• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.10
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• pp.1323-1328
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• 2011

In the current design process for the lower arm used in automobile parts, an optimal solution of its various design variables should be found through exploration of the design space approximated using the response surface model formulated with a first- or second-order polynomial equation. In this study, a multi-level computational DOE (design of experiment) was carried out to explore the design space showing nonlinear behavior, in terms of factors such as the total weight and applied stress of the lower arm, where a fractional-factorial orthogonal array based on the artificial neural network model was introduced. In addition, the tolerance robustness of the optimal solution was estimated using a tolerance optimization with six sigma constraints, taking into account the tolerances occurring in the design variables.

• Journal of Microbiology and Biotechnology
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• v.26 no.11
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• pp.2012-2018
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• 2016

Coxsackievirus B3 (CVB3) is the main cause of acute myocarditis and dilated cardiomyopathy. Plant extracts are considered as useful materials to develop new antiviral drugs. We had previously selected candidate plant extracts, which showed anti-inflammatory effects. We examined the antiviral effects by using a HeLa cell survival assay. Among these extracts, we chose the Amomi Cardamomi (Amomi) extract, which showed strong antiviral effect and preserved cell survival in CVB3 infection. We investigated the mechanisms underlying the ability of Amomi extract to inhibit CVB3 infection and replication. HeLa cells were infected by CVB3 with or without Amomi extract. Erk and Akt activities, and their correlation with virus replication were observed. Live virus titers in cell supernatants and viral positive- and negative-strand RNA amplification were measured. Amomi extract significantly increased HeLa cell survival in different concentrations ($100-10{\mu}g/ml$). CVB3 capsid protein VP1 expression (76%) and viral protease 2A-induced eIF4G1 cleavage (70%) were significantly decreased in Amomi extract ($100{\mu}g/ml$) treated cells. The levels of positive- (20%) and negative-strand (80%) RNA were dramatically decreased compared with the control, as revealed by reverse transcription-PCR. In addition, Amomi extract improved mice survival (51% vs 26%) and dramatically reduced heart inflammation in a CVB3-induced myocarditis mouse model. These results suggested that Amomi extract significantly inhibited Enterovirus replication and myocarditis damage. Amomi may be developed as a therapeutic drug for Enterovirus.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.115-121
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• 2020

The primary aim of this paper is to discuss the historical development or grammaticalization of English adverbial -ly suffix and provide a diachronic analysis of manner adverbs and sentence adverbs from the perspective of secondary grammaticalization. The grammaticalization includes both the primary grammaticalization from a lexical to a grammatical and the secondary grammaticalization from a less grammatical to a more grammatical status. The emergence of the manner adverbs is due to the primary grammaticalization from OE adjectival suffix -lic to ME adverbial suffix -ly. In contrast, the emergence of sentence adverbs is due to the secondary grammaticalization from manner adverbs in VP domain to sentence adverbs in TP domain with grammatical features of tense and modality. This paper concludes that the secondary grammaticalization of the English adverbial -ly suffix includes the change from manner adverbs to sentence adverbs which obtain a new grammatical function of tense and modality.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.4 no.4
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• pp.286-294
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• 2011

Cable modems typically are implemented by a forward error correction(FEC) scheme. The ITU-T Recommendation J-38 Annex B specifies using 64- and 256- quadrature amplitude modulation (QAM) and extended RS coding scheme. In implementing the cable modem, there are some problems to fabricate and fitting on FPGA chip. First, many clocks are needed in implementing cable modem because of different code rate and different modulation types. To reduce the number of clocks, we use the two memories, which are different clock speed for reading and writing data. Second, this system lost the bit-synchronization and frame-synchronization in decoder, the system recognize that all data is error. This paper solves the problems by using simple 5-stage registers and unique sync-word. Based on solutions for about problems, the cable modem is fabricated on FPGA chip name as Vertex II pro xc2vp30-5 by Xilinx, and we confirmed the effectiveness of the results.

