• Journal of Acupuncture Research
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• 제24권2호
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• pp.221-229
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• 2007

Oxidative damage to DNA, proteins, lipids and other molecules may contribute to the development of neurodegenerative disease. This study was designed to find out whether Ursi Fel ${\cdot}$ Bovis Calculus Herbal-Acupuncture Solution(UBHAS) can scavenge nitric oxide(NO) or not. NO concentration was estimated after treatment with Vit. C or 1, 10, $100{\mu}g/m{\ell}$ of UBHAS. There was no significant scavenging effect of UBHAS on NO in 1, $100{\mu}g/m{\ell}$ group. while significant scavenging in $l0{\mu}g/m{\ell}$ group after 2hrs. UBHAS showed significant scavenging effects on NO in 1, 10, $100{\mu}g/m{\ell}$ group after 6hrs. There was a significant scavenging effect in 10, $100{\mu}g/m{\ell}$ group. even though no significant in $1{\mu}g/m{\ell}$ group after 12, 24 hrs. This study showed that UBHAS might be used for aging related disease. These results suggest that UBHAS has scavenging effect on NO. however, further studies are required to investigate the antioxidative effects of it.

• 대한한의학회지
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• 제18권1호
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• pp.430-445
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• 1997

In order to know the effects of Calculus $Bovis{\cdot}F디$ Ursi aqua-acupuncture ($C{\cdot}F$ aqua-acupuncture) to the liver damage, we carried out the treatment of $C{\cdot}F$ aqua-acupuncture and injection of Kam-Du-Tang on the liver damaged rat which is induced by aconitine, and then ultrastructural study has been to the liver tissue. The results were as follows: 1. In the hepatic cell of normal group, the nuclear envelope is round and electro-density of nucleoplasm is relatively low, and have one or two large nucleolus. Cell organelle is developed rough endoplasmic reticulum(RER) and many mitochondria, glycogen granules, smooth endoplasmic reticulum(SER) and Golgi apparatus. 2. In 24 hours control group, nuclear envelope is very irregular, RER and most of cell organell is shown that destroyed by aconitine. This is similar to the 48 hours control group. In 72 hours control group, RER is recovered somewhat but cristae of mitochondria is not seen the shape 3.In 24 hours $C{\cdot}F$ aqua-acupuncture group, nuclear envelope is very irregular and cristernae is very dilatable and many mitochondria is dilationed and the cristae is not definite like the control group. In 48 hours $C{\cdot}F$ aqua-acupuncture group, nuclear envelope is relatively round and chromatin is regular. Cristernae of RER and ribosme is somewhat imperfect but is similar the normal group, and the cristae of mitchondria is shown definitely like the normal group. In 72 hours $C{\cdot}F$ aqua-acupuncture group, nuclear envelope is round and cell organell is similar to normal group. 4. In 24 hours Kam-Du-Tang group, nuclear envlope is very irregular and cell organelles are destroyed by the effects of aconitine. In 48 hours Kam-Du-Tang group, nuclear envelope is somewhat irregular but chromatin is relatively regular. RER is seperated regularly through the cytoplasm, but cannot make the structure of lamina, and cistennae is very dilationed. many of glycogen granules is seperated regularly. In 72 hours Kam-Du-Tang group, RER makes the lamina. Mitochondria is a little but inner space is dilationed so the shape of is not definite and a lot of glycogen granules are accumulated in several places. It see the above result, hepatic cell that is damaged by aconitine is effected chiefly by the $C{\cdot}F$ acupuncture and effect of acupuncture is similar to the detoxicated effect of Kam-Du-Tang.