• 대한세포병리학회지
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• 제12권2호
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• pp.73-80
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• 2001

The prevalence of Epstein-Barr virus(EBV) in the uterine cervix was investigated to define the possible etiologic role in cervical carcinogenesis. The viral genotyping and LMP-1 30bp deletion were also stooled. The materials included 169 uterine cervical swabs(152 within normal limits, 12 atypical squamous cells of uncertain significance, 3 low grade intraepithelial lesions, and 2 high grade squamous intraepithelial lesion) and 104 uterine cervical tissues obtained from hysterectomy specimens(32 carcinoma in situ, 9 microinvasive squamous cell carcinomas, 37 invasive squamous cell carcinomas, 7 adenocarcinomas, 7 adenosquamous carcinomas, and 12 cervicitis). EBV detected by PCR for EBNA-1 was positive in 52(56.5%) of 92 invasive and noninvasive cervical carcinomas, and 80(48.8%) of 164 inflammatory or normal cervices. The viruses detected in carcinomas were all type A, and LMP-1 30bp deletion form was more frequent in premalignant and malignant cervical lesions than in nonneoplastic cervices. From the above results, it may be concluded that EBV is one of common viruses detected in uterine cervix of Korean women, and type A virus and LMP-1 30bp deletion form may have a role in cervical carcinogenesis.

• Radiation Oncology Journal
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• 제10권2호
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• pp.227-236
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• 1992

1979년 3월부터 1986년 12월까지 과거에 아무런 치료를 받지 않은 자궁경부암 IIB병기 환자 232명을 서울대학병원 치료방사선과에서 치료하였다. 대상 환자들은 FlGO 방식으로 병기가 결정되었으며, 대다수의 환자에게 골반 외부 방사선 조사 및 강내 조사가 병용되어 치료되었다. 이학적 검사소견, 혈액 검사소견, 내과적 질환의 과거력, 조직학적 소견 및 복부-골반 전산화단층촬영 소견등의 치료전 인자들이 분석되었으며 이들 인자들의 5년 국소 치료율, 5년 무병 생존율 및 5년 생존율 등에 대한 잠재적인 예후적 유의성을 밝히기 위해 단변수분석과 다변량분석을 시행하였다. 조직학적 소견, 자궁내진시 자궁방결합조직의 침윤, 전산화단층촬영상 대동맥 임파절의 전이등이 자궁경부암 IIB 병기에서 예후적 유의성을 갖는 것으로 판명되었다.

• 대한임상검사과학회지
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• 제37권3호
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• pp.197-206
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• 2005

To determine the correlation between mast cells(MCs) and neoangiogenesis in the growth and progression of cervical cancer, we investigated mast cell density(MCD), microvessel density(MVD) and the expression of vascular epithelial growth factor(VEGF) in cervical intraepithelial neoplasia and invasive suqamous cell carcinoma of the uterine cervix. Forty-five cervical intraepithelial neoplasia(CIN I, II and III), 15 microinvasive carcinomas, 15 invasive squamous cell carcinomas and 20 normal cervical epithelia were included in this study. MCs were stained with anti-c-Kit antibody and alcian blue, microvessels with anti-factor VIII antibody and VEGF with anti-VEGF antibody. The adjacent fields of both normal and neoplastic epithelium were used for counting MCs and microvessels. Computerized image analysis was used to evaluate MCD and MVD. MCD and MVD were the mean numbers per $1mm^2$ counted in 5-10 high and low power fields respectively. In both c-Kit and alcian blue stained sections, MCD progressively increased along the continuum from CIN I to invasive squamous cell carcinoma(p<0.001). MVD increased significantly with cervical neoplasia progression, from CIN to invasive squamous cell carcinoma (p<0.001). In double c-Kit and Factor VIII-stained sections, MCs were mainly present in the areas adjacent to newly formed blood vessels. However, there were no significant differences in MCD and MVD between normal epithelum and CIN I. A strong correlation was also observed between MCD and MVD. In double VEGF and alcian blue-stained sections, VEGF was expressed in only MCs. Strong VEGF-positive MCs were particularly abundant around the tumorous region. Our results suggest that MCs may upregulate neoangiogenesis by VGEF secretion in the development and progression of cervical neoplasia.

