• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2005년도 추계학술대회 논문집
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• pp.135-140
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• 2005

항만과 해역에 설치되는 수직벽의 일례로 육상 및 유입되는 오염수의 오염 유출 방지를 위한 차수기능을 갖는 차수벽과 교량이나 댐, 갑문 둥의 하천 또는 해양구조물을 축조하는 동안 물이 들어오는 것을 방지하기 위하여 임시로 설치되는 가물막이(cofferdam)벽 등이 있다 이들 차단벽의 구조역학적인 설계 인자 중 유입수 유동 특성과 설치 지역의 지반 특성이 중요한 의미를 가진다고 판단된다. 본 연구에서는 이러한 수직 차단벽 주위의 유체역학적 특성 파악의 일례로 수직벽의 하단에 틈새를 갖는 파공(perforation)이 발생하였을 때 이들 파공의 개도율 변화에 따른 유동특성을 고찰하는 하나의 방안으로 입자영상유속계(Particle Image Velocimetry)를 이용하여 수직벽 후류 특성을 실험적으로 고찰하였다.

• Journal of Korean Medical Science
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• 제33권53호
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• pp.322.1-322.14
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• 2018

Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD. Methods: We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea. Results: Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total $CO_2$ content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model. Conclusion: Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.

• Journal of Microbiology and Biotechnology
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• 제31권6호
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• pp.890-901
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• 2021

The 11α-hydroxylation of canrenone can be catalyzed by Aspergillus ochraceus in bioreactors, where the geometry of the impeller greatly influences the biotransformation. In this study, the effects of the blade number and impeller diameter of a Rushton turbine on the 11α-hydroxylation of canrenone were considered. The results of fermentation experiments using a 50 mm four-blade impeller showed that 3.40% and 11.43% increases in the conversion ratio were achieved by increasing the blade number and impeller diameter, respectively. However, with an impeller diameter of 60 mm, the conversion ratio with a six-blade impeller was 14.42% lower than that with a four-blade impeller. Data from cold model experiments with a large-diameter six-blade impeller indicated that the serious leakage of inclusions and a 22.08% enzyme activity retention led to a low conversion ratio. Numerical simulations suggested that there was good gas distribution and high fluid flow velocity when the fluid was stirred by large-diameter impellers, resulting in a high dissolved oxygen content and good bulk circulation, which positively affected hyphal growth and metabolism. However, a large-diameter six-blade impeller created overly high shear compared to a large-diameter four-blade impeller, thereby decreasing the conversion ratio. The average shear rates of the former and latter cases were 43.25 s^-1 and 35.31 s^-1, respectively. We therefore concluded that appropriate shear should be applied in the 11α-hydroxylation of canrenone. Overall, this study provides basic data for the scaled-up production of 11α-hydroxycanrenone.

• Korean Circulation Journal
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• 제52권5호
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• pp.368-378
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• 2022

Background and Objectives: Recurrence rates after radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients are not low especially in non-paroxysmal AF. The diameter of left atrium (LA) has been widely used to predict the recurrence after RFCA for decades. However, LA diameter represents structural remodeling of LA and does not reflect electrical remodeling. We aimed to determine the predictive value of electrical remodeling of LA which is represented by the amount of low voltage zone (LVZ). Methods: We performed a retrospective cohort analysis of AF patients who underwent de novo RFCA in a single-center. Results: A total of 3,120 AF patients with de novo RFCA were analyzed. Among these patients, 537 patients underwent an electroanatomic mapping with bipolar voltage measurement of LA. The diameter of LA and flow velocity of LA appendage (LAA) differed significantly according to quartile group of LVZ area and percentage: patients with high LVZ had large LA diameter and low LAA flow velocity (p<0.001). Freedom from late recurrence (LR) was significantly lower in patients with high LVZ area and percentage (p<0.001). The diameter and surface area of LA had area under curve (AUC) of 0.592 and 0.593, respectively (p=0.002 for both). The predictive value of LVZ area (AUC, 0.676) and percentage (AUC, 0.671) were both superior compared with LA diameter (p=0.011 and 0.027 for each comparison). Conclusions: In conclusion, LVZ can predict freedom from LR after RFCA in AF patients. Predictive value was higher in parameters reflecting electrical rather than structural remodeling of LA.

• 대한임상검사과학회지
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• 제56권3호
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• pp.277-287
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• 2024

경두개 도플러(transcranial doppler, TCD) 초음파는 뇌혈류를 평가하는 데 중요한 비침습적 도구로, 뇌혈관 질환의 진단과 모니터링에 널리 사용되고 있다. 본 논문은 TCD의 중요성을 재확인하고, 검사 방법 및 주의 사항을 정리하여 실무자에게 가이드를 제공하고자 한다. TCD는 혈류 속도 변화를 평가하여 뇌혈관 협착, 폐색, 혈류 역학적 변화를 평가한다. 그러나 혈류 속도만으로는 혈류량 증가와 혈관 직경 감소를 구분하기 어렵다. 따라서 임상 소견과 혈류 역학적 변화를 통합적으로 고려한 종합적 접근이 필요하다. TCD 결과의 신뢰성은 검사자의 기술에 크게 의존하므로 표준화된 절차와 지속적인 교육 및 훈련이 필요하다. TCD 분석의 자동화와 인공지능(AI) 기술의 발전은 정확성과 신뢰성을 향상시킬 수 있는 잠재력을 가지고 있다. 향후 연구는 이러한 새로운 기술들을 검증하고 임상에 적용하는 데 중점을 두어야 한다. 본 논문은 TCD의 중요성, 검사 방법, 주의사항을 검토하며, 실무자에게 유용한 가이드를 제공하고자 한다. TCD의 지속적인 발전과 임상 적용 확대가 뇌혈관 질환의 진단 및 치료에 기여하기를 기대한다.

