• Journal of Advanced Marine Engineering and Technology
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• 제19권2호
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• pp.1-9
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• 1995

The processing paper has devoted to the theory of the flow equations, the basic derivative procedure, the meaning of a valve flow coefficient $C_v$, the valve Reynolds R$R_{ev}$ and its application for liquid control valves, which applicable under the condition of a non-critical flow and the case of piping geometry factor $F_p$=1.0. However there is no information on the effects of fittings, a critical flow and the flow resistance coefficient of a valve equivalent to that of pipe which is conveniently used in the piping design. Since the piping systems of plants or ships generally contain various fittings such as expanders and reducers due to different size between pipes and valves and there may occur a critical flow, that a mass flowrate is maintained to be constant, due to the pressure drop in a piping when a liquid is initially maintainder ar a saturated temperature or at nearby corresponding to upstream pressure, system designer should have a knowledge of the effect to flow due to fittings and the critical flow phenomenon of a liquid. This study is performed to inform system designers with the critical flow phenomenon of a liquid, a valve resistance coefficient, a valve geometry factor and their applications.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 춘계학술대회논문집
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• pp.1128-1133
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• 2003

A gas driven heat pump (GHP) core design comprises internal combustion engine, compressors incorporated to a cooling/heating system, rubber mountings and belt transmissions. Main excitation farces are generated by an engine, compressors themselves and belt fluctuation. It leads to high vibration level of the mount that can cause damage of GHP elements. Therefore an appropriate design of the mounting system is crucial in terms of reliability and vibration reduction. In this paper oscillation of the engine mount is explored both experimentally and analytically. Experimental analysis of natural frequencies and operational frequency response of the GHP engine mounting system enables to create simplified model for numerical and analytical investigations. It is worked out criteria f3r vibration abatement of the isolated structure. Influence of bracket stiffness between engine and compressors, suspension locations and damper performance is investigated. Ways to reduce excitation forces and improve dynamic performance of the engine-compressor mounting system are considered from these analyses. Implementation of the proposed approach permits to choose appropriate rubber mountings and their location as well as joining elements design A phase matching technique can be employed to control forces from main exciters. It enables to changing vibration response of the structure by control of natural modes contribution. Proposed changes lead to significant vibration reduction and can be easily utilized in engineering practice.

• Journal of Electrochemical Science and Technology
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• 제2권4호
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• pp.211-215
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• 2011

Flexible sheets consisting of acrylonitrile-butadiene rubber (NBR) and carbon nanotube (CNT) are newly prepared varying the composition (CNT 20-25 wt.%) for use as a current collector of supercapacitor electrodes. The as-prepared CNT/NBR is electrodeposited with aniline using potentiodynamic cyclic voltammetry to yield a polyaniline (PANI)/CNT/NBR composite electrode. It is confirmed that the electrical conductivity of CNT/NBR current collector can be enhanced as the content of CNT increases. Cyclic voltammetry result shows that the sample of PANI/CNT(25 wt.%)/NBR composite achieves a maximum specific capacitance ($134.9\;F\;g^{-1}$) at $5\;mV\;s^{-1}$. Such supercapacitor application is possibly originated from the synergistic effects consisting of higher polarity of nitrile groups in NBR, conducting pathway of CNT, and electroactive property of PANI.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7825-7829
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• 2014

