• Title/Summary/Keyword: Uterine cervix

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Cytology of the Uterine Cervico-vaginal Smear of Clear Cell Adenocarcinoma in Uterine Cervix - Report of a Case - (자궁경부 투명세포 샘암종의 자궁경부질 세포학적 소견 - 1예 보고 -)

  • Maeng, Lee-So;Kim, Kyouug-Mee;Kang, Chang-Suk;Lee, An-Hi
    • The Korean Journal of Cytopathology
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    • v.15 no.2
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    • pp.116-119
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    • 2004
  • Primary clear cell adenocarcinoma of uterine cervix is rare and cytomorphology in the vaginal smear have not been previously described in Korean literatures. The cytologic characteristics of clear cell adenocarcinoma of the uterine cervix include : malignant cells with abundant, finely vacuolated cytoplasm ; hobnail appearance, and distinctive basement membrane-like hyaline materials within cellular aggregates. A 36-year-old woman presented with vaginal bleeding. Cytologic examination of vaginal smear and histopathologic examination of a radical hysterectomy specimen allowed the diagnosis of hemorrhagic tumor in the uterine cervix as a clear cell adenocarcinoma. Cytologic findings were very characteristic. The tumor cells had abundant, pale, finely vacuolated cytoplasm with indistinct cytoplasmic membrane. The nuclei were round to oval with finely dispersed chromatin. Extracellular basement membrane-like hyaline substance, which stained a light green color in Papanicolaou's preparation, was frequently observed within the cancer cell clusters.

Composite Tumor of Adenocarcinoma and Small Cell Neuroendocrine Carcinoma of the Uterine Cervix -A Case Report- (자궁 경부의 선암과 혼합된 신경내분비 소세포 암종 - 1 증례 보고 -)

  • Park, Hye-Rim;Lee, Yong-Woo;Park, Young-Euy
    • The Korean Journal of Cytopathology
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    • v.1 no.1
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    • pp.111-120
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    • 1990
  • Small cell neuroendocrine carcinoma of the uterine cervix is a distinct subtype of cervical cancer that appears analogous to oat cell carcinoma and carcinoid tumors of the lung. It has been assumed to be derived from the neural crest via argyrophilic cells in the normal endocervix. We have recently encountered a case of small cell neuroendocrine carcinoma of the uterine cervix coexisting with adenocarcinoma which was argyrophil negative. A 66-year-old multiparous woman was admitted because of vaginal bleeding for 2 months. Cervicovaginal smear revealed several scattered clusters and sheets of monotonous small cells with some peripheral palisading in the background of hemorrhage and necrosis. Radical hysterectomy specimen revealed an ulcerofungating tumor on endocervical canal which was composed of two components. Major component of the tumor was made up of monomorphic population of small oval-shaped tumor cells arranged in sheets and partly in acinar structures or trabecular fashion. Other component was adenocarcinoma, endocervical well-differentiated type. Argyrophilia was present on the Grimelius stain and immunohistochemical studies revealed diffuse positivity to neuron-specific enolase and carcinoembryonic antigen. Electron microscopic examination showed clusters of small round to oval cells, which had a few well-formed desmosomes and several membrane-bound, dense-core neurosectetory granules.

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Cytologic Features of Glassy Cell Carcinoma of the Uterine Cervix - Three Cases Report - (자궁 경부의 유리질 세포 암종의 세포학적 소견 - 3예 보고 -)

  • Jeon, Seok-Hoon;Paik, Seung-Sam;Lee, Won-Mi;Jang, Se-Jin;Park, Yong-Wook;Park, Moon-Hyang;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.7 no.2
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    • pp.197-201
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    • 1996
  • Glassy cell carcinoma is an unusual neoplasm of the uterine cervix that accounts for $1{\sim}2%$ of all cervical malignancy. It is a rapidly progressive and biologically aggressive disease with poor response to therapy. This tumor is considered to be a poorly differentiated mixed adenosquamous carcinoma. The cytologic findings are characterized by tumor cells arranged predominantly in syncytial like aggregates and an inflammatory background. The tumor cells have moderate amounts of eosinophilic or amphophilic cytoplasm, which is often finely granular. The nuclei are relatively large and have fine chromatin with prominent eosinophilic nucleoli. Cytologically, glassy cell carcinoma is most likely to be confused with large cell nonkeratinizing squamous cell carcinoma and with atypical reparative cells. Herein, we report three cases of glassy cell carcinoma of the uterine cervix diagnosed by cervicovaginal smear and confirmed by histologic section with review of literatures.

