• 한국식품조리과학회지
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• 제15권1호
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• pp.68-72
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• 1999

식품 산업의 가공화, 인스탄트화에 따른 식품 보존을 위하여 합성식품보존제의 사용이 증가하고 있는 실정이다. 그러나, 인체에 대한 유해성이 문제로 대두되면서 이를 대체할 천인 보존제의 개발이 절실히 요구되고 있는 실정이다. 따라서 본 연구는 우리나라 야산에서 쉽게 구할 수 있는 구황 식물인 질경이를 메탄올로 추출하여 식품 부채 미생물에 대한 항균력을 실험한 결과, 2,000 $\mu\textrm{g}$/ml 도에서 B. subtilis, L. monocytogenes 및 V. parahaemolyticus의 증식을 완전히 억제하였다. 질경이가 첨가된 국수와 떡은 대조군에 비하여 미생물의 집락이 적게 생겼으며 5, 3, 1% 순으로 총균수가 적었는데 대조군보다 총균수가 적었다. 질경이를 첨가한 국기 관능적 특성은 씹힘성과 전반적인 바람직한 정도는 유의적인 차이(P<0.05)를 보였는데 1% 첨가군이 5% 첨가군보다 더 좋았다. 떡의 경우는 모든 항목에서 3% 첨가군이 우수하게 평가되었다(P<0.05).

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3681-3685
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• 2012

Background: In breast cancer, estrogen receptors have been demonstrated to interact with transcription factors to regulate target gene expression. However, high-throughput identification of the transcription regulation relationship between transcription factors and their target genes in response to estradiol is still in its infancy. Purpose: Thus, the objective of our study was to interpret the transcription regulation network of MCF7 breast cancer cells exposed to estradiol. Methods: In this work, GSE11352 microarray data were used to identify differentially expressed genes (DEGs). Results: Our results showed that the MYB (v-myb myeloblastosis viral oncogene homolog [avian]), PGR (progesterone receptor), and MYC (v-myc myelocytomatosis viral oncogene homolog [avian]) were hub nodes in our transcriptome network, which may interact with ER and, in turn, regulate target gene expression. MYB can up-regulate MCM3 (minichromosome maintenance 3) and MCM7 expression; PGR can suppress BCL2 (B-cell lymphoma 2) expression; MYC can inhibit TGFB2 (transforming growth factor, beta 2) expression. These genes are associated with breast cancer progression via cell cycling and the $TGF{\beta}$ signaling pathway. Conclusion: Analysis of transcriptional regulation may provide a better understanding of molecular mechanisms and clues to potential therapeutic targets in the treatment of breast cancer.

• 대한화학회지
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• 제60권4호
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• pp.225-234
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• 2016

The activity of 34 sulfonamide derivatives has been estimated by means of multiple linear regression (MLR), artificial neural network (ANN), simulated annealing (SA) and genetic algorithm (GA) techniques. These models were also utilized to select the most efficient subsets of descriptors in a cross-validation procedure for non-linear -log (IC50) prediction. The results obtained using GA-ANN were compared with MLR-MLR, MLR-ANN, SA-ANN and GA-ANN approaches. A high predictive ability was observed for the MLR-MLR, MLR-ANN, SA-ANN and MLR-GA models, with root mean sum square errors (RMSE) of 0.3958, 0.1006, 0.0359, 0.0326 and 0.0282 in gas phase and 0.2871, 0.0475, 0.0268, 0.0376 and 0.0097 in solvent, respectively (N=34). The results obtained using the GA-ANN method indicated that the activity of derivatives of sulfonamides depends on different parameters including DP03, BID, AAC, RDF035v, JGI9, TIE, R7e+, BELM6 descriptors in gas phase and Mor 32u, ESpm03d, RDF070v, ATS8m, MATS2e and R4p, L1u and R3m in solvent. In conclusion, the comparison of the quality of the ANN with different MLR models showed that ANN has a better predictive ability.

• 한국재료학회지
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• 제17권10호
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• pp.509-515
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• 2007

In order to fabricate adhesiveless 2-layer flexible copper clad laminate (FCCL) used for COF (chip on film) with high peel strength, polyimide (PI; Kapton-EN, $38\;{\mu}m$) surface was modified by reactive $O_2^+$ and $N_2O^+$ ion beam irradiation. 300 mm-long linear electron-Hall drift ion source was used for ion irradiation with ion current density (J) higher than $0.5\;mA/cm^2$ and energy lower than 200 eV. By vacuum web coating process, PI surface was modified by linear ion source and then 10-20 nm thick Ni-Cr and 200 nm thick Cu film were in-situ sputtered as a tie layer and seed layer, respectively. Above this sputtered layer, another $8-9{\mu}m$ thick Cu layer was grown by electroplating and subsequently acid and base resistance and thermal stability were tested for examining the change of peel strength. Peel strength for the FCCLs treated by both $O_2^+$ and $N_2O^+$ ion irradiation showed similar magnitudes and increased as the thickness of tie layer increased. FCCL with Cu (200 nm)/Ni-Cr (20 nm)/PI structure irradiated with $N_2O^+$ at $1{\times}10^{16}/cm^2$ ion fluence was proved to have a strong peel strength of 0.73 kgf/cm for as-received and 0.34 kgf/cm after thermal test.

