• Title/Summary/Keyword: Variable stress

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A Study on the Environment for Lowbirth Weight Infants in Neonatal Intensive Care Unit in the United States (신생아집중간호단위 환경과 저체중출생아의 반응에 대한 연구)

  • Han Kyung Ja
    • Child Health Nursing Research
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    • v.4 no.2
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    • pp.159-176
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    • 1998
  • In effort to conduct comparative study on the caregiving environment of Neonatal Intensive Care Unit(NICU) in both U. S and Korea, this study was been conducted first in the U.S. Purpose : The purpose of this study is to identify the physical environment and direct caregiving practices to lowbirth weight infants in NICU in the US. It also aims to examine the NICU outcome status and behavioral reponses of lowbirth weight infants. Methods : A study design using descriptive and inferential statistics was been conducted through an observational, field method. A sample of 15 preform infants admitted to NICU were recruited for the study. The subjects were those with birth weight between 1,000 gm to 1,500 gm, born at the gestation period of 27 to 33 weeks, and without any chromosomal or other genetic anomalies, major congenital infections, or maternal illness. Thirty minutes observation(three times of ten minutes of continuous observation)of the infant's behavior and physiological status, and an four-hour observation of the physical environment and direct care giving procedures were been conducted on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. The data to be collected were in four areas : the demograghic characteristics of the infants, the physical environment and care giving procedures, the frequency of the infant's designated behavior and physiological response, and NICU outcome variables. A descriptive analysis and Kruskal-Wallis, Pearson r were been applied according to variable characteristics. Results : 1. Mother's mean age was 29.47. The sample consisted of 6 males and 9 females. Mean gestational ages were 29.17 weeks. Mean birth weight was 1236.33g. Mean Apgar scores at one minute were 6.6, and 7.8 at five minutes. 2. The location for the incubator was in the distance from the light, X-ray screens and nursing station, in proximity to side-lamp, telephone and faucet on the third day after birth. The location for the incubator was in the distance from the light and radio on the tenth day and in proximity to nursing station on the day of dischage from the NICU or at 34weeks postconception. 3. Nesting was the most applying aids to the infants. And foot roll, shielding and plastic frame were frequently using by nurses for facilitating well modulated restful posture. 4. There were statistically significant changes in the patterns of physical environment included locating the infant's incubator and bedding, specific aids to self regulation on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. 5. Statistically significant changes were not appeared in the patterns of direct caregiving procedure to the infants included stress inducing or reducing manipulations on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. 6. The stress response of the infants in NICU were significantly reduced as the infants grow older. 7. There were not statistically significant correlation between the physical envronment and the stress responses of the infants in NICU. 8. There were statistically significant correlation between the direct caregiving procedure to the infants and the stress response of the infants in NICU in the second and third observation on the day three. 9. Average weight gain per day from birth to discharge was 38.73g, number of days in the hospital was 42.60, number of days before bottle feeding was 3.6. Postconception age starting bottle feed ing was 31/sup +5/ weeks. Number of days on mechanical ventilator was average 7.64, 11.42 was an average number of days of oxygen need. Conclusion : It, thus, appears that to minimize the sensorymotor stimulation for the low birthweight preterm infant in NICU, manipulation of care giving practices to the babies whatever the stress inducing or reducing procedures, have to be limited in the immediate early stage after birth. And it needed to be reexamine to identify the appropriate and specific physical environment and the patterns of direct caregiving to the low birthweight preform infant as the infants grow older in NICU.

