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The Evaluation of Hybrid-Volumetric Modulated Arc Therapy for Lung Cancer Radiation Therapy (폐암 방사선 치료 시 Hybrid-Volumetric Modulated Arc Therapy의 유용성 평가)

  • Lee, Geon Ho;Kang, Hyo Seok;Choi, Byoung Joon;Park, Sang Jun;Jung, Da Ee;Lee, Du Sang;Ahn, Min Woo;Jeon, Myeong Soo
    • The Journal of Korean Society for Radiation Therapy
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    • v.29 no.2
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    • pp.19-26
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    • 2017
  • Objectives: In the Lung, the VMAT rotates continuously and examines radiation. That increases the low doses to normal lung. Due to that, the incidence of radiation pneumonia among radiation side effects may increase. The cause of radiation pneumonia is the lower dose area of the lungs. The H-VMAT was applied to patients who applied to reduce radiation in the lower doses of the lungs. We wanted to assess the usefulness of the H-VMAT by comparing the radiation doses to the low dose areas of the lungs and the normal organs. Materials and Methods: A total of 26 patients who applied for a H-VMAT procedure were applied to the patient. The prescription dose applied to total dose 44 Gy from 22 divisions. For each patient, a plan was implemented with Conventional RT, VMAT and H-VMAT. Conventional RT was carried out in four to five fields each, considering the size, location, shape, and location of the PTV. In the case of a VMAT plan, the two Half ARC, three Half ARC method and the two Full ARC were planned. The H-VMAT was planned by adding two Static fields in the VMAT, taking into account the dose of the lung and the tolerance dose of the organs. Results: In the NSCLC, the lung doses $V_5$ and $V_{10}$ of the lungs except for the treatment plan volume were the lowest with $55.40{\pm}13.39%$ and $32.05{\pm}11.37%$ of H-VMAT. And, in the SCLC, the lung doses of V5 and V10 were the lowest at $64.32{\pm}16.15%$ and $35.50{\pm}9.91%$, respectively. The spinal dose of VMAT in NSCLC was $21.15{\pm}4.02Gy$, which was 7.94 Gy lower than other treatment methods. The lowest spinal dose was delivered at $19.72{\pm}1.82Gy$ for SCLC. The mean dose delivered to the esophagus was also $17.44{\pm}2.04Gy$ and $17.84{\pm}9.20Gy$ in SCLC and NSCLC, respectively. Conclusion: When comparing the value of the surrounding normal organ dose, the VMAT showed that less doses were transmitted from the heart, esophagus and spinal cord than the rest of the treatment plan. However, it was similar to VMAT in normal organs except for the spinal cord. VMAT has increased doses of some normal organs but did not exceed the tolerance dose. It showed a low value in $V_5$, $V_{10}$. When comparing Conventional RT, VMAT, and H-VMAT, If the dose to the heart, esophagus and spinal cord is lower than the tolerance dose, it is thought to reduce the incidence of radiation pneumonia by applying H-VMAT that show the benefits of low doses of the lungs.

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MULTIPLE SOLUTIONS OF A PERTURBED YAMABE-TYPE EQUATION ON GRAPH

  • Liu, Yang
    • Journal of the Korean Mathematical Society
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    • v.59 no.5
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    • pp.911-926
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    • 2022
  • Let u be a function on a locally finite graph G = (V, E) and Ω be a bounded subset of V. Let 𝜀 > 0, p > 2 and 0 ≤ λ < λ1(Ω) be constants, where λ1(Ω) is the first eigenvalue of the discrete Laplacian, and h : V → ℝ be a function satisfying h ≥ 0 and $h{\not\equiv}0$. We consider a perturbed Yamabe equation, say $$\{\begin{array}{lll}-{\Delta}u-{\lambda}u={\mid}u{\mid}^{p-2}u+{\varepsilon}h,&&\text{ in }{\Omega},\\u=0,&&\text{ on }{\partial}{\Omega},\end{array}$$ where Ω and ∂Ω denote the interior and the boundary of Ω, respectively. Using variational methods, we prove that there exists some positive constant 𝜀0 > 0 such that for all 𝜀 ∈ (0, 𝜀0), the above equation has two distinct solutions. Moreover, we consider a more general nonlinear equation $$\{\begin{array}{lll}-{\Delta}u=f(u)+{\varepsilon}h,&&\text{ in }{\Omega},\\u=0,&&\text{ on }{\partial}{\Omega},\end{array}$$ and prove similar result for certain nonlinear term f(u).

