• Natural Product Sciences
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• v.18 no.3
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• pp.141-146
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• 2012

Veronica peregrina (Scrophylariaceae) has been widely used as a Korean traditional medicine for the treatment of various pathological conditions including infection, hemorrhage and gastric ulcer. In the current study, we investigated the inhibitory effect of methanolic extracts of V. Peregrina (VPM) on the LPS-mediated nitric oxide (NO) production in mouse (C57BL/6) peritoneal macrophages. NO production was significantly down-regulated by the treatment of VPM dose dependently. To evaluate the mechanism of the inhibitory action of VPM on NO production, we performed iNOS enzyme activity assay and checked the change of inducible nitric oxide synthase (iNOS) levels by Western blotting. Although VPM did not affect iNOS enzyme activity, iNOS protein expression was attenuated by VPM indicating VPM inhibits NO production via suppression of iNOS enzyme expression. In addition, VPM attenuated the expression of another pro-inflammatory mediator such as cyclooxygenase-2 (COX-2) in a dose dependent manner. We also found that VPM can reduce trypsin-induced paw edema in mice. Based on this study, we suggest that V. peregrina may be beneficial in diseases which related to macrophage-mediated inflammatory disorders.

• Restorative Dentistry and Endodontics
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• v.27 no.6
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• pp.587-599
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• 2002

Extracellular single unit recordings were made from the ventral posteromedial thalamic (VPM) nociceptive neurons to determine mechanoreceptive field (RF) and response properties. A total of 44 VPM thalamic nociceptive neurons were isolated from rats anesthetized with urethane-chloralose. Based on responses to various mechanical stimuli including touch, pressure and pinch applied to the RF, 32 of 44 neurons were classified as nociceptive specific (NS) neuron. The other 12 neurons, classified as wide dynamic range (WDR), showed a graded response to increasingly intense stimuli, with a maximum discharge to noxious pinch. The VPM nociceptive neurons showed various spontaneous activity ranged from 0-6 Hz. They were located throughout the VPM, and had an contralateral RF including mainly intraoral (and perioral) regions. The RF size was relatively small, and very few neurons had a receptive field involving 3 trigeminal divisions. The NS neurons activated only by pressure and pinch stimuli had high mechanical thresholds compared to WDR neurons activated also by touch stimuli. The VPM nociceptive neurons were tested with suprathershold graded mechanical stimuli. Most of 21 NS and 8 WDR neurons showed a progressive increase in number of spikes as mechanical stimulus intensity was increased. In some neurons, the responses reached a peak before the highest intensity was given. Application of 5 mM $CoCl_2{\;}(10{\;}{\mu}\ell)$ solution to the trigeminal subnucleus caudalis did not produce any significant changes in the spontaneous activity, RF size, mechanical threshold, and response to suprathreshold mechanical stimuli of 9 VPM nociceptive neurons tested. 17 of 33 VPM nociceptive neurons responded to noxious heat as well as noxious mechanical stimuli applied to their RF. Application of the mustard oil, a small-fiber excitant and inflammatory irritant, to the right maxillary first molar tooth pulp induced an immediate but short-lasting neuronal discharges upto approximately 4 min in 16 of 42 VPM nociceptive neurons. These results suggest that VPM thalamic nucleus may contribute to the sensory discriminative aspect of orofacial nociception.

• Journal of Advanced Navigation Technology
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• v.18 no.5
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• pp.437-444
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• 2014

The integrated modular avionics (IMA) system has quite a number of line repalceable moduels (LRMs) in a cabinet. The LRM performs functions like line replaceable units (LRUs) in federated architecture. The video processing module (VPM) acts as a video bus bridge and gateway of ARINC 818 avionics digital video bus (ADVB). The VPM is a LRM in IMA core system. The ARINC 818 video interface and protocol standard was developed for high-bandwidth, low-latency and uncompressed digital video transmission. FPGAs of the VPM include video processing function such as ARINC 818 to DVI, DVI to ARINC 818 convertor, video decoder and overlay. In this paper we explain how to implement VPM's Hardware. Also we show the verification results about VPM functions and IP core performance.

