• Journal of Korean Society of Water and Wastewater
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• v.34 no.1
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• pp.45-52
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• 2020

Even though sewers have been conventionally designed to prevent from sediment deposition using a specified minimum velocity or shear stress at a particular depth of flow or with a particular frequency of occurrence, it was appreciated that these methods do not consider the characteristics and concentration of the sediment and the specific hydraulic conditions of the sewer with sediment. In this study, a densimetric Froude number formula was suggested considering particle diameter and volumetric concentration of the sediment as well as flow depth and flowrate, based on several domestic field inspections, which was compared with other formulas proposed by previous investigators. When the sediment concentration was not considered, the calibration coefficient of 0.125-1.5 to the densimetric Froude numbers of this study was needed to obtain the similar ones with previous investigators'. For the densimetric Froude number formula obtained with consideration of sediment concentration, the exponent value of term C_v was almost the same as that of previous results and that of d₅₀/R_h was similar for F_r < 2.2.

• Proceedings of the Korean Vacuum Society Conference
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• 2000.02a
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• pp.128-128
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• 2000

박막의 탄성 특성을 평가하는 방법으로 nano-indentation, Brillouin light scattering measurement, ultrasonic surface wave measurement, bulge test, vibration membrane method 등 여러 가지가 제시되어 왔다. 이러한 방법들은 필름의 두께가 일정 두께 이상이 되어야 정확한 측정이 가능한 방법으로 매우 얇은 박막에서도 탄성특성을 평가할 수 있는 freehang, bridge 방법이 제시되었으며, 이 방법은 간단한 식각 공정을 통해 매우 얇은 박막에도 적용시킬 수 있다는 장점을 가지고 있다. 본 연구에서는 아주 얇은 박막에서도 탄성특성을 평가할 수 있는 freehang 방법을 이용하여 순수한 Diamond-like carbon (DLC) 필름과 Sidl 첨가된 DLC 필름의 탄성 특성을 평가하고자 한다. 실험에서 사용한 필름은 rf-PACVD 장비를 이용하여 증착하였다. 이때 전극과 플라즈마 사이의 바이어스 음전압은 -400 Vb로 합성압력은 10mTorr로 고정하였다. 사용한 반응 가스는 벤젠(C6H6), 그리고 벤젠과 희석된 실렌(SiH4 : H2 = 10 : 90)이며, 희석된 실렌의 첨가량을 조절하여 필름 내에 일정량의 Si을 함유시켰다. 각각의 조건에서 증착시간을 조절하여 필름의 두께를 변화시켰으며, KOH(5.6mol) 용액을 이용하여 습식 식각을 함으로써 freehang을 제작하였다. 이때 식각액에 의한 DLC 필름의 손상은 관찰되지 않았다. 필름의 잔류 응력을 측정하기 위해 200$\pm$10 혹은 100$\pm$5$\mu\textrm{m}$ 두께의 얇은 (100) Si wafer를 5$\times$50 mm2의 strip 형태로 절단하여 사용하였다. 필름의 압축 잔류 응력에 의해 발생한 필름/기판 복합체의 곡률은 laser 반사법과 $\alpha$-step profiler를 이용하여 측정하였으며, 이 결과를 Brenner 등에 유도된 식을 이용하여 잔류 응력을 계산하였다. 또한 제작된 frddhang은 광학 현미경과 전자주사현미경에 의해 관찰되었다. 이렇게 제작된 freehang을 이용하여 필름이 기판에 부착되기 위해 필요한 변형률을 측정하고, 독립적으로 측정된 필름의 잔류 응력을 박막의 응력-변형률 관계식에 적용하여 biaxial elastic modulus, E/(1-v)를 구할 수 있었다. 측정 결과 필름의 잔류 응력과 biaxial elastic modulus는 필름의 두께가 감소함에 따라 감소하는 경향을 나타냈으며, 같은 두께의 필름인 경우, 식각 깊이에 따른 biaxial elastic modulus 의 변화를 통해 최적의 식각 깊이를 알 수 있었다.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.266-266
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• 2010