Culture Conditions of Geobacillus kaustophilus DSM 7263 for Production of Thermophilic Extracellular Lipase (내열성 extracellular lipase 생산을 위한 Geobacillus kaustophilus DSM 7263의 배양조건)

  • Jeon, Sung-Jong;Kang, Hyun-Woo
    • Journal of Life Science
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    • v.20 no.6
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    • pp.902-906
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    • 2010
  • A producer of thermophilic extracellular lipase, Geobacillus kaustophilus DSM 7263, was selected from various microorganisms of the Geobacillus genus. We investigated optimum conditions for mass production of G. kaustophilus lipase. Among the different natural oil media, olive oil was optimal for enzyme production. The maximum amount of enzyme production was obtained when G. kaustophilus was grown in a medium containing 0.5% olive oil as a carbon source. The pH and temperature for optimal growth were pH 8.0 and $55^{\circ}C$, respectively, while the optimum pH and temperature for lipase production were pH 6.0 and $50^{\circ}C$, respectively. In the presence of $Mg^{2+}$ and $Mn^{2+}$, lipase production was dramatically enhanced by 247% and 157%, respectively, whereas enzyme production was inhibited by $Zn^{2+}$, $Cu^{2+}$, and $Cd^{2+}$. The addition of 0.1% (v/v) triton X-100 increased lipase production and cell growth when compared to the negative control.

Local Convective Mass Transfer and Flow Structure Around a Circular Cylinder with Annular Fins (환상핀이 부착된 원봉 주위의 3차원 박리 유동구조 및 물질전달 특성 해석)

  • 박태선;성형진
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.15 no.6
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    • pp.2132-2146
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    • 1991
  • Extensive experiments were carried out to investigate the mass transfer and flow structures around a circular cylinder with annular fins in crossflow. The naphthalene sublimation method was employed to measure the circumferential and longitudinal variations of mass transfer from the circular cylinder between annular fins and H is the height of the fin from the cylinder surface. A remarkable enhancement of mass transfer due to the horseshoe vortices was observed near the corner junction between the annular fin and circular cylinder. The present results indicate that the local circumferential Sherwood number shows the higher values on the front stagnation point. The maximum augmentation of mass transfer rate at the center of cylinder is found near L/H-0.15 due to the separation bubble along the annular fins. The secondary flows, which are the corner vortices V2 and V3 near the end wall of the annular fin, are fairly predicted from the distributions of local Sherwood number in the spanwise direction. The average Sherwood number of overall surface at L/H=0.15 is larger 2.0 times than that of without annualr fins. The correlations of total average mass transfer rate with L/H and Re$_{L}$ can also be obtained.d.

A Study About Electrical Properties and Fabrication Schottky Barrirer Diode Prepared on Polar/Non-Polar of 6H-SiC (극성/무극성 6H-SiC 쇼트키 베리어 다이오드 제조 및 전기적 특성 연구)