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Induction of Thioredoxin by Oxidative Stress and Overexpression of Thioredoxin in Lung Cancer Tissue (산화 스트레스에 의한 Thioredoxin의 발현과 폐암조직에서의 발현)

  • Lee, Jang-Hoon;Kim, Hyung-Jung;Ahn, Chul-Min;Kim, Sung-Kyu;Lee, Won-Young
    • Tuberculosis and Respiratory Diseases
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    • v.46 no.3
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    • pp.327-337
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    • 1999
  • Background: Reactive oxygen species are involved in multi-stage process of carcinogenesis. The moot of cancer cell lines and cancer cells in tumor tissue produce reactive oxygen species and on the other hand, the activities of catalase, Mn- and CuZn-superoxide dismutase in tumor cells are usually low. These persistent oxidative stress in tumor tissue facilitates tumor invasion and metastasis. 12-kDa thioredoxin, which regulates the intracellular redox potential with glutathione and glutaredoxin is involved in cell activation, proliferation, differentiation and redox-mediated apoptosis. It is also purified as 14-kDa and 10-kDa eooinophilic cytotoxic enhancing factor(ECEF) from human histiocytic cell(U937) and 10-kDa ECEF has more than 20 times eosinophilic stimulation activity than 14-kDa ECEF. It has been reported that adult T-cell leukemia, squamous cell carcinoma of uterine cervix, and hepatocellular carcinoma show increased amounts of human thioredoxin and thioredoxin mRNA is increased in lung cancer. In this study, we investigated the expression of conventional antioxidant enzymes such as catalase, CuZn-SOD, and glutathione peroxidase and thioredoxin in lung cancer tissue compared to adjacent normal lung tissue and the induction of thioredoxin in macrophage cells after treatment of oxidative stress and endotoxin Methods: We measured the amount of conventional antioxidant enzymes such as catalase, CuZn-SOD, and glutathione peroxidase and thioredoxin in lung cancer tissue compared to adjacent normal lung tissue by immunoblot analysis and the induction of thioredoxin in mouse monocyte-macrophage cells(RAW 264.7) by treatment of 5 ${\mu}M$ menadione and 1 ${\mu}g/ml$ endotoxin Results: On immunoblot analysis, the expression of 12-kDa thioredoxin was increased in lung cancer tissue compared to paired normal lung tissue. but the expression of catalase and CuZn-SOD were decreased in lung cancer tissue compared to paired normal tissue and the expression of glutathione peroxidase in lung cancer was variable. The expression of truncated thioredoxin was also increased in lung cancer. When mouse monocyte-macrophage cells were treated with 5 ${\mu}M$ menadione and 1 ${\mu}g/ml$ endotoxin, the expression of thioredoxin was peaked at 12 hrs and sustained to 48 hrs. Conclusion: In contrast with other conventional antioxidants, the expression of 12-kDa and truncated thioredoxin in lung cancer were increased and it is closely associated with persistent oxidative stress in tumor microenvironment. Considering especially the biological functions of truncated thioredoxin, the increased amount of truncated thioredoxin has significant role in tumor growth through cell proliferation.

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A Study on Relationship between Physical Elements and Tennis/Golf Elbow