Objective: To investigate the effect of high expression of XAF1 in vivo or in vitro on lung cancer cell growth and apoptosis. Methods: 1. The A549 human lung cancer cell line was transfected with Ad5/F35 - XAF1, or Ad5/F35 - Null at the same multiplicity of infection (MOI); (hereinafter referred to as transient transfected cell strain); XAF1 gene mRNA and protein expression was detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting respectively. 2. Methyl thiazolyl tetrazolium (MTT) and annexin V-FITC/PI double staining were used to detect cell proliferation and apoptosis before and after infection of Ad5/F35 - XAF1 with Western blotting for apoptosis related proteins, caspase 3, caspase - 8 and PARP. 3. After the XAF1 gene was transfected into lung cancer A549 cells by lentiviral vectors, and selected by screening with Blasticidin, reverse transcription polymerase chain reaction (RT-PCR) and Western blotting were applied to detect mRNA and protein expression, to establish a line with a stable high expression of XAF1 (hereinafter referred to as stable expression cell strain). Twenty nude mice were randomly divided into groups A and B, 10 in each group: A549/XAF1 stable expression cell strain was subcutaneously injected in group A, and A549/Ctrl stable cell line stable expression cell strain in group B (control group), to observe transplanted tumor growth in nude mice. Results: The mRNA and protein expression of XAF1 in A549 cells transfected by Ad5/F35 - XAF1 was significantly higher than in the control group. XAF1 mediated by adenovirus vector demonstrated a dose dependent inhibition of lung cancer cell proliferation and induction of apoptosis. This was accompanied by cleavage of caspase -3, -8, -9 and PARP, suggesting activation of intrinsic or extrinsic apoptotic pathways. A cell strain of lung cancer highly expressing XAF1 was established, and this demonstrated delayed tumor growth after transplantation in vivo. Conclusion: Adenovirus mediated XAF1 gene expression could inhibit proliferation and induce apoptosis in lung cancer cells in vitro; highly stable expression of XAF1 could also significantly inhibit the growth of transplanted tumors in nude mouse, with no obvious adverse reactions observed. Therefore, the XAF1 gene could become a new target for lung cancer treatment.

• 화약ㆍ발파
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• 제28권1호
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• pp.19-26
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• 2010

이 논문은 필리핀 석회석 광산에 적용한 연구 결과로서 이 광산에서는 파쇄석 입도분포가 좋지 않고 벽면의 유지나 파쇄석 더미의 분산이 불량하였다. 기폭패턴을 대각선 방식에서 V 타입으로 바꾸고 전색장을 조정하여 저항과 가스압의 유지기간을 향상시켰다. 이를 통하여 발파결과가 향상되었다. 특히 공당발파영역이 넓어진 것으로써 그 성과를 확인할 수 있다. 공당발파영역은 기존의 $8.96m^2$에서 $12m^2$로 넓어졌다. 화약계수는 증가하였고 대괴의 수는 감소하였으며, 전방적재기의 행정시간이 감소하였다. 또 공전 시간이 줄었으며 적재높이가 향상되었다.

• Journal of Biosystems Engineering
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• 제31권2호
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• pp.108-114
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• 2006

This study was conducted to design and fabricate a controller for variable-rate application of granular fertilizer based on physical and chemical information, to analyze the performance of the controller and characteristics of a discharger. The result of the study are summarized as follows: 1. The charge ratios of discharger by accumulation heights of fertilizer in hopper were examined, and the variations in charge ratio were $72.58{\sim}93.33%$ and $63.14{\sim}94.42%$ for the fertilizers Super 21 and Sinsedae, respectively. The charge ratio also decreased as the rotational speed of discharger increased. 2. The coefficient of variation of discharge amount by rotational speed and discharge time of discharger were in the range of $2.94{\sim}11.23%$ and $2.82{\sim}10.80%$ for the fertilizer of Super 21 and Sinsedae. Except the rotational speed of 12 rpm, the coefficient of variation for discharge amount were relatively small with 4% more or less 3. In order to evaluate the rotational speed of discharger, the control signal in the range of $0{\sim}5V$ was subdivided into the 50 steps by 0.1V. The regression equation for the rotational speed of discharger was Y=55.984X-79.174(X: input voltage, V, Y: discharger speed, RPM) and the $R^2$ was 0.99. 4. In order to evaluate the performance of the controller for variable-rate application of granular fertilizer, settling time to unit step input was examined. The settling time varied from 0.8sec to 1.4 sec.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1987년도 Proceedings of Korea-Japan Panax Ginseng Symposium 1987 Seoul Korea
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• pp.29-37
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• 1987

