• Title/Summary/Keyword: Variance of Analysis

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Bioequivalence Evaluation of the Tiropramide Formulation by GC/MS (티로프라미드 주사제의 생물학적 동등성 평가를 위한 GC/MS 방법)

  • Myung, Seung-Woon;Kim, Myungsoo;Kim, Hye-Young;Kwak, Hyun-Tae;Min, Hye-Ki;Sohn, Dong-Ryul;Hong, Young-Hun
    • Analytical Science and Technology
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    • v.14 no.3
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    • pp.221-229
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    • 2001
  • The bioequivalence study of two tiropramide products was evaluated in 16 health male volunteers following intra-muscular injection. Test product was Tiram$^{(R)}$ injection (S Pharm. Co, Ltd.) and reference product was Tiropa$^{(R)}$ injection(D Pharm. Co., Ltd.). The drug concentration in plasma was determined by GC/MS for over a period of 8 hours after injection. Analysis of variance reveal that there are no differences in AUC (area under the plasma concentration-time curve from time zero to infinity), Cmax (maximum plasma concentration) and Tmax (time to reach Cmax). The differences of mean AUC, Cmax and Tmax between two products were 0.73, -1.385 and -12.994%, respectively. Minimum detectable differences (%) at ${\alpha}=0.05$ were all less than 20% given as a guideline (10.05, 17.90 and 19.01% for AUC, Cmax and Tmax, respectively). From these results, the two formulations of tiropramide are bioequivalent and thus, may be prescribed interchangeably.

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Prediction of weight loss of low temperature storage tomato (Tiwai 250) by non-destructive firmness measurement (비파괴적인 경도 측정을 통한 저온저장 토마토(티와이250)의 감모율 예측)

  • Cui, Jinshi;Yoo, Areum;Yang, Myongkyoon;Cho, Seong In
    • Food Science and Preservation
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    • v.24 no.2
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    • pp.181-186
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    • 2017
  • This study was conducted to investigate the weight loss, firmness, external color and vitamin C (VC) content of tomatoes (Lycopersicon esculentum) using non-destructive method to measure identical tomato samples during 15 days storage at low temperature and high humidity. Tomatoes were harvested at the light red stage, sorted, box packed and then stored in thermo-hygrostat ($10{\pm}1^{\circ}C$, $90{\pm}10%RH$). The quality changes in weight loss, firmness and external color were measured every 3 day interval. Weight loss was increased by $1.13{\pm}0.15%$, but it may not be considered to affect quality. Surface color of fruit was changed, especially in lightness and hue angle value. The color values were analyzed by analysis of variance (ANOVA), and the results were significant (p<0.001). Firmness of fruit declined during storage, but it did not decrease in direct proportion. On the storage of day 15, firmness was decreased to 40% of initial state. At last, all the experiment data are summarized and the relationship between firmness and weight loss is analyzed to construct a linear regression mathematical model that can predict the weight loss with the firmness value measured by non-destructive method. This research result could be useful in helping tomato exporters and suppliers to get real-time quality factor by using proposed method and regression model.

Variation of Determinant Factor for Seoul Metropolitan Area's Housing and Rent Price in Korea (수도권 주택가격 결정요인 변화 연구)

  • Lee, Kyung-Ae;Park, Sang-Hak;Kim, Yong-Soon
    • Land and Housing Review
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    • v.4 no.1
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    • pp.43-54
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    • 2013
  • This This paper investigates the variation of the factors to determinate housing price in Seoul metropolitan area after sub-prime financial crisis, in Korea, using a VAR model. The model includes housing price and housing rent (Jeonse) in Seoul metropolitan area from 1999 to 2011, and uses interest rate, real GDP, KOSPI, Producer Price Index and practices to impulse response and variance decomposition analysis to grasp the dynamic relation between a variable of macro economy and and a variable of housing price. Data is classified to 2 groups before and after the 3rd quater of 2008, when sub-prime crisis occurred; one is from the 1st quater of 1999 to the 3rd quater of 2008, and the other is from the 2nd quater of 1999 and the 4th quater of 2011. As a result, comparing before and after sub-prime crisis, housing price is more influenced by its own variation or Jeonse price's variation instead of interest rate and KOSPI. Both before and after sub-prime financial crisis, Jeonse price is also influenced by its own variation and housing price. While after sub-prime financial crisis, influences of Producer Price Index, KOSPI and interest rate were weakened, influence of real GDP is expanded. As housing price and housing rent are more influenced by real economy factors such as GDP, its own variation than before sub-prime financial crisis, the recent trend that the house prices is declined is difficult to be converted, considering domestic economic recession and uncertainty, continued by Europe financial crisis. In the future to activate the housing business, it ia necessary to promote purchasing power rather than relaxation of financial and supply regulation.

