• Korean Journal of Mathematics
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• 제30권3호
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• pp.539-553
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• 2022

In the present paper, we aim to obtain several approximation properties of Stancu form Szász-Mirakjan-Durrmeyer operators based on Bézier basis functions with shape parameter λ ∈ [-1, 1]. We estimate some auxiliary results such as moments and central moments. Then, we obtain the order of convergence in terms of the Lipschitz-type class functions and Peetre's K-functional. Further, we prove weighted approximation theorem and also Voronovskaya-type asymptotic theorem. Finally, to see the accuracy and effectiveness of discussed operators, we present comparison of the convergence of constructed operators to certain functions with some graphical illustrations under certain parameters.

• 대한수의학회지
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• 제51권4호
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• pp.267-275
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• 2011

Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is one of the most important nosocomial pathogens worldwide and the emergence of this strain has become a major clinical problem. In this study, we investigated the prevalence of MRSA and their genetic characteristics in 69 S. aureus isolated from humans and animals. In human isolates, higher antimicrobial resistance rates were observed against penicillin (80.6%), followed by erythromycin (11.9%) and tetracycline (9.0%). All of them were susceptible to clindamycin, enrofloxacin, novobiocin, pirlimycin, trimethoprim/sulfamethoxazole and vancomycin. The resistance patterns in animal isolates were similar to those of human isolates. Two (2.9%) MRSA strains were isolated from human (n = 1) and animal (n = 1), and these isolates were confirmed as carrying the mecA gene. One isolate originating from human was resistant to 7 drugs and the other isolate derived from animal was resistant to 11 drugs. Staphylococcal cassette chromosome mec (SCCmec) variant IIIB was identified in animal isolate but SCCmec type of an isolate from human was not exactly determined. Two MRSA isolates showed unrelated PFGE pattern between them. Our results indicated although the frequency of MRSA isolates from humans and animals was low, a continuous surveillance and monitoring should be called for to prevent the contamination and spread of MRSA in the community. To our knowledge, this is the first time that SCCmec type variant IIIB was detected from animals in Korea.

• Plant Resources
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• 제7권2호
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• pp.141-146
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• 2004

Frequent occurrence of off-type plants in a given cultivar has been a serious problem in both breeder's and farmer's fields. An experiment was designed to examine the differences in rate of occurrence of off-type plants among Tongil-type cultivars (high yielding cultivars derived from indica/japonica hybridization) from which the possible cause of higher occurrence of off-type plant in a specific cultivar was deduced. Among five Tongil-type cultivars examined for morphological variant in the field, only one cultivar, Dasanbyeo, had off-type plants. When analyzed with SSR markers, off-type plants showed different band patterns from original cultivar, having several extra bands in addition to cultivar-specific band, suggesting that off-type plants were originated from Dasanbyeo, rather than originated from mixing or mishandling of seed materials with other cultivars. The possible cause of off-type occurrence seems to be natural pollination with other cuItivars adjacent to the original cultivar during seed multiplication. This was supported from the observation that self-crossed progeny of the off type plants showed a wide range of variation of agronomic traits which could not be observed when there was a smaller introduction of genes to the fixed germplasm as happened in the case of cultivar mutation. Another evidence supported this idea that Dasanbyeo showed much of difference in floral organ and behavior to other cultivar to be subjected to higher out-crossing than other cultivars examined.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6403-6409
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• 2013

Purpose: Biallelic germline variants of the 8-hydroxyguanine (8-OG) repair gene MYH have been associated with colorectal neoplasms that display somatic $G:C{\rightarrow}T:A$ transversions. However, the effect of single germline variants has not been widely studied, prompting the present investigation of monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC) in a Chinese population. Patients and Methods: Between January 2006 and December 2012, 400 cases of sporadic CRC and 600 age- and sex-matched normal blood donors were screened randomly for 7 potentially pathogenic germline MYH exons using genetic testing technology. Variants of heterozygosity at the MYH locus were assessed in both sporadic cancer patients and healthy controls. Univariate and multivariate analyses were performed to determine risk factors for cancer onset. Results: Five monoallelic single nucleotide polymorphisms (SNPs) were identified in the 7 exon regions of MYH, which were detected in 75 (18.75%) of 400 CRC patients as well as 42 (7%) of 600 normal controls. The region of exon 1 proved to be a linked polymorphic region for the first time, a triple linked variant including exon 1-316 $G{\rightarrow}A$, exon 1-292 $G{\rightarrow}A$ and intron 1+11 $C{\rightarrow}T$, being identified in 13 CRC patients and 2 normal blood donors. A variant of base replacement, intron 10-2 $A{\rightarrow}G$, was identified in the exon 10 region in 21 cases and 7 controls, while a similar type of variant in the exon 13 region, intron 13+12 $C{\rightarrow}T$, was identified in 8 cases and 6 controls. Not the only but a newly missense variant in the present study, p. V463E (Exon 14+74 $T{\rightarrow}A$), was identified in exon 14 in 6 patients and 1 normal control. In exon 16, nt. 1678-80 del GTT with loss of heterozygosity (LOH) was identified in 27 CRC cases and 26 controls. There was no Y165C in exon 7 or G382D in exon 14, the hot-spot variants which have been reported most frequently in Caucasian studies. After univariate analysis and multivariate analysis, the linked variant in exon 1 region (p=0.002), intron 10-2 $A{\rightarrow}G$ (p=0.004) and p. V463E (p=0.036) in the MYH gene were selected as 3 independent risk factors for CRC. Conclusions: According to these results, the linked variant in Exon 1 region, Intron 10-2 $A{\rightarrow}G$ of base replacement and p. V463E of missense variant, the 3 heterozygosity variants of MYH gene in a Chinese population, may relate to the susceptibility to sporadic CRC. Lack of the hot-spot variants of Caucasians in the present study may due to the ethnic difference in MYH gene.

