• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.15 no.1
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• pp.37-42
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• 2004

Electrolarynx(EL), battery operated vibrators which are held against the neck by on-off button, has been widely used as a verbal communication method among post-laryngectomized patients. EL speech can produce easily without need of any additional surgery or special training and be used with any other methods. This institute developed a neck-typed EL named "Blueton" in commperation with EL Company Linkus, which consists of 3 parts : Vibrator part, Control part, Battery part. In this study we evaluated the acoustic characteristics of the produced voices by Blueton compared with Servox-inton using MDVP. Three EL users (2 full time users, 1 part time user) were participated. The results revelaed that NHR higher in Servox than Blueton and intensity is higher in Blueton than Servox. The spectra for vowels produced by EL speakers are mixed signals combined with talkers' vocal output and electrolarynx noise. The spectra pattern is similar with two ELs. High, SPI index and vowel spectra from MDVP demonstrated characteristics of both electrolarynxes related to noise signal. This finding suggests that Blueton helps to provide one of useful rehabilitation options in the post laryngectomy patients.

• Clinics in Shoulder and Elbow
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• v.21 no.4
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• pp.220-226
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• 2018

Background: This study introduces a surgical technique with good clinical outcome useful in the treatment of osteoporotic displaced 3- or 4-part proximal humeral fractures. Methods: From May 2014 to February 2016, 16 patients with displaced 3- or 4-part proximal humeral fractures were treated by application of a locking plate with an endosteal strut allograft via a deltoid splitting approach with a minimum follow-up of 12 months. The allograft was inserted through a fractured gap of the greater tuberosity to support the humeral head and then fixed by a locking plate with meticulous soft tissue dissection to protect the axillary nerve. Surgical outcomes were evaluated by the American Shoulder and Elbow Surgeons (ASES) and visual analogue scale (VAS) scores, radiological imaging, and clinical examination. Fixation failure on radiographs was defined as a >$5^{\circ}$ loss of neck shaft angle (NSA) compared to that on an immediate postoperative radiograph. Avascular necrosis (AVN) of the humeral head was also evaluated. Results: In all cases, complete union was achieved. The ASES and VAS scores were improved to $85.4{\pm}2.1$ and $3.2{\pm}1.3$, respectively. Twelve patients (75.0%) had greater than a $5^{\circ}$ change in NSA; the average NSA change was $3.8^{\circ}$. Five patients (31.3%) had unsatisfactory ranges of motion exhibiting a <$100^{\circ}$ active forward flexion. No axillary nerve injuries or AVN were observed at the last follow-up. One patient was converted to reverse total arthroplasty due to severe pain and functional deficit. Conclusions: Minimally invasive fixation via a locking compression plate and an endosteal fibula strut allograft in Neer classification 3-or 4-part fractures with severe osteoporosis in elderly patients can achieve good clinical results.

• Journal of Veterinary Science
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• v.22 no.5
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• pp.47.1-47.10
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• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Journal of Korean Society of Forest Science
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• v.103 no.3
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• pp.359-367
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• 2014

This study was carried out to determine the effects of seed storage methods and pre-treatments on seed germination, soil types and shading conditions on potted seedlings growth of S. sieboldiana var. pendula and S. sieboldiana for. xanthocarpa, endemic species in Korea. The seed germination rate of S. sieboldiana var. pendula was the highest at 48.6% when seeds were treated with stratification for 60 days and then soaked in 100 ppm $GA_3$. And seed germination rate of S. sieboldiana for. xanthocarpa was the highest at 51.4% when seeds were pre-chilled for 30 days and then soaked in 100 ppm $GA_3$. And potted seedlings of S. sieboldiana var. pendula showed the best quality under 50% shading in bedsoil with the growth characteristics of plant height (41 cm), number of leaves(8), leaf width (16 cm), leaf length (18 cm), root length (22 cm), fresh weight(aerial part/root part; 20/6.9 g) and dry weight(aerial part/root part; 4.5/2.0 g). And potted seedlings of S. sieboldiana for. xanthocarpa showed the best quality under non-shading in bedsoil with the growth characteristics of plant height (39 cm), number of leaves(10), leaf width (12 cm), leaf length (15 cm), root length (22 cm), fresh weight (aerial part/root part; 21/13 g) and dry weight (aerial part/root part; 4.2/2.2 g). Therefore, seeds treated with stratification or prechilling and then soaked in $GA_3$ were effective in germination of S. sieboldiana var. pendula and S. sieboldiana for. xanthocarpa, and potted seedlings should be cultivated in bedsoil under non or 50% shading condition.