Effect of Different Surface Treatment on the Shear Bond Strength between Yttria-Tetragonal Zirconia Polycrystal and Non-10-Methacryloyloxydecyl Dihydrogen Phosphate-Containing Resin Cement

  • Lee, Yoon;Yi, Young-Ah;Kim, Sin-Young;Seo, Deog-Gyu
    • Journal of Korean Dental Science
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    • v.7 no.2
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    • pp.49-57
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    • 2014
  • Purpose: To evaluate the effect of different surface treatment methods (yttria-tetragonal zirconia polycrystal [Y-TZP] primers, air-abrasion, and tribochemical surface treatment) on the shear bond strength between (Y-TZP) ceramics and etch-and-rinse non-10-methacryloyloxydecyl dihydrogen phosphate (MDP)-containing resin cements. Materials and Methods: Y-TZP ceramic surfaces were ground flat with 600-grit silicone carbide abrasives paper and then divided into seven groups of ten. They were treated as the following: untreated (control), Monobond Plus (IvoclarVivadent), Z-PRIME Plus (Bisco Inc.), ESPE Sil with CoJet (3M ESPE), air-abrasion, Monobond Plus with air-abrasion, and Z-PRIME Plus with air-abrasion. The surface of Y-TZP specimens was analyzed under a scanning electron microscope (SEM). Non-MDP-containing cements were placed on the surface-treated Y-TZP specimens. After thermocycling, shear bond strength test was performed. Bond strength values were statistically analyzed using one-way analysis of variance and Student-Newman-Keuls multiple comparison test (P<0.05). Result: The Z-PRIME Plus treatment in combination with air-abrasion produced the highest bond strength ($14.94{\pm}1.70MPa$) followed by Monobond Plus combined with air-abrasion ($10.70{\pm}1.71MPa$), air-abrasion ($10.47{\pm}1.60MPa$), ESPE Sil after CoJet treatment ($10.38{\pm}0.87MPa$), Z-PRIME Plus application ($10.00{\pm}1.70MPa$), and then Monobond Plus application ($9.25{\pm}0.86MPa$). The control ($6.70{\pm}1.49MPa$) indicated the lowest results (P<0.05). The SEM results showed different surface morphologies according to surface treatment methods compared with the Y-TZP control. Conclusion: The shear bond strength between the Y-TZP ceramic and the non-MDP-containing resin cement was the greatest when the surface was treated with air-abrasion and MDP-containing Z-PRIME Plus primer.

Health-Promoting Behaviors of the Women Workers at the Manufacturing Industry -Based on the Pender's Health Promotion Model- (제조업 여성 근로자의 건강증진행위 관련 요인 분석 -Pender의 건강증진모형 적용-)

  • Yun, Soon Nyoung;Kim, Jeong Hee
    • Korean Journal of Occupational Health Nursing
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    • v.8 no.2
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    • pp.130-140
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    • 1999
  • The purpose of this study was to identify health promoting behaviors(HPBs) and the related determinants affecting to women workers health based on the New Health Promotion Model by Pender(1996). Data were collected by self-reported questionnaires from 208 women workers at the 8 electronic manufacturing factories under the permission of data collection and cooperation with health managers in the factories during the period from September to October 1999. For data analysis. Descriptive statistics, ANOVA, Pearson's correlation and Stepwise multiple regression with SPSS/PC+7.5 version were used. The results were as follows : 1. The average score for the HPBs, consisted of 6 subdimensions was 2.05. The highest mean score was 2.29 in 'Spiritual growth' and the lowest one was 1.66 in 'Physical activity'. 2. No significant difference between general charateristics and HPBs were found. 3. HPBs were positively related to 'Prior related behavior'(r=0.369, p<0.1), 'Perceived self-efficacy'(r=0.340, p<.01), 'Activity-related affect'(r=0.252, p<.01). 'Social support'(r=0.350, p<.01). 'Commitment to a plan action'(r=0.374, p<.01). There was no significant correlation between perceived health status, perceived barriers to action and HPBs. 4. The most important variable in HPBs was 'Commitment to a plan action'. It was explained 14.0% out of the total variance of HPBs. 'Commitment to a plan action', 'Prior related behavior', 'Social support', 'Self-efficacy' and 'Perceived barriers to action' explained 23.0%. According to the results of this study, the suggestions were as follows: 1. It is necessary to develop program for improving the physical activity and health responsibility of women workers at the manufacturing industry. 2. To facilitate and maintain HPBs of women workers, nurses may enhance and plan mutually interactive active HPBs with women workers. 3. Social support at the level of individual workers, supervisors, and the organization is required in order to conduct health promotion program at the factories. 4. Significantly related variables to HIPBs should be identified the direct and indirect paths among them further more.