• Genomics & Informatics
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• 제2권3호
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• pp.126-130
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• 2004

T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The protein known as signal transducers and activators of transcription 6 (STAT6) is a key transcription factor involved in both IL-4- and -13-mediated biological responses. Two polymorphisms of the STAT 6 gene (exon 1 and G2964A variant) have been found. We investigated whether these STAT6 gene polymorph isms were associated with allergic rhinitis. Blood samples for genetic analysis were obtained from 285 individuals with allergic rhinitis and from 271 healthy subjects without atopic disease. The G2964A variant of the STAT6 gene was genotyped using PCR-RFLP analysis. The GT repeat polymorphism in exon 1 of the STAT6 gene was genotyped by fragment analysis. There was no association between the 2964A variant and GT repeat polymorphism in exon 1 of the STAT6 and allergic rhinitis in a Korean population (both p > 0.05). Our results suggest that a combination of STAT6 gene polymorphisms is not a useful marker for predicting allergic rhinitis.

• Mycobiology
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• 제32권2호
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• pp.88-94
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• 2004

Protoplasts of the wild type strain of Pleurotus osteatus were mutagenized with UV light, and 3,000 colonies were examined for abnormal mycelial and fruiting phenotypes. Forty one strains displayed variant phenotypes in mycelia and fruiting processes. The variant phenotypes were classified into 6 groups: (1) auxotrophic strains, which are incapable of growing on minimal media and can only grow when provided with their specific requirements; (2) abnormal vegetative strains, which grow very slowly on minimal and complete media; (3) primordiumless strains, which fail to develop to the formation of primordia; (4) maturationless strains, which form primordia, but do not form mature fruiting bodies; (5) specifically colored strains, which have Specific bluish grey or bluish white pileus; (6) poorly spored strains, which fail to produce basidiospore or which produce few spores. These variant strains may be useful in genetic breeding programs and for the studies of fungal development and genetics.

• 한국전산구조공학회논문집
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• 제29권1호
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• pp.53-60
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• 2016

본 연구는 NO96 화물창의 BOG(boil off gas), BOR(boil off rate)을 감소시키기 위한 노력으로 단열재료 및 단열층을 변화시켜서 개발된 NO96-GW, NO96-L03의 방열구조에 대해서 BOG, BOR 값을 계산하고 단열성능을 비교 평가하였다. 두가지의 변형된 NO96 모델을 기존의 NO96 방열과 단열층 및 단열재료의 차이점을 비교하고, 각각의 열저항 및 BOG/BOR 값의 비교 결과를 제시하였다. 열저항 값은 유한요소해석법을 이용하여 계산되었으며, 준정적 열평형 상태를 가정하여 열유속과 온도분포를 통하여 단열성능을 비교하였다. 계산에 사용된 화물창의 모든 재료물성치는 온도 의존값으로서 반영하여 $-163^{\circ}C$에서의 극저온 상태에서 특성을 반영되었다. 각 화물창의 BOG, BOR 계산은 국부 열전달 해석을 통해 방열판에서 발생하는 열유속을 계산하고, 등가모델을 적용하여 계산하는 과정으로 수행되었으며, 그 결과를 각 화물창의 단열성능을 비교 평가하기 위해서 검토하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제14권1_2호
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• pp.160-168
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• 1992

저자는 31세 여자환자의 좌측하악부에서 매복된 제3대구치 주위의 함치성 낭종에서 기원한 Group 3a type의 다방성의 낭종성 법랑아세포종을 경험하여 병소에 포함된 치아 발거슬 및 enucleation/curettage로 현재까지 재발없이 치유되었기에 병리조직학적 소견을 중심으로 문헌고찰과 함께 보고하는 바이다.

• Parasites, Hosts and Diseases
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• 제61권2호
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• pp.154-162
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• 2023

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked recessive disorderliness. It induces severe anemia when a patient with G6PD deficiency is exposed to oxidative stress that occurs with administration of an antimalarial drug, primaquine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be important in Myanmar.

• Journal of Microbiology and Biotechnology
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• 제33권12호
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• pp.1587-1594
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• 2023

Since its first report in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a grave threat to public health. Virus-specific countermeasures, such as vaccines and therapeutics, have been developed and have contributed to the control of the viral pandemic, which has become endemic. Nonetheless, new variants continue to emerge and could cause a new pandemic. Consequently, it is important to comprehensively understand viral evolution and the roles of mutations in viral infectivity and transmission. SARS-CoV-2 beta variant encode mutations (D614G, N501Y, E484K, and K417N) in the spike which are frequently found in other variants as well. While their individual role in viral infectivity has been elucidated against various therapeutic antibodies, it still remains unclear whether those mutations may act additively or synergistically when combined. Here, we report that N501Y mutation shows differential effect on two therapeutic antibodies tested. Interestingly, the relative importance of E484K and K417N mutations in antibody evasion varies depending on the antibody type. Collectively, these findings suggest that continuous efforts to develop effective antibody therapeutics and combinatorial treatment with multiple antibodies are more rational and effective forms of treatment.