• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2335-2340
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• 2014

Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured -15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at $38^{\circ}C$ over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.

• 한국방사선학회논문지
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• 제15권3호
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• pp.293-299
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• 2021

CT 장치를 이용하여 주기적인 검사를 시행하는 환자의 불가항력적 방사선 피폭을 줄이기 위해 다양한 스캔 파라미터 중 X선의 투과력과 밀접한 관전압의 변화를 통해 환자 선량을 감소시킬 수 있는 스캔 방법을 알아보았다. 실험결과 일반적으로 임상에서 많이 적용하는 120 kVp 대신 100 kVp를 적용하여 스캔 시 CTDI가 약 41 % 감소하였다. 또한 화질 변화정도는 CT value는 1046.1±3.7 HU, Pixel value는 71.4±7.9로 측정되었으며 통계분석결과 큰 차이가 없는 것으로 분석되었다(0.05

• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.102-107
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• 2015

Purpose: Human parechovirus (HPeV) and enterovirus (EV) are causative agents of a sepsis-like illness in neonates and of infections of the central nervous system in young children. The objectives of this study were to assess the prevalence of HPeV3 and EV infection in young children with a sepsis-like illness or with meningitis in Jinju, Korea. Methods: Cerebrospinal fluid (CSF) samples were collected from 267 patients (age range, 1 day to 5 years) and assessed for HPeV and EV by performing reverse transcription polymerase chain reaction assay. Amplification products of the VP3/VP1 region of HPeV and of the VP1 region of EV were sequenced to identify the virus type. Results: HPeV and EV were detected in 3.4% and 7.5% of the total CSF samples assessed, respectively. The age distribution of EV-positive patients (median age, 1.4 months) had a significantly broader range than that of HPeV-positive patients (median age, 7.8 months). The peak seasons for HPeV and EV infection were spring and summer, respectively. The clinical symptoms for HPeV and EV infection were similar, and fever was the most common symptom. Pleocytosis was detected in 22.2% of HPeV-positive patients and 35.5% of EV-positive patients. The VP3/VP1 gene sequence of the nine Korean strains clustered most closely with the Japanese strain (AB759202). Conclusion: The data indicate that HPeV infection is predominant in young infants (<6 months) and that meningitis without pleocytosis was caused by both HPeV and EV infection in children.

• 대한원격탐사학회지
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• 제16권1호
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• pp.73-86
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• 2000

Pushbroom위성 영상의 카메라 모델링을 위한 대표적 방법들을 구현하고 성능을 분석하였다. 구현된 모델들은 벡터 진행 모델, Gugan and Dowman(GD)의 모델, 상용 소프트웨어의 근간을 이루는 Orun and Natarajan(ON)의 모델, Direct Linear Transformation(DLT)모델이다. 서울/경기지역 의 SPOT 영상에 대해 지상기준점의 수를 1개에서 23개까지 변화하면서 카메라 모델을 수립하였다. 지상기준점이 6개 미만인 경우에는 벡터 진행 모델이 최고 2.7픽셀의 정확도를 보인 반면 이외의 모델들은 사용할 수 없다. 6개 이상인 경우에는 ON모델이 최고 1픽셀의 정확도로 가장 우수한 성능을 보인다. 이때 벡터 진행 모델은 최고 1.5픽셀의 정확도를 갖는다. GD모델은 모델 변수간의 상관관계로 인하여 대부분의 경우 모델 수립에 실패하였다. DLT모델의 정확도는 특정 지상기준점의 포함여부에 따라 1∼4픽셀 사이에서 진동한다. 모델링의 부산물로서 벡터 진행 모델은 위성궤도 추정에 응용할 수 있는 장점이 있다 향후 연구 과제로는 위에서 열거한 정확도로부터 지상기준점에 내재한 오차 제거, 벡터 진행 모델의 성능 향상 등이 있다.

