• Korean Journal of Exercise Nutrition
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• v.16 no.1
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• pp.11-17
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• 2012

The purposes of this study were to investigate the effects of acute exercise on blood vaspin, glucose level, and inflammatory cytokines in middle-aged women with pre-diabetes. Nineteen middle-aged women (normal women, n = 11) and women with pre-diabetes(n = 8), who were apparently healthy and not taking any medications affecting their blood pressure or blood glucose, participated. Body fatness parameters including body mass index, body fat percentage, and waist circumference were measured using a bio-impedance analyzer. Resting blood pressure was measured in duplicate, and mean values were used for the data analysis. Regardless of group assignments, all subjects participated in a 3-day consecutive walking exercise at an intensity of 65% VO_2max targeting an energy expenditure of 1200 kcal (400 kcal per day). The major outcome variables included total cholesterol, triglycerides, high-density lipoprotein cholesterol, glucose, vaspin, interleukin-6, and adiponectin levels. Unlike normal women, women with pre-diabetes had a significant improvement in the homeostatic model assessment of insulin resistance (p < 0.025) with no significant group difference in response to acute exercise. The findings suggest that acute exercise results in a significant improvement in insulin sensitivity without any change in serum vaspin levels in women with pre-diabetes.

• Journal of Life Science
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• v.19 no.1
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• pp.81-86
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• 2009

The purpose of the present study was to examine effect of 12 week regular aerobic exercise on ST-segment and QTc interval in middle age type 2 diabetes mellitus (T2DM) patients. The subjects consist of 13 type 2 diabetes mellitus (T2DM) patients in middle age men and all of them had no other complications. Subjects participated in aerobic exercise training for 12 weeks. They started to exercise for $20{\sim}60$ min at $60{\sim}80%$ of $HR_{max}$, (exercise intensity has been increased gradually) per day, $3{\sim}5$ times a week. The results were compared before and after. Weight and BMI, % body fat, fasting glucose, HOMA-IR, $_{peak}DBP$ were significantly decreased and $_{peak}HR$, $_{peak}VO_2$, exercisre time were significantly increased after 12 week aerobic exercise. Also, QTc interval and ST-segment were significantly decreased during at rest, peak exercise after 12 week aerobic exercise. Conclusionally, 12 week aerobic exercise may be improvement in decreased cardiovascular mortality factors (ST-segment) and abnormal autonomic dysfunction (QTc interval) and potentially increased exercise capacity.

• The Korean Journal of Rehabilitation Nursing
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• v.4 no.1
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• pp.7-19
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• 2001

The Objectives of this research is to determine the effect of aerobic exercise program on health status and physical fitness in patients after the stem cell transplantation. This research design is one-group pretest-post test design. Sixteen subjects were selected from one university hospital in Seoul for the study, they was carried out aerobic exercise three to five times a week for 12 weeks. The period of data collection was from February to July, 2000. The collected data was analysed by descriptive analysis, paired t-test, content analysis SAS program was used for the statistical analysis. The results are as follows : 1. There was a significant improvement in the Physical functioning, Vitality and Reported change (t=2.39, p=0.03; t=2.35, p=0.03; t=2.58, p=0.02) but no change was observed in the Role physical, General health perception, Bodily pain, Social functioning, Role emotional and Mental health. 2. There was a significant improvement in the physical fitness (higher VO2 max, t=2.43, p=0.02; lower systolic pressure, t=-4.09, p=0.001; lower diastolic pressure, t=-3.43, p=0.002; lower pulse rate, t=-3.43, p=0.004; higher muscle sustaining power, t=2.79, p=0.015; higher muscle power, t=5.18 p=0.000; higher power of beginning, t=5.55, p=0.001; higher the sense of equilibrium, t=3.57, p=0.003; higher Hemoglobin, t=5.92, p=0.000; higher Hematocrit, t=5.38, p=0.000). Therefore, this study will provide a theoretical back ground for patients after stem cell transplantation to understand the importance of physical exercise and maintain physical exercise; and for other researches to refer to the results for exercise protocol of rehabilitation program.