  • Choi, Jungmin;Park, Jungwoo;Kim, Hyunseung
    • Journal of the Ergonomics Society of Korea
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    • v.36 no.3
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    • pp.183-196
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    • 2017
  • Objective: The purpose of this research was to assess the agreement between job physical risk factor analysis by ergonomists using ergonomic methods and physical examinations made by occupational physicians on the presence of musculoskeletal disorders of the upper extremities. Background: Ergonomics is the systematic application of principles concerned with the design of devices and working conditions for enhancing human capabilities and optimizing working and living conditions. Proper ergonomic design is necessary to prevent injuries and physical and emotional stress. The major types of ergonomic injuries and incidents are cumulative trauma disorders (CTDs), acute strains, sprains, and system failures. Minimization of use of excessive force and awkward postures can help to prevent such injuries Method: Initial data were collected as part of a larger study by the University of Utah Ergonomics and Safety program field data collection teams and medical data collection teams from the Rocky Mountain Center for Occupational and Environmental Health (RMCOEH). Subjects included 173 male and female workers, 83 at Beehive Clothing (a clothing plant), 74 at Autoliv (a plant making air bags for vehicles), and 16 at Deseret Meat (a meat-processing plant). Posture and effort levels were analyzed using a software program developed at the University of Utah (Utah Ergonomic Analysis Tool). The Ergonomic Epicondylitis Model (EEM) was developed to assess the risk of epicondylitis from observable job physical factors. The model considers five job risk factors: (1) intensity of exertion, (2) forearm rotation, (3) wrist posture, (4) elbow compression, and (5) speed of work. Qualitative ratings of these physical factors were determined during video analysis. Personal variables were also investigated to study their relationship with epicondylitis. Logistic regression models were used to determine the association between risk factors and symptoms of epicondyle pain. Results: Results of this study indicate that gender, smoking status, and BMI do have an effect on the risk of epicondylitis but there is not a statistically significant relationship between EEM and epicondylitis. Conclusion: This research studied the relationship between an Ergonomic Epicondylitis Model (EEM) and the occurrence of epicondylitis. The model was not predictive for epicondylitis. However, it is clear that epicondylitis was associated with some individual risk factors such as smoking status, gender, and BMI. Based on the results, future research may discover risk factors that seem to increase the risk of epicondylitis. Application: Although this research used a combination of questionnaire, ergonomic job analysis, and medical job analysis to specifically verify risk factors related to epicondylitis, there are limitations. This research did not have a very large sample size because only 173 subjects were available for this study. Also, it was conducted in only 3 facilities, a plant making air bags for vehicles, a meat-processing plant, and a clothing plant in Utah. If working conditions in other kinds of facilities are considered, results may improve. Therefore, future research should perform analysis with additional subjects in different kinds of facilities. Repetition and duration of a task were not considered as risk factors in this research. These two factors could be associated with epicondylitis so it could be important to include these factors in future research. Psychosocial data and workplace conditions (e.g., low temperature) were also noted during data collection, and could be used to further study the prevalence of epicondylitis. Univariate analysis methods could be used for each variable of EEM. This research was performed using multivariate analysis. Therefore, it was difficult to recognize the different effect of each variable. Basically, the difference between univariate and multivariate analysis is that univariate analysis deals with one predictor variable at a time, whereas multivariate analysis deals with multiple predictor variables combined in a predetermined manner. The univariate analysis could show how each variable is associated with epicondyle pain. This may allow more appropriate weighting factors to be determined and therefore improve the performance of the EEM.

A study on asymmetric load on circular shaft due to engineering characteristics of discontinuous rock masses (불연속암반의 공학적 특성에 따른 원형수직구 편하중에 관한 연구)

  • Shin, Young-Wan;Moon, Kyoung-Sun;Joo, Kyoung-Won
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.10 no.2
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    • pp.119-128
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    • 2008
  • In the case of a circular shaft, it is expected that asymmetric loads should apply on the surface rather than symmetric loads due to geographical factors and the non-homogeneity of the jointed rock masses. In this study, discontinuous numerical analysis was carried in order to analyze the characteristics of asymmetric load distribution on the wall of the circular shaft due to anisotropy caused by heterogeneity of rock masses affected by the discontinuities like as a Joint. And it was also analyzed that the effect of the mechanical properties varied with the rock mass rating and horizontal stress with depth had influence in the asymmetric load on the wall of the shaft. In the case of considering the effect of the joint as variable, asymmetric load ratio $(R_p)$, which was defined as the ratio of the load subtracted minimum from maximum to minimum, was below 25% in the hard rock. As regarding the variation of the rock mass rating with depth as variable, the value of $R_p$ was below than 25% in the hard rock, and the value between 30% and 40% in the soft rock. On the other hand, the $R_p$ of fractures rock was between $45{\sim}50%$ which value was much higher than that in better rock mass rating.

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A Meta-analysis of variables related to organizational commitment of social workers (사회복지사의 조직몰입과 관련된 변인에 관한 메타분석)

  • Lee, Jung-Gun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.11
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    • pp.455-464
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    • 2020
  • This study examined the correlation between the variables related to the organizational commitment of social workers. The research results are as follows. First, the overall effect size of the variable group had an intermediate effect size. Among the four organizational commitment-related variables, the job-related negative variable had the largest effect size. Next, the group of positive variables related to the organization, the group of positive variables related to the job, and the group of individuals related to the individual were in order. Second, among the individual-related variables, experience, gender, and education showed a small effect size, and other factors were close to the small effect size. In the group of positive variables related to organization, all variables except for transactional leadership and organizational fairness, which had a medium effect size, showed a large effect size. The job-related positive variables showed a large effect size only for job satisfaction, and customer orientation and job suitability were close to the large effect size. The turnover intention, which is a group of job-related negative variables, had a large effect size and job stress showed a medium effect size.

