• 디지털산업정보학회논문지
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• 제18권3호
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• pp.97-110
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• 2022

The case study looks into the case of the "extreme" market segmentation strategy of company L with its top luxury windows and door brand "Lonchel". Company L has long enjoyed a leading position in the Korean windows and doors mass market. However, it went against their already well-established flagship brand and created a completely new one called "Lonchel", pursuing an extreme market segmentation strategy focusing on the small niche market of highest-income customers exclusively. The strategy has turned out to be successful and the company has gained long-lasting competitive advantages. In this vein this study analyzes the market environment in which the top-tier brand "Lonchel" appeared, the concept of the extreme positioning and the smallest viable market, the characteristics of target customers, the company's analysis of and response to them, and the analysis of products to meet their needs. The brand operation plan and promotion will be also reviewed. Through this, we intend to draw implications related to the extreme positioning strategy that a company may pursue in a target market of small groups of people.

• 한국컴퓨터산업학회논문지
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• 제7권4호
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• pp.447-454
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• 2006

1980년 이후로 치매, 파킨슨병, 운동신경질환 등 뇌질환 발생률이 급증하고 있으며 영국, 미국, 일본, 독일, 스페인의 발생률을 조사한 결과, 알츠하이머병을 포함한 치매 사망률이 남성경우 3배 이상 증가했고, 파킨슨병과 운동신경질환 등 뇌질환 사망률은 남녀가 약 50%씩 늘어난 것으로 나타났다. 유전적 이유로 보면 DNA변화로 추측되나 이에 대한 입증은 수백년이 걸리므로 실제 원인은 환경적 요인일 수 밖에 없다. 특히, 우려할 것은 급속히 증가하는 노인인구로 인한 노인성 질환 및 뇌질환의 대책이 무엇보다 요구되는 우리실정으로 발병하면 치료가 어렵고, 후유증이 심각하므로 무엇보다 예방이 중요하다. 위험인자와 발생위험을 조기에 알아낼 수 있도록 뇌혈관을 수시로 자가검사가 가능한 Cerebrovascular Ultrasonogram (뇌혈관 초음파)를 구현하여 특성 시험과 모델링화 하여 성능의 우수성을 입증하여 정리하였다. 차후 시스템을 보완하면 다른질병의 뇌질환 환자에도 적용이 될 것이고, 본 연구에서는 시제품을 직접 제작하여 비정형화 특성을 연구하고 접근해 보고자 노력하였다.

• 한국작물학회지
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• 제68권3호
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• pp.216-223
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• 2023

This study aimed to identify and compare the characteristics of Elymus humidus on common wheat (Triticum aestivum L. cv. Chinse Spring, CS). The seed length, width, height, and weight of E. humidus were smaller than those of the CS. In particular, the germination rate of E. humidus was substantially lower than that of CS. In the anatomical dissection of the leaf, E. humidus showed a considerably different xylem diameter of the main vascular bundle in the main vein; however, there was no difference in the phloem of the main vascular bundle compared with the xylem and phloem of the main vascular bundle in the main vein of CS, although E. humidus showed a leaf structure similar to that of CS. In addition, E. humidus had a thinner epidermis than that of CS. Regarding stomatal traits, E. humidus showed a graminoid stomata type similar to that of CS. On the adaxial and abaxial sides, the density, length, and width of the stomata in E. humidus were smaller than those in CS, whereas the distance between stomata in E. humidus was greater than that in CS. The chromosomes of E. humidus were classified as long and short based on their respective lengths. Long chromosomes were classified based on the ratio of the long arm to the short arm e.g., 1:1 or 2:1. Short chromosomes showed the same trend and some short chromosomes were microsatellites. To evaluate genetic diversity, 38 barley EST markers with polymorphisms between E. humidus and CS were selected from 236 barley EST markers.