• Radiation Oncology Journal
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• v.16 no.1
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• pp.81-86
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• 1998

Purpose : To generate the axial, coronal and sagittal images from conventional simulation images, as a preliminary study of broad-beam simulator CT. Methods and Materials : Volumetric filtered back-projection was performed using 90 sheets of films from conventional simulator for every $4^{\circ}$ gantry angle. Two mAs exposure condition for 120kvp beam qualify at SFD 140cm was given to each film. Outside the silhouette portion was removed and scatter component was deconvolved before back-projection. Results : The axial, the sagittal and the coronal images with same spatial resolutions over all direction could be obtained. But image quality was very poor. Conclusion : CT images could be obtained using broad-beam. Scatter deconvolution technique was effective for this reconstruction. The fact that same spatial resolutions over all direction tells us the possibility of application of this technique to DRR or Simulator-CT. But the quality of image should be improved for clinical application practically.

• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.291-297
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• 2018

Coxsackievirus B3 (CVB3) is a very well-known causative agent for viral myocarditis and meningitis in human. However, the effective vaccine and therapeutic drug are not developed yet. CVB3 infection activates host cell AKT signaling. Inhibition of AKT signaling pathway may attenuate CVB3 replication and prevent CVB3-mediate viral myocarditis. In this study, we determined antiviral effect of the selected natural plant extract to develop a therapeutic drug for CVB3 treatment. We screened several chemically extracted natural compounds by using HeLa cell-based cell survival assay. Among them, Linum usitatissimum L. extract was selected for antiviral drug candidate. L. usitatissimum extract significantly decreased CVB3 replication and cell death in CVB3 infected HeLa cells with no cytotoxicity. CVB3 protease 2A induced eIF4G1 cleavage and viral capsid protein VP1 production were dramatically decreased by L. usitatissimum extract treatment. In addition, virus positive and negative strand genome amplification were significantly decreased by 1 mg/ml L. usitatissimum extract treatment. Especially, L. usitatissimum extract was associated with inhibition of AKT signal and maintain mTOR activity. In contrast, Atg12 and LC3 expression were not changed by L. usitatissimum extract treatment. In this study, the potential AKT signal inhibitor, L. usitatissimum extract, was significantly inhibited viral genome replication and protein production by inhibition of AKT signal. These results suggested that L. usitatissimum extract is a novel therapeutic agent for treatment of CVB3-mediated diseases.

• Journal of radiological science and technology
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• v.46 no.6
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• pp.543-551
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• 2023

In this study, the aim was to assess the shielding performance of different 3D printing materials, specifically those produced using FDM, SLA, and CJP methods, with a focus on their application as shielding devices in clinical settings. Additionally, the weight of lead shielding materials can evoke reluctance in pediatric patients undergoing X-ray imaging. A total of 12 materials were printed using their respective 3D printers. These materials were then subjected to X-ray testing using diagnostic X-ray equipment and an exposure meter. The goal was to evaluate their shielding capabilities in comparison to 1 mm lead. The results of this evaluation revealed that VisiJet PXL-Pastel, produced using the CJP method, exhibited the highest shielding performance. Therefore, VisiJet PXL-Pastel by CJP method was selected for the creation of a shielding device designed for pediatric reproductive organs. Subsequent tests demonstrated that both the newly created shielding device and conventional lead shielding equipment achieved the same maximum shielding rate at 50 kVp. Specifically, the shielding rate for the 3D printed device was measured at 84.53%, while the conventional lead shielding equipment, categorized as Apron1 (85.74%), Apron2 (99.98%), and Apron3 (99.04%), demonstrated similar performance. In conclusion, the CJP-produced VisiJet PXL-Pastel material showcased excellent radiation shielding capabilities, allowing for anatomical observations of the target organs and their surrounding structures in X-ray images. Furthermore, its lower weight in comparison to traditional lead shielding materials makes it a clinically practical and useful choice, particularly for pediatric applications.