This study was devised to observe the cytotoxlc activities of petroleum-ether extract of Panax ginseng root(crude Gx) and its partially purified fraction from silicon acid column chromatography(7:3 CX) against sarcoma-180(5-180) and Walker carcinosarcoma 256(Walker 256) in vivo, and murine leukemic lymphocytes(L1210) and human rectal cancer cell(HRT-18) and human colon cancer cells(HT-29 and HCT-48) in vitro . Each cell-line was cultured in medium containing serial concentrations of the crude Gx or 7:3 Gx in vitro. A highly lipid soluble compound in the extract of Panax ginseng root was cytocidal to murine leukemic cells and human colon and rectal cancer cells in vitro In the meantime, ginseng saponin derivatives did not cytotoxic effects at its corresponding concentration. The growth rates of the cancer cells in medium containing ginseng extracts were inhibited gradually to a significant degree roughly in proportion to the increase of the extract concentration. The cytotoxic activity of 7:3 Gx was about 3 times more potent than that of crude Gx, one unit of cytotoxic activity against L121f cells being equivalent to 2.54$\mu\textrm{g}$ and 0.88 $\mu\textrm{g}$ for the crude Gx and 7:3 Gx, respectively. The Rf value of the active compound on silica -gel thin layer chromatography with petroleum-ether/ethyl ether/acetic acid mixture (90:10:1, v/v/v) as a developing solvent was 0.23. The survival times of mice inoculated with S-180 cells were extended about 1.5 to 2 times by the 7:3 Gx treatment compared with their control group. The significantly decreased hemoglobin values of rats after inoculation with Walker 256 were recovered to normal range by oral administration of the crude Gx. The synthetic levels of protein, DNA and RNA in human colon and rectal cancer cells were significantly diminished by treatment with the crude Gx, which can explain a part of the origin of its anticancer activity.

• Asian-Australasian Journal of Animal Sciences
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• 제33권2호
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• pp.294-304
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• 2020

Objective: The study was conducted to evaluate the effects of the absorbent (a mixture of activated carbon and hydrated sodium calcium aluminosilicate) on growth performance, blood profiles and hepatic genes expression in broilers fed diets naturally contaminated with aflatoxin. Methods: A total of 1,200 one-day-old male chicks were randomly assigned to 6 treatments with 10 replicate cages per treatment. The dietary treatments were as follows: i) control (basal diets); ii) 50% contaminated corn; iii) 100% contaminated corn; iv) control+1% adsorbent; v) 50% contaminated corn+1% absorbent; vi) 100% contaminated corn+1% absorbent. Results: During d 1 to 21, feeding contaminated diets reduced (p<0.05) body weight (BW), average daily gain (ADG), and average daily feed intake (ADFI), but increased (p<0.05) feed-to-gain ratio (F/G). The absorbent supplementation increased (p<0.05) BW, ADG, and ADFI. There were interactions (p<0.05) in BW, ADG, and ADFI between contaminated corn and absorbent. Overall, birds fed 100% contaminated diets had lower (p<0.05) final BW and ADG, but higher (p<0.05) F/G compared to those fed control diets. The absorbent addition increased (p<0.05) serum albumin concentration on d 14 and 28 and total protein (TP) level on d 28, decreased (p<0.05) alanine transaminase activity on d 14 and activities of aspartate aminotransferase and alkaline phosphatase on d 28. Feeding contaminated diets reduced (p<0.05) hepatic TP content on d 28 and 42. The contaminated diets upregulated (p<0.05) expression of interleukin-6, catalase (CAT), and superoxide dismutase (SOD), but downregulated (p<0.05) glutathione S-transferase (GST) expression in liver. The absorbent supplementation increased (p<0.05) interleukin-1β, CAT, SOD, cytochrome P450 1A1 and GST expression in liver. There were interactions (p<0.05) in the expression of hepatic CAT, SOD, and GST between contaminated corn and absorbent. Conclusion: The results suggest that the naturally aflatoxin-contaminated corn depressed growth performance, while the adsorbent could partially attenuate the adverse effects of aflatoxin on growth performance, blood profiles and hepatic genes expression in broilers.

• 한국산림과학회지
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• 제61권1호
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• pp.60-68
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• 1983