• Journal of Mechanical Science and Technology
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• v.16 no.11
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• pp.1379-1394
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• 2002

In case of a single input single output (SISO) system with a nonlinear term, a signal compression method is useful to identify a system because the equivalent impulse response of linear part from the system can be extracted by the method. However even though the signal compression method is useful to estimate uncertain parameters of the system, the method cannot be directly applied to a unique system with hysteresis characteristics because it cannot estimate all of the two different dynamic properties according to its motion direction. This paper proposes a signal compression method with a pre-processor to identify a unique system with two different dynamics according to its motion direction. The pre-processor plays a role of separating expansion and retraction properties from the system with hysteresis characteristics. For evaluating performance of the proposed approach, a simulation to estimate the assumed unknown parameters for an arbitrary known model is carried out. A motion platform with several single-rod cylinders is a representative unique system with two different dynamics, because each single-rod cylinder has expansion and retraction dynamic properties according to its motion direction. The nominal constant parameters of the motion platform are experimentally identified by using the proposed method. As its application, the identified parameters are applied to a design of a sliding mode controller for the simulator.

• Journal of the Korean Society of Safety
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• v.17 no.1
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• pp.72-78
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• 2002

Among the disposal techniques of inorganic wastewater sludges from industries most of sludges were dealed with buring underground inefficiently. But we have tried to recycle the resources that exhausted inorganic sludges were properly blended to certain ratioes to make lightweight aggregate, that means manufacturing of it can be possible through blending of various components, drying, sintering, cooling and crushing to certain sizes that are needed by consumers. As disposal method of inorganic wastewater sludge is changed to environmentally fraternative method, this method could be very useful to make lightweight aggregates for decoration of building and the other so many purposes of those usages. That could be economically useful due to expected income for buring costs of ordinary disposal method form industries and sales income after manufacturing it. The second important profit is saving foreign currency from purchasing self-developed lightweight aggregate insteas of importing expensive foreign product. This product will be also very impressive to user because of the fraternative lightweight to be composed of apatite structure that is important part of human body.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.268-274
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• 2003

Most currently known molecular structures were determined by X-ray crystallography or Nuclear Magnetic Resonance (NMR). These methods generate a large amount of structure data, even far small molecules, and consist mainly of three-dimensional atomic coordinates. These are useful for analyzing molecular structure, but structure elements at higher level are also needed for a complete understanding of structure, and especially for structure prediction. Computational approaches exist for identifying secondary structural elements in proteins from atomic coordinates. However, similar methods have not been developed for RNA due in part to the very small amount of structure data so far available, and extracting the structural elements of RNA requires substantial manual work. Since the number of three-dimensional RNA structures is increasing, a more systematic and automated method is needed. We have developed a set of algorithms for recognizing secondary and tertiary structural elements in RNA molecules and in the protein-RNA structures in protein data banks (PDB). The present work represents the first attempt at extracting RNA structure elements from atomic coordinates in structure databases. The regularities in the structure elements revealed by the algorithms should provide useful information for predicting the structure of RNA molecules bound to proteins.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.4 no.2
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• pp.45-51
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• 2001

This study was carried out to select the useful plants for the revegetation of flooded slopes in dams, lakes and streams. In this study, four woody plants were investigated for their survival and growth in nursery with various flooding conditions. The results are as follows: Salix gracilistyla showed a very high survival rate and grew continuously under the complete flooding condition. Especially, it grew better under partly flooding condition than non-flooding condition. Amorpha fruticosa showed growth disorder when the flooding period was over 30 days, but the part of stem which was flooded in water adapted itself by branching the adventitious roots. Wisteria floribunda showed respectively high flooding tolerance until 30 days. Lespedeza bicolor were very weak in excessive moisture and flooding conditions. This study confirmed Salix gracilistyla, Amorpha fruticosa and Wisteria floribunda are efficient woody plants for covering the flooded slopes of dam and various impoundment sites.

• The KIPS Transactions:PartB
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• v.9B no.2
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• pp.231-236
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• 2002

The classification of the speech-sound block comes from the multi-resolution analysis property of the discrete wavelet transform, which is used to reduce the computational time for the pre-processing of speech recognition. The merging algorithm is proposed to extract vapid speech-sounds in terms of position and frequency range. It performs unvoiced/voiced classification and denoising. Since the merging algorithm can decide the processing parameters relating to voices only and is independent of system noises, it is useful for extracting valid speech-sounds. The merging algorithm has an adaptive feature for arbitrary system noises and an excellent denoising signal-to-noise ratio and a useful system tuning for the system implementation.

• Korean Management Science Review
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• v.30 no.2
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• pp.11-30
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• 2013

Small and medium-sized enterprises (SMEs) constitute an important part of current industrial economies. Information technologies can be useful strategic weapons for SMEs by enhancing their competitiveness. Categorized as one kind of cloud computing, SaaS is a computing resource and software sharing model which can be accessed via the Internet. Based on virtualization technology, SaaS is expected to improve the efficiency and quality of the IT service level in SMEs. This study attempts to identify the determinants of SaaS adoption intention among Korean SMEs. Through the lens of the theory of planned behavior, this study adopts technological, organizational, environmental factors to explore the determinants of cloud computing adoption intention. The research population is the SMEs that have been funded by the Korean government. Partial least square method was used for empirical analysis of 190 samples collected through on-line survey. The results show that the positive attitude is influenced by business process improvements. Vender support and top management support are positively associated with subjective norm. Vendor support, top management support can relieve perceived behavior control factors. Government support directly influences adoption intention of cloud computing. These findings can provide useful strategy for both SMEs and vendors of SaaS.