마그네트론 스퍼터링을 이용하여 질소와 탄소를 함유한 티타늄 화합물을 합성하고, 조성 변화에 따른 색상 변화를 통해 티타늄 화합물로 구현할 수 있는 색상에 대해서 알아보았다. 스퍼터 타겟은 4"X1/4" 크기의 고순도(99.99%) 티타늄을 사용하였다. 시편은 알코올과 아세톤에서 각각 5분간 초음파 세척된 SUS304를 사용하여, 진공용기에 시편을 장착하고 압력을 $3{\times}10^{-6}\;Torr$까지 배기한 후, Ar 가스를 주입하여 진공도가 $2{\times}10^{-2}\;Torr$에 이르면 펄스 전원 공급 장치를 이용하여 800 V의 전압으로 1시간 동안 글로우 방전을 시켜 시편 청정을 실시하였다. 시편 청정이 끝나면 다시 $3{\times}10^{-6}\;Torr$까지 진공배기를 실시하고, Ar 가스를 진공용기 내로 공급하여 $1{\sim}3{\times}10^{-3}\;Torr$에서 스퍼터링을 실시하여 완충층으로 티타늄 박막을 코팅하였다. 티타늄 화합물은 티타늄을 스퍼터링 하면서 진공용기 내에 질소와 메탄가스를 적절한 비율로 공급함으로써 코팅하였다. 박막 증착 시 시편 온도는 $200^{\circ}C$, 타겟과의 거리는 12 cm를 유지하였으며, 시편을 회전시켜 코팅하였다. 티타늄 화합물의 두께와 미세구조, 조성 그리고 색상은 투과전자현미경(transmission electron microscope, TEM), 글로우 방전 분광기(glow discharge light spectroscope, GDLS), 및 색차계(spectrophotometer)를 사용하여 각각 분석하였다. TEM 분석결과 TiN의 박막 두께는 약 300 nm로 공극이 존재하지 않는 치밀한 다결정 구조를 나타내었고, TiCN은 약 600 nm로 TiN과 두 배의 두께 차이를 보였다. 이는 탄소의 공급원인 메탄가스의 주입으로 증착률이 증가한 것으로 판단된다. 또한 소량의 질소와 메탄가스의 유량 조절로 화합물의 조성을 변화시킬 수 있었으며, 이러한 조성 변화는 화합물의 색상변화로 나타났다. 따라서 본 연구에서 얻어진 결과를 외관 코팅 분야에 응용한다면 다양한 색상 구현과 외관의 경도, 내마모성, 내식성의 향상 등 많은 장점을 가질 것으로 판단된다.

• Journal of Welding and Joining
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• v.18 no.2
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• pp.49-56
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• 2000

Recently developed Austenite stainless steel, 309L was used to overlay on 3Cr-1Mo-V-Ti-B steels, using Electroslag welding process, which wide electrodes were adopted. Transition region in welding interlayer relating to disbonding crack was investigated. Also, the effect of welding condition on the width of transition region and coarsening grains of the austenite were studied. 1) With increasing welding speed the width of martensite at transient region was increased, but the amount of delta ferrite in weld metal was reduced, being fine grained. 2) The form of martensite at the transition region was occurred by reversible transformation during cooling since the interdiffusion of Cr and Ni from weld metal and Fe and C from base metals at the transition region, causes to lowering the concentration of Cr and Ni at the transition region, leading to increasing Ms point. 3) With increasing welding speed, the grain of austenite formed at the welding interface was finer. With increasing welding current under the same welding speed, the grain size of the austenite was finer. At high current, original grain size of the austenite is coarse, but the austenite has fine grains because the austenite was transformed to martensite during cooling. 4) In the case of high welding speed, the width of martensite at the welding interface was increased, but the grain size of austenite at the welding interface was finer. This indicates that the inhibition of disbonding crack may be achieved through dispersening fine carbides in the gain boundary.

• Korean Journal of Materials Research
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• v.19 no.1
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• pp.33-36
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• 2009

Inorganic-organic composite thin-film-transistors (TFTs) of ZnO nanowire/Poly(3-hexylthiophene) (P3HT) were investigated by changing the nanowire densities inside the composites. Crystalline ZnO nanowires were synthesized via an aqueous solution method at a low temperature, and the nanowire densities inside the composites were controlled by changing the ultrasonifiaction time. The channel layers were prepared with composites by spin-coating at 2000 rpm, which was followed by annealing in a vacuum at $100^{\circ}C$ for 10 hours. Au/inorganic-organic composite layer/$SiO_2$ structures were fabricated and the mobility, $I_{on}/I_{off}$ ratio, and threshold voltage were then measured to analyze the electrical characteristics of the channel layer. Compared with a P3HT TFT, the electrical properties of TFT were found to be improved after increasing the nanowire density inside the composites. The mobility of the P3HT TFT was approximately $10^{-4}cm^2/V{\cdot}s$. However, the mobility of the ZnO nanowire/P3HT composite TFT was increased by two orders compared to that of the P3HT TFT. In terms of the $I_{on}/I_{off}$ ratio, the composite device showed a two-fold increase compared to that of the P3HT TFT.

