• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.30 no.2
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• pp.74-82
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• 2019

Objectives: The objective of this study was to investigate clinical and neuropsychological factors associated with treatment response and adverse events of atomoxetine in children with attention-deficit/hyperactivity disorder (ADHD) in Korea. Methods: Children with ADHD were recruited at the Department of Psychiatry of Asan Medical Center from April 2015 to April 2018. Diagnoses of ADHD and comorbid psychiatric disorders were confirmed with the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. The subjects were subsequently treated with atomoxetine for 12 weeks and illness severity was scored using the ADHD Rating Scale, Clinical Global Impression-Severity scale (CGI-S) and/or Improvement scale (CGI-I), at pre- and post-treatment. They also completed the Advanced Test of Attention (ATA), while their caregivers completed the Korean Personality Rating Scale for Children (KPRC) at pre- and post-treatment. Independent t-test, Fisher's exact test, ${\chi}^2$ test, mixed between-within analysis of variance and correlation analysis were used for statistical analysis. Results: Sixty-five children with ADHD (mean age: $7.9{\pm}1.4years$, 57 boys) were enrolled, of which, 33 (50.8%) were treatment responders. Scores on the social dysfunction subscale of the KPRC (p=0.021) and commission errors on the visual ATA (p=0.036) at baseline were higher in treatment non-responders than in responders; however, the statistical significances disappeared after adjusting for multiple comparisons. Mood changes were also observed in 13 subjects (20.0%), and three of them discontinued atomoxetine due to this. Additionally, atomoxetine-emergent mood change was observed more frequently in girls (p=0.006), while the intelligence quotient (p=0.040) was higher in those subjects with mood changes than in those without. Conclusion: The results of our study suggest that clinical and neuropsychological factors could be associated with treatment response or adverse events of atomoxetine in children with ADHD. Further long-term studies with larger samples are needed.

• Journal of Korean society of Dental Hygiene
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• v.19 no.5
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• pp.677-688
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• 2019

Objectives: The purpose of this study was to examine the perception of dental hospital accreditation and the awareness and practice of infection control in dental hygienists. Methods: A self-reported questionnaire was completed by 238 dental hygienists working at dental hospitals in Gwangju Jeonnam and analyzed from October 24, 2016 to September 22, 2017. Data were analyzed with the independent t-test, one-way analysis of variance, Pearson's correlation analysis, and multiple regression analysis using the Statistical Package for the Social Sciences software, version 21.0. Results: Compared to non-accredited dental hospitals, all three variables were high for accredited dental hospitals. In accredited dental hospitals, healthcare accreditation expectancy effects correlated to awareness (r=0.407) and practice (r=0.533) of infection control, and awareness of infection control correlated to its practice (r=0.725). In non-accredited dental hospitals, healthcare accreditation expectancy effects correlated to awareness of infection control (r=0.239), and awareness of infection control correlated to its practice (r=0.481). Accredited dental hospitals showed healthcare accreditation expectancy effects (${\beta}=0.258$) and awareness of infection control (${\beta}=0.556$), and non-accredited dental hospitals were influenced by the number of employees (${\beta}=0.567$) and awareness of infection control (${\beta}=0.376$). Conclusions: It is necessary to develop efficient and systematic infection control programs to improve the awareness and practice of infection control in dental hygienists and patient's safety in the clinical field.

• Journal of Korean Dental Hygiene Science
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• v.5 no.2
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• pp.73-83
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• 2022

Background: This study was aimed at reducing depression and improving the quality of life and oral health of the elderly Koreans by elucidating the effect of depression on their life quality and oral health. Methods: Original data from the 8th National Health and Nutrition Survey (2019) were analyzed and implemented. The elderly (age≥65years) Koreans were enrolled. The oral health status was determined using the Decayed, Missing, Filled Teeth (DMFT) index and subjective self-report. The quality of life was quantified as the sum of score of each item in the Euro Qol-5 dimension (EQ-5D) and Health-related Quality of Life Instrument with 8 Items (HINT-8). The t-test, one-way analysis of variance, correlation analysis, and multiple regression analysis were performed to statistically compare the quality of life, oral health status, and oral health status according to the depression status. Results: EQ-5D and HINT-8 scores differed significantly with the history of depression, current depression, stress perception, depression for 2 weeks, and annual suicidal intention (p≤0.05). The DMFT index score differed significantly with the depression diagnosis and depression for 2 weeks (p≤0.05). EQ-5D, HINT-8, and DMFT index differed significantly with all oral health behavior variables (p≤ 0.05). Conclusions: The results of this study could serve as a basis to formulate oral health programs for the elderly to reduce depression and improve the quality of life.

