• 제목/요약/키워드: Urine volume

검색결과 274건 처리시간 0.031초

Effects of the Acute and Subacute Administration of 1-(N-methyl) piperazinyl-3-phenyl-isoquinoline on Rat Kidney

  • Lim, Dong-Koo;Park, Sun-Hee;Noh, Eun-Young;Kim, Han-Soo;Cho, Won-Jea
    • Toxicological Research
    • /
    • 제16권1호
    • /
    • pp.47-52
    • /
    • 2000
  • To evaluate the renal toxicity of the antitumor agent, 1-(N-methyl) piperazinyl-3-phenyl-isoquinoline(CWJ-$\alpha$-5), rats were terated with CWJ-$\alpha$-5 (acute : 100mg/kg, i.p., single and subacute : 10mg/kr, i.p., daily for 7 days). The changes in the body weights, water consumption, kidney weights and urine volume after and during the treatment were observed. The concentrations of urinary creatinine, the activities of N-acetyl-$\beta$-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), $\gamma$-glutamyl transpeptidase ($\gamma$-GT) and lactate dehydrogenase (LDH) in 24 hr urine were also determined. The body weight and water consumption were decreased after the acute and subacute administration. However, the excretion of urine was not changed except the 1 day after the acute treatment. The excretion of creatinine was significantly decreased from 1 day after acute administration and continuously decreased. Also the excretion of creatinine was decreased during subacute administration. However, the protein excretion did not changed in both treatment. Those indicate that CWJ-$\alpha$-5 might decrease the metabolic rate of muscle. The urinary activities of NAG, AAP, $\gamma$-GT, and LDH were significantly affected by the drug treatment. The urinary activities of NAG, AAP and $\gamma$-GT were significantly increased 1 and 3 days after the acute administration and then returned to the control value. However, the urinary activities of LDH were increased 7 days after acute treatment. During subacute treatment, the urinary activities of $\gamma$-GT were not changed. However, the urinary activities of NAG, AAP and LDH were only significantly increased after the third administration. These results indicate that either the high acute dose or the subacute administration with low dose of the compound might induce a temporal damage in the kidney cells.

  • PDF

홀스타인 육성우의 계절별 분뇨 배설량 및 특성에 관한 연구 (Quantity and Characteristics of Manure Produced by Holstein Heifer at Different Seasons)

  • 최동윤;곽정훈;박치호;정광화;김태일;김재환;유용희;양창범;최홍림
    • 한국축산시설환경학회지
    • /
    • 제12권3호
    • /
    • pp.123-132
    • /
    • 2006
  • 우리나라에서 사육되고 있는 젖소 육성우의 분뇨배설량을 구명하기 위하여 육성우 6두를 공시하여 축산연구소 낙농우사에서 봄, 여름, 가을, 겨울 등 4계절에 걸쳐 각각 10일간 시험을 수행하였으며, 그 결과는 다음과 같다. 1. 건물섭취량은 평균 6.7kg으로 봄, 여름, 가을 및 겨울이 각각 4.6, 8.3, 7.1, 6.8kg으로 봄이 가장 낮은 섭취량을 보였으며, 음수량은 평균 $19.3{\ell}$로, 여름이 $21.8{\ell}$로 가장 많았고 봄과 겨울이 $18.3{\ell}$로 낮았으나 계절별 유의차는 보이지 않았다. 2. 분뇨배설량을 계절별로 조사한 결과, 봄 13.7kg, 여름 23.8kg, 가을 25.0kg, 겨울 20.2kg으로 봄이 가장 낮았으며(p<0.05), 전체 평균 분뇨배설량은 20.3kg이였고, 체중대비 분뇨의 비율은 5.6%였다. 3. 체중과 분뇨배설량간($R^2=0.7816$), 체중과 사료섭취량간($R^2=0.7296$)의 상관관계가 비교적 높았으나, 음수량과 분뇨배설량, 사료섭취량과 분뇨배설량간의 상관관계는 비교적 낮았다. 4. 분뇨의 수분 및 pH를 분석해 본 결과, 분의 뇨의 평균 수분 함량은 각각 83.5, 94.6%였으며, pH는 각각 7.4, 7.6 수준이었다. 5. 분뇨중 오염물질 농도는 분의 $BOD_5,\;COD_{Mn}$, SS, T-N 및 T-P는 각각 18,048, 50,114, 119,833, 2,519, $427mg/{\ell}$였고, 뇨는 각각 5,434, 6,550, 825, 3,616, $28mg/{\ell}$였다. 6. 분뇨중 비료성분은 분의 N, $P_2O_5,\;K_2O$가 각각 0.25, 0.10, 0.14%였고, 뇨는 각각 0.36, 0.006, 0.31%였다.도는 3m 지점에서 $446.6\;{\mu}g/m^3$ 이었으나 20 m 지점에서는 $156.3\;{\mu}g/m^3$로 34.9% 수준이었고 PM10 34.9%, PM2.5 48.7%, PM1.0 86.8% 수준이었다.

