• BMB Reports
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• v.47 no.5
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• pp.241-248
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• 2014

CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to ${\alpha}{\beta}$ T cells reminiscence of peptide antigen presentation by MHC-I molecules. CD1d is the only member of Group 2 and presents foreign and self lipid antigens to a specialized subset of ${\alpha}{\beta}$ T cells, NKT cells. NKT cells are involved in diverse immune responses through prompt and massive production of cytokines. CD1d-dependent NKT cells are categorized upon the usage of their T cell receptors. A major subtype of NKT cells (type I) is invariant NKT cells which utilize invariant $V{\alpha}14-J{\alpha}18$ TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alpha chains. Engineered CD1d molecules with modified intracellular trafficking produce either type I or type II NKT cell-defects suggesting the lipid antigens for each subtypes of NKT cells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result of antigen-driven selection, the intracellular metabolic pathways of lipid antigen are a key in forming the functional NKT cell repertoire.

• Journal of the Korean Society of Costume
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• v.50 no.4
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• pp.53-61
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• 2000

The purpose of this study is to classify the characteristics of color communication tools and the color range applied in the Korean fashion industry. To collect the color sample and related references, a questionnaire was distributed during the time period, December, 1995 to June, 1996. From the responses, 2641 color samples used by 109 domestic brands, from 1993 spring/summer to 1996 spring/summer, were collected and analyzed. The data was measured by L*a*b*, and the H V/C formula found in the Munsell notation was used to calculate the data. To classify the color range served for the fashion industry, the distribution of colors are analyzed by difference of season and fabric. The results of this study are as follows : 1. Dominant colors in the Korean fashion industry are Red, Yellow-red, Yellow, purple-blue and low chromatic range colors. 2. While high value colors, such as pale, light greyish, light, dull, dark and vivid tone colors, are dominant in the spring/summer season, low value colors, such as greyish, dark greyish. and deep tone colors and warm colors such as Red, Yellow-red, are prevalent in the fall/winter season. 3. The number of colors commonly used for color planning is less than 20 colors, and both hue and tone are considered important when making color selections. 4. All brands take consumers' color preferences into consideration for color planning, and most of them also take color trends into account. 5. Hue and tone color characteristics analyzed by types of fabrics show more seasonal influence than the fabric itself.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.13-18
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• 2003

Reduced activation ferritic steel, JLF-1 steel (Fe-9Cr-2W-V-Ta), is one of the promising candidate materials for fusion reactor applications. Fracture toughness ($J_IC$) and tensile tests were carried out at room temperature and elevated temperature ($400^{\circ}C$). Two types of CT specimen were prepared to examine the effect of rolling direction on the fracture toughness of JLF-1 steel. Four types of tensile specimen were also prepared to investigate the property by the rolling direction and welding. The Micro Vickers hardness was measured at various distances of a cross section of the TIG joints of JLF-1 steel according to the heating history of each position. Finally, the fracture surface was observed by scanning electron microscopy (SEM).

• Journal of Advanced Marine Engineering and Technology
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• v.19 no.2
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• pp.1-9
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• 1995

The processing paper has devoted to the theory of the flow equations, the basic derivative procedure, the meaning of a valve flow coefficient $C_v$, the valve Reynolds R$R_{ev}$ and its application for liquid control valves, which applicable under the condition of a non-critical flow and the case of piping geometry factor $F_p$=1.0. However there is no information on the effects of fittings, a critical flow and the flow resistance coefficient of a valve equivalent to that of pipe which is conveniently used in the piping design. Since the piping systems of plants or ships generally contain various fittings such as expanders and reducers due to different size between pipes and valves and there may occur a critical flow, that a mass flowrate is maintained to be constant, due to the pressure drop in a piping when a liquid is initially maintainder ar a saturated temperature or at nearby corresponding to upstream pressure, system designer should have a knowledge of the effect to flow due to fittings and the critical flow phenomenon of a liquid. This study is performed to inform system designers with the critical flow phenomenon of a liquid, a valve resistance coefficient, a valve geometry factor and their applications.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.10
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• pp.1626-1635
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• 1997

It is important to ensure the reliability of the first localized reactor vessel steel. To satisfy with this purpose, a study on the impact/hardness, low cycle fatigue(LCF), crack growth rate(da/dN) and fracture toughness( ) of base material(BM) and weld metal(WM) were performed under room temperature air and corrosion conditions. A summary of the results is as folows : (1) Charpy impact absorbed energy of BM was the highest value, heat affected zoon(HAZ) and the lowest, WM. The hardness of BM was similar to HAZ. (2) Coefficients of Manson equation using the monotonic tensile test data were obtained for the present material. (3) The effects of stress ratio and ambient (120.deg. C and NaCl) condition on da/dN were investigated, da/dN with NaCl condition expressed the highest value. (4) The results of Charpy V-notch impact test had good correlation with $K_{IC}$ characteristics and the lowest curve of $K_{IC}$ for BM was derived, more researches about WM and HAZ are required hereafter.

