• Journal of Microbiology and Biotechnology
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• v.17 no.2
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• pp.348-358
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• 2007

Metallothionein, a cysteine-rich stress response protein that is naturally induced by a variety of immunologic stressors, has been shown to suppress autoimmune disorders through mechanisms not yet fully defined. In the present study, we examined the underlying mechanisms by which metallothionein might mediate such regulation of autoimmunity. $Na\ddot{i}ve\;CD4^+$ T cells from metallothionein-deficient mice differentiated to produce significantly less IL-10, $TGF-{\gamma}$, and repressor of GATA, but more $IFN-{\gamma}$ and T-bet, when compared with those from wild-type mice. The levels of IL-4 and GATA-3 production were not different between the two groups of mice. Conversely, treatment with exogenous metallothionein during the priming phase drove $na\ddot{i}ve$ wild-type $CD4^+\;T$ cells to differentiate into cells producing more IL-10 and $TGF-{\beta}$, but less $IFN-{\gamma}$ than untreated cells. Metallothionein-primed cells were hyporesponsive to restimulation, and suppressive to T cell proliferation in an IL-10-dependent manner. Lymphocytes from metallothionein-deficient mice displayed significantly elevated levels of AP-1 and JNK activities in response to stimulation compared with those from wild-type controls. Importantly, transgenic mice overexpressing metallothionein exhibited significantly reduced susceptibility to collagen-induced arthritis and enhanced IL-10 level in the serum, relative to their nontransgenic littermates. Taken together, these data suggest that metallothionein is able to promote the generation of IL-10-and $TGF-{\beta}$-producing type 1 regulatory T-like cells by downregulating JNK-dependent AP-1 activity. Thus, metallothionein may play an important role in the regulation of Th1-dependent autoimmune arthritis, and may represent both a potential target for therapeutic manipulation and a critical element in the diagnostic assessment of disease potential.

• Korean Security Journal
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• no.2
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• pp.61-81
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• 1999

While the progress of preparation for the 2002 World Cup games goes on the environment is changing by industrializations development of science and specialization of technology, because of that recently the crime has also became intellectual so the importance on countermeasure of safety has raised. The countermeasure for safety The stadium is a limited space where amount of population could be concentrated, so that in a moment there could be a great casualties by terrorism, specially there should be efficient countermeasures for bomb terrorism. So to be prepared for the problems that had been appeared on bomb terrorism activities of North Korea around the world, we should know about the inspection environment and special inspection environment, and for the prevention first of all I've studied on suitable way to inspect the stadiums secondly to plan on specialized training of the necessary personnel on inspection and finally efficiency of use on inspection equipment. With there following plans we could make perfect safety countermeasures focused on prevention for the successful World Cup games.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.18 no.35
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• pp.79-88
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• 1995

The Quality Assurance System proposed in this study is based on the functional deployment of quality, which is an integration of the FAST(Functional Analysis System Techique) in VE(Value Engineering) and the Quality Development Method of TQC(Total Quality Control). The proposed Quality Function Deployment is proved to be an efficient tool for the consistent management of quality Assurance in every stages of product life cycle. The purpose of this study is therefore to develop practical and systematic methods for quality assurance activities, so as to satisfy the consumer's needs at the most economic level. To verify the feasibility of this approch, a case study is performed.

• Korean Parent-Child Health Journal
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• v.3 no.1
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• pp.15-26
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• 2000

These days Women have repented their past when they were inactive in attaining their own rights and they've payed attentions in gaining their fundamental rights, especially health rights. The spread of contraception use is important to fulfill women's health right. There are a lot of meanings in the contraception use. It makes women can control their reproductive activities such as pregnancy, delivery, and raising children etc. It gives each woman has autonomy of her life. The review reveals high contraceptive rate and high experienced artificial abortion rate in Korea. It means Korean married couples use contraception inefficiently. From 1970's to 1980's, most of the researches in contraceptions were descriptive and survey studies. Since 1990's, the studies have researched in the feministic perspectives. In order to understand experiences of contraceptive behaviors, qualitative researches through indepth interview did. But the number of researches were limited. The relating factors to contraceptive behavior are knowledge, communication between couples, efficiency of contraceptives, self efficacy, attitudes toward contraception, national policy, mass media, public opinion, age, parity, abortion history, ever-used contraceptive method and educational level. Theses factors affect contraception directly and indirectly. Therefore. researches about contraceptives in the future must focus on development of contraceptive behavior assessment tools and further study should be comprehensive and multidementional.

• Journal of Elementary Mathematics Education in Korea
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• v.14 no.3
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• pp.843-863
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• 2010

The basic purpose of 2007 revision curriculum is content of activity oriented, management of differentiated instruction, communication, introduction of story mathematics, mathematical exploration and problem solving ability and so on. In this paper, we investigate some characteristics of number teaching in the primary school of New Zealand. Especially, focused on materials and methods and so on. So we've got the following results. First, there are no fundamental differences in materials and methods in teaching number between Korea and New Zealand but in New Zealand there are no national textbook like us so there is a possibility not to teach number systematically like our Korea. On the contrary, they divide number region from one to six level and are offering achievement objects, suggestive learning experiences, sample assessment activities for each level and also they do not guide activities itself in detail like us and so have learners themselves think about the given problems. Second, there is a strategy stage in getting knowledge about number in New Zealand and so children can take advantage of this steps according to the type of problems. Third, it must be developed some materials and idea to reach the learning purpose rousing interest of children.