  • PDF

음곡(陰谷) 백복령(白茯苓)약침이 Lipopolysaccharide로 유도된 흰쥐의 염증성 신(腎) 손상에 미치는 영향 (The Effect of Hoelen Herbal-acupuncture at $KI_{10}$ on Lipopolysaccharide Induced Nephritis in Rats)

  • 김민식;김병수;임윤경
    • Journal of Acupuncture Research
    • /
    • 제31권2호
    • /
    • pp.65-74
    • /
    • 2014
  • Objectives : The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at $KI_{10}$(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats. Methods : The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 mg/kg) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at $KI_{10}$ three times a week. Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-${\alpha}$, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO). Results : HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats. Conclusions : HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.

음곡에 시술한 구맥 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향 (Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats)

  • 김경민;이현;강희정;이용흠;임윤경
    • Korean Journal of Acupuncture
    • /
    • 제26권1호
    • /
    • pp.61-77
    • /
    • 2009
  • Objective : This study aimed to evaluate the effects of Dianthi Semen Herba herbal-acupuncture (DS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat. Methods : Rats were injected with LPS and treated with DS-HA at KI10 3 times for a week(DS-HA), N.P. group was treated 26 gauge needle at KI10, saline group was treated with normal saline at KI10. To estimate the effects of DS-HA at KI10 on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine TNF-${\alpha}$, CINC-1 in serum, urinal volume and creatinean and total protein in urine, reanl TNF-${\alpha}$, renal MPO were measured and histological analysis of renal tissue was performed. Results : DS-HA at KI10 significantly decreased WBC and neutrophil in blood and BUN and creatinin in serum, MPO in kidney, and significantly increased urinary volume in LPS-stimulated rats. DS-HA at KI10 reduced accumulation of neutrophil in renal tissue of LPS-stimulated rats. Conclusions : Taken together, DS-HA at KI10 has a protective or therapeutic effect for nephritis in LPS-stimulated rat. Therefore, it is suggested that DS-HA at KI10 may be an useful therapeutics in clinical field after further researches.

