• KSII Transactions on Internet and Information Systems (TIIS)
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• 제4권2호
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• pp.78-97
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• 2010

Route discovery in wireless mobile networks requires a considerable amount of resources due to the mobility of the hosts. Therefore, it would be wise to utilize the effort already invested in existing paths. This paper proposes an efficient way to reuse, whenever possible, existing paths when a new path is being established. In our proposed algorithm, called Route Reutilization Routing (RRR), the reusability is accomplished by the notion of the dynamic proactive zones (DPZ), through which nearby existing path information is disseminated. By utilizing the information stored in DPZs, RRR can achieve considerable savings over other on-demand routing algorithms that use flooding. The unique feature of the proposed algorithm is that DPZs are created and destroyed dynamically around the existing paths, whereas proactive zones are formed around the nodes throughout the network in other route finding algorithms. Even though using DPZs may not result in the shortest path between source and destination, simulation results show the considerable reduction in traffic needed to find a path and therefore increases the available bandwidth for data transmission.

• BMB Reports
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• 제42권12호
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• pp.817-822
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• 2009

Type-1 phosphatase (PP-1) was assessed in foot muscle (FM) and hepatopancreas (HP) of estivating (EST) Otala lactea. Snail PP-1 displayed several conserved traits, including sensitivity to inhibitors, substrate affinity, and reduction in size to a 39 kDa catalytic subunit (PP-1c). During EST, PP-1 activity in FM and HP crude extracts was reduced, though kinetics and protein levels of purified PP-1c isoforms were not altered. PP-1c protein levels increased and decreased in nuclear and glycogen-associated fractions, respectively, during EST. Gel filtration determined that a 257 kDa low $K_m$ PP-1$\alpha$ complex decreased during estivation whereas a 76 kDa high $K_m$ complex increased in EST. Western blotting confirmed that the 76 kDa protein consisted of PP-1$\alpha$ and nuclear inhibitor of PP-1 (NIPP-1). A suppression of PP-1 activity factors in the overall metabolic rate depression in estivating snails and the mechanism is mediated through altered cellular localization and interaction with binding partners.

• 동의신경정신과학회지
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• 제19권2호
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• pp.123-132
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• 2008

Objective: This clinical research is conducted to find out coping strategies and anxiety of patients with chronic pain, and the correlation between pain coping strategy and anxiety. Method: 50 subjects who came to the local oriental clinic answered the questionnaires about VPMI(Vanderbilt Pain Management Inventory) and SAS(The Self-rating Anxiety Scale). Then we researched the characteristics of pain coping strategies and the correlation. Results: 1. The mean scores of passive coping, active coping, and SAS are 29.62, 17.90, and 38.32 respectively. 2. In the analysis of nonparametric test, the female subjects tend to take more passive coping than the male. The older subjects tend to take less active coping than the younger. Subjects who reported more intense pain tend to take more passive coping. 3. There is significant difference between passive coping and anxiety. Conclusion: Pain coping strategies are related with age, sex, intensity of pain, and anxiety. The therapeutic intervention of decreasing passive coping and increasing active coping may be useful to manage the chronic pain. Further study is needed to find out more adequate inquiries of active coping.

• 한국정보시스템학회지:정보시스템연구
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• 제3권
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• pp.71-82
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• 1994

Knowledge acquisition, maintenance of knowledge base, and validation and verification of knowledge are the addressed bottlenecks of building successful knowledge based systems. Along with the increment of interesting in the knowledge based systems, the organization needs to develop a new one although it has a similar one. This causes several serious problems including knowledge redundancy and maintenance of knowledge base. This paper present three models of the reusable knowledge base which might be the solution to the above problem. Three models are : 1) multiple knowledge bases for a single AI application, 2) multiple knowledge bases for multiple AI applications, 3) a single knowledge base for multiple AI applications. A new approach to build such a reusable knowledge base in a homogeneous environment is presented. Our model combines the essential object-oriented techniques with rules in a consistent manner. Important aspects of applying object-oriented techniques to AI are discussed (inheritance, encapsulation, message passing), and some potential problems in building an AI application (decomposition technique of knowledge, search time, and heterogeneous environment) are pointed out. The models of a reusable knowledge base provide several amenities : 1) reduce the knowledge redundancy, 2) reduce the effort of maintenance of the knowledge base, 3) reuse the resource of the multiple domain knowledge bases, 4) reduce the development time.

• Journal of Preventive Medicine and Public Health
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• 제42권6호
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• pp.343-348
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• 2009

The final decision of study design in molecular and genetic epidemiology is usually a compromise between the research study aims and a number of logistical and ethical barriers that may limit the feasibility of the study or the interpretation of results. Although biomarker measurements may improve exposure or disease assessments, it is necessary to address the possibility that biomarker measurement inserts additional sources of misclassification and confounding that may lead to inconsistencies across the research literature. Studies targeting multi-causal diseases and investigating gene-environment interactions must not only meet the needs of a traditional epidemiologic study but also the needs of the biomarker investigation. This paper is intended to highlight the major issues that need to be considered when developing an epidemiologic study utilizing biomarkers. These issues covers from molecular and genetic epidemiology (MGE) study designs including cross-sectional, cohort, case-control, clinical trials, nested case-control, and case-only studies to matching the study design to the MGE research goals. This review summarizes logistical barriers and the most common epidemiological study designs most relevant to MGE and describes the strengths and limitations of each approach in the context of common MGE research aims to meet specific MEG objectives.