• 한국방사선학회논문지
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• 제17권7호
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• pp.1041-1047
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• 2023

고 해상력 CT에 해당하는 관자뼈 CT는 높은 관전압과 얇은 단면두께 등의 적용으로 스캔 선량이 인접 부위 검사보다 높다. 이에 검사조건 중 재구성 알고리즘을 변화 적용하여 검사 선량을 줄이면서 병변에 대한 민감도가 우수한 알고리즘을 찾아 유의성과 임상 기초자료 제공 가능성을 알아보았다. 그 결과 100 kVp로 관전압을 낮추어 적용 시 선량이 약 35.6% 감소하였고, 100 kVp로 획득한 Raw data에 Definition 알고리즘 적용 시 SNR, CNR이 우수하였으며 다른 알고리즘과 비교 시 통계적으로 유의한 차이를 보였다(p<0.05). 그리고 구조적 유사도를 비교한 결과 SSIM index가 ROI 별 0.776, 0.813, 0.741로 분석되었다. 따라서 관자뼈 CT 스캔에서 알고리즘 변경적용은 CT 검사로 발생하는 선량을 일부 감소시킬 수 있고 임상 기초자료 측면에서 매우 의미가 있다고 생각한다.

• Journal of Korean Neurosurgical Society
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• 제57권5호
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• pp.359-363
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• 2015

Objective : Ventriculoperitoneal (VP) shunt complication is a major obstacle in the management of hydrocephalus. To study the differences of VP shunt complications between children and adults, we analyzed shunt revision surgery performed at our hospital during the past 10 years. Methods : Patients who had undergone shunt revision surgery from January 2001 to December 2010 were evaluated retrospectively by chart review about age distribution, etiology of hydrocephalus, and causes of revision. Patients were grouped into below and above 20 years old. Results : Among 528 cases of VP shunt surgery performed in our hospital over 10 years, 146 (27.7%) were revision surgery. Infection and obstruction were the most common causes of revision. Fifty-one patients were operated on within 1 month after original VP shunt surgery. Thirty-six of 46 infection cases were operated before 6 months after the initial VP shunt. Incidence of shunt catheter fracture was higher in younger patients compared to older. Two of 8 fractured catheters in the younger group were due to calcification and degradation of shunt catheters with fibrous adhesion to surrounding tissue. Conclusion : The complications of VP shunts were different between children and adults. The incidence of shunt catheter fracture was higher in younger patients. Degradation of shunt catheter associated with surrounding tissue calcification could be one of the reasons of the difference in facture rates.

• Journal of Microbiology and Biotechnology
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• 제26권8호
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• pp.1398-1403
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• 2016

The simultaneous detection and accurate identification of hepatitis A virus (HAV) is critical in food safety and epidemiological studies to prevent the spread of HAV outbreaks. Towards this goal, a one-step duplex reverse-transcription (RT)-PCR method was developed targeting the VP1/P2B and VP3/VP1 regions of the HAV genome for the qualitative detection of HAV. An HAV RT-qPCR standard curve was produced for the quantification of HAV RNA. The detection limit of the duplex RT-PCR method was 2.8 × 10¹ copies of HAV. The PCR products enabled HAV genotyping analysis through DNA sequencing, which can be applied for epidemiological investigations. The ability of this duplex RT-PCR method to detect HAV was evaluated with HAV-spiked samples of fresh lettuce, frozen strawberries, and oysters. The limit of detection of the one-step duplex RT-PCR for each food model was 9.4 × 10² copies/20 g fresh lettuce, 9.7 × 10³ copies/20 g frozen strawberries, and 4.1 × 10³ copies/1.5 g oysters. Use of a one-step duplex RT-PCR method has advantages such as shorter time, decreased cost, and decreased labor owing to the single amplification reaction instead of four amplifications necessary for nested RT-PCR.