  • PDF

Urological Evaluation of Tethered Cord Syndrome

  • Park, Kwanjin
    • Journal of Korean Neurosurgical Society
    • /
    • 제63권3호
    • /
    • pp.358-365
    • /
    • 2020
  • To describe how to perform urological evaluation in children with tethered cord syndrome (TCS). Although a common manifestation of TCS is the development of neurogenic bladder in developing children, neurosurgeons often face difficulty in detecting urological problems in patients with TCS. From a urological perspective, diagnosis of TCS in developing children is further complicated due to the differentiation between neurogenic bladder dysfunctions and transient bladder dysfunctions owing to developmental problems. Due to the paucity of evidence regarding evaluation prior to and after untethering, I have shown the purpose and tools for evaluation in my own practice. This may be tailored to the types of neurogenic bladder, developmental status, and risks for deterioration. While the urodynamic study (UDS) is the gold standard test for understanding bladder function, it is not a panacea in revealing the nature of bladder dysfunction. In addition, clinicians should consider the influence of developmental processes on bladder function. Before untethering, UDS should reveal synergic urethral movement, which indicates an intact sacral reflex and lack of TCS. Postoperatively, the measurement of post-void residual urine volume is a key factor for the evaluation of spontaneous voiders. In case of elevation, fecal impaction, which is common in spinal dysraphism, should be addressed. In patients with clean intermittent catheterization, the frequency-volume chart should be monitored to assess the storage function of the bladder. Toilet training is an important sign of maturation, and its achievement should be monitored. Signs of bladder deterioration should be acknowledged, and follow-up schedule should be tailored to prevent upper urinary tract damage and also to determine an adequate timing for intervention. Neurosurgeons should be aware of urological problems related to TCS as well as urologists. Cooperation and regular discussion between the two disciplines could enhance the quality of patient care. Accumulation of experience will improve follow-up strategies.

생물학적 모니터링을 이용한 분무기 형태에 따른 피레스로이드 농약 노출량 평가 (Evaluation of Exposure to Pyrethroid Pesticides according to Sprayer Type using Biological Monitoring)

  • 송재석;최홍순;유호영;박병곤;권대호
    • 농약과학회지
    • /
    • 제20권4호
    • /
    • pp.300-304
    • /
    • 2016
  • 이 연구의 목적은 살포기의 종류에 따른 피레스로이드 농약의 노출량을 평가하고자 하였다. 피레스로이드계 농약의 노출을 평가하기 위하여 사과 농작업자의 소변중 피레스로이드계 농약의 대사물질을 평가하였다. 결과에서는 살포량이 SS기 살포 그룹이 동력분무기 그룹보다 높았다. 하지만, 살포량과 살포면적을 통제하기 위하여 다변량 분석법으로 분석한 결과 SS기 살포자와 동력분무기 살포자의 노출량은 차이가 없었다. 농약노출에 대한 정확한 모델을 만들기 위해서는 농약 노출에 관련된 인자들이 통제되어야하고 추가적인 연구가 필요하다고 할 수 있다.

결핵성 뇌수막염에 동반된 뇌성 염분소실증후군(Cerebral salt wasting syndrome) 1예 (A Case of Cerebral Salt Wasting Syndrome Associated with Tuberculous Meningitis)

  • 이자영;이은실;이재형;임은주;김형수;장지선;김현규;김두만;박용범;이재영;모은경
    • Tuberculosis and Respiratory Diseases
    • /
    • 제59권3호
    • /
    • pp.306-310
    • /
    • 2005
  • 저자들은 결핵성 뇌수막염을 가진 31세 남자환자에서 심한 다뇨와 저나트륨혈증, 저혈압, 요중 염분소실이 동반되어 있어 CSWS로 진단하고 항결핵제 투여와 식염수, 염류코르티코이드의 투여 후 임상적 호전을 보인 증례 1예를 경험하였기에 보고하는 바이다.

양돈농가에서의 돈사배출수 발생량 및 이화학적 특성 (Characteristics and Quantity of Wastewater Produced by Swine Farms)

  • 곽정훈;최희철;강희철;최동윤;김재환;한정대;전병수;김형호
    • 한국축산시설환경학회지
    • /
    • 제7권3호
    • /
    • pp.173-176
    • /
    • 2001
  • 양돈농가에서의 계절별 돈사배출수 발생량은 돈사내에서 스크레퍼 및 인력으로 돈분을 분리수거하여 분은 퇴비화하고 배출수는 활성오니법을 이용하여 정화처리하고 있는 농가를 6농가를 선정하여 돈사배풀수랸 및 배출수의 특성을 조사한 결과는 다음과 같다. 1. 돈사배출수량의 평균배출량은 4.15 l/일/두였으며, 계절별로는 여름철 5.02, 겨울철 4.11, 겨울철에 3.44, 봄철에 4.04 l/일.두로 여름철에 가장 많은 세정수가 발생되었다. 2. 돈사배출수 조사농가의 돈분은 수분 함량은 평균 82.9%였고 돈분의 BOD 및 SS농도는 각각 56,847mg/l, 119,750mg/l였으며, 돈사배풀수의 BOD, SS농도는 각각 2,951, 1,983mg/$\ell$였다.