• Animal Bioscience
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• v.36 no.12
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• pp.1796-1805
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• 2023

Objective: This study aims to identify heat shock protein70-2 (HSP70-2) and protamine-1 (PRM1) mRNA and protein in Madura bull sperm and demonstrate their relation as bull fertility biomarkers. Methods: The Madura bull fertility rates were grouped based on the percentage of first service conception rate (%FSCR) as high fertility (HF) (79.04%; n = 4), and low fertility (LF) (65.84%; n = 4). mRNA of HSP70-2 and PRM1 with peptidylprolyl isomerase A (PPIA) as a housekeeping gene were determined by quantitative real-time polymerase chain reaction, while enzyme-linked immunoassay was used to measure protein abundance. In the post-thawed semen samples, sperm motility, viability, acrosome integrity, and sperm DNA fragmentation index were analyzed. Data analysis was performed on the measured parameters of semen quality, relative mRNA expression, and protein abundance of HSP70-2 and PRM1, among the bulls with various fertility levels (HF and LF) in a one-way analysis of variance analysis. The Pearson correlation was used to analyze the relationship between semen quality, mRNA, proteins, and fertility rate. Results: Relative mRNA expression and protein abundance of HSP70-2 and PRM1 were detected and were found to be highly expressed in bulls with HF (p<0.05) and were associated with several parameters of semen quality. Conclusion: HSP70-2 and PRM1 mRNA and protein molecules have great potential to serve as molecular markers for determining bull fertility.

• Journal of Microbiology and Biotechnology
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• v.28 no.9
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• pp.1517-1526
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• 2018

Investigating bacterial diversity and its metabolic capabilities is crucial for interpreting the ecological patterns in a desert environment and assessing the presence of exploitable microbial resources. In this study, we evaluated the spatial heterogeneity of physicochemical parameters, soil bacterial diversity and metabolic adaptation at meter scale. Soil samples were collected from two quadrats of a desert (Thar Desert, India) with a hot, arid climate, very little rainfall and extreme temperatures. Analysis of physico-chemical parameters and subsequent variance analysis (p-values < 0.05) revealed that sulfate, potassium and magnesium ions were the most variable between the quadrats. Microbial diversity of the two quadrats was studied using Illumina bar-coded sequencing by targeting V3-V4 regions of 16S rDNA. As for the results, 702504 high-quality sequence reads, assigned to 173 operational taxonomic units (OTUs) at species level, were examined. The most abundant phyla in both quadrats were Actinobacteria (38.72%), Proteobacteria (32.94%), and Acidobacteria (9.24%). At genus level, Gaiella represented highest prevalence, followed by Streptomyces, Solirubrobacter, Aciditerrimonas, Geminicoccus, Geodermatophilus, Microvirga, and Rubrobacter. Between the quadrats, significant difference (p-values < 0.05) was found in the abundance of Aciditerrimonas, Geodermatophilus, Geminicoccus, Ilumatobacter, Marmoricola, Nakamurella, and Solirubrobacter. Metabolic functional mapping revealed diverse biological activities, and was significantly correlated with physicochemical parameters. The results revealed spatial variation of ions, microbial abundance and functional attributes in the studied quadrats, and patchy nature in local scale. Interestingly, abundance of the biotechnologically important phylum Actinobacteria, with large proposition of unclassified species in the desert, suggested that this arid environment is a promising site for bioprospection.

• Journal of the Korean Society of Costume
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• v.58 no.1
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• pp.133-150
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• 2008

The purpose of this study was to recognize of the sizing system and analyze the fitting on formal pants of the on-line shopping mall for plus-sized women. To pursue this purpose, the investigation of the sizing system was focused on 22 online companies. The formal pants of 7 companies was selected among them. And actual sizes were compared with the guidance sizes of goods. For the assessment about the fitting on formal pants of 7 online companies, these came to make on to 16 obese women with 'A' body shaped and 'O' body shaped. A data analysis used the SPSS 14.0 statistics program. To verify the difference, this study used the variance analysis and Duncan's test for the postmortem verification. The result was as follows. 1. All of 22 companies were using the symbol such as 88, 99, 100 and 110 in the present condition of sizing system. The information about products size was presenting the products size not to be the body size. the guidance sizes of products were different from actual sizes of 7 companies to be assorted. Therefore, the guidance sizes of goods could not accomplish the facility. 2. According to the fitting-tests by the sensory assessment, the obese women with 'A' body shaped, did the dissatisfaction at the items of the hip circumference, abdominal region, crotch deep and pants length. The obese women with 'O' body shaped, did the dissatisfaction at the the items of crotch deep and pants length.

• Journal of Environmental Health Sciences
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• v.24 no.2
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• pp.134-144
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• 1998

A comprehensive air quality monitoring was carried out to investigate the criteria concentration of air pollutant in indoor of subway stations of Seoul City. The samples were collected twice per year (the first and the second half of the year) at each sampling point from February to September in 1997. Sampling point of subway stations was ticket office and platform. The measurement of indoor air pollutants such as sulfur dioxide(SO$_2$), nitrogen dioxide(NO$_2$), carbon monoxide(CO), carbon dioxide(CO$_2$), total suspended particulate(TSP) was performed to determine the indoor air quality. Heavy metals(Pb, Cd, Cu, Cr, As, Hg) were also measured together with those air pollutants. The annual average concentration of CO$_2$ and TSP in subway stations were relatively high while those of heavy metals were within 10% of environmental recommended standard concentration in all stations. As results of regression analysis between line and line of air factors, the concentrations of CO, CO$_2$, TSP, Pb, Cd, Cr and Cu were highly correlated, but those of $SO_2, NO_2$ and Hg were not correlated. As results of regression analysis between ticket office and platform, the concentrations of heavy metals such as Cr and Cu were highly correlated. Results of oneway analysis of variance between the first and the second half of the year air factors also indicated that CO, CO$_2$, Cd, Cu, Hg were significant($\alpha$=0.01), respectively. The average contration of total suspended particulate(TSP) in subway line No. 1 was shown high concentration(200 $\mu g/m^3\cdot$ day) level.