• Journal of Life Science
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• v.15 no.2 s.69
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• pp.220-224
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• 2005

The purpose of the present study is to investigate the effects of long-term exercise program on exercise capacity and cognitive function (MMSE) in male patients with dementia. 24 male patients were divided into two experimental groups : the exercise group (n=12) and the control group (n=12). The exercise group participated in regular exercise program for 12 months, and their exercise capacity (cardiopulmonary function, muscle strength, muscular endurance, flexibility, balance, agility) and MMSE (Mini-mental state examination) levels were evaluated at baseline (pre), after 6 months (mid) and after 12 months (post). The subjects carried on group-exercise of $VO_{2}max\;30\~60\%$, $30\~60$ minute a day, $2\~3$ times per week. Statistical techniques for data analysis was paired samples t-test. The level of statistical significance was ${\le}.05.$ The results of this study were summarized as follows: In the exercise group, there were significant differences in cardiopulmonary function, muscle strength, muscular endurance and MMSE at the times of pre & mid and pre & post, there were significant differences in balance and agility at the time of pre & post only, whereas there was no significant difference in flexibility following the long-term exercise. In the control group, there were no significant differences in all the times. Based on the results of this particular study, one year exercise program increases on the cognitive function & exercise capacity in male patients with dementia.

• Journal of Korean Biological Nursing Science
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• v.3 no.1
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• pp.29-40
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• 2001

The purpose of this study was to investigate the effect of exercise training on work capacity, psychologic functions and quality of life in hemodialysis patients. Forteen hemodialysis patients, 3 males, 11 females, age ranged from $23{\sim}58$ years($42.3{\pm}0.4$) were selected and assessed using a modified Bruce protocol on a treadmill. The 3 months supervised exercise training consisted of 60 minites session thrice weekly on the treadmill, bicycle and arm ergometer at $40{\sim}60%$ of maximum $O_2$ consumption. The changes of maximum $O_2$ consumption, psychologic test and quality of life questionnaire in 14 patients before and after 3 months exercise training have been measured. The mean maximum $O_2$ consumption($VO_2$ max) of exercises increased by 23% after training(pre-and postexercise $26.3{\pm}4.6ml$/kg/min vs $29.8{\pm}4.9ml$/kg/min, p=0.013). There was significant reduction in anxiety score(p=0.004) and significant improvement in quality of life score(p=0.031) after training. The result of this study indicated that a structured exercise training for hemodialysis patients provides many benefits. These result suggest the exercise training can improve the work capacity, psychologic functions and quality of life outcomes in hemodialysis patients.

• The Journal of Internal Korean Medicine
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• v.43 no.3
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• pp.423-435
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• 2022

Purpose: The purpose of this study was to confirm the clinical efficacy of Gyeongok-go. Methods: Public/Publisher MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), Excerpta Medica dataBASE (EMBASE), Research Information Sharing Service (RISS), ScienceON, Korean Traditional Knowledge Portal (KTKP), and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled clinical trials administering Gyeongok-go as an intervention, published from inception to December 31, 2021. The risk-of-bias of the included trials was assessed with the Cochrane risk-of-bias tool for randomized trials version 2. From the experimental and control groups of the selected trials, the mean value (or rate) of each outcome was extracted and statistically compared. Results: Statistically significant mean differences were in VO₂max (MD 6.82), post-exercise heart rate (MD -8.76 at 5 min, -11.58 at 30 min, -14.6 at 60 min), senescence scale (MD -6.52), Th1 cells and Th2 cells in pulmonary tuberculosis (MD 2.79 and -1.64), yin-deficient and qi-deficient score (MD -9.64 and -9.76), and phlegm-dampness score (MD 5.56). Overall risk-of-bias was 20% low risk, 80% some concerns, and 0% high risk. There were no reports of adverse events. Conclusions: Gyeongok-go is likely to have the effect of improving cardiorespiratory endurance, increasing fatigue recovery ability, reducing senescence, and enhancing immune function in tuberculosis patients. Also, it is more suitable for those who are yin-deficient or qi-deficient, and those with phlegm-dampness probably need caution.

• Molecules and Cells
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• v.27 no.5
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• pp.557-562
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• 2009

We examined the effects of the NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative DNA damage in response to acute and chronic exercises. One hundred three subjects were recruited, among which 26 healthy subjects (CC: 12, TC: 12, and TT: 2) were studied during rest, exercise at 85% $VO_2max$, and recovery before and after 8 weeks of treadmill running. Lymphocyte DNA damage increased significantly in response to exercise (p < 0.05). There were no significant differences in plasma MDA, SOD concentrations and lymphocyte DNA damage between CC genotype and T allele group, but significant endurance training differences were observed. Endurance training increased exercise time to exhaustion in both the CC genotype and T allele groups (p < 0.05) but no significant difference was found between groups. The results of the current study with young, healthy, Korean men are interpreted to mean that 1) the majority had the CC genotype of the NADPH oxidase p22phox C242T polymorphism (82.5%: CC, 15.5%: TC, 1.9%: TT), 2) acute exercise increased lymphocyte DNA damage, 3) endurance training significantly increased exercise time to exhaustion, and alleviated lymphocyte DNA damage, and 4) The NADPH oxidase p22phox C242T polymorphism, however, did not alter lymphocyte DNA damage or exercise performance at rest, immediately after exercise, or during recovery.