• 산업진흥연구
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• 제9권1호
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• pp.189-202
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• 2024

지구상에 분포하고 있는 수맥 자체가 해로운 것이 아니라 수맥으로부터 발생하는 수맥 파가 인체 건강에 해롭다는 것이다. 지구의 고유진동수는 7.83Hz인데 깊은 잠을 자기 위해서는 이 진동수보다 낮은 델타파로 2~3.99Hz의 상태로 내려가야만 가장 깊은 잠을 잘 수 있어 건강을 유지할 수가 있다. 그렇지만 수맥 파가 있는 곳에서 잠을 자게 되면 수맥 파가 뇌파를 간섭하여 잠을 잘 자지 못하고, 악몽을 꾸기도 하고, 자고 일어나도 몸이 개운하지 못하고 피로가 다 풀리지 않아 쉽게 지치고 피곤함을 느끼게 된다. 이 같은 현상이 지속해서 이루어지다 보면 몸의 저항력이 떨어지고 면역력이 약해져서 결과적으로 병을 유발하는 원인이 될 수 있고, 각종 질병을 얻게 되어 건강을 해칠 수가 있다. 즉 수맥파로부터 가장 안전하고 간단히 대처할 수 있는 효과적인 방법은 수맥이 있는 곳은 피하고, 수맥이 없는 곳으로 잠자는 자리만 바꿔도 건강하고 행복한 생활을 할 수 있다는 것을 사례를 통해서 규명하고자 한다.

• Journal of Information Technology Applications and Management
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• 제19권4호
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• pp.227-242
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• 2012

It is a daunting task to theorize the process effectiveness of IT convergence based service model. Despite the criticalness of investigating process enhancement impact of IT-convergence based service model, the theoretical research in this field is relatively scarce, possibly due to the too wide and comprehensiveness of research scope. In this vein, we conducted exploratory study to understand the contributional impact of IT convergence based service model on resolving service process limitations. We first identified five IT convergence based service models in the area of typical service industry, which include entertainment, learning, location based services, tourism, and healthcare. Our research model classified value creation factors of the IT convergence model in twofold. The one is defined as basic value creation factor of the IT convergence, which is treated as the second-order factor that consists of two first-order factors of mobile functionality and Internet with digital contents merging functionality. The other is defined as service process limitations resolving factor which are comprised with the two first-order factors of simultaneousity and perishability. Both the second-order factors are modeled, each respectively, with the two first-order factors in formative manner. Using PLS, empirical validation is executed to analyze each value creating factor's contribution impact on the relative advantage, as well as the mediating effect of basic value creation factor on resolving service process limitations. On the basis of the insights revealed from this paper, further theory building research could be elaborated in the area of IT convergence applications for service industry.

• Journal of Veterinary Science
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• 제25권4호
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• pp.58.1-58.8
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• 2024

Importance: Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish (Clarias macrocephalus x C. gariepinus). Objective: This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW). Methods: In total, 140 catfish (each about 100-120 g BW) were divided into two groups (n = 70). Blood samples (0.6-0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector. Results: The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 ㎍/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%). Conclusions and Relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2004년도 춘계학술발표대회
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• pp.187-187
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• 2004

Gene delivery is one of the keen interests in animal industry as well as research on gene function. Some of the in vivo gene delivery techniques have been successively used in various tissues for the gene therapy and transgenesis. Despite intensive efforts, it still remains to overcome problems of limited local and regional administration and low transgene expression. (omitted)

• 한국식품과학회지
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• 제40권4호
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• pp.455-459
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• 2008

