• 약학회지
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• 제54권1호
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• pp.1-7
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• 2010

Valerian (Valeriana officinalis L.) is a perennial that has been used for medicinal purposes from the ancient times and valerian preparations including root and rhizome extracts are known to possess a variety of biological activities such as anticonvulsant, antidepressant, sleep aid, tranquilizer, and anti-HIV activities. Main components of the extracts were classified according to the structural features. Importantly, one of the main components, isovaleramide, has drawn our attention due to the concise structure, broad spectrum, and low toxicities. The general aspects including generation of this interesting molecule, a variety of activities, pharmacokinetic properties, derivatization, and fusion with other known drugs were described. Isovaleramide has been isolated from valerian probably as an isolation artifact after treatment of ammonia to prepare ammoniated tincture, and is known to exhibit anticonvulsant, anxiolytic, sedative, and sleep aid activities without distinct side effects such as excessive sedation and decreasing muscle tone. It was also found to be well absorbed into the circulation system without specific cytotoxicity and genotoxicity. The derivatives of isovaleramide, valpromide, valrocemide and valnoctamide were also briefly discussed.

• 한국연초학회지
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• 제25권1호
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• pp.80-86
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• 2003

The contents of valepotriates, valerenic acid and their derivatives as mild sedative and antispamodic principles in two Korean valerian roots (Valeriana officinalis var. latifolia Miq. and V. fauriei var. dasycarpa Hara) were investigated and were compared with those in European valerian roots(Valeriana officinalis L.) by BPLC method. Among valepotriate compounds, valtrate was detected as a small amount in two Korean valerian roots, and iso-valtrate and dihydrovaltrate were detected as a trace amount. Among valerenic acid and their derivatives, valerenic acid were contained from 0.9∼3.46 mg/g base on dry weight. Over the vegetation periods investigated, the content of valepotriates remained more or less constant, hut the content of valerenic acid reached its maximum in 3-year old age. The compound isolated from Korean V. officinalis var. latifolia was elucidated as valerenic acid by spectroscopic data such as GC-MS, $^1$H-NMR and $^{13}$ C-NMR, and comparison of GC retention time with that of authentic compound.

• 한국연초학회지
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• 제14권1호
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• pp.66-78
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• 1992

The essential oil of Korean valerian root ( Valeriana fauriei roar. dasycarpa Hara) was isolated by simultaneous distillation Sl extraction. The oil content of fresh root was 0.7% (wb) and that of dried root was 2.1 5 (db) and sensory analysis of the oil indicated sweet-balsamic, woody and floral characteristic aroma notes. The oil was fractionated into one hydrocarbon fraction and three oxygenated hydrocarbon fractions by using silica gel column chromatograpy. Each fraction was analyzed by capillary GC and GC-MS. Out of 81 characterized compounds, the major compounds were a-pinene, camphene, $\beta$-pinene, bornyl acetate, borneol , bornyl iso-valerate and sesquiphellandrene and the characteristic floral and woody aroma of neutral fraction of Korean valerian root could be due to be the presence of oxygenated compounds such as borneol, bornyl acetate, bornyl iso-valerate, p-ionone ana $\beta$-ionone epoxide. Comparing the yield of Korean valerian root with those from other origins reported, oil content of Korean valerian root was higher than those of European and Indian origins.

• 한국약용작물학회지
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• 제4권2호
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• pp.109-113
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• 1996

광릉쥐오줌풀과 넓은잎쥐오줌풀을 표고가 다른 지역에서 생육시켜 유효성분의 차이를 조사하였다. 정유함량은 산지에 따른 차이가 인정되지 않았으나, 정유조성은 미미한 차이를 보였다. 양적으로 많이 함유된 성분은 광릉쥐오줌풀에서는 모든 지역에서 bornyl acetate 및 sesquiterpene alcohol이었고, 넓은잎쥐오줌풀에서는 borneol, bornyl actate 및 ${\beta}\;-sesquiphellandrene$이었다. 유럽산과 네팔산의 주요 약리성분으로 알려져 있는 valepotriate 화합물 중 valtrate가 광릉쥐오줌풀 및 중국산쥐오줌풀에서 미량 검출되었으며, 이의 함량은 산지에 따라 큰 차이는 없었다.

• 한국식품영양학회지
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• 제31권1호
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• pp.104-108
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• 2018

The purpose of this study was to establish valerenic acid as a marker compound for the standardization of ethanol extract of Valerinan officinalis (valerian) root as a functional health food. We established valerenic acid as a marker compound using HPLC. HPLC was used to quantify the marker compound in the valerian extract after validation of methods with linearity, accuracy, and precision. The specificity for retention time was met by comparative analysis of the valerian extract and standard compound using HPLC. The method showed high linearity of the calibration curve with a coefficient of correlation ($R^2$) of 0.9999. The limit of quantification (LOQ) was $10{\mu}g/mL$. The accuracy of measurement was 99.88~00.68% and the relative standard deviation (RSD) value was 0.59%. In addition, our analytical method yielded a 29% mean content of valerenic acid in the valerian ethanol extract. These results indicate that the established HPLC method facilitated the determination of marker compounds in the valerian extract for the standardization of health functional foods.