Discrete Optimum Design of Sinusoidal Corrugated Web Girder (사인형 주름웨브보의 이산화 최적구조설계)

  • Shon, Su Deok;Yoo, Mi Na;Lee, Seung Jae
    • Journal of Korean Society of Steel Construction
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    • v.24 no.6
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    • pp.671-682
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    • 2012
  • The use of sinusoidal corrugated web girder for the box-type girders and gable steel main frames has recently been increasing very much. The reasons are that the thin web of the girder affords a significant weight reduction compared with rolled beam and welded built-up girder, and that corrugation prevents the buckling failure of the web. Improvements of the automatic fabrication process makes mass production of the corrugated web and unit possible, and applications of this girder have been extended considerably. Thus, the research for the optimum design processer considering the production data is needed practically. For doing this research, we develope the discrete optimum structural design program in consideration of production list data for the research, and the program apply to the single girder under the uniform load and the concentrated load as numerical example. We consider objective function as minimum weight of the girder, and use slenderness ratio, stress of flanges and corrugated web, and the girder deflection as the constraint functions. And also the Genetic Algorithms is adopted to search the global minimum point by using the production list as a discrete design variable. Finally, to verify the optimality of the design, we conduct a comparison of the results of the discrete optimum design with those of the continuous one, and also analyze the characteristics of the optimum cross-section.

Study of Deepsea Mining Robot "MineRo" Using Table of Orthogonal Arrays (직교 배열표를 이용한 심해저 채광로봇 미내로의 주행 특성 연구)

  • Lee, Chang-Ho;Kim, Hyung-Woo;Choi, Jong-Su;Yeu, Tae-Kyeong;Lee, Min-Uk;Oh, Jae-Won;Hong, Sup
    • Journal of Ocean Engineering and Technology
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    • v.28 no.2
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    • pp.152-159
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    • 2014
  • KRISO(Korea Research Institute of Ships & Ocean Engineering) designed and manufactured a pilot mining robot called "MineRo" in 2012. MineRo is composed of four track modules. In general, much time and money are needed for deep-sea tests. Therefore, a numerical analysis to predict the dynamic behaviors has to be performed before a deep-sea test. In the numerical analysis, the information about the mining robot and soil properties are the most important factors to analyze the driving performance and dynamic response of MineRo. A terra-mechanics model of extremely cohesive soft soil is implemented in the form of the relationships between the normal pressure and sinkage, and between the shear stress and shear displacement. It is possible to acquire information about MineRo from the CAD model in the design phase. The Wong model is applied to the terra-mechanics model. This model is necessary to acquire many soil coefficients for a numerical analysis. However, in soil testing, the amount of soil property data obtained is limited. Moreover, it is difficult to analyze all of the cases for the many soil coefficients. In this paper, the dynamic behaviors of MineRo are analyzed according to the driving velocity, steering ratio, and variable extremely cohesive soft soil properties using a table of orthogonal arrays. The dynamic responses of MineRo are the turning radius, sinkage, and slip ratio. The relationships between the dynamic responses and variable soil properties are derived for MineRo.

