• 한국동물생명공학회지
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• 제36권1호
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• pp.17-24
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• 2021

In this study, the potential toxicity of isoprocarb was demonstrated using zebrafish embryos. We treated isoprocarb (0, 29, and 58 mg/L) to the zebrafish embryos for 72 h then, we estimated morphological changes and apoptotic cell numbers. The increasing extent of apoptosis from the anterior to posterior region of developing zebrafish larvae was correlated with toxicity in the overall development process, including growth and normal organ formation. The appearance of abnormalities in the isoprocarb-treated groups in comparison to normal developing zebrafish larvae was verified using quantitative image analysis based on ImageJ software program. The vascular system comprising a complex interconnection of blood vessels was visualized in vessel-fluorescent transgenic zebrafish (fli1:eGFP). The main vasculature was malformed on isoprocarb treatment, and this was also related to cardiac defects. Taken together, normal embryonic development in zebrafish was interrupted owing to the acute toxicity of isoprocarb.

• Journal of Ginseng Research
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• 제47권4호
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• pp.506-514
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• 2023

Dementia has become one of the most important diseases threatening human health. Alzheimer's disease (AD) and vascular dementia (VaD) have the highest incidence rates among the types of dementia, but until now, therapeutic methods have been limited. Panax ginseng has been used in China for thousands of years to treat dementia, and modern medical studies have found that it contains multiple active components, such as ginsenosides, polysaccharides, amino acids, volatile oils and polyacetylenes, many of which have therapeutic effects in treating AD and VaD. Studies have found that ginsenosides have multitarget therapeutic effects in treating dementia, such as regulation of synaptic plasticity and the cholinergic system, inhibition of Aβ aggravation and tau hyperphosphorylation, anti-neuroinflammation, anti-oxidation effects and anti-apoptosis effects. Other active components of Panax ginseng, such as gintonin, oligosaccharides, polysaccharides and ginseng proteins, also have therapeutic effects on AD and VaD. The effectiveness of ginseng-containing Chinese medicine compounds has also been confirmed by clinical and basic investigations in treating AD and VaD. In this review, we summarized the potential therapeutic effects and related mechanisms of Panax ginseng in treating AD and VaD to provide some examples for further studies.

• Smart Structures and Systems
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• 제16권4호
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• pp.593-606
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• 2015

This paper presents a novel concept of healing some of the damages in wind turbine blades (WTBs) such as cracks and delamination. This is achieved through an inherent functioning autonomous repairing system. Such wind turbine blades have the benefit of reduced maintenance cost and increased operational period. Previous techniques of developing autonomous healing systems uses hollow glass fibres (HGFs) to deliver repairing fluids to damaged sites. HGFs have been reported with some limitations like, failure to fracture, which undermines their further usage. The self-healing technique described in this paper represents an advancement in the engineering of the delivery mechanism of a self-healing system. It is analogous to the HGF system but without the HGFs, which are replaced by multiple hollow channels created within the composite, inherently in the FRP matrix at fabrication. An in-house fabricated NACA 4412 WTB incorporating this array of network hollow channels was damaged in flexure and then autonomously repaired using the vascular channels. The blade was re-tested under flexure to ascertain the efficiency of the recovered mechanical properties.

• Journal of Ginseng Research
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• 제20권4호
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• pp.416-430
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• 1996

With the progress of chemical researches in ginseng studies, efforts to elucidate the pharmacological actions of ginseng have been greatly increased. The majority of ginseng reaserches in the past has been performed with crude extracts from ginseng roots to verify scientifically the empirical application of ginseng in men and animals recently. Ginseng reaserches have been done mostly with pure ginsenosides and there has been a shift in focus to the various biochemical pathways. It was demonstvated that ginseng had diverse effects by modulating the second-messenger system, such as cyclic nucleotides. calcium The demonstration in 1987 of the formation of nitric oxide(NO, endothelium-derlled rectating factor) by an enzyme in vascular endothelial cells opened up a new area of biological reaserches of ginseng. It was shown that vascular relaxations induced by glnsenosides are mediated by release of nitric oxide from endothelial cells. According to the literature search from'hledline". There have been 737 original and review articles during the last 30 years. In these review articles, an attempt has been made to summalize some results from some of these published papers. Ginseng has a wide range of phal.macologtcal and therapeutical actions. It acts on the centralral nervous system and cardiovascular system, promotes immune function and metabolism. Possesses anti-stress. Anti-cancer and anti-ageing activities, and so on.o on.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.136-143
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• 2019

Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology, characterized by bilateral steno-occlusive changes at the terminal portion of the internal carotid artery and an abnormal vascular network formation at the base of the brain. MMD has an intrinsic nature to convert the vascular supply for the brain from internal carotid (IC) system to the external carotid (EC) system, as indicated by Suzuki's angiographic staging. Insufficiency of this 'IC-EC conversion system' could result not only in cerebral ischemia, but also in intracranial hemorrhage from inadequate collateral anastomosis, both of which represent the clinical manifestation of MMD. Surgical revascularization prevents cerebral ischemic attack by improving cerebral blood flow, and recent evidence further suggests that extracranial-intracranial bypass could powerfully reduce the risk of re-bleeding in MMD patients with posterior hemorrhage, who were known to have extremely high re-bleeding risk. Although the exact mechanism underlying the hemorrhagic presentation in MMD is undetermined, most recent angiographic analysis revealed the characteristic angio-architecture related to high re-bleeding risk, such as the extension and dilatation of choroidal collaterals and posterior cerebral artery involvement. We sought to update the current management strategy for hemorrhagic MMD, including the outcome of surgical revascularization for hemorrhagic MMD in our institute. Further investigations will clarify the optimal surgical strategy to prevent hemorrhagic manifestation in patients with MMD.

• 대한물리의학회지
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• 제17권4호
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• pp.27-35
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• 2022

PURPOSE: A Mat Pilates exercise program and a stretching program were conducted for elderly women to determine how the two interventions affect their autonomic nervous system. METHODS: The subjects of this study were 20 elderly women over 65 who regularly used a welfare center located in C city of Chungnam. The subjects were assigned randomly to the following two groups: 10 people in the breathing and mat Pilates exercise program group (PG) and 10 people in the breathing and stretching program group (SG). RESULTS: The present study design is randomized controlled trial. Vascular age was decreased significantly in the PG (p < .05). The mean stress index was reduced significantly in the PG (p < .05), and the amount of change was significantly larger in the PG than in the SG (p < .05). The health index was significantly lower in the PG than the SG (p < .05), and the amount of change in the PG was significantly more prominent than in the SG (p < .05). CONCLUSION: The Mat Pilates program was effective in improving the vascular age, average stress index, and health index of elderly women. In particular, it was significantly more effective than the stretching exercise program in improving the average stress and health indices.

• 대한수의학회지
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• 제28권1호
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• pp.137-143
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• 1988

국내(國內)에서 분리(分離)된 porcine enterovirus(serotype 3)를 초유(初乳)를 섭취(攝取)하지 않은 자돈(仔豚)에 경구감염(經口感染) 시킨 후 회백뇌척수염(灰白腦脊髓炎)을 나타내는 시기(時期)에 중추신경계(中樞神經系) 혈관내피세포(血管內皮細胞)를 전자현미경적(電子顯微鏡的)으로 관찰(觀察)하였던 바 다음과 같은 결과(結果)를 얻었다. 척수(脊髓) 및 소뇌(小腦) 혈관내피세포(血管內皮細胞)에서는 picornavirus의 특징적(特徵的)인 virus결정체(結晶體)가 출현(出現)하였고 virus결정체(結晶體)는 rough ER과 밀접하게 연결되어 있었으며 수막(髓膜)의 혈관내피세포(血管內皮細胞)에서도 전자밀도(電子密度)가 높은 virus양(樣) 입자(粒子)들의 응집체(凝集體)가 관찰(觀察)되었다. 세포소기관(細胞小器官)의 변화(變化)로는 mitochondria의 확장(擴張)과 cristae의 소실(消失), rough ER의 확장(擴張)과 ribosome의 탈락(脫落)이 현저하였다. 또한 혈관주위강(血管周圍腔)의 확장(擴張)과 임파구(淋巴球)의 침윤(浸潤), 현관내피세포(血管內皮細胞)의 세포막(細胞膜)과 기저막(基底膜)의 파괴(破壞)가 인정(認定)되었다.