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Optimization of biomethane production by biogas upgrading process using response surface mothodolgy (반응표면분석을 이용한 바이오가스 고질화공정을 통한 바이오메탄)

  • Park, Seong-Bum;Sung, Hyun-Je;Shim, Dong-Min;Kim, Nack-Joo
    • Journal of Energy Engineering
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    • v.23 no.2
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    • pp.62-73
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    • 2014
  • This research was focused to apply response surface methodology for optimization of bio-methane production by biogas upgrading process. Methane concentration(Y1) and methane efficiency(Y2) on biogas upgrading process were mathematically described as being modeled by the use of the Box-Behnken design on response surface methodology. The results of ANOVA(analysis of variance) about models, the probability value of the methane concentration and methane recovery response surface model are 0.0001 and 0.0001, respectively and coefficient of determination($R^2$) are 0.9788 and 0.9710, respectively. The response surface model is proved of high reliability and suitability. The operation pressure had the greatest influence to methane concentration than other operation parameters and the PSA rotary valve velocity had the greatest influence to methane recovery than other operation parameters. Optimal condition of biogas upgrading process for production of $100Nm^3/hr$ bio-methane were operation pressure 8.0bar and outlet flow rate 31.55RPM, respectively. At that operation condition the methane concentration of bio-methane was 97.13% and methane recovery in biogas upgrading process was 75.89%.

Mapping QTLs for Agronomic Traits Using an Introgressin Line Population from a Cross between Ilpumbyeo and Moroberekan in Rice (일품벼/모로베레칸 이입계통을 이용한 농업형질 관련 QTL 분석)

  • Ju, Hong-Guang;Kim, Dong-Min;Kang, Ju-Won;Kim, Myung-Ki;Kim, Yeon-Gyu;Ahn, Sang-Nag
    • Korean Journal of Breeding Science
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    • v.40 no.4
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    • pp.414-421
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    • 2008
  • We conducted a QTL analysis of agronomic traits using 117 $BC_3F_5$ and $BC_3F_6$ lines developed from a cross between Ilpumbyeo and Moroberekan. Genotypes of 117 $BC_3F_5$ lines were determined using 134 simple sequence repeat (SSR) markers. A total of 832 Moroberekan chromosome segments with 410 homozygous and 422 heterozygous, respectively, were detected, and the genetic distance of introgression segments ranged from 0.5 cm to 112.1 cm. A linkage map constructed using 134 SSR markers was employed to characterize quantitative trait loci (QTL). The 117 $BC_3F_5$ and $BC_3F_6$ lines were evaluated for seven agronomic traits at two locations in 2006 and 2007 and at one location in 2007. A total of 26 QTLs were identified for seven traits including days to heading, and the phenotypic variance explained by each QTL ranged from 9.2% to 24.2%. Moroberekan alleles contributed positive effects in the Ilpumbyeo background at eleven QTL loci including panicle length and spikelets per panicle. Five QTLs, two for days to heading and one each for culm length, panicle length and spikelets per panicle were consistently detected in every occasions indicating that these QTLs are stable. Among them, two QTLs, spp6 for spikelets per panicle and pl6 for paniclel length were localized in the similar region. Increase in spikelets per panicle at this locus might be due to the increase in panicle length, because both traits were associated with increase in spikelets per panicle and panicle length due to the presence of the Moroberekan allele. These Moroberekan QTLs might be useful in breeding programs to develop high-yielding cultivars.