• 한국작물학회지
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• 제42권6호
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• pp.814-820
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• 1997

국내 자생종인 광릉쥐오줌풀의 재배법을 구명하는 기초자료를 얻고자 질소, 인산, 칼리를 각각 무처리, 6, 9, 12kg/10a 등 4수준으로 처리하여 생육 및 뿌리 수량을 조사하고 정유성분을 분석하였다. 그 결과를 요약하면 다음과 같다. 1. 쥐오줌풀의 생육 및 뿌리 수량은 질소, 인산, 칼리를 각각 103당 9kg 시용한 구에서 가장 높았고, 비료효율은 질소 > 칼리 > 인산 순이었다. 2. 추출물 및 정유 함량은 질소, 인산, 칼리를 각각 103당 9kg 시용한 구에서 가장 높았으며, 그외 처리간 차이는 크지 않았다. 3. 정유성분 조성은 시비량에 따라 차이가 있었는데, 주요 성분의 조성은 대체적으로 각 비료당 9kg/10a시비수준에서 높았고, 그 이상 시용량이 증가되면 감소되었다.

• 한국약용작물학회지
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• 제3권2호
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• pp.81-83
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• 1995

토양수분함량의 차이가 쥐오줌풀의 지하부생육 및 뿌리의 엑스함량에 미치는 영향을 조사하기 위하여 광룽쥐오줌풀 (Valeriana jauriei var. dasycarpa HARA)을 사용하여 토양수분을 최대용수량의 30, 45, 55, 70, 70 및 90%로 조절하여 pot시험으로 수행하였던 바 얻어진 결과는 다음과 같다. 1. 엽장 및 엽폭은 토양수분함량이 증가 할수록 미미한 증가를 보였으나 엽병장 및 근장은 80%까지 토양수분함량이 증가할수록 직선적인 증가를 보였다. 2. 토양수분함량과 근수량 및 근의 엑스함량간에는 고도의 정의 상관이 인정되었다. 3. 쥐오줌풀의 생육의 최적수분함량은 최대용 수량의 $80{\sim}90%$ 였다.

• 생약학회지
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• 제26권2호
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• pp.175-178
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• 1995

The study was conducted to investigate the effect of cultivation area with different sea levels on essential oil in the root of Valeriana fauriei var. dasycarpa Hara (Valerianaceae). The total content of the essential oil was not different in various cultivation area, however, its composition varied. The major components were bornyl acetate and sesquiterpene alcohol in three cultivation areas. Among the valepotrate components known as major active components in Europe and Nepal valerian, valtrate was detected in a small amount, but the quantity was not changed.

• 한국약용작물학회지
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• 제3권2호
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• pp.77-80
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• 1995

한국산 광릉쥐오줌풀에 대한 광합성 및 호흡특성과 아울러 광합성의 일중(日中)변화와 이와 관련된 특성 및 생육상황에 미치는 온도의 영향을 조사하였던 그 결과는 다음과 같다. 1. 온도와 쥐오줌풀 잎의 광합성간에는 고도로 유의한 2차곡선회귀가 인정되었으며, 이 회귀식에 의해 산출한 최대광합성을 위한 은도는 $17.7^{\circ}C$이었다. 2. 쥐오줌풀 잎의 기공수는 잎의 표면에서 약 $25/mm^2$, 이면에서 $85mm^2$이었으며 기공의 크기는 $21{\sim}30/{\mu}m$로 나타났다. 3. 온도와 쥐오줌풀의 엽폭 및 근중간에는 각각 고도로 유의한 2차곡선회귀가 인정되었으며 이 회귀식에 의해 산출한 근생장(根生長)의 최적온도는 약 $20.3^{\circ}C$이었다.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.298-305
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• 2023

This study aimed to examine the effects of several essential oils on insomnia in dementia patients following transdermal treatment (aromatherapy). The mean change rates (%) of sleep biomarkers were compared between the single essential and jojoba (vehicle) oil massage groups in this study. The lavender (L) essential oil massage group demonstrated a significant decrease in the mean change rate (%) of 24-h urinary free cortisol, whereas the valerian (V) essential oil massage group demonstrated a significant increase in the mean change rate (%) of serum 5-hydroxytryptamine. In addition, a significant increase in the mean change rate (%) of 24-h urinary norepinephrine was observed in the chamomile (C) essential oil massage group only. Based on these results, valerian, lavender, and chamomile oils were mixed in different ratios to produce blending oils A (L:C:V=2:2:1), B (L:C:V=3:1:1) and C (L:C:V=1:3:1). The highest level of serum 5-hydroxytryptamine was observed after administering blending oil A. These results suggest that blending oil A might possess therapeutic effects against insomnia. Overall, it is hypothesized that the optimally blended essential oil will produce synergic effects when combined with hypnotic drugs.