영농기술(營農技術)이 정체(停滯)되고 있었던 전근대사회(前近代社會)의 유제(遺制)로서 마을에서 총유적(總有的)으로 이용(利用)하여 오던 농용공유림(農用公有林)은 근대화과정(近代化過程)에 행정적(行政的)으로 거의 국공유화(국공유화)되었으나 아직도 기명공유(記名共有), 마을회소유(會所有), 생산조합소유(生産組合所有), 산림계소유(山林契所有), 산림계대부국공유(山林契貸付國公有) 등(等) 다양(多樣)한 등기명의(登記名儀)의 마을소유림(所有林)이 남아 있다. 한편, 산림계(山林契)의 조직(組織)은 여러개의 자연부락(自然部落)으로 되어 있음으로 자연부락별(自然部落別)로 갖고 있는 마을 소유림(所有林)의 관리(管理)는 산림계장(山林契長)으로부터 유리(遊離)될 수 밖에 없는 실정(實情)에 있다. 이들을 산림조합계통(山林組合系統)으로 일원화(一元化)시키는 조치(措置)가 고려(考慮)되어야 할 것이다. 마을소유림(所有林)의 이용(利用)은 아직도 연료(燃料)나 묘지(墓地)에 큰 비중(比重)이 주어지고 있다고는 하나 영농기술(營農技術)과 농가경제수준(農家經濟水準)이 향상(向上)된 오늘날 생산조합적(生産組合的) 경영방식(經營方式)에 의한 경제림조성(經濟林造成)에 더 큰 관심을 가지게 되었다. 이 공유림생산조합(公有林生産組合)을 군산림조합(郡山林組合)과 유기적(有機的)으로 연계(連繫)시켜 지역산림(地域山林)의 생산력(生産力) 향상(向上)을 선도(先導)케 하여야 한다. 그러나 아직도 마을소유림(所有林)의 경영(經營)은 조방적(粗放的)이어서 경영(經營)과 보호(保護)에 대하여 아무런 계획(計劃)과 대책(對策)을 갖지 않은 방치상태(放置狀態)에 있다. 특히 작은 면적규모(面積規模)로 방치(放置)되어 있는 마을소유림(所有林)의 공동경영(共同經營)을 조장(助長)하기 위하여 적정면적(適正面積)의 확보(確保)를 지원(支援)하여야 할 것이며 경영(經營)에 부적합(不適合)한 과소면적(過小面積)의 마을소유림(所有林)과 구성원(構成員)이 여러마을에 걸쳐 있어서 노동생산성(勞動生産性)을 높일 수 없는 공유림(公有林)은 해체(解體)하여 사유화(私有化)되도록 유도(誘導)하는 것이 바람직하다. 산림이용(山林利用)이 농민적(農民的) 이용(利用)으로부터 임업적(林業的) 이용(利用)의 방향(方向)으로 발전(發展)함에 따라 산림(山林)의 가치(價値)가 증대(增大)하고 이로 인(因)하여 마을소유림(所有林)의 총유권분쟁(總有權紛爭)이 자주 일어나고 있다. 생산조합명의(生産組合名儀)로 등기이전(登記移轉)을 시키는 등(等) 분쟁(紛爭)의 예방(豫防)과 조정(調停)으로 주민(住民)의 신뢰(信賴)를 회복(回復)시키고 경영(經營)에 대한 참여의식(參與意識)을 높이도록 하여야 할 것이다.

• Archives of Pharmacal Research
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• 제28권7호
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• pp.791-798
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• 2005

The hepatoprotective activity of flavonol glycosides rich fraction (F-2), prepared from 70% alcohol extract of the aerial parts of V calcarata Desf., was evaluated in a rat model with a liver injury induced by daily oral administration of $CCl_4$ (100 mg/kg, b.w) for four weeks. Treatment of the animals with F-2 using a dose of (25 mg/kg, b.w) during the induction of hepatic damage by $CCl_4$ significantly reduced the indices of liver injuries. The hepatoprotective effects of F-2 significantly reduced the elevated levels of the following serum enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including glutathione (GSH) content, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. In addition, it normalized liver malondialdehyde (MDA) levels and creatinine concentration. Chromatographic purification of F-2 resulted in the isolation of two flavonol glycosides that rarely occur in the plant kingdom, identified as quercetin-3,5-di-O-$\beta$-D-diglucoside (5) and kaempferol-3,5-di-O-$\beta$-D-diglucoside (4) in addition to the three known compounds identified as quercetin-3-O-$\alpha$-L-rhamnosyl- (${\rightarrow}6$)-$\beta$-D-glucoside [rutin, 3], quercetin-3-O-$\beta$-D-glucoside [isoquercitrin, 2] and kaempferol-3-O-$\beta$-D-glucoside [astragalin, 1]. These compounds were identified based on interpretation of their physical, chemical, and spectral data. Moreover, the spectrophotometric estimation of the flavonoids content revealed that the aerial parts of the plant contain an appreciable amount of flavonoids (0.89%) calculated as rutin. The data obtained from this study revealed that the flavonol glycosides of F-2 protect the rat liver from hepatic damage induced by $CCl_4$ through inhibition of lipid peroxidation caused by $CCl_4$ reactive free radicals.