Reliability-Based Design Optimization of 130m Class Fixed-Type Offshore Platform (신뢰성 기반 최적설계를 이용한 130m급 고정식 해양구조물 최적설계 개발)

  • Kim, Hyun-Seok;Kim, Hyun-Sung;Park, Byoungjae;Lee, Kangsu
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.34 no.5
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    • pp.263-270
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    • 2021
  • In this study, a reliability-based design optimization of a 130-m class fixed-type offshore platform, to be installed in the North Sea, was carried out, while considering environmental, material, and manufacturing uncertainties to enhance its structural safety and economic aspects. For the reliability analysis, and reliability-based design optimization of the structural integrity, unity check values (defined as the ratio between working and allowable stress, for axial, bending, and shear stresses), of the members of the offshore platform were considered as constraints. Weight of the supporting jacket structure was minimized to reduce the manufacturing cost of the offshore platform. Statistical characteristics of uncertainties were defined based on observed and measured data references. Reliability analysis and reliability-based design optimization of a jacket-type offshore structure were computationally burdensome due to the large number of members; therefore, we suggested a method for variable screening, based on the importance of their output responses, to reduce the dimension of the problem. Furthermore, a deterministic design optimization was carried out prior to the reliability-based design optimization, to improve overall computational efficiency. Finally, the optimal design obtained was compared with the conventional rule-based offshore platform design in terms of safety and cost.

Analysis of personality level of students of industrial-field specialized high schools and Meister high schools (공업계열 특성화고 및 마이스터고 학생의 인성 수준 조사 분석)

  • Kim, Minwoong;Kim, Taehoon
    • Journal of vocational education research
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    • v.36 no.1
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    • pp.23-46
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    • 2017
  • The purpose of this study is to analyze the personality level of industrial-field specialized high schools and Meister high schools. The study objective for this is to analyze the differences per background variable and personality level of students of industrial-field specialized high schools and to analyze the differences per background variable and personality level of students of industrial-field Meister high schools. The study result is as follows. First, students of industrial-field specialized high schools showed personality level above normal in all 10 virtues, but this value fell short of the average for high school students suggested in Hyeon et al(2014). Second, students of industrial-field Meister high schools showed personality level above normal in all 10 virtues, and compared to the average for high school students suggested in Hyeon et al.(2014), categories of consideration and communication, manners, honesty/courage, and justice showed values below average. Third, students of industrial-field specialized high schools and Meister high schools showed differences in personality level according to nurturing style of parents, respect for teachers, stress for academic achievement, and school satisfaction, and additionally, students of Meister high schools showed differences in personality level according to career plans. That is, when the student perceived his/her parents to put higher value on his/her happiness rather than academic achievement, when the student respected the teacher, and when the student was more satisfied with te school life, the student showed higher personality level, and in case of students of Meister high schools, the student with detailed plan for his/her career showed high personality level than the student who has not yet decided on his/her career.

Latent Profile Analysis of Korean Adult Gamblers' Psychological Characteristics and Their Differences in Levels of Problematic Gambling (잠재프로파일 분석을 이용한 성인 도박자의 심리적 특성과 문제도박 수준의 차이)

  • Jaehwan, Kim;Seongeun, Oh;Sungho, Jang
    • Korean Journal of Culture and Social Issue
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    • v.28 no.4
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    • pp.577-595
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    • 2022
  • The purposes of the study is to classify the psychological characteristics of gamblers using by latent profile analysis and to identify the consequences according toof the latent profiles. The subjects of the study are 473 adults gamblers who responded to a online survey about gambling patterns, basic psychological needs(BPNs), and mental health status(MHS) such as stress, depression, and anxiety. Using latent profile analysis known as the person-centered analysis, the results showed that psychological characteristics of gamblers were classified into three groups: 'Lower MHS-BPNs', 'Middle MHS-BPNs', and 'Upper MHS-BPNs'. Also, the as outcome variable, levels of problematic gambling(KCPGI) showed significant differences across the latent profiles such as Problem gambling(M=11.393) on 'Lower MHS-BPNs', Moderate-risk gambling(M=4.277) on 'Middle MHS-BPNs' and Low-risk gambling (M=1.718) on 'Upper MHS-BPNs'. Overcoming the limitations of variable-centered analysis in the existing studies, this study providesreveals new insights onin the psychological characteristics of gamblers and how different latent profiles of gamblers may be in theirdistinct levels of problematic gambling. Finally, limitations of the study and future directions for research on gambling problems are discussed.