• 콘크리트학회논문집
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• 제29권4호
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• pp.345-351
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• 2017

이 연구에서는 철근콘크리트 기둥의 휨 연성에 대한 보조 띠철근으로서 ACI 318-14에서 제시하는 크로스타이의 대체로서 V-타이 보조 띠철근의 효율성을 평가하였다. 작용 축하중비를 주요 변수로 일정 축하중과 반복 횡하중을 받는 기둥에서 파괴모드 및 횡하중-횡변위 관계를 측정하였다. 기둥의 최대 휨 내력 이후, 크로스타이의 $90^{\circ}$ 갈고리가 서서히 열리면서 주철근의 조기 좌굴 및 코어 콘크리트의 심각한 손상을 동반한 반면, V-타이의 뽑힘 현상은 기둥의 파괴 시까지 나타나지 않았다. 최대 내력의 80% 시점에서 V-타이 기둥의 일손상 지수 값은 크로스타이 기둥에 비해 축력비가 0.25, 0.4 및 0.55일 때 각각 2.4배, 2.3배 및 5.2배 높았다. 즉, 기둥의 휨 연성에 대한 기존 크로스타이 대비 V-타이의 효율성은 축력비가 높을수록 현저하였다.

• 천문학회보
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• 제41권2호
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• pp.46.3-46.3
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• 2016

We present the ALMA Cycle 2 results "Two New SiO Maser Sources in High-Mass Star-Forming Regions" which was published in the Astrophysical Journal (Vol. 826, P157, 2016). Silicon monoxide (SiO) masers are rare in star forming regions, with the exception of five known SiO maser sources. However, we detected two new SiO maser sources from infrared loud clumps of the high-mass star forming regions G19.61-0.23 and G75.78+0.34 using the KVN single dish. High angular resolution observations with ALMA and JVLA toward G19.61-0.23 suggest that the deeply embedded young stellar object (YSO) of SMA 1 is powering the SiO masers. In addition, the SiO v=1, J=1-0 line shows four spike features while the v=2 maser shows combined features of one spike and broad wing components, implying energetic activities of the YSO of SMA 1 in the G19.61-0.23 hot molecular core. The SiO v=0, J=2-1 emission shows bipolar outflows in NE-SW direction with respect to the center of the SiO maser source. A high angular resolution map of the SiO v=1, J=2-1 maser in G75.78+0.34 shows that the SiO maser is associated with the CORE source at the earliest stage of high-mass star formation. Therefore, the newly detected SiO masers and their associated outflows will provide good probes for investigating this early high-mass star formation.

• 한국지진공학회논문집
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• 제8권3호
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• pp.97-103
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• 2004

철골 중심가새골조의 경우 접합비용의 절감을 위해 가새가 설치된 스팬을 제외한 기둥들은 통상 중력기둥으로 설계된다. 따라서 중력기둥이 미치는 P-${\Delta}$ 효과를 내진성능 평가에 적절히 반영할 필요가 있다. 본 연구에서는 철골 중심가새골조의 중력기둥이 유발하는 P-${\Delta}$ 효과를 가상의 의지기둥(leaning column) 개념에 의해 간편하게 모델링할 수 있는 해석기법을 예시하였다. 역V형 가새골조를 사례로 하여 FEMA 273의 비선형정적해석법에 의한 내진성능평가를 수행하고 동적 P-Δ 증폭계수 적용에 있어서의 문제점을 지적하였다. 본 연구의 결과에 의할 때 P-${\Delta}$ 효과는 중심가새골조의 내진성능평가에 무시할 수 없는 영향이 있는 것으로 밝혀졌다. 아울러 기존연구에서 제시된 인장보강재에 의한 역V형 가새골조의 보강법은 내진성능향상에 매우 효과적임을 확인하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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• pp.291-293
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• 2003

Energy markets of the Northeast Asia countries and in particular South Korea are perspective enough from the standpoint of export of energy resources from Russia. South Korea Power System has been rapidly growing. However, recently it has been confronted with difficulties in regard to constructing new Power Stations and especially Hydro Power Plants. Therefore it is mutually beneficial to build electric tie to South Korea in order to use highly effective Power of Northeast Asia. In this paper, we describe the maximum available transmission power through interconnected line without loss of stability in power system. For this simulation, the AC transmission system is assumed appropriate for this preliminary study. The transmission system will pass through territory of North Korea and connect to 765 kV Network near Seoul with long distance.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.912-917
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• 2003

In this paper a new truss modeling technique for describing the beam shear resistance mechanism is proposed based on the reinterpretation of the well-known relationship between shear and the rate of change of bending moment in a reinforced concrete beam subjected to combined shear and moment loads. The core of the model is that a new perspective on the shear resistance can be gained by viewing the internal stress filed in terms of the superposition of two base components of shear resistance; arch action and beam action. The arch action can be described as a simple tied-arch which is consisted of a curved compression chord and a tension tie of the longitudinal steel, while the beam action between the two chords can be modeled as a membrane shearing element with forming a smeared truss action. The compatibility of deformation associated to the two action is taken into account by employing an experimental factor or internal state force factor a. Then the base equation of V=dM/dx is numerically duplicated. The new model was examined by the 362 experimental results. The shear strength predicted by the internal force state factor a show better correlation with the tested values than the present shear design.

• 한국군사과학기술학회지
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• 제14권3호
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• pp.509-516
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• 2011

In this paper, a ground penetrating radar(GPR) system is implemented for landmine detection. The performance of the GPR system is associated with the characteristics of local soil and buried target. The choice of the center frequency and the bandwidth of the GPR system are the key factors in the GPR system design. To detect a small and shallow target, the higher frequencies are needed for high depth resolution. We have been designed, fabricated and tested a new impulse generator using step recovery diodes. The measured impulse response has an amplitude of 6.2V and a pulse width of 250ps. The implemented GPR system has been tested real environmental conditions and has proved its ability to detect a small buried target.