• 대한의용생체공학회:의공학회지
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• 제37권1호
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• pp.31-38
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• 2016

For the patients with bladder dysfunction, measurement of urine volume inside the bladder is very critical to avoid bladder failure. In measuring urine volume inside a bladder, low-resolution 3D ultrasound images are widely used. However, urine volume estimation from 3D ultrasound images is prone to big errors and inconsistency because of low spatial resolution and low signal-to-noise ratio of ultrasound images. We developed a new robust volume estimation algorithm which is not computationally expensive. We tested the algorithm on a lab-built ultrasound bladder phantom and volunteers. The average error rate of the human bladder volume estimation was 5.9% which was better than the commercial machine.

• 전자공학회논문지SC
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• 제42권5호
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• pp.35-42
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• 2005

본 연구에서 방광 내벽과 외벽사이의 거리를 측정하여 뇨량을 계산하는 시스템에 적용하기 위한 방광용 초음파 변환기를 설계하고 개발하였다. 뇨량 측정 시스템은 방광에서 오줌을 배출하기 전의 양을 측정함으로써 뇨실금 환자의 치료 과정을 도와주게 된다. 이 실험의 결과로, 뇨량을 더 정확하게 측정할 수 있고 또한 뇨실금 방지 시스템을 개발할 수 있다. 본 연구를 통하여 개발되는 시스템은 뇨실금과 야뇨증 환자를 더 오래 더 건강한 삶을 살 수 있도록 해줄 수 있을 것이다.

• 동의생리병리학회지
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• 제16권2호
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• pp.257-261
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• 2002

This experimental study was designed to investigate the effect of water extracts of Chukchunwhan on the urine metabolism in rat. The results are summarized as follows ; 1. Treatment with Chukchunwhan-extracts increased excreted-urine volume of rat at the first week, however markedly decreased the excreted-urine volume at 2nd week. 2. Chukchunwhan-extracts inhibited the high level of excreted-urinary protein from rat for two weeks. 3. Chukchunwhan-extracts did not affect on the excreted-urine components of rat except for urinary protein. The results suggest that water-extracts of Chukchunwhan can be applicable to the abnormal volume of urine without medical poisoning, which have been used in the all sort of urinary diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.775-780
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• 2012

8-isoprostane (8-$isoPGF_{2{\alpha}}$) is a reliable marker and considered a gold standard for lipid peroxidation. There are very few reports of 8-isoprostane levels in cancer patients, and in patients undergoing chemotherapy. Oxidative stress is however expected and has been observed in patients with cancer. This study measured 8-isoprostane levels in urine by ELISA of 25 patients undergoing chemotherapy for advanced non-small cell lung cancer, at cycles 1, 2, and 3 of treatment. It considers the creatinine clearance of the patients, and correction of 8-isoprostane levels by creatinine clearance, and overnight urine volume methods. The average 8-isoprostane levels in urine increased more than 6 to 12 fold on chemotherapy treatment, from $532{\pm}587$ pg/mL at cycle $1,6181{\pm}4334$ at cycle 2, and $5511{\pm}2055$ at cycle 3. Similar results were obtained if 8-isoprostane levels were corrected for overnight urine volume, giving averages of $285{\pm}244{\mu}g$ at cycle $1,4122{\pm}3349$ at cycle 2, and $3266{\pm}1200$ at cycle 3. No significant difference was seen in average total overnight urine volume or number of urinations between chemotherapy cycles except for a large variation in urine volume between cycle 2 and 3. Creatinine levels were significantly different only between cycles 1 and 2 (p=0.016). In conclusion, cisplatin therapy has been shown to induce high levels of lipid peroxidation in lung cancer patients and can be assessed from the 8-isoprostane marker in overnight urine, with or without urine volume correction.

• 센서학회지
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• 제17권1호
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• pp.81-85
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• 2008

This paper addressed real-time urine monitoring device for intensive care patients. The device was developed to detect and count each urine drop using optical sensor and calculate the current urine output volume and its hourly rate. In experiment, the water volume scale of drainage bottle was observed and compared with the count of the device so that the volume of each drop was found to vary with the dropping rate per minute. From this measurement, the relationship equation was derived to estimate the total water volume from the drop rate (correlation coefficient : r= 0.99). The developed device could be applied to count patient's urine drop successfully. Therefore, this device can be used to monitor intensive care patient's urine status in real-time.