• Journal of the Korean Society of Costume
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• v.57 no.4 s.113
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• pp.9-17
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• 2007

Somatotype is human body shape and physique type which can be classified not only by the size, but also by the shape or posture of the body. Postural variations in the alignment of the back, shoulder, and neck can have an adverse effect on the fit of garments designed to hang from the shoulders. There have been some previous studies about the lateral upper torso by analyzing photographic measurements. In this study, 3D body scan images were used to classify the side somatotype of upper lateral method even though they are major data in the classification of upper torso. This study focused on following objective.; 1) To apply new and developing technology into the apparel industry analyzing 3D body scan images. 2) To classify upper laterla torso using the data through the new improver technology, 3D body scanner. 3) To propose basic materials for well fitted garments for each type of figure. The test subjects for this study were two hundreds nine female aged 19 years and up who were recruited in Cornell university body scan research team. Seventeen Variables(12 angles, 5 lengths) out of 3D body scan data were measured based on these landmarks and applied to analyze. The result of factor analysis indicated that 6 factors were extracted through factor analysis and orthogonal rotation by the method of Varimax and those factors comprise 62.5% of total variance. And the somatotype of upper body is classified into 3 types of figures according to cluster analysis; Bent forward posture, Straight posture, Swayback posture. Future study could be addressed about the somatotype of body by the age group based on the large database with wide variety of age.

• Imaging Science in Dentistry
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• v.48 no.3
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• pp.161-165
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• 2018

Purpose: To evaluate the usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases. Materials and Methods: Ten patients with oral and maxillofacial diseases and 28 volunteers drawn from our student doctors were examined by shear wave elastography with a 14-MHz linear transducer using an Aplio 300 apparatus (Canon Medical Systems, Otawara, Japan). A statistical analysis of the shear elastic modulus(kPa) of healthy tissue (the sublingual gland, submandibular gland, anterior belly of the digastric muscle, and geniohyoid muscle) in the 28 volunteers was performed using 1-way repeated measures analysis of variance with the Tukey honest significant difference test. The maximum shear elastic modulus(kPa) of 8 patients with squamous cell carcinoma (SCC) and 2 patients with benign lesions was evaluated with the Mann-Whitney U test. The analysis used a 5% significance level. Results: The mean shear elastic modulus of the sublingual gland ($9.4{\pm}3.7kPa$) was lower than that of the geniohyoid muscle ($19.2{\pm}9.2kPa$, P=.000) and the anterior belly of the digastric muscle ($15.3{\pm}6.1kPa$, P=.004). The maximum shear elastic modulus of the SCCs($109.6{\pm}14.4kPa$) was higher than that of the benign lesions($46.4{\pm}26.8kPa$, P=.044). Conclusion: Our results demonstrated the usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases. Shear wave elastography has the potential to be an effective technique for the objective and quantitative diagnosis of oral and maxillofacial diseases.

• Investigative Magnetic Resonance Imaging
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• v.22 no.2
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• pp.79-85
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• 2018

Purpose: To determine the impact of pseudoglandular formation on apparent diffusion coefficient (ADC) values of hepatocellular carcinoma (HCC) in diffusion-weighted imaging (DWI), and to validate the results using histopathological grades. Materials and Methods: We assessed 182 HCCs surgically resected from 169 consecutive patients. Each type of tumor pseudoglandular formation was categorized into "non-," "mixed-," or "pure-," based on official histopathology reports. The ADC for each tumor was independently measured, using the largest region of interest on the ADC map. Data were assessed using the analysis of variance test, with Bonferroni correction for post hoc analysis to stratify the relationship of ADCs with pseudoglandular formation, followed by subgroup analysis according to the histopathological tumor grades. Results: The mean ADC was significantly higher in pure pseudoglandular lesions (n = 5, $1.29{\pm}0.08{\times}10^{-3}mm^2/s$) than in non-pseudoglandular lesions (n = 132, $1.08{\pm}0.17{\times}10^{-3}mm^2/s$; P = 0.003) or mixed-pseudoglandular lesions (n = 45, $1.16{\pm}0.24{\times}10^{-3}mm^2/s$; P = 0.034). The ADC values and pseudoglandular formation were significantly correlated in moderately differentiated HCCs (n = 103; r = 0.307, P = 0.007), while well- (n = 19) and poorly-differentiated HCCs (n = 60) did not show significant correlation (r = 0.105 and 0.068, respectively; P = 0.600 and 0.685, respectively). Conclusion: The degree of pseudoglandular formation could be one of the determinants of ADC in DWI of HCCs-especially moderately differentiated HCCs-while its influence does not appear to be significant in well- or poorly differentiated HCCs.