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Extranodal Malignant Lymphoma Concurrent Involving Female Urethra and Cervix: a Case Report

  • Kim, Dong Chan;Kim, You Me
    • Investigative Magnetic Resonance Imaging
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    • v.24 no.3
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    • pp.168-173
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    • 2020
  • Extranodal lymphoma presents in almost one-third of all non-Hodgkin lymphoma cases. The gastrointestinal tract, skin, and central nervous system are common sites of involvement, whereas the urethra and cervix are very rare. To the best of our knowledge, this is the first report on concurrent extranodal involvement of the uterine cervix and urethra. We report imaging findings of malignant lymphoma involving urethra and cervix concurrently in a 79-year-old female patient with literature review. The magnetic resonance imaging showed huge intermediate to high signal intensity mass on T2 weighted images and strong homogeneous enhancement in uterine cervix and periurethral area, but no surrounding architectural disruption.

Cytologic Features of Malignant Lymphoma of the Uterine Cervix - A case report - (자궁경부 악성 림프종의 경부-질 도말소견 - 1 증례 보고 -)

  • Kim, Nam-Hoon;Park, Chan-Kum;Ko, Young-Hyeh;Park, Moon-Hyang;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.6 no.1
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    • pp.76-79
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    • 1995
  • The uterine cervix is an uncommon site of primary non-Hodgkin's lymphoma (NHL). Although the cytologic findings of NHLs are well known, most cervicovaginal smear of uterine NHLs give lower diagnostic yield than common epithelial malignancy because abnormal cells do not appear in the sample in the absence of surface ulceration. Herein, we describe cytologic findings of a case of uterine cervical NHL which was initially diagnosed by cervicovaginal smear. The tumor cells were relatively uniform, isolated, large-sized with scanty cytoplasm and round or indented nuclei. The nuclei had stippled chromatin and small nucleoli. Histologically and immunohistochemically the tumor was proven to be large cell lymphoma of T-cell lineage.

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Cytologic Features of Villoglandular Adenocarcinoma of the Uterine Cervix - A Report of Two Cases - (자궁목 융모샘 샘암종의 세포 소견 -2예 보고-)

  • Kim, Bohng-Hee
    • The Korean Journal of Cytopathology
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    • v.17 no.2
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    • pp.136-142
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    • 2006
  • Villoglandular adenocarcinoma of uterine cervix has recently been described, and is characterized by good prognosis and occurrence in young women, except a small number of cases. Morphologically, it exclusively shows villoglandular growth and mild to moderate nuclear atypia, the cytologic diagnoses have been frequently missed due to interpretation error. We report here on the cytologic findings of two cases, and both cases were not diagnosed as adenocarcinoma before punch biopsy. One of these cases showed previously described characteristic features such as high cellularity and large tissue fragments with long villous fronds lined by columnar cell with mild nuclear atypia. The other showed moderate cellularity of somewhat smaller clusters without long villous structures. The clusters showed marked nuclear overlapping and the nuclei showed distinct moderate atypia with hyperchromasia and coarse chromatin pattern. The nucleoli were indistinct. Recognition of these features will be helpful to avoid underdiagnosis as a benign lesion, although diagnosis is still difficult in a portion of the cases.

Cytologic Analysis of Microinvasive Squamous Cell Carcinoma of the Uterine Cervix (자궁경부 미소침윤성 편평세포암종의 세포학적 분석)

  • Kim, Eun-Kyung;Kim, Yee-Jeong;Park, Jong-Sook;Kim, Hy-Sook
    • The Korean Journal of Cytopathology
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    • v.5 no.2
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    • pp.99-105
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    • 1994
  • We studied cervical cytology of 175 cases of histologically confirmed microinvasive squamous cell carcinoma of the uterine cervix in Cheil General Hospital from 1991 to 1993. Excluding 32 cases of insufficient smear, 143 cases were reviewed in view of background, cellularity, smear pattern, nuclear chromatin and presence of nucleoli. The characteristic findings of microinvasive carcinoma were syncytia and/or individual tumor cells in the focally necrotic inflammatory background. Nuclear chromatin was clear or fine. Nucleoli were observed in 55%. The prediction rate of microinvasive carcinoma was 74%. There is no significant relationship between the cellular features and depth of invasion.