• 대기
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• 제19권1호
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• pp.79-91
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• 2009

Seoul National University General Circulation Model (SNUGCM) has been run for 100 years to obtain daily temperature and meridional velocity at the Northern lower stratosphere. The model results are compared with the NCEP/NCAR reanalysis data. The polar temperature and the eddy heat flux from the model show that the model-produced climatology has well-known cold bias and weaker planetary wave activities. The model climatology also has a lag in the seasonal evolution. The relationship between the model-produced polar temperature and the eddy heat flux is investigated with respect to the interannual and decadal time scales. The interannual variation of the polar temperature is related with both total and stationary eddy heat flux in January and March, which is in agreement with observation. The model, however, does not reproduce the relationship between the decadal variation of the polar temperature and transient eddy heat flux, which is revealed in the observed data.

• 제어로봇시스템학회논문지
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• 제19권5호
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• pp.423-428
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• 2013

This paper investigates a boundary tracking problem using multiple quadrotor UAVs to detect and track the boundary of physical events. We set the boundary estimation problem as a classification problem of the region in which the physical events occur, and employ SVL (Support Vector Learning). We also demonstrate a velocity vector field which is globally attractive to a desired closed path with circulation at the desired speed and a virtual phase for stabilizing the collective configuration of the multiple quadrotors. Experimental results with multiple quadrotors show that this study provides good performance of the collective boundary tracking.

• 한국환경과학회지
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• 제11권1호
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• pp.25-32
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• 2002

In order to control of water quality in Jeju harbor, variation of physical oceanographic environments was estimated using material cycle model. It is composed of the three-dimensional hydrodynamic model for the simulation at water flow and material cycle model for the simulation of water quality. The three dimensional hydrodynamic model simulation of the circulation and mixing in Jeju Harbor has been conducted forced by Sanzi River Discharge, Tidal elevation, wind and Solar heat in case of August and November, 2000 and February and May, 2001, respectively. The results of numerical model and observation show that the model can produce realistic results of current in the harbor. The monthly variation of velocity pattern are not so much changed are found In Jeju Harbor. The residual current was forced by temperature, salinity, density, wind and tidal current. The residual current of August, 2000 are the strongest among four month. It can be explained that the density effect can be important role in residual current at Jeju Harbor. As the results of salinity distribution simulation, very low concentration of all levels were simulated in August, 2000. The flowrate of Sanzi river was investigated 77,760 ㎥ /d in August, 2000. Therefore, pollutant loadings from Sanzi river should be considered for water quality management in Jeiu harbor.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2003년도 한국우주과학회보 제12권2호
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• pp.34-34
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• 2003

To better understand how high-latitude electric fields influence thermospheric dynamics, we study winds in the high-latitude lower thermosphere using the Thermosphere-Ionosphere-Electrodynamics General Circulation Model of the National Center for Atmospheric Research (NCAR/TIEGCM). In order to compare with Wind Imaging Interferometer (WINDII) observations the model is run for the conditions of 1992-1993 southern summer. The association of the model results with the interplanetary magnetic field (IMF) is also examined to determine the influences of the IMF-dependent ionospheric convection on the winds. The wind patterns show good agreement with the WINDII observations, although the model wind speeds are generally weaker than the observations. It is confirmed that the influences of high-latitude ionospheric convection on summertime thermospheric winds are seen down to 105 km. For negative and positive IMF By the difference winds, with respect to the wind during null IMF conditions, show significantly strong anticyclonic and cyclonic vortices, respectively, down to 105 km. For positive IMF Bz the difference winds are largely confined to the polar cap, while for negative IMF Bz they extend to subauroral latitudes. The IMF Bz-dependent diurnal wind component is strongly correlated with the corresponding component of ionospheric convection velocity down to 108 km and is largely rotational. The influence of IMF By on the lower thermospheric summertime zonal-mean zonal wind is substantial at high latitudes, with maximum wind speeds being 60 m/s at 130 km around 77 magnetic latitude.

• 한국환경과학회지
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• 제18권9호
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• pp.941-952
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• 2009

The urban microscale wind field around the air quality monitoring station was investigated in order to check how a building complex influences it. For this study as the high density areas Jwa-dong and Yeonsan-dong monitoring sites in Busan were chosen. As the direction of inflow which is perpendicular to the building of the monitoring station was expected to cause the considerable variation of the wind field, that direction was selected. The model Envi-met was used as the diagnostic numerical model for this study. It is suitable for this investigation because Envi-met has the microscale resolution. After simulating it, on the leeward side around a building complex the decrease of flow velocity and some of vortexes or circulation area were discovered. In addition, on the edge of the top at the building and at the back of the building the upward flow was developed. If the sampling hole of monitoring site were located in this upward flow, it would be under the influence of upward flow from the near street.