• Journal of Elementary Mathematics Education in Korea
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• v.14 no.2
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• pp.441-463
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• 2010

This study purposes to examine the learning achievements, attitude and reactions of elementary school students in fifth grade in mathematics after inducing to use of learning-notebook on mathematics. To achieve the purpose, this study focuses on the following matters. First, we develop the ways to write thoughts and activities in solving problems on learning-notebook for elementary school student in fifth grade. Second, we analyze the effects of the students' learning achievements after applying the ways to them in every mathematics learning activities at home and in school, etc. Third, this study examine the attitudes and reactions of the students toward mathematics after observing the learning activities and interviewing them. The results are summarized as follows. First, using learning-notebook helps to improve the performance of students. The average point of the final examination went up to 90.67 while the average of the first level test was 70.75. And almost each student's result have improved. Second, the interviews with the students show that they feel sense of accomplishment, their mathematical attitude has changed to be positive, and they've actively participated in class by using the learning-notebook. The students felt confidence and achievement and they were more interested in studying mathematics when they use the learning-notebook. Further, the students used the notes in doing their homework and at home studying. Finally, the learning-notebook had a good influence on the relationships between students and teachers. Moreover, learning-notebook serves as a medium that connects teacher and student's work.

• Journal of the Korea Society of Computer and Information
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• v.20 no.3
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• pp.157-167
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• 2015

In this study, we studied the influence that the stress placed on children (originating from presence of two cultures at multi-cultural families) can have on adapting to school, and further assessed the control effect of teachers' support as a protection factor. In order to achieve the goal of the research, we identified samples of children between Grades 3-6 who came from multi-cultural families to carry out surveys. Based on the results of our analysis, the experience of discrimination and language conflicts experienced by children from multi-cultural families affected their academic activities (among adaptation factors to school experiences), while teachers' support appeared to have a control effect. However, for the influence of language conflicts on friend relationships (among adaptation factors to school experiences), teachers' support did not have a control effect. As such, based on this research result, we've proposed plans to improve school adaptation of children from multicultural families.

• Journal of Microbiology and Biotechnology
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• v.10 no.4
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• pp.514-517
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• 2000

Abstracts Six shikonin metabolites were obtained from human intestinal bacteria, Bacteriodes fragilis subsp. thetaotus. following biotransformation. The transformation of shikonin (1) was performed anaerobically for 3 day at $37^{\circ}C$ in thc bacterial suspension of B. Fagilis which was cultured overnight in GAM broth. The incubation mixture \vas extracted with EtGAc Lo give a dark-brown residue. The residue was apphed to a silica gel column, which was eluted successively with hexane (Fr. A), $CHCl_3$ (Fr. B), and $CHCl_3$:MeOH (9:I) (Fr. C). Six metabolites. Fr.A (2 and 3), Fr. B (6 and 7), and Fr. C (4 and 5) were isolated by repeated silica gel column chromatography, preparatlVe TLC, followed by Sephadex LH-20. In vitro cytotoxicities were tested against human tumor cell lines; PC-3 (prostate), ACHN (renal), A549 (lung), SW620 (colon), KS62 (leukemia), and Du145 (prostate). The shikonin metabolites 2. 4, 5, and 6 showed weaker cytotoxicity than the parenL shikonin (1). whereas shikonin monomenc metabolite 3 ($ED_{50}{\;}O.44-{\;}1.22{\;}\mu\textrm{g}/ml$) and dimeric metabolite 7 ($ED_{50}{\;}O.48-{\;}2.35{\;}\mu\textrm{g}/ml$) exhibited stronger activities compared with adriamycin, which was used as the positive control.ontrol.

• Journal of Fisheries and Marine Sciences Education
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• v.17 no.1
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• pp.1-17
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• 2005

The purpose of this study is to prepare the way for the prevention and improvement of the ocean environment pollution and destruction by researching and analyzing the degree of interests in the ocean environment which the students of seaside vocational high schools have. The concerns of this study are as follows: 1. The vocational high school students in the seaside cities of Busan and Pohang have recognized that the ocean is the object of the highest potential of development and that through the degree of their recognition that they should better preserve the ocean environment prior to a high degree of local seaside development. 2. Although they have recognized that the ocean environment has a great influence on the life of people, their interests in the environment is low. Also, it is shown that they get their knowledge and information through TV. 3. They've understood that the main factor of ocean contamination concerns the home and the causes of ocean contamination are sewage and waste material from daily life. Moreover, their answers reveal that they believe that they should participate in a sanitization activity for the ocean environment voluntarily and put trash into nearby trash cans as opposed to inconsiderately throwing away trash on the beach. 4. Their answers also show that they recognize the elements that can best preserve the ocean environment start at home and with government, and school services through experience activities are the most effective for the education of the ocean environment.

• KIEAE Journal
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• v.11 no.2
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• pp.113-122
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• 2011

About 30% of the total annual energy consumption on the earth is used in the architectural activities, including construction, maintenance management, and demonstration of a building. Also, 40% of the natural resource consumption, 50% of $CO_2$ emissions, and 20%~50% of industrial waste emissions are produced from a building. Unfortunately, the percentage of its energy consumption is staidly increasing year by year, about 8% every year, and it recently causes a sustainable architectural concept to come to the fore globally. Indeed, the importance of the sustainable architecture is increasingly becoming a worldwide trend. BIM(Building Information Modeling) is considered a new paradigm and a powerful method in building design, construction and maintenance. BIM has characteristics similar to a building's systems. All of the components in a model have a parametric relationship to each other. Understanding and capitalizing on these interrelationships typically takes numerous iterations that span multiple projects. Optimizing the integrated strategies and technologies for a high-performance, sustainable design requires a continual look at understanding how they work together to deliver the best potential. Throughout all of these concepts, we are going to be using a variety of tools that revolve around a BIM model. Some of the tools will require a heavier use of BIM than others, but all of them will utilize the model geometry you've created as part of your design. This study presents importance and validity of energy performance analyzation in the pre-design phase for the sustainable architecture with the support of Building Information Modeling (BIM) technology.