• Progress in Medical Physics
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• v.9 no.1
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• pp.29-35
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• 1998

There has been necessity of an air free ionization chamber using the gold-crystal-aluminium plates, henceforth called the crystal chamber. The crystal chamber formed of parallel plates is very small in size and has more response for absorbed dose of therapeutic radiation beams. The gold plate on the crystal facing the photon and electron beam acts as an intensifier of signals and crystal plate as an ionization medium respectively. Both the copper guard ring and the aluminum collecting electrode are connected to an electrometer. Using high energy photon (6, 15 MV) and electron (9, 12, 15, 18 MeV) beams, the responses of the crystal chamber are evaluated against a PTW Farmer-type chamber at a field size of 10${\times}$10cm$^2$ and 100 cm SSD. The responses of crystal chamber for therapeutic radiation electron and photon beams are greater in magnitude by several order than Farmer. The crystal chamber has good linearity without correction factor C$\_$t,p/ with respect to the signals, a reading reproduction with good accuracy and precision less than 0.5%, and has other useful functions in measuring radiation beams.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6753-6759
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• 2015

Background: Loss of function of the p53 gene is implicated in defective apoptotic responses of tumors to chemotherapy. Although the pro-apoptotic roles of eugenol and capsaicin have been amply reported, their dependence on p53 for apoptosis induction in gastric cancer cells is not well elucidated. The aim of the study was to elucidate the role of p53 in the induction of apoptosis by eugenol and capsaicin in a human gastric cancer cell line, AGS. Materials and Methods: AGS cells were incubated with or without various concentrations of capsaicin and eugenol for 12 hrs, in the presence and absence of p53 siRNA. Cell cycling, annexin V and expression of apoptosis related proteins Bax, Bcl-2 ratio, p21, cyt c-caspase-9 association, caspase-3 and caspase-8 were studied. Results: In the presence of p53, capsaicin was a more potent pro-apoptotic agent than eugenol. However, silencing of p53 significantly abrogated apoptosis induced by capsaicin but not that by eugenol. Western blot analysis of pro-apoptotic markers revealed that as opposed to capsaicin, eugenol could induce caspase-8 and caspase-3 even in the absence of p53. Conclusions: Unlike capsaicin, eugenol could induce apoptosis both in presence and absence of functional p53. Agents which can induce apoptosis irrespective of the cellular p53 status have immense scope for development as potential anticancer agents.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.4
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• pp.27-39
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• 2015

This study addressed the process to construct, operate, verify the test beds, which had been equipped with a variety of core technologies such as WAVE, Road-Radar, Smart Tolling developed by Smart Highway Project. We have met our research goals, but there were limitations to secure the performance and user feedback because of small scale and short operating time. So, we will enhance user safety, convenience and comfort by accumulating and analyzing big data then improving testbeds and related technologies through subsequent research projects for a long time.

• Journal of Haehwa Medicine
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• v.11 no.1
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• pp.85-90
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• 2002

From June 1th to December 31th 2001, the study was carried out 285 person who came to the Daejon oriental hospital for the examination of CVA. The result was as follows : 1. Hyperlipidemia patient is 41%, 50's is the highest. 2. In the case of Hyperlipidemia patient, Taeyum type is 49%, Soyang type is 36% and Soyum type is 15%. but in the Control group Taeyum type is 36%, Soyang type is 44% and Soyum type is 20%. 3. In the case of Abnormal EKG, Hyperlipidemia group is 34%, Control group is 32%. 4. In the case of Liver disease, Hyperlipidemia group is 17%, Control group is 9%. 5. In the case of Diabet mellitus, Hyperlipidemia group is 30%, Control group is 7%. 6. In the case of Hypertension, Hyperlipidemia group is 50%, Control group is 42%.

• Korean Journal of Plant Resources
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• v.6 no.1
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• pp.13-23
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• 1993

To data, many types of compounds having antineoplastic activity have been isolated from higher plants, that is, alkalodids, terpenes, lignans, steroids and so on. Some of ther were isolated from Indonesian plants, Curcuma xanthorrhiza and Eurycoma longifolia. Bisaborane type compounds were compounds were isolated as antimeoplastic compounds againest Sarcoma 180A from C. xanthorrhiza, and quassinoids and euryrene type triterpenes from triterpenes from El longifolia. Casearines, a kind of diterpene, had been isolated as cytotxic components from Casearia sylvestris distributed in South America. RA series Cyclic hexapeptides isolated from Rubia akane and R. cordifolia also have strong antineoplastic activity against various types of tumors. Till now, 16 kinds of RA series compounds were isolated and named as RA-I~XVI. Moreover, monoglucoside of RA-V newly isolated from same plant. Many kinds of derivatives including natural RA compounds were tested for QSAR, and one of them, RA-VII was screened up as a most suitable substance as an antitumor agent. RA-VII(=RA 700) has strong cytotoxic activity against KB cells, P388 lymphocytic leukemia and MM2 mammary carcinoma cells. In some solution, three conformers of RA-VII were observed by NMR. It was discussed the relationship between conformation and activity. Total synthesis was already completed, but there is left room for improvement. Phase I clinical trials for RA-VII has been finished, then Phase II trials will be started before long.