• 영어영문학
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• 제64권3호
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• pp.329-345
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• 2018

Sun Yung Shin's poetry collection Skirt Full of Black (2007) brings the author's personal history as a Korean female adoptee to bear upon poetic language in daring formal experiments, instantiating the liminal state of being shuttled across borders to land in an in-between state of marginalization. Other Korean American poets have also drawn on the experience of transnational adoption and racialization explore the literary potential of English to materialize haunting memories or the untranslatable yet persistent echoes of a lost home that gestures across linguistic boundaries, as seen in the case of Lee Herrick or Jennifer Kwon Dobbs. Shin however dismantles the referential foundation of English as a language she was transplanted into through formal transgressions such as frazzled syntax, atypical typography, decontextualized punctuation marks, and phonetic and visual play. The power to signify and thereby differentiate one entity or meaning from another dissipates in the cacophonic feast of signs in Skirt Full of Black; the word fragments of identificatory markers that turn racialized, gendered, and culturally contained subjects into exotic things lose the power to define them as such, and instead become alterities by departing from the conventional meaning-making dynamics of language. Expanding on the avant-garde legacy of Korean American poets Theresa Hak Kyung Cha and Myung Mi Kim to delve further into the liminal space between Korean and American, referential and representational, or spoken and written words, Shin carves out a space for discreteness that does not subscribe to the hierarchical ontology of differential value assignment.

• Clinical Endoscopy
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• 제55권3호
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• pp.372-380
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• 2022

Background/Aims: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods: Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. Results: The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%-5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of -5.78%. Conclusions: There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권5호
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• pp.261-270
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• 2019

Background: People with the Ehlers-Danlos Syndromes (EDS), a group of heritable disorders of connective tissue, often report experiencing dental procedure pain despite local anesthetic (LA) use. Clinicians have been uncertain how to interpret this apparent LA resistance, as comparison of EDS and non-EDS patient experience is limited to anecdotal evidence and small case series. The primary goal of this hypothesis-generating study was to investigate the recalled adequacy of pain prevention with LA administered during dental procedures in a large cohort of people with and without EDS. A secondary exploratory aim asked people with EDS to recall comparative LA experiences. Methods: We administered an online survey through various social media platforms to people with EDS and their friends without EDS, asking about past dental procedures, LA exposures, and the adequacy of procedure pain prevention. Among EDS respondents who both received LA and recalled the specific LA used, we compared agent-specific pain prevention for lidocaine, procaine, bupivacaine, mepivacaine, and articaine. Results: Among the 980 EDS respondents who had undergone a dental procedure LA, 88% (n = 860) recalled inadequate pain prevention. Among 249 non EDS respondents only 33% (n = 83) recalled inadequate pain prevention (P < 0.001 compared to EDS respondents). The agent with the highest EDS-respondent reported success rate was articaine (30%), followed by bupivacaine (25%), and mepivacaine (22%). Conclusions: EDS survey respondents reported nearly three times the rate of LA non-response compared to non-EDS respondents, suggesting that LAs were less effective in preventing their pain associated with routine office dental procedures.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2765-2769
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• 2014

Background: Oesophageal cancer presents high incidence rates in the so-called Brazilian-Uruguayan belt. Materials and Methods: The present study included 1,170 participants (234 cases and 936 controls) which were analyzed by unconditional multiple logistic regression in order to examine risk of oesophageal squamous cell carcinoma (OESCC) associated with several food groups. Results: Boiled red meat (OR 2.59, 95%CI 1.69-3.97), lamb meat (OR 1.64, 95%CI 1.07-2.51), processed meat (OR 1.49, 95%CI 1.01-2.21), whole milk (OR 1.78, 1.19-1.68), fresh vegetables and fruits (OR 0.42, 95%CI 0.27-0.63), mate consumption (OR 2.04, 95%CI 1.32-3.16), and black tea (OR 0.10, 95%CI 0.04-0.28) were significantly associated with risk of OESCC. Conclusions: Hot beverages (mate) and hot foods (boiled meat) appear to be important determinants in the risk of OESCC, allowing the penetration of carcinogens in tobacco and alcohol into the oesophageal mucosa.

• BMB Reports
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• 제46권1호
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• pp.25-30
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• 2013

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and $p21^{Cip1}$ and $p27^{Kip1}$ expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. $G^1$ arrest, up-regulation of cell cycle-regulatory proteins $p21^{Cip1}$ and $p27^{Kip1}$ was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins.