dominance of the cerebrum by area, so is helpful for accurate and quantitative determination of cerebral lateralization.

• Journal of Nutrition and Health
• /
• 제16권4호
• /
• pp.253-262
• /
• 1983

A survey was undertaken to investigate relationship between nutritional status and physical growth and behavior of school children. Dietary intakes, environmental factors, physical growth, personality, and cognitive development were measured in 323 children of 4 th and 6th grader in the urban and rural arcas. The results are summarized as follows : 1) The average intakes of the food groups and nutrients except ascorbic acid were lower in rural children. Comparing the intakes of the rural children with RDA of the Korean children, 64.0% of them in protein, 99.3% in calcium, 84.6% in iron, and 73.5% in riboflavin consumed less than 75% of RDA. Environmental factors were significantly related to the nutrient intakes 2) Height, weight, and head circumference were significantly related to the nutrient intakes. Retarded growth due to malnutrition was supposed in the $rural^{1)}$ area. 3) Some domains of personality were significantly related to nutrient intakes. 4) Environmental factors, physical growth, and nutrient intakes made independent contribution to variation in cognitive performance and their relative importance depended on the particular cognitive domain when stepwise multiple regression analyses were undertaken. Environmental stimulation was largely associated with verbal usage, and economic status and nutrient intakes with numerical reasoning. Above findings support that nutritional deprivation retards brain growth and performance on various cognitive dimensions of children. Therefore, amelioration of the several adverse social, economical, environmental influences as well as the improvement of dietary intake is required to bring about a substantial enhancement of the physical growth and the mental development of children.