STZ 투여로 제 1형 당뇨를 유발시킨 다음 B. sarmienti 에탄올 추출물을 8주간 급여 후 혈당 및 혈중지질 변화를 알아보았다. 시험기간 동안 당뇨대조군 및 당뇨실험군의 체중증가는 정상군과 비교하여 유의적으로 낮게 나타났으며, B. sarmienti 에탄올 추출물 급여가 당뇨실험군에서의 체중변화에는 영향을 미치지 않는 것으로 조사되었다. 또한 수분섭취량, 사료섭취량, 혈당 모두 정상군과 비교하여 당뇨대조군 및 당뇨실험군에서 8주 동안 유의적으로 높게 지속되었다. 혈중 총 콜레스테롤, HDL-콜레스테롤, LDL-콜레스테롤 변화를 측정한 결과 정상군과 비교할 때 당뇨대조군에서는 상대적으로 증가하였으나, B. sarmienti 에탄올 추출물 투여로 유의적인 감소현상과 함께 정상군과 유사한 수준을 유지 하였다. 특히, B. sarmienti 에탄올 추출물 투여로 인한 혈중 총 콜레스테롤 변화는 BE0 29.1%, BE1 26.1%, BE2 23.6%로 평균 26.2%의 감소효과를 나타내었다. 또한 혈중 중성지방 변화는 BE0 55.6%, BE1 64.1%, BE2 68.4%로 평균 62.7%의 감소현상을 나타내었다. 혈중 콜레스테롤 및 중성지방은 B. sarmienti 에탄올 추출물 투여의 농도 의존적 감소현상은 관찰할 수 없었으나, 혈중지질 개선에 많은 영향을 미치는 것으로 조사되었다. 본 연구에는 제 1형 당뇨모델에서 8주 동안 B. sarmienti 에탄올 추출물을 투여하면서 혈당조절 효과는 관찰할 수 없었으나, 혈중지질 성분인 triglycerides, 총 콜레스테롤 및 LDL 콜레스테롤의 수준을 떨어뜨리는 효과가 있는 것으로 조사되었다. 결론적으로 B. sarmienti 에탄올 추출물 투여가 고혈당을 중심으로한 지질대사 이상과 함께 많은 합병증 유발이 문제시 되고 있는 당뇨병의 체내 지질대사 개선에 효과가 있을 것으로 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권1호
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• pp.44-52
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• 2020

Objective: Minerals are one of the important nutrients for supporting the growth of sheep grazing in the highland, northwest of China. The experiment was conducted to investigate the relationship of both macro and micro minerals in sheep grazing in the highlands of six districts located in the Qilian Mountain of China. Methods: Samples of herbage (n = 240) and soil (n = 240) were collected at random in a "W" shape across the area designated for harvesting from 24 farms, where the sheep commonly graze in October (winter) for mineral analyses. In addition, serum samples were taken via jugular vein from 20 sheep per farm from 24 farms (n = 480 samples in total) for serum minerals analyses. Mean values of macro and micro minerals were statistically compared among districts and the correlations among soil-plant-animal were statistically analyzed and correlations were regressed, as well. Results: The results revealed that there were variations for both macro and micro minerals among districts. Statistical analysis of the correlation coefficients between herbage and sheep were significantly different for most of the minerals but not for P, Cu, and Se. Many correlation regression coefficients were found significantly different among minerals of herbage, soil, and sheep serum especially those of K, Na, Fe, Mn, and Zn (between herbage and sheep serum), and Fe and Mn (between herbage and soil), Na, Fe, Mn, and Zn (between soil and sheep serum), respectively. The regression coefficient equations derived under this experiment for prediction of Ca (R² = 0.618), K (R² = 0.803), Mg (R² = 0.767), Na (R² = 0.670), Fe (R² = 0.865),Zn (R² = 0.950), Mn (R² = 0.936), and Se (R² = 0.630), resulted in significant R² values. Conclusion: It is inferred that the winter herbage minerals in all the districts were below the recommended levels for macro minerals which indicated there would be some mineral deficiencies in sheep grazing the herbage in these regions. Supplemental minerals may therefore play an important role in balancing the minerals available from the herbage in winter and would lead to increased productivity in sheep on the highland areas of China. These findings could be potentially applied to the other regions for improving the livestock productivity.

• 한국식품영양학회지
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• 제22권4호
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• pp.542-547
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• 2009

Brine mineral water(BMW) has recently gained attention as a new water resource due to its biological activities. In this study, BMW from the Geumjin area(Gangneung-city, Korea) was evaluated for its growth inhibition, anti-metastasis and anti-angiogenesis activity against cancer cells. The in vitro cytotoxicity was measured by CCK assay, and the anti-metastasis activity was estimated by lung metastasis in vivo. The in vitro incubation of mouse splenic cells with BMW that had been diluted more than 4-fold showed no effect on the cell growth when compared to a control group. Additionally, BMW inhibited the growth of the EL-4, L5178Y-R and colon26-M3.1 cancer cell lines in a dose-dependent manner. In vivo evaluation of the anti-metastasis activity of BMW in BALB/c mice inoculated with the colon26-M3.1 cell line revealed dose-dependent inhibition in response to treatment with samples that were diluted by up to 9 times. Finally, treatment with BMW effectively suppressed the growth of vascular endothelial growth factor(VEGF) added human umbilical vein endothelial cells. Overall, these results suggest that BMW has anti-cancer activity.