• 한국환경복원기술학회지
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• 제11권2호
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• pp.66-74
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• 2008

In recent years, the view centered conservation for eco-system is getting important rather than development from human oriented perspective. As a result, the concept "Sustainable development", that is seeking harmony between conservation and development, appeared so that we researched distribution and status of vascular plants a site of project in the Bukkyungnam substation. The main findings from the study is as follows. The vascular plants a site of project in the Bukkyungnam substation area was listed 435 taxa; 93 families, 269 genera, 377 species, 1 subspecies, 51 varieties and 6 forms. Specific plant species by floral region were total 25 taxa; Acer palmatum (Planted species), Asperula lasiantha in Class III, Caryopteris incana, Cirsium schantarense in Class II, 21 taxa (Dryopteris erythrosora, Chloranthus japonicus, Salix glandulosa, Alnus hirsuta, Quercus variabilis, Ulmus parvifolia, Clematis patens, Rubus hirsutus, Euphorbia pekinensis, Cayratia japonica, Grewia biloba var. parviflora, Vaccinium oldhami, Microstegium japonicum, Hosta capitata, Polygonatum falcatum, etc.) in Class I. Based on the list of Korean endemic plants, 10 taxa were recorded; Cephalotaxus koreana, Populus tomentiglandulosa (Planted species), Indigofera koreana, Forsythia koreana (Planted species), Paulownia coreana (Planted species), Asperula lasiantha, Weigela subsessilis, Adenophora triphylla var. hirsuta, Carex okamotoi, Lilium amabile and based on the list of the rare plants by the Forest ResearchInstitute, 2 taxa were recorded in the studied areas; Lilium callosum (Preservation priority order; No. 191), Aristolochia contorta (No. 151). The naturalized plants in this site were 13 families, 22 genera, 28 taxa and naturalization rate was 6.4% of all 435 taxa vascular plants.

• BMB Reports
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• 제41권2호
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• pp.164-169
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• 2008

The tumor suppressor gene p53 regulates apoptotic cell death and the cell cycle. In this study, we investigated the role of p53 in nitric oxide (NO)-induced apoptosis in vascular smooth muscle cells (VSMCs). We found that the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) increased apoptotic cell death in p53-deficient VSMCs compared with wild-type cells. The heme oxygen-ase (HO) inhibitor tin protoporphyrin IX reduced the resistance of wild-type VSMCs to SNAP-induced cell death. SNAP promoted HO-1 expression in both cell types. HO-2 protein was increased only in wild-type VSMCs following SNAP treatment; however, similar levels of HO-2 mRNA were detected in both cell types. SNAP significantly increased the levels of non-heme-iron and dinitrosyl iron-sulfur clusters in wild-type VSMCs compared with p53-deficient VSMCs. Moreover, pretreatment with FeSO4 and the carbon monoxide donor CORM-2, but not biliverdin, significantly protected p53-deficient cells from SNAP-induced cell death compared with normal cells. These results suggest that wild-type VSMCs are more resistant to NO-mediated apoptosis than p53-deficient VSMCs through p53-dependent up-regulation of HO-2.

• 융합정보논문지
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• 제12권4호
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• pp.119-125
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• 2022

심혈관계 활성이 예측되는 phenylephrine, isoprenaline, prazosin의 단독 및 병용 투여에서 혈관수축 억제능을 관찰하였고 아직 보고가 빈약한 수축성 조절 기전에 대해 조직 선택적 조절 가설을 세워서 조사하였다. 내피가 손상된 혈관을 수조내에 현수시켰고 혈관에 의한 기계적 신호가 등장력 변환기에서 전기적 신호로 변환되어 생리측정기에 표시되었다. 내피가 손상된 혈관에서 phenylephrine은 조직에 비선택적으로 지속적인 수축을 유지하였고 phenylephrine과 병용된 isoprenaline은 등척성 수축 실험에서 흉부, 복부 대동맥 등 조직에 비선택적으로 평활근에 대한 직접 작용으로 수축성을 일시적으로 감소시켰고 phenylephrine과 병용된 prazosin은 조직에 비선택적으로 평활근에 대한 직접 작용으로 수축성을 지속적으로 감소시켰다. 따라서 일부 조직에서 adrenergic beta receptor 밀도가 감소되거나 수용체 결합력이 감소되거나 수용체 결합 후 신호전달이 감소되거나 약물의 분포가 감소되어 isoprenaline이 phenylephrine의 지속적 작용에 대해 일시적으로 억제하고 prazosin이 지속적으로 억제하는 것으로 생각된다.