  • Kim, Kyung-Min;Park, Sung-Hyun;Lee, Won-Jae;Shin, Byoung-Chul
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.23 no.8
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    • pp.587-592
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    • 2010
  • We have fabricated schottky barrier diode (SBDs) using polar (c-plane) and non polar (a-, m-plane) n-type 6H-SiC wafers. Ni/SiC ohmic contact was accomplished on the backside of the SiC wafers by thermal evaporation and annealed for 20minutes at $950^{\circ}C$ in mixture gas ($N_2$ 90% + $H_2$ balanced). The specific contact resistance was $3.6{\times}10^{-4}{\Omega}cm^2$ after annealing at $950^{\circ}C$. The XRD results of the alloyed contact layer show that formation of $NiSi_2$ layer might be responsible for the ohmic contact. The active rectifying electrode was formed by the same thermal evaporation of Ni thin film on topside of the SiC wafers and annealed for 5 minutes at $500^{\circ}C$ in mixture gas ($N_2$ 90% + $H_2$ balanced). The electrical properties of SBDs have been characterized by means of I-V and C-V curves. The forward voltage drop is about 0.95 V, 0.8 V and 0.8 V for c-, a- and m-plane SiC SBDs respectively. The ideality factor (${\eta}$) of all SBDs have been calculated from log(I)-V plot. The values of ideality factor were 1.46, 1.46 and 1.61 for c-, a- and m-plane SiC SBDs, respectively. The schottky barrier height (SBH) of all SBDs have been calculated from C-V curve. The values of SBH were 1.37 eV, 1.09 eV and 1.02 eV for c-, a- and m-plane SiC SBDs, respectively.

Enviromental Influences on Gentamicin Pharmacokinetics by Using Population Pharmacokinetic Methods (모집단 약물동태학 방법에 의한 겐타마이신 약물동태에 미치는 환경의 영향)

  • Burm, Jin-Pil
    • YAKHAK HOEJI
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    • v.56 no.1
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    • pp.48-54
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    • 2012
  • Enviromental differences in gentamicin pharmacokinetics by using population pharmacokinetic methods were compared with 20 Korean patients and 24 Korean-American appendicitis patients. Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum (NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant (K), the slope (KS) of the relationship between K versus creatinine clearance ($C_{cr}$), the apparent volume of distribution (V), the slope (VS) of the relationship between V versus weight, gentamicin clearance (CL) and the slope (CS) of the relationship between CL versus $C_{cr}$ and the V. The output includes two marginal probability density function (PDF), means, medians, modes, variance and CV%. The mean K (KS) were $0.402{\pm}0.129\;h^{-1}(0.00486{\pm}0.00197\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ and $0.411{\pm}0.135\;h^{-1}(0.00475{\pm}0.00180\;[h{\cdot}ml/min/1.73\;m^2]^{-1})$ for Korean and Korean-American populations, respectively. The mean V (VS) were not different at $14.3{\pm}3.6l(0.241{\pm}0.0511l/kg)$ and $15.1{\pm}3.84l(0.239{\pm}0.0492l/kg)$ for Korean and Korean-American populations, respectively (p>0.2). The mean CL (CS) were $5.68{\pm}1.69l/h(0.0714{\pm}0.0222l/kg[h{\cdot}ml/min/1.73\;m^2])$ and $5.70{\pm}1.77l/h(0.0701{\pm}0.0215l/kg[h{\cdot}ml/min/1.73\;m^2])$ for Korean and Korean-American populations, respectively. There were no enviromental differences in gentamicin pharmacokinetics between Korean and Korean-American appendicitis patients.

Effects of Adsorption Sites of the Polycrystalline Ir Surface on Potentially Deposited H (수소 전착에 관한 다결정 Ir표면의 흡착부위 효과)