• Parasites, Hosts and Diseases
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• v.58 no.2
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• pp.173-179
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• 2020

Leishmaniasis is a prevalent cause of death and animal morbidity in underdeveloped countries of endemic area. However, there is few vaccine and effective drugs. Antimicrobial peptides are involved in the innate immune response in many organisms and are being developed as novel drugs against parasitic infections. In the present study, we synthesized a 5-amino acid peptide REDLK, which mutated the C-terminus of Pseudomonas exotoxin, to identify its effect on the Leishmania tarentolae. Promastigotes were incubated with different concentration of REDLK peptide, and the viability of parasite was assessed using MTT and Trypan blue dye. Morphologic damage of Leishmania was analyzed by light and electron microscopy. Cellular apoptosis was observed using the annexin V-FITC/PI apoptosis detection kit, mitochondrial membrane potential assay kit and flow cytometry. Our results showed that Leishmania tarentolae was susceptible to REDLK in a dose-dependent manner, disrupt the surface membrane integrity and caused parasite apoptosis. In our study, we demonstrated the leishmanicidal activity of an antimicrobial peptide REDLK from Pseudomonas aeruginosa against Leishmania tarentolae in vitro and present a foundation for further research of anti-leishmanial drugs.

• Journal of Industrial and Engineering Chemistry
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• v.68
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• pp.117-123
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• 2018

Recently, aqueous method has attracted lots of attention because it enables the solution-processed metal oxide thin film with high electrical properties in low temperature fabrication condition to various flexible devices. Focusing the development of aqueous route, many researchers are only focused on metal oxide materials. However, for expansive application of the aqueous-based metal oxide films, the systematic study of performance change with process variables for the development of aqueous-based metal oxide insulator film is urgently required. Here, we propose importance of process variables to achieve high electrical-performance metal oxide insulator based on the aqueous method. We found that the significant process variables including precursor solution temperature and humidity during the spincoating process strongly affect chemical, physical, and electrical properties of $AlO_x$ insulators. Through the optimization of significant variables in process, an $AlO_x$ insulator with a leakage current value approximately $10^5$ times smaller and a breakdown voltage value approximately 2-3 times greater than un-optimized $AlO_x$ was realized. Finally, by introducing the optimized $AlO_x$ insulators to solutionprocessed $InO_x$ TFTs, we successfully achieved $InO_x/AlO_x$ TFTs with remarkably high average field-effect mobility of ${\sim}52cm^2V^{-1}\;s^{-1}$ and on/off current ratio of 106 at fabrication temperature of $250^{\circ}C$.

• Journal of Ginseng Research
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• v.26 no.2
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• pp.74-78
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• 2002

To develop a new traditional ginseng liquor by using rice and ginseng, the physicochemical properties and overall acceptability of ginseng liquors made by addition of different concentration (1-8%) of ginseng in some kinds of rice mash were investigated and compared. The Ilpum-4 traditional ginseng liquor which was prepared by adding 4% ginseng into Ilpum rice mash showed the best acceptability in the sensory evaluation test and high ethanol content (15.6%), and its angiotensin-converting enzyme inhibitory activity and electron-donating ability were better than those of the other ginseng liquors. The Ilpum-4 traditional ginseng liquor contained 0.53% (w/v) of crude saponin and it was mainly composed of ginsenoside Rg$_1$.

• Archives of Pharmacal Research
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• v.27 no.7
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• Journal of Soil and Groundwater Environment
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• v.19 no.4
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• pp.45-51
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• 2014

In accordance with the view on remediated soil as a resource, this study assessed the applicability of soil washing with the neutral phosphate for remediation of arsenic (As)-contaminated soil. Three soil samples of different land uses (i.e., rice paddy, upland field and forest land) were collected from the study site, and the aqua regia-extractable As concentrations were 59.2, 30.8 and 53.1 mg/kg, respectively. Among the neutral phosphate reagents, ammonium phosphate showed the highest As washing efficiency. The optimized washing condition was 2-hr washing with 0.5M ammonium phosphate solution (pH 6) and soil to liquid ratio of 1 : 5. The extraction efficiencies of As did not guarantee the residual soil As concentrations to satisfy the Korea soil regulatory level (i.e., Worrisome level) in the three soil samples. To enhance washing efficiency, the As-contaminated soil was submerged in washing solution (1 : 1, w/v) for 24 hr and 1-hr washing with 0.5M ammonium phosphate solution was tested. As extraction efficiencies of 36.1 (rice paddy), 21.4 (upland field) and 26.4% (forest land) were attained, which satisfied the Worrisome level for Region 1 (25 mg/kg of As) in rice paddy, but not in upland field and forest land.