• Korean Journal of Medicinal Crop Science
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• v.10 no.1
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• pp.1-4
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• 2002

This study was carried out to know the effect of light intensity, temperature and $CO_2$ concentration on photosynthesis and transpiration in Hovenia dulcis Thunb. Light compensation point was $2.4\;{\mu}mol\;m^{-2}\;s^{-1}$ and light saturation point was $1033\;{\mu}mol\;m^{-2}\;s^{-1}$. The optimum temperature for photosynthesis was $25^{\circ}C$ at $1000\;{\mu}mol\;m^{-2}\;s^{-1}$ light intensity. $CO_2$ compensation point was 67 vpm and $CO_2$ saturation point was 707 vpm. Transpiration rate was increased to about $2\;mmol\;m^{-2}\;s^{-1}$ with increasing of light intensity to $1750\;{\mu}mol\;m^{-2}\;s^{-1}$ and to above $4\;mmol\;m^{-2}\;s^{-1}$ with increasing of temperature from $18^{\circ}C$ to $36^{\circ}C$. however It was gradually reduced as $CO_2$ concentration increased from 21 vpm to 800 vpm.

• Korean Journal of Medicinal Crop Science
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• v.9 no.3
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• pp.232-237
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• 2001

This study was carried out to know the effect of light intensity, temperature and $CO_2$ concentration on photosynthesis and transpiration in yacon(Polymnia sonchifolia Poepp.& Endl.). Light compensation point was ${58\;{\mu}mol\;m^{-2}\;s^{-1}}$and light saturation point was ${1708\;{\mu}mol\;m^{-2}\;s^{-1}}$. Transpiration rate was increased to about 4 mmol${m^{-2}\;s^{-1}}$ with increasing of light intensity to ${2193\;{\mu}mol\;m^{-2}\;s^{-1}}$. The optimum temperature for photosynthesis was ${24^{\circ}C}$ in air. Photosynthesis was gradually reduced as transpiration rate increased from 4 to 8 mmol ${m^{-2}\;s^{-1}}$ in different air temperature. $CO_2$ compensation point was 63 vpm and $CO_2$ saturation point was 1155 vpm and light saturation point was enhanced with increasing of $CO_2$ concentration from 350 vpm to 1300 vpm.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.3
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• pp.129-132
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• 2004

Single unit responses of the ventral posterior medial (VPM) thalamic neurons to stimulation were monitored in anesthetized rats during activation of contralateral primary somatosensory (SI) cortex by GABA antagonist. The temporal changes of afferent sensory transmission were quantitatively analyzed by poststimulus time histogram (PSTH). Mainly, afferent sensory transmission to VPM thalamus was facilitated (15 neurons of total 23) by GABA antagonist (bicuculline) applied to contralateral cortex, while 7 neurons were suppressed. However, when ipsilateral cortex was inactivated by GABA agonist, musimol, there was significant suppression of afferent sensory transmission of VPM thalamus. This suppressed responsiveness by ipsilateral musimol was not affected by bicuculline applied to contralateral cortex. These results suggest that afferent transmission to VPM thalamus may be subjected to the interhemispheric modulation via ipsilateral cortex during inactivation of GABAergic neurons in contralateral SI cortex.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.2A
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• pp.129-136
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• 2005

A multiplier generator, VPM_Gen (Variable-Precision Multiplier Generator), which generates Verilog-HDL models of multiplier cores with user-defined bit-width specification, is described. The bit-widths of operands are parameterized in the range of $8-bit{\sim}32-bit$ with 1-bit step, and the product from multiplier core can be truncated in the range of $8-bit{\sim}64-bit$ with 2-bit step, resulting that the VPM_Gen can generate 3,455 multiplier cores. In the case of truncating multiplier output, by eliminating the circuits corresponding to the truncation part, the gate counts and power dissipation can be reduced by about 40% and 30%, respectively, compared with full-precision multiplier. As a result, an area-efficient and low-power multiplier core can be obtained. To minimize truncation error, an adaptive error-compensation method considering the number of truncation bits is employed. The multiplier cores generated by VPM_Gen have been verified using Xilinx FFGA board and logic analyzer.