• 센서학회지
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• 제9권4호
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• pp.256-267
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• 2000

본 논문에서는 뇨실금 환자들에 대한 지원 기술의 일환으로 인체에 무해하고 비침습적인 초음파를 이용하여 배뇨시기를 알려주는 뇨의 경보기용 뇨량검출 센서의 개발과 이를 이용한 방광 벽간거리와 뇨량과의 상관관계에 관하여 연구하였다. 개발된 센서의 중심 주파수는 2.25 MHz이며, 이는 인체내로의 침투력이 비교적 좋으면서도 분해능이 높아 오차를 감소시킬 수 있게 설계하였다. 이 센서를 이용하여 방광 전 후벽간의 거리를 검출하여 이로부터 뇨량을 정량적으로 측정하기 위한 기초 실험을 실시하였다. 기초실험은 건강한 성인 남자 3명을 대상으로 초음파 뇨량검출 센서를 이용한 초음파 RF 반사신호 획득장치와 초음파 진단기에 의한 2가지 방법으로 이루어졌고 그 결과 뇨량과 벽간거리와의 사이에는 높은 상관성이 있음을 확인할 수 있었다. 결론적으로, 실험 결과를 토대로 하여 제작된 초음파 뇨량검출용 센서는 뇨실금 환자로 하여금 배뇨시기를 알려주는 뇨의 경보 시스템으로 활용될 수 있으며, 보건 복지적인 측면에서 현대사회에 기여할 공헌도가 매우 클 것이라 생각된다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.385.2-385.2
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• 2002

Cornus officinalis has been used as protective drug for liver and kidney function. In order to evaluate the effect on renal function of Corni Fructus. We measured urine volume, chemical parameters(urea nitrogen. creatinine, uric acid). electrolytes($Na^{+}$, $K^{+}$, $Cl^{-}$) in serum and urine. Furosemide showed significant urine volume. serum and urine parameters, but Corni Fructus showed normal level parameters by dose increasing in rats.

• 사상체질의학회지
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• 제15권3호
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• pp.187-196
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• 2003

The aim of this thesis is to examine the effect of the diuretics in the Sasang constitutional medicine those are not categorized to the diuretic in the established herbal medicine by the way of measuring the change of body edema and the quantity of body moisture through the inbody test, along with the urine volume taken for 24 hours 1. We medicated the diuretic suggested by the DongyiSuseBowon東醫壽世保元 into the tested group and measured the change of the urine volume, the quantity of body moisture and the degree of body edema. The results are the followings below. 1) Soeumin The change in the urine volume and body moisture showed no responsibility, but the degree of body edema decreased with the responsibility. 2) Soyangin All of the degree of body edema and the urine volume, and body moisture showed decrease. 3) Taeumin The urine volume and body moisture increased but showed no responsibility. Also the degree of body edema decreased within the normal limit which can not be accepted. 4) The medicine of the Sasang Constitutional Medicine can not be simply thought to be the diuretic, but it has the function that excretes the moisture which functions negatively in the body and causes edema, as well as the function of the adjustment of metabolism that preserves the normal amount of moisture. This is the good example which is the concept of the adjustment therapy suggested by The Sasang Constitutional Medicine 2. Through the results above, we can find that the diuretic suggested by The Sasang Constitutional Medicine functions in the way that is differently explained by the herbal medicine.

• Clinical and Experimental Pediatrics
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• 제50권5호
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• pp.430-435
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• 2007

Even though we drink and excrete water without recognition, the amount and the composition of body fluid remain constant everyday. Maintenance of a normal osmolality is under the control of water balance which is regulated by vasopressin despite sodium concentration is the dominant determinant of plasma osmolality. The increased plasma osmolality (hypernatremia) can be normalized by the concentration of urine, which is the other way of gaining free water than drinking water, while the low plasma osmolality (hyponatremia) can be normalized by the dilution of urine which is the only regulated way of free water excretion. On the other hand, volume status depends on the control of sodium balance which is regulated mainly by renin-angiotensin-aldosterone system, through which volume depletion can be restored by enhancing sodium retention and concomitant water reabsorption. This review focuses on the urine concentration and dilution mechanism mediated by vasopressin and the associated disorders; diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion.

• 대한약침학회지
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• 제10권1호통권22호
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• pp.23-36
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• 2007

Objective : We performed this study in order to investigate the effects of Paljeongsan-gamibang(八正散加味方) on the renal failure. Methods : We injected 8ml/kg of 50% glycerol on the rats. And then administered Paljeongsan-gamibang extract ; 209mg/200g/day to sample group during 3 days and observed the body temperature, urine volume, stool volume and the levels of creatinine, glucose, inorganic phosphorus, Na+, K+, Cl-, threonine, tyrosine in blood and creatinine, glucose, threonine, tyrosine in urine. Results : 1, The sample group administered Paljeongsan-gamibang showed a suppressive effect of body temperature, an improving effect in capability of concentrating urine at convoluted tubule and showed an increasing effect of stool volume. 2. The sample group administered Paljeongsan-gamibang showed a lowering effect in creatinine level in blood and showed an increasing effect in the levels of inorganic phosphorus, Na+, K+, Cl-, threonine and tyrosine in blood. 3. The sample group administered Paljeongsan-gamibang showed an increasing effect in creatinine level in urine and showed a lowering effect in the levels of glucose, inorganic phosphorus, threonine and tyrosine in urine. Conclusions : Conclusively, Paljeongsan-gamibang was recognized to have a curative effect against the damage of rat kidney induced by 50% glycerol, especially to improve the capability of reabsorption in proximal convoluted tubule.