Impacts of Relative Advantage of Fast Food Restaurant's O2O Service and Consumer Involvement on Consumer Engagement, and Store Loyalty: Focused on MZ Generationsin Untact Consumption Era

  • LEE, Young-Eun;LEE, Yong-Ki
    • The Korean Journal of Franchise Management
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    • v.11 no.2
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    • pp.41-51
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    • 2020
  • Purpose: Fast food franchise companies are trying a variety of innovative services to increase their competitiveness in response to changes in population composition in the fast food market and rapid changes in consumption trends due to technological development. From this point of view, franchise companies that have focused on offline store operations are providing O2O (offline to online) service as a core service for customer convenience. This new attempt is a strategy to increase loyalty by applying an interaction method based on understanding the characteristics of new generation consumers. However, existing studies are focused on the relationship between O2O service and acceptance, so very little is known about how O2O service affects customer loyalty. Therefore, this study examines the impacts of customer involvement and relative advantages of fast food O2O service on customer brand engagement (cognitive and affective engagement) and store loyalty for MZ(Millennials - Z) generations. Research design, data, and methodology: In order to achieve the purposes of this research, several hypotheses were developed. The data were collected from 247 questionnaires in their 16-30s and were analyzed using SPSS 22.0 and SmartPLS 3.0 program. Measurement model analysis was carried out to assess convergent and discriminant validity. Also, common method bias was tested using the values of VIF (variance inflation factor). The hypotheses was tested using structural equation modeling. Result: First, involvement has a positive effect on cognitive and affective engagement. Second, relative advantages have has a positive effect on cognitive and affective engagement. Third, cognitive influences affective engagement. Finally, both cognitive and affective engagement affect store loyalty, but affective engagement has a stronger effect on store loyalty than cognitive engagement. Conclusions: In the process of consumer-brand interaction, it was confirmed that store loyalty was influenced by cognitive and affective engagement sequentially. However, the results show that affective engagement has a relatively stronger on store loyalty than cognitive engagement. Therefore, it is necessary to establish an O2O service strategy to maintain long-term loyal customers by inducing cognitive participation with high-involved consumer, as well as affective interaction, in order to obtain new customers and increase customer loyalty.

Regional Variation of EQ-5D Index and Related Factors in Community Health Survey: Major Role of Psychosocial Factors in Korea (지역사회건강조사에서 EQ-5D index의 지역간 변이와 관련 요인: 사회심리적 요인의 중요성)

  • Kim, Eunsu;Nam, Hae-Sung
    • Journal of agricultural medicine and community health
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    • v.45 no.4
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    • pp.183-193
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    • 2020
  • Objectives: As an ecological study, this study was performed to identify the community-level variation of health related quality-of-life (HRQOL), and to explore the factors that explain the variation, using 2017 Korean Community Health Survey (KCHS) data. Methods: Community health indicators of KCHS, which are correlated with the EQ-5D index of Si-gun-gu districts, were selected as independent variables. Multiple linear regression model was used to derive factors that explain regional variations in the EQ-5D index. Results: The EQ-5D index variation in 229 districts nationwide was 1.1 times for extremal quotient (EQ) and 1.0 for coefficient of variance (CV). The Si-gun-gu districts with the EQ-5D index in the lower 25% were more distributed in the province (27.7%) than in the metropolitan area (20.3%). As a result of multiple linear regression analysis, the depressed mood experience rate, perceived stress rate, suicide ideation rate, and physician diagnosed arthritis rate were derived as major factors of the variation. Conclusions: In order to reduce the gap in HRQOL between the districts, the priority of local health policies should be placed on the above factors including psychosocial factors.

Key Factors Affecting Customer's Repurchase Intention in the Context of Sharing Economy Platform: Focused on Airbnb (공유 경제 플랫폼 고객들의 재구매 의도에 영향을 미치는 요인들: Airbnb 사례를 중심으로)

  • Park, Daeyeong;Yoon, Jiyoung;Jeong, Yunji;Kim, Byoungsoo
    • Journal of Digital Convergence
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    • v.18 no.12
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    • pp.231-242
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    • 2020
  • Due to fierce market competition and COVID-19, it becomes increasingly important for sharing economic platform companies to develop a long-term relationship with customers. In this regard, this study explores the mechanism of customer's repurchase decision making in the context of Airbnb. This study posits customer satisfaction and brand image as the key factors in forming customer's repurchase intention toward Airbnb. It also investigates the effects of price fairness, authentic experience, enjoyment, Airbnb trust and host trust on customer's repurchase intention. This study validated the research hypothesis with 154 customers using Airbnb. The analysis results showed that both customer satisfaction and brand image have a significant impact on repurchase intention and explain 62.0% of its variance. Enjoyment, true experience, and Airbnb trust had significant effects on customer satisfaction, while price fairness and host trust had no significant impact on it. The results revealed that price fairness, authentic experience, enjoyment, and Airbnb trust are significantly associated with brand image, while host trust is not significantly related to it. The results of this study are expected to provide academic and practical implications by enhancing the understanding of customer's repurchasing decision in the context of sharing economic platform.