• 한국전자통신학회논문지
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• 제8권11호
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• pp.1777-1784
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• 2013

본 연구는 필라테스 매트 운동을 통해 신체조성과 혈관탄성도의 변화를 확인하고 향후 노인 건강 증진을 위한 운동프로그램시 근거자료로 활용하고자 시도하였다. 노인 여성 30명을 대상으로 대조군과 운동군으로 분류하여 운동군은 1회 60분씩, 매주 3회 총 12주간 필라테스 매트 운동을 실시하였다. 신체조성에서는 골격근량(p<.01)과 체지방률(p<.01)이 통계적으로 유의한 감소가 있었고, 체지방량에서는 통계적으로 유의한 차이가 없었다. 혈관탄성도에서는 수축기 혈압(p<.01)과 말초 동맥압(p<.01)이 통계적으로 유의한 감소가 있었고, 이완기혈압과 대동맥압에서는 통계적으로 유의한 차이가 없었다.. 결론적으로 12주간 필라테스 매트 운동은 노인 여성의 신체조성과 혈관탄성도에 긍정적인 효과가 있음을 알 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제36권6호
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• pp.251-263
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• 2015

Scaffolds play a crucial role in the tissue engineering. Biodegradable polymers with great processing flexibility and biocompatability are predominant scaffolding materials. New developments in biodegradable polymers and their nanocomposites for the tissue engineering are discussed. Recent development in the scaffold designs that mimic nano and micro features of the extracellular matrix (ECM) of bones, cartilages, and vascular vessels are presented as well.

• Journal of Chest Surgery
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• 제55권3호
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• pp.197-205
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• 2022

Background: The integrated design of the HeartMate 3 (Abbott Laboratories, Chicago, IL, USA) affords flexibility to place the pump within the pericardium or thoracic cavity. We sought to determine whether the presence of a left ventricular assist device (LVAD) in either location has a meaningful impact on overall patient outcomes. Methods: A retrospective cohort study was conducted of all 165 patients who received a HeartMate 3 LVAD via a median sternotomy from November 2014 to August 2019 at our center. Based on operative reports and imaging, patients were divided into intrapleural (n=81) and intrapericardial (n=84) cohorts. The primary outcome of interest was in-hospital mortality, while secondary outcomes included postoperative complications, cumulative readmission incidence, and 3-year survival. Results: There were no significant between-group differences in baseline demographics, risk factors, or preoperative hemodynamics. The overall in-hospital mortality rate was 6%, with no significant difference between the cohorts (9% vs. 4%, p=0.20). There were no significant differences in the postoperative rates of right ventricular failure, kidney failure requiring hemodialysis, stroke, tracheostomy, or arrhythmias. Over 3 years, despite similar mortality rates, intrapleural patients had significantly more readmissions (n=180 vs. n=117, p<0.01) with the most common reason being infection (n=68/165), predominantly unrelated to the device. Intrapleural patients had significantly more infection-related readmissions, predominantly driven by non-ventricular assist device-related infections (p=0.02), with 41% of these due to respiratory infections compared with 28% of intrapericardial patients. Conclusion: Compared with intrapericardial placement, insertion of an intrapleural HM3 may be associated with a higher incidence of readmission, especially due to respiratory infection.

• Journal of Yeungnam Medical Science
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• 제36권3호
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• pp.183-191
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• 2019

Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated with a decrease in the speed of information processing, psychomotor efficiency, attention, mental flexibility, and visual perception. Longitudinal epidemiological studies of type 1 DM have indicated that chronic hyperglycemia and microvascular disease, rather than repeated severe hypoglycemia, are associated with the pathogenesis of DM-related cognitive dysfunction. However, severe hypoglycemic episodes may contribute to cognitive dysfunction in high-risk patients with DM. Type 2 DM has been associated with memory deficits, decreased psychomotor speed, and reduced frontal lobe/executive function. In type 2 DM, chronic hyperglycemia, long duration of DM, presence of vascular risk factors (e.g., hypertension and obesity), and microvascular and macrovascular complications are associated with the increased risk of developing cognitive dysfunction. The pathophysiology of cognitive dysfunction in individuals with DM include the following: (1) role of hyperglycemia, (2) role of vascular disease, (3) role of hypoglycemia, and (4) role of insulin resistance and amyloid. Recently, some investigators have proposed that type 3 DM is correlated to sporadic Alzheimer's disease. The molecular and biochemical consequences of insulin and insulin-like growth factor resistance in the brain compromise neuronal survival, energy production, gene expression, plasticity, and white matter integrity. If patients claim that their performance is worsening or if they ask about the effects of DM on functioning, screening and assessment are recommended.