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Ultrasonography, Affected Age, Hematology and Clinical Signs according to Open or Closed Cervix in Dogs with Pyometra

  • Lee, Jun-Am;Kim, Ill-Hwa;Hwang, Dae-Youn;Kang, Hyun-Gu
    • Journal of Veterinary Clinics
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    • v.33 no.6
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    • pp.362-367
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    • 2016
  • The aim of the study was to evaluate ultrasonographic findings, affected age, hematology, blood chemistry and clinical signs according to open or closed cervix in 102 bitches presented for treatment of pyometra. The prevalence of pyometra according to breed was observed in Maltese 22.5%, Yorkshire Terrier 13.7% and Shih Tzu 12.7%. The mean age of dogs was $9.6{\pm}0.3years$, and open cervix pyometra was more prevalent than closed cervix pyometra. Clinical signs included anorexia, vaginal discharge, depression, polyuria/polydipsia, vomiting, and abdominal distension. The concentration of BUN and the activity of ALP in dogs with closed cervix pyometra were significantly higher than those in dogs with open cervix pyometra (p < 0.05). The white blood cell and neutrophils in dogs with closed cervix pyometra were significant higher than those in dogs with open cervix pyometra (p < 0.05). Ultrasonographic findings of the uterus with open or closed cervix pyometra showed variable patterns. The uterine wall was variable in appearance, from thick and irregular to smooth and thin. The uterine wall was thicker in open cervix pyometra than in closed cervix pyometra. The luminal cavity included smaller amount of anechoic fluid in open cervix pyometra than in closed cervix pyometra.

Comparison on the Deep Learning Performance of a Field of View Variable Color Images of Uterine Cervix (컬러 자궁경부 영상에서 딥러닝 기법에서의 영상영역 처리 방법에 따른 성능 비교 연구)

  • Seol, Yu Jin;Kim, Young Jae;Nam, Kye Hyun;Kim, Kwang Gi
    • Journal of Korea Multimedia Society
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    • v.23 no.7
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    • pp.812-818
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    • 2020
  • Cervical cancer is the second most common female cancer in the world. In Korea, cervical cancer accounts for 13 percent of female cancers and 4,200 cases occur annually[1]. The purpose of this study is to use a deep learning model to identify the possibility of lesions in the cervix and to evaluate the efficient image preprocessing in order to diagnose diverse types of cervix in form. The study used 4,107 normal photographs of uterine cervix and 6,285 abnormal photographs of uterine cervix. Two types of image preprocessing were resized to square. The methods are cropping based on height and filling the space up and down with black images. In addition, all images were resampled to 256×256. The average accuracy of cropped cases is 94.15%. The average accuracy of the filled cases is 93.41%. According to the study, the model performance of cropped data was slightly better. But there were several images that were not accurately classified. Therefore, the additional experiment with pre-treatment process based on cropping is needed to cover images of the cervix in more detail.

Association of Educational Levels with Survival in Indian Patients with Cancer of the Uterine Cervix

  • Krishnatreya, Manigreeva;Kataki, Amal Chandra;Sharma, Jagannath Dev;Nandy, Pintu;Gogoi, Gayatri
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3121-3123
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    • 2015
  • The main objective of this paper was to assess the influence of educational level on the survival of uterine cervix cancer patients in our population. A total of 224 patients were registered in our registry, of which 178 had information on stage and different educational levels. The overall median survival (MS) was 23 months, with values of 18.5, 20.7 and 41.3 months for the illiterate, literate and qualified groups, respectively. In the illiterate patients, stage I was seen in 2.6% and stage IV in 11.8%, while in other 2 groups stage I was seen in 10% to 17% of patients at the time of diagnosis. The survival probability at around 50 months was around 42%, 30% and 26% (approximately) for qualified, literates and illiterates respectively [Log Rank (Mantel-Cox) showed p=0.023]. Emphasis on imparting education to females can be a part of comprehensive cancer control programme for improving the overall survival in patients with carcinoma of the uterine cervix in our population.