• Imaging Science in Dentistry
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• v.54 no.2
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• pp.159-169
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• 2024

Purpose: The aim of this study was to evaluate the influence of different cone-beam computed tomography (CBCT) acquisition protocols on reducing the effective radiation dose while maintaining image quality. Materials and Methods: The effective dose emitted by a CBCT device was calculated using thermoluminescent dosimeters placed in a Rando Alderson phantom. Image quality was assessed by 3 experienced evaluators. The relationship between image quality and confidence was evaluated using the Fisher exact test, and the agreement among raters was assessed using the kappa test. Multiple linear regression analysis was performed to investigate whether the technical parameters could predict the effective dose. P-values<0.05 were considered to indicate statistical significance. Results: The optimized protocol (3 mA, 99 kVp, and 450 projection images) demonstrated good image quality and a lower effective dose for radiation-sensitive organs. Image quality and confidence had consistent values for all structures (P<0.05). Multiple linear regression analysis resulted in a statistically significant model. The milliamperage (b=0.504; t=3.406; P=0.027), kilovoltage peak (b=0.589; t=3.979; P=0.016) and number of projection images (b=0.557; t=3.762; P=0.020) were predictors of the effective dose. Conclusion: Optimized CBCT acquisition protocols can significantly reduce the effective radiation dose while maintaining acceptable image quality by adjusting the milliamperage and projection images.

• Journal of radiological science and technology
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• v.40 no.2
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• pp.187-195
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• 2017

Early diagnosis for upper facial trauma is difficult by using the standard Water's view (S-Water's) in general radiograph due to overlapping of anatomical structures, the uncertainty of patient positioning, and specific patients with obese, pediatric, old, or high-risk. The purpose of this study was to analyze appropriate exposure angles through a comparison of two different protocols (S-Water's vs. reverse Water's view (R-Water's)) by using a head phantom. A head phantom and general radiograph with 75 kVp, 400 mA, 45 ms 18 mAs, and SID 100 cm. Images of R-Water's were obtained by different angles in the range of $0^{\circ}$ to $50^{\circ}$, which adjusted an angle at 1 degree interval in supine position. Survey elements were developed and three observers were evaluated with four elements including the maxillary sinus, zygomatic arch, petrous ridge, and image distortion. Statistical significant analysis were used the Krippendorff's alpha and Fleiss' kappa. The intra-class correlation (ICC) coefficient for three observers were high with maxillary, 0.957 (0.903, 0.995); zygomatic arch, 0.939 (0.866, 0.987); petrous ridge, 0.972 (0.897, 1.000); and image distortion, 0.949 (0.830, 1.000). The high-quality image (HI) and perfect agreement (PA) for acquired exposure angles were high in range of the maxillary sinus ($36^{\circ}-44^{\circ}C$), zygomatic arch ($33^{\circ}-40^{\circ}$), petrous ridge ($32^{\circ}-50^{\circ}$), and image distortion ($44^{\circ}-50^{\circ}$). Consequently, an appropriate exposure angles for the R-Water's view in the supine position for patients with facial trauma are in the from $36^{\circ}$ to $40^{\circ}$ in this phantom study. The results of this study will be helpful for the rapid diagnosis of facial fractures by simple radiography.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.327-335
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• 2016

The study is enforce to study image quality evaluation of condition provide the IEC and combination of clinical conditions each quality of radiation that image quality to assess the conditions provided to IEC in the clinical environment to conduct image quality assessment of the digital radiography system in the detector have environmental limits. First, image quality evaluation was evaluated by measuring the MTF, NPS using four quality of radiation and Using MCNPX simulation lastly DQE make a image quality evaluation after calculating the particle fluence to analyze spectrum quality of radiation. Second, Using MCNPX simulation of four quality of radiation was evaluated absorbed dose rate about electronic 1 per unit air, water, muscle, bone by using Radiation flux density and energy, mass-energy absorption coefficient of matter. Results of evaluation of image quality, MTF of four quality of radiation was satisfied diagnosis frequency domain 1.0 ~ 3.0 lp/mm of general X-ray that indicated 1.13 ~ 2.91 lp/mm spatial frequency. The NPS has added filter, spatial frequency 0.5 lp/mm at standard NPS showed a tendency to decrease after increase. Unused added filter, spatial frequency 0.5 lp/mm at standard NPS showed a certain NPS result value after decrease. DQE in 70 kVp / unuesd added filter(21 mm Al) / SID 150 cm that patial frequency 1.5 lp/mm at standard showed a tendency to decrease after certain value showed. Patial frequency in the rest quality of radiation was showed a tendency to decrease after increase. Results of evaluation of absorbed dose, air < water < muscle < bone in the order showed a tendency to increase. Based on the results of this study provide to basic data that present for the image quality evaluation method of a digital radiation imaging system in various the clinical condition.