• 산업융합연구
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• 제21권3호
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• pp.171-179
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• 2023

본 연구는 중년여성 18명을 대상으로 저항성 운동군 A그룹 6명(1RM 40-60%), 유산소 운동군 B그룹 6명(VO2max 60-70%), 유연성 운동군 C그룹(10~60 sec/sets) 6명으로 무선 배정하여 12주간 주 3회(월, 수, 금) 1일 50~60분의 운동 형태에 따른 신체구성과 염증인자, 혈관내피 성장인자에 미치는 영향을 알아보기 위하여 비교·분석한 결과, 첫째, 염증인자의 변화에서는 CRP 및 IL-6의 시기의 주효과에서는 유의한 차이(p<.05)가 나타났다. 둘째, 혈관내피 성장인자의 변화에서는 VEGF의 시기의 주효과 및 시기×그룹의 상호작용에서는 유의한 차이(p<.05)가 나타났다. 본 연구의 결과를 토대로 운동 형태에 따른 염증인자와 혈관내피 성장인자에 관한 다양한 각도의 연구와 개선을 위한 기초 자료로 활용되기를 기대한다.

• Archives of Reconstructive Microsurgery
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• 제8권2호
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• pp.115-119
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• 1999

In breast reconstruction with a free flap following mastectomy, the recipient vessels most widely used are in the axillary system, which limits flap movement and flexibility in breast shaping. In addition, scarring and fibrosis can make dissection of the vessels difficult. We have performed 43 breast reconstructions using a free transverse rectus abdominis myocutaneous(TRAM) flap. In 10 cases out of 20 delayed reconstruction, we anastomosed to the internal mammary vessels rather than subscapular system. There has been no flap failure. The surgical techniques, advantages and limitations of the internal mammary system are presented. The internal mammary vessel are compared with the axillary vessels as a recipient vascular system.

• 생명과학회지
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• 제15권2호
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• pp.220-224
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• 2005

1년간의 운동이 남성 치매환자의 운동능력과 인지기능에 미치는 영향을 연구한 결과, 운동군의 경우 심폐지구력, 근력, 근지구력 및 MMSE는 운동전에 비해 운동중과 운동후 유의하게 증가하였고, 평형성과 민철성은 운동후 유의하게 증가하였으나 유연성은 유의한 차이가 없었다. 반면, 통제군은 모든 시기에서 유의한 차이가 나타나지 않았다. 이상의 결과를 볼 때, 1년간의 운동은 남성 치매환자의 운동능력과 인지기능을 향상시켜 환자들에게 자신감과 성취감을 얻을 수 있는 기회를 주었고, 나아가 독립적인 일상생활을 영위하고 삶의 질을 높이는데 크게 이바지 할 것으로 기대된다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.280-283
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• 1997

Human cervical spine has to protect the neural components and vascular structures. Also, it must have the flexibility afforded by an extensive range of motion to integrate the head with the body and environment. Because of these two-sided features, human cervical spine has very complicated shapes and their injury mechanisms are not fully understood yet. We have developed analytical model of human CS by using the finite element method. The model has been verified with in vivo and in vitro experimental results. From the qualitative analysis of simulation results, we were able to explain some of the fundamental mechanisms of neck pain. Further more, this FE model of human CS can be used as an analytical tool or biomechanical design of the clinical device and safety restraints.

• International Journal of Industrial Entomology and Biomaterials
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• 제1권1호
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• pp.59-64
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• 2000

The preparation of PVA/Chitosan/Fibroin (PCF)-blended sponge sheets and wound healing effects of these sheets in rats were investigated. We excised the skin off rat, including the dermis, approximately 2${\times}$2 cm in size. The wound was coveted with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12 days later showed the increase of a vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroini alone of in various combinations. Wound healing was accelerated in the order of PVA/chitosan/Fibroin (PCF)-blended sponge>Chitosan/Fibroin (CF)-blended sponge$\geq$Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

• 대한관절경학회지
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• 제10권2호
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• pp.135-140
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• 2006

불안정성 견관절에 대한 진단과 치료는 정형외과 영역에서 가장 어려운 분야 중에 하나이다. 관절와 위에서 움직이는 상완골두의 아탈구와 정상적인 전이, 통증과 기능 저하를 일으키는 이완의 정도는 구별하기가 용이하지 않는 경우가 많다. 불행하게도 이 불안정성을 일으키는 모든 병변에 시행할 수 있는 가장 좋은 한가지의 치료법은 개발되어 있지 않다. 그러므로 불안정성의 방향과 정도뿐만 아니라 동반된 문제까지도 정확히 진단하는 것이 절대 필요하다. 해부학적 결손은 반드시 확인해야 한다. 불안정성에 대한 봉합술의 실패에 영향을 미칠 수 잇는 흔한 요인은 다음과 같다. 정확한 해부학적 병리소견을 확인하는 올바른 진단, 올바른 치료 방법에 대한 이유, 필요 없는 내고정물의 사용이나 불안정성, 관절염, 신경 및 혈관 손상 등을 남길 수 있는 도달법의 사용과 같은 기술적 결함 등이 있다. 술후 견관절의 안정성, 유연성, 지구력을 회복시켜 강도높은 스포츠나 노동에 복귀할 수 있는 잘 준비된 재활을 통해 추가적인 손상을 막아야 한다.