• 대한수의학회지
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• 제28권2호
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• pp.261-270
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• 1988

This study was performed to investigate the effect of gestation on the histological and histochemical changes of the uterine cervix of the native Korean cattle. A total of 110 cows obtained from the Chonhuk abattoir were divided into six groups. The 1st group was of 9 non-pregnant cows and 101 singleton pregnant cows were grouped into 5 groups from pregnant I to pregnant V according to gestation periods by means of crown rump length measures. For light microscopy the tissues were fixed in 10% neutral formalin and processed routinely for paraffin sections The $6{\mu}m$ sections were taken and stained with H-E, Alcian blue pH 1.0, Alcian blue pH 2.5, Alcian blue pH 2.5/PAS, PAS reaction, toluidin blue, and trichrome. The results obtained were as follows: 1. The cervical lengths and widths were increased in relation to advancing gestation. 2. The cervical folds of the pregnant groups were increased and complicated with many branches, and the cervical muscosal epithelia were increased in according to advancing gestation. 3. As advancing gestation, the tunics muscularis of cervix was increased following moderate distribution of fibroblast and vascularity, meanwhile decreased mast cells were found. 4. The cervical mucosubstance was composed of mixed mucopolysaccharides; the acid mucus was increased from the early pregnant state but the neutral mucus was found after pregnant IV, and the mucus was stained deeply in each staining in the fold cavity in according to gestation state.

• Journal of Yeungnam Medical Science
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• 제16권2호
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• pp.296-301
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• 1999

자궁의 MMMT와 자궁내막암을 감별진단할 수 있는 자기공명영상 소견을 알아보기 위하여 자궁적출술에 의해 병리적으로 확인된 5례의 MMMT와 14례의 자궁내막암을 대상으로 종괴의 크기, 자궁근층 및 자궁경부의 침범 유무, 종괴의 성장 양상, 신호강도와 조영증강의 정도 및 양상을 후향적으로 분석하였다. 종괴의 장경은 MMMT가 1.5-9cm(평균, 5.7cm)이었고, 자궁내막암은 0.5-6.0cm(평균, 2.5cm)이었다. MMMT 5례 중 3례에서 자궁경부의 침범이 확인되었는데, 이들은 자궁강과 자궁경부의 내강을 확장시키면서 외자궁구로 성장하는 양상을 보였으며, 자궁내막암은 14례 중 1례에서만 자궁경부 침범이 확인되었다. 자궁근층 침범의 유무, T1- 및 T2-강조영상에서의 신호강도와 균일성, 조영증강의 정도와 양상은 별다른 차이가 없었다. 이상의 결과에서, MMMT와 자궁내막암을 감별할 수 있는 특이한 소견은 확인할 수 없었으나, 종괴가 5cm 이상으로 크고, 자궁경부 내강을 확장시키면서, 자궁경부를 침범하는 경우에는 MMMT의 가능성을 고려해야 할 것으로 생각한다.

• 한국광학회:학술대회논문집
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• 한국광학회 2005년도 하계학술발표회
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• pp.178-179
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• 2005

• 한국광학회:학술대회논문집
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• 한국광학회 2006년도 동계학술발표회 논문집
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• pp.189-190
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• 2006

• 대한세포병리학회:학술대회논문집
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• 대한세포병리학회 1993년도 제7차 춘계학술대회 초록집
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• pp.8.1-8.1
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• 1993

• 대한세포병리학회:학술대회논문집
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• 대한세포병리학회 1991년도 제5차 춘계학술대회 초록집
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• pp.6.1-6.1
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• 1991

• Radiation Oncology Journal
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• 제1권1호
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• pp.103-109
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• 1983

47 out of 56 cases of intact uterine cervix cancer treated by radiation at the Hanyang University Hospital were followed 18 months or more after treatment. (7 patients died before 18 months, 2 cases lost to follow-up). Age distribution reveal 5 cases in 30's, 18 cases in 40's, 17 cases in 50's, 7 cases in 60's. Histologically, all cases were squamous cell type except one case of adenocarcinoma. 1. 45 cases were treated by combined external Co-60 irradiation and intracavitary irradiation by Cs-137 small sources. 1 case was treated by external irradiation only, and 1 case by intracavitary only. 2. Rectal injuries were observed in 13 cased (27.6%), 4 cases in Grade 1, 8 cased in Grade 2 and 1 cases in Grade 3 which needed surgical management. 3. Average intervals of rectal injury following treatment was 9.2 months varying from 5 to 15 months. 4. Relation between rectal injury and point A dose reveal 6 cases between 7000-7999 rad and 6 cases between 8000-8999 rad and 1 case above 9000 rad. Even though there is no direct relation between point A dose and rectal injury, it is expected that rectal injury increases as point A dose increase. 5. In the normal condition, rectal injury can't be attributed to one major cause. Radiation dose, small source distribution, general condition of patients, local anatomy of the individual patient, history of PID and previous surgery, all play complex roles.