• The Korean Journal of Pain
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• v.8 no.1
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• pp.25-30
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• 1995

Anlgesic agents against visceral pain typically rely on a noxious chemical irritation of the peritoneum, e. g., acetic acid and phenylquinone writhing test. While useful, this type of assay depends upon an acute inflammation and the release of local alogens. Further, ethical and scientific constraints prevent repeated assessments in a single animal, thereby compounding the difficulty of assessing tolerance development to analgesic agents. To overcome these constraints, Colburn et al. developed a model for mechanical visceral pain model (VPM) based on a repeatable and reversible duodenal distention in the rat. A chronic indwelling intraduodenal balloon catheter is well tolerated and upon inflation produces a writhing response graded in proportion to distention. This response is inhibited by morphine in a dose dependent manner. We found that a model for visceral pain was thought to be a great value.

• Journal of Korean Society of Forest Science
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• v.73 no.1
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• pp.1-8
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• 1986

Relationship between distribution of tree species and salt concentration in soil was studied in order to understand the salt tolerance of tree species in the middle part of Korean east coast and its results were as follows; 1) The tree species in the area mostly consist of Pinus thunbergii, Pinus densiflora, Rosa rugosa, Lespedeza bicolor, Amorpha fruticosa, Quercus dentata, Rhododendron mucronulatum, Rohinia pseudoacacia and others. 2) Pinus thunbergii was dominant species and Rosa rugosa gradually disappeared at the distance from the beach line to 200 meters toward inland. Pinus thunbergii tended to disappear gradually and Pinus densiflora was dominant at the distance from 200 meters to 300 meters inland. 3) Pinus thunbergii was dominant below 50 meters in altitude while Pinus densiflora was dominant above 50 meters. 4) NaCl content tended to decrease as proceeding to inland, higher altitude and to shallow depth of soil. 5) Change in pH in terms of distance toward inland and altitude was not significant, but change in pH along soil depth was conspicuously decreasing from pH 7.0 of top soil to pH 6.5 50cm below. 6) Pinus thunbergii was densely distributed to the area where soil NaCl content was higher than 100 vpm, while Pinus densiflora dominated the area of less than 100 vpm. Rosa rugosa was shown to dominate the area of over 100 vpm soil NaCl content. 7) NaCl content in tree tended to decrease, as proceeding to inland, rapidly within 150 meters distance from the beach line and gradually at further distances. NaCl content in leaf was about 600 ppm, branch 350ppm and root 250 ppm.

• Journal of Plant Biology
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• v.38 no.2
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• pp.195-201
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• 1995

The present study was made of the effects of abscisic acid(ABA) and calcium ions on dark respiration in protoplasts isolated from the basal intercalary meristematic tissues of oat (Avena sativa L.) seedlings. The influences of calcium channel blockers diitiazem(DTZ), verapamil(VPM), and $LaCl_2$ and the calmodulin antagonist trifluoperazine(TFP) on protoplast respiration activities were also investigated in order to evaluate the possible involvement of calcium channels and calmodulin during the dark respiration. The ABA only caused an 21% inhibition of protoplast respiration at $10^{-6}\;M$, but the extent of inhibition was very low by calcium treatments in the absence of ABA. In the presence of $10^{-6}\;M$ ABA, however, this inhibition of respiration increased by the increment of calcium ions concentrations. Treatments of DTZ and VPM were all found to restore the calcium-dependent inhibition of protoplast respiration by ABA and it was the same in thc $LaCl_2$ treatment except at $10^{-4}\;M$. At concentration from $10^{-6}\;M\;to\;10^{-4}\;M$, TFP also restored an inhibition of respiration. These results support the possibility that ABA increases plasmalemma permeability to calcium ions which might then bind to calmodulin to regulate oat protoplast dark respiration.ration.