  • Chun Jang Ho;Mun Kyeong Hyeon
    • Journal of the Korean Electrochemical Society
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    • v.2 no.3
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    • pp.144-149
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    • 1999
  • The two distinct adsorption sites and transition between the under and over-potentially deposited hydrogen (UPD H and OPD H) on the polycrystalline iridium (poly-Ir) surface in the 0.2 M LiOH electrolyte have been studied using the phase-shift method. At the forward and backward scans, the UPD H peak occurs on the cyclic voltam-mogram. The transition region on the phase-shift profile or the Langmuir adsorption isotherm occurs at ca. -0.80 to -0.95 V vs. SCE. At the transition region (-0.80 to -0.95 V vs. SCE), the equilibrium constant (K) for H adsorption transits from $7.9\times10^{-2}\;to\;1.5\times10^{-4}$ and vice versa. Similarly, the standard free energy $({\Delta}G_{ads})$ of H adsorption transits from 6.3 to 21.8kJ/mol and vice versa. The UPD H and OPD H on the poly-Ir surface act as two distinguishable electroadsorbed H species. Both the UPD H peak and the transition region are attributed to the two distinct adsorption sites of the UPD H and OPD H on the poly-Ir surface.

EFFECTS OF AMINES ON COPPER ETCHING WITH H$_2$SO$_4$-$H_2O$$_2$ SYSTEMS

  • Kobayashi, Katsuyoshi;Minami, Naoki;Chiba, Atsushi
    • Journal of the Korean institute of surface engineering
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    • v.32 no.3
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    • pp.377-384
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    • 1999
  • The corrosion of copper in $H_2$$SO_4$ $-H_2$$O_2$ etching solutions with amines was investigated at various flow rates (v). Amine additives give a retardation of $H_2$$O_2$ decompositions, increases in both corrosion rates and etch factor, and a protection of etched copper surfaces. However n-alkylamine additives acted as corrosion inhibitors at v < 10cm/s, those acted as corrosion accelerators at v of 10-220cm/s. The maximum corrosion rate was obtained with about 0.1 molal concentration of additives. Steric effects of substituted groups suppressed the acceleration of copper corrosion. The increases in both corrosion rates and flow rates gave the increase in etch factor. Corrosion rates with n-alkylamine increased in the order of ethylamine < n-propylamine < n-butylamine, those with butylamine isomers tert- < sec- < iso- < n-butylamine, and those with amine additives of different number of substituted groups tri- < di- < mono-n-propylamine, respectively.

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GLOBAL W1,2p ESTIMATES FOR NONDIVERGENCE PARABOLIC OPERATORS WITH POTENTIALS SATISFYING A REVERSE HÖLDER CONDITION

  • Pan, Guixia;Tang, Lin
    • Journal of the Korean Mathematical Society
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    • v.54 no.5
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    • pp.1357-1377
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    • 2017
  • In this article, we first give the $L^p$ boundedness of the operator $D^2L^{-1}$ with BMO coefficients and a potential V satisfying an appropriate reverse $H{\ddot{o}}lder$ condition, then obtain global $W^{1,2}_p$ estimates for the nondivergence parabolic operator L with VMO coefficients and a potential V satisfying an appropriate reverse $H{\ddot{o}}lder$ condition.

The Contact Characteristics of Ferroelectrics Thin Film and a-Si:H Thin Film (강유전성 박막의 형성 및 수소화 된 비정질실리콘과의 접합 특성)

  • 허창우
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2003.05a
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    • pp.501-504
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    • 2003
  • In this paper, for enhancement of property on a-Si:H TFTs We measure interface characteristics of ferroelectrics thin film and a-Si:H thin film. First, SrTiO$_3$ thin film is deposited bye-beam evaporation. Deposited films are annealed for 1 hour in N2 ambient at 150$^{\circ}C$ ∼ 600$^{\circ}C$. Dielectric characteristics of deposited SrTiO$_3$ films are very good because dielectric constant shows 50∼100 and breakdown electric field are 1∼1.5MV/cm. a-SiN:H,a-Si:H(n-type a-Si:H) are deposited onto SrTiO$_3$ film to make MFNS(Metal/ferroelectric/a-SiN:H/a-Si:H) by PECVD. After the C-V measurement for interface characteristics, MFNS structure shows no difference with MNS(Metal/a-SiN:H/a-Si:H) structure in C-V characteristics but the insulator capacitance value of MFNS structure is much higher than the MNS because of high dielectric constant of ferroelectrics.

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