  • PDF

삼종(三種)의 복합한약제(複合韓藥劑) 투여(投與)가 요중(尿中) 5-Hydroxyindoleacetic Acid에 미치는 영향에 관(關)한 연구(硏究) (Effect of the Three Recipes Treatment on the Urinary 5-HIAA Excretion)

  • 이종진;은항석
    • 동의신경정신과학회지
    • /
    • 제2권1호
    • /
    • pp.3-18
    • /
    • 1991
  • Serotonin was chemically identified as 5-hydrowytryptamin which occurs in plants, animals, and human beings. The end product of metabolism was excreted as 5-HIAA in urine. Many scientists, specially biochemist and psychiatrist reported that the change of serotonin concentration caused mental disorder and pathological condiions such as schizophrenia and carcinoid. This study was carried out to observe the urinary 5-HIAA excretion rates changed by three recipes treatment (Kamisoyosan, Ondamtang, kalgunhaegitang) according to the classification of endogenous, exogenous and non-exo-endogenous, causes of disease. The urinary 5-HIAA excretion rates before and after three recipes treatment on normal groups divided into three groups on the basis of physical constitutional differences and on patients groups, divided into three groups according to the causal factor were measured. The results were as follows; 1. The urinary 5-HIAA volume of patients groups appeared non-exoendogenous, endogenous, exogenous causes of disease in order of three causative classification. 2. The urinary 5-HIAA volume of Normal groups was $2.50{\pm}088mg/24hrs$(range $0.30{\sim}6.90mg/24hrs$) 3. Thr urinary 5-HIAA volume was $3.70{\pm}0.89mg/24hrs$(range $0.90{\sim}6.50mg/24hrs$) before kamisoyosan treatment and $3.20{\pm}0.72mg/24hrs$ (range $0.80{\sim}6.20mg/24hrs$) after the treatment. 4. The value was $2.60{\pm}0.10mg/24hrs$ (range $0.60{\sim}6.50mg/24hrs$) before Ondamtange treatment and $2.00{\pm}0.12mg/24hrs$(range $0.20{\sim}6.10mg/24hrs$) after the treatment. 5. The value was $4.30{\pm}0.75mg/24hrs$(range $0.92{\sim}6.50mg/24hrs$) before kalgunhaegitang treatment and $3.10{\pm}0.10mg/24hrs$(range $0.80{\sim}5.80mg/24hrs$) after the treatment. Considering the above-mentioned the study on the changes of urinary 5-HIAA volume will make a significant contribution to the diagnosis and the evaluation of therapeutic effect successive research and modified application will be in need.

  • PDF

당뇨병성 방광병증으로 진단된 배뇨장애 환자 치험 1례 (A Case Study of a Patient Diagnosed as Diabetic Cystopathy with Dysuria)

  • 김미경;김보람;김용형;최동준;한창호;정승현;신길조;이원철
    • 대한한방내과학회지
    • /
    • 제29권4호
    • /
    • pp.1123-1129
    • /
    • 2008
  • There's a case of a 74-year-old male patient who was recommended urethral catheterization because of voiding problem which is diagnosed as diabetic cystopathy. According to the Differentiation of Symptoms(辨證), we classified his situation as kidney yang deficiency (腎陽虛衰), prescribed Uchasingi-hwan(牛車腎氣丸). and treated with moxibustion and electroacupuncture. After nine days of such treatments, he started voiding himself without catheterization, and the volume of residual urine decreased. So we report this case.

  • PDF