• Korean Journal of Occupational Health Nursing
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• v.23 no.2
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• pp.97-105
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• 2014

Purpose: The purpose of this study was to identify the link between health-related physical fitness level and cardiovascular disease-related risk factors in adult male workers. Methods: We tested cardiovascular disease-related risk factors (waist circumference, SBP, DPB, fasting glucose, TC, HDL-C, TG, LDL-C) and health-related physical fitness ($VO_2max$, grip, Sit-up, Flexibility, Body fat) and divided health-related physical fitness level of the subjects into 3 groups - A (very good, n=56), B (good, n=59), and C (below-average, n=57) according to the criterion of the Health and Fitness counseling guidelines of KOSHA. The statistical techniques such as standard deviation, one-way ANOVA and multiple regression (p<.05) were used. Results: There were significant differences between group C and group B & A (p<.001) in waist circumference, DBP, Fasting glucose, HDL-C, TG, LDL-C. In TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Group C was higher than group B and A. Conclusion: On the basis of these results, we identified that improvement of health-related physical fitness level positively effects on the decrease of cardiovascular disease-related risk factors.

• Journal of the Korean Society of Physical Medicine
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• v.16 no.2
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• pp.9-21
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• 2021

PURPOSE: This study examined the effects of an eight weeks twenty meters walk on the cardiorespiratory fitness and strength of the shoulder extensor, hip extensor, and dorsiflexor of stroke survivor outpatients in two tertiary hospitals in Osogbo, Nigeria. METHODS: A purposive sampling technique was used to select 21 registered right or left outpatient hemiplegic stroke survivors in a pre- and post-test experimental research design. The research questions were presented using the descriptive statistics of frequency, percentage, mean, and standard deviation. The differences between the mean of the cardio-respiratory indices and the muscle strength were tested by repeated measures analysis of variance followed by Bonferroni post-hoc test for multiple comparisons. RESULTS: No significant differences in heart rate were observed at week 0 compared to week 4. A significant decrease was recorded in the parameter at week 8, compared to week 4. Moreover, there were significant decreases in blood pressure and respiratory rate in week 0, compared to week 4, and in the respiratory rate, compared to week 8. In contrast, significant elevations in VO2 max were observed in week 0, compared to week 4, and in the week 4, compared to week 8. Furthermore, significant elevations in muscular strength were documented when comparisons were made at weeks 0, 4, and 8. CONCLUSION: Eight weeks of twenty meters walk aerobic exercise improve the cardio-respiratory fitness and muscular strength of stroke survivor outpatients.

• Korean Journal of Exercise Nutrition
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• v.16 no.2
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• pp.113-122
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• 2012

This study assessed the amount of energy consumed and fat deposition after endurance training in order to review the effect of 4-week endurance exercise on resting metabolic rate of a mouse during and after exercise and the effect of exercise. A total of 19 seven-week-old ICR male mice were used as the study subject. Those mice were divided into sedentary group (Sed) and trained group (Tr) after a week of environment adaption. The Tr group was trained with endurance exercise five times a week for four weeks. Weight and the amount of food intake were daily weighed and resting metabolic rate and metabolic rate after exercise were assessed before starting exercise and on the fourth week after training. Metabolic rate during exercise were measured four weeks after training. At the end of breeding period, statistically significant difference was shown in weights of trained and sedentary groups (p < 0.05). During a resting period, no significant difference was shown in oxygen intake, respiratory exchange ratio, and the amount of carbohydrate and fat oxidized. Moreover, no significant difference was shown in excess post-exercise oxygen consumption (EPOC) of an hour period after training. In contrast, the maximal oxygen uptake (VO₂ max) was approximately 11.1% higher in trained group after training compare to before. However, there was no significant difference in respiratory exchange ratio and carbohydrate and fat oxidization. During exercise, oxygen uptake, carbon dioxide production, and respiratory exchange ratio in energy metabolism during exercise showed no significant difference. However, significant difference was exhibited in the amount of fat oxidized in both groups. Summing up those results, endurance exercise could be concluded to be effective in weight control. However, weight loss is thought to be resulted from increase in fat oxidization during exercise unlike the conclusion made from previous studies where weight loss is prominently influenced by energy metabolism during a resting period and increased fat oxidation during post-exercise recovery. All experimental procedures were carried out at the Animal Experiment Research Center of Konkuk University. This study was conducted in accordance with the ethical guidelines of the Konkuk University Institutional Animal Care and Use Committee.