• 대한방사선기술학회지:방사선기술과학
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• 제47권1호
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• pp.1-6
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• 2024

In Recent years, there has been a noticeable increase in the global incidence of breast cancer, with approximately 2.3 million cases of female breast cancer reported worldwide in 2020. Numerous studies are currently underway to enhance the accuracy of breast cancer diagnosis through the development of digital mammography detectors. This study aims to create Monte Carlo simulation-based mammographic anti-scatter grids and investigate their utility in evaluating the performance of digital mammography detector. Two types of mammographic anti-scatter grids, MAM-CP and Senographe 600T HF, were created using Monte Carlo simulation software (MCNPX 2.7.0), with grid ratios of 3.7 : 1 and 5 : 1, respectively. The grid physical characteristics (sensitivity, exposure factor, contrast improvement ratio) were calculated based on the KS C IEC60627 in the simulations using two X-ray qualities, RQA-M2 (28 kVp) and MW4 (35 kVp). As the X-ray tube voltage increased from 28 kVp to 35 kVp, sensitivity and exposure factor exhibited a decreasing trend, while contrast improvement ratio demonstrated an increasing trend. With an increase in grid ratio from 3.7 : 1 to 5 : 1, all physical characteristics showed an upward trend. Our results were consistent with a previous study that conducted measurements of physical properties using a real phantom. However, the pattern of change in the contrast improvement ratio with X-ray tube voltage differed from the previous study.

• 한국진공학회지
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• 제19권2호
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• pp.81-90
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• 2010

층과 층 사이의 정전기적인력, 수소결합 또는 공유결합을 이용하여 층당 두께를 수 옹스트롱에서부터 수십 나노미터까지 제조할 수 있으며 박막의 표면 형태를 흡착시키고자 하는 물질 및 박막 후처리 공정을 통해 제어할 수 있으며 더 나아가, 삽입하는 물질의 특성에 따라 박막의 기능성을 집적화 및 다양화시킬 수 있다. 본 연구에서는 이러한 층상자기조립방법의 특성을 이용하여 반사방지막, 초소수성 필름 및 전기화학센서로의 응용가능성을 제시하였다. 반사방지막의 경우, 구형의 블록공중합체를 유리기판 위에 다층박막으로 적층시킴으로써 박막 굴절률을 1.25까지 감소시켰고 이를 통해 약 99.5%의 빛 투과도를 달성할 수 있었다. 더 나아가 바이오물질인 엔자임을 다층박막에 삽입시킬 경우, 활성 산소를 분해시키는 전기화학센서로의 제조가 가능함을 보인다. 본 연구는 본인이 이미 발표한 논문(J. Am. Chem. Soc. 128, 9935 (2006); Adv. Mater. 19, 4364 (2007); Electro. Mater. Lett. 3, 163 (2007))들을 정리하여 층상자기조립법에 관해 소개하는 논문이다.

• The Journal of the Acoustical Society of Korea
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• 제25권2E호
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• pp.49-55
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• 2006

Compressional wave velocity (Vp), shear wave velocity (Vs), elastic and physical properties, and electrical resistivity for two core sediments obtained from Southeastern Yellow Sea Mud (SEYSM) were measured and computed. The sediments consist of homogeneous mud (mostly silt and clay) with shells and shell fragments. As a result, the mean grain size is uniform ($7.5-8.5{\Phi}$ throughout the core sediments. However, physical properties such as wet bulk density and porosity show slightly increasing and decreasing patterns with depth, compared to the mean grain size. The compressional (about 1475 m/s in average) and shear wave (about 60 m/s in average) velocities with depth accurately reflect the pattern of wet bulk density and porosity. Electrical resistivity is more closely correlated with compressional wave velocity than physical properties. The computed Vp/Vs and Poisson's ratios are relatively higher (more than 10) and lower (approximately 0.002) than Hamilton's (1979) data, respectively, suggesting the typical characteristics of soft and fully water-saturated marine sediments. Thus, the Vp/Vs ratio in soft and unconsolidated sediments is not likely sufficient to examine lithology and sediment properties. Relationships between the elastic constant and physical properties are correlated well. The elastic constants (Poisson's ratio, bulk modulus, shear modulus) given in this paper can be used to characterize soft marine sediments saturated with seawater.