• 동의생리병리학회지
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• 제20권5호
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• pp.1350-1354
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• 2006

The purpose of this study is to refort the effect of oriental demonstration treatments for the incontinence of urine and stool by cerebrovascular disease. He was treated with herbal medication, acupunture, moxibustion and physical therapy. Through oriental demonstration treatments, Improvement in incontinence of urine and stool by cerebrovascular disease, therefore reported here. The study suggests that therapeutic value of oriental demonstration treatments for the incontinence of urine and stool by cerebrovascular disease will De higher if more clinical studies and researching more cases are accomplished.

• 대한한의학회지
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• 제30권5호
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• pp.77-87
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• 2009

Objectives: This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, an oriental medical therapy for stroke patients with constipation, on physiological indexes and the brain edema of rats. Methods: Brain edema was induced by the middle cerebral artery occlusion (MCAO); Natrii sulfas was administered once after the MCAO. At 3, 6, 15, 24, 48 hours after reperfusion, physiological indexes such as fecal weight, urine volume and water content in stool were assessed, and at 48 hours after reperfusion the edema index was measured. Results: 1. Purgation therapy with Natrii sulfas significantly improved the reduction of fecal weight caused by ischemic insult (P<0.05). 2. Purgation therapy with Natrii sulfas significantly improved the reduction of urine volume caused by ischemic insult (P<0.05). 3. Purgation therapy with Natrii sulfas significantly improved the reduction of water content in stool caused by ischemic insult (P<0.05). 4. Purgation therapy with Natrii sulfas did not improve the neurological symptom caused by ischemic insult. 5. Purgation therapy with Natrii sulfas did not attenuate the total infarct volume caused by ischemic insult. 6. Purgation therapy with Natrii sulfas attenuated the brain edema caused by ischemic insult (P<0.05). Conclusions: These results suggest that purgation therapy with Natrii sulfas improves some important symptoms and has a protective effect on the brain edema caused by ischemic insult.

• 약학회지
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• 제51권2호
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• pp.96-102
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• 2007

Measurement of globotriaosylceramide (Gb3, ceramide trihexoside) in urine has clinical importance for monitoring after enzyme replacement therapy in Fabry disease patients. The disease is an X-linked lipid storage disorder that results from a deficiency of the enzyme ${\alpha}$-galactosidase A (${\alpha}$-Gal A). The lack of ${\alpha}$-Gal A causes an intracellular accumulation of glycosphingolipids, mainly Gb3. A simple, rapid, and highly sensitive analytical method for Gb3 in urine was developed without labor-extensive pre-treatment by electrospray ionization MS/MS (ESI-MS/MS). Only simple 5-fold dilution of urine is necessary for the extraction and isolation of Gb3 in urine. Gb3 in diluted urine was dissolved in dioxane containing C17:0 Gb3 as an internal standard. After centrifugation it was directly injected and analyzed through guard column by in combination with multiple reaction monitoring mode of ESI-MS/MS. Eight isoforms of Gb3 were completely resolved from urine matrix. C24:0 Gb3 occupied 50% of total Gb3 as a major component in urine. Linear relationship for Gb3 isoforms was found in the range of 0.005${\sim}$5.0 ${\mu}$g/ml. The limit of detection (S/N=5) was 0.005 ${\mu}$g/ml and limit of quantification was 0.05 ${\mu}$g/ml for C24:0 Gb3 with acceptable precision and accuracy. Correlation coefficient of calibration curves for 8 Gb3 isoforms ranged from 0.9598 to 0.9975. This method could be useful for rapid and sensitive 1st line Fabry disease screening, monitoring and/or diagnostic tool for Fabry disease.

• Childhood Kidney Diseases
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• 제23권2호
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• pp.128-133
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• 2019

Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a systemic vasculitis characterized by purpura, arthritis, abdominal pain, and nephritis. Gastrointestinal involvement can manifest as pain, intussusception, intestinal bleeding, and intestinal perforation. We report a case of fulminant HSP at an age of eight in 1994, with multiple complications of intra-thoracic bleeding, massive intestinal perforation, nephritis, and various skin rashes. The brisk bleeding findings of intestinal on Technetium-99m-labeled red blood cell scan ($^{99m}Tc$ RBC scan) were well matched to those of the emergency laparotomy and the resected intestine. The patient's abdominal conditions improved gradually but nodular skin eruptions developed newly apart from improving preexisting lower limb rashes and the urine findings continued abnormal, so skin and kidney biopsy were done for the diagnosis. After cyclosporine therapy, skin eruptions and urine findings returned to normal gradually. On a follow-up after 25 years in 2019, the patient is 33-year-old, healthy without any abnormality on blood chemistries and urine examination.

• 보험의학회지
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• 제2권1호
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• pp.75-81
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• 1985

Urine contains protein and nucleic acid(urea, uric acid, creatinine, ammonia, amino acids), various organic and inorganic materials, vitamin, hormone, enzyme etc. The examination of gualitative or quantitative change of the above mentioned materials and picking up the abnormal materials are useful to diagnose diseases. The test strip for examination of urine is applied to the routine test, monitoring of medical therapy and recurrence, self monitoring, and screeing in preventive medicine. We have been using multitest strip for checking the bacterial infection(nitrite), PH, protein, glucose, ketone body, urobilinogen, bilirubin and occult blood. So it is possible to diagnose three groups of diseases as follows, abnormal metabolism of the carbohydrate, diseases of kidney and other urogenital system, diseases of hepatobiliary system and hemolytic disease causing abnormal metabolism of bile juice.

• 한국임상수의학회지
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• 제21권1호
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• pp.62-65
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• 2004

A 13-year-old, male Maltese was refered to Veterinary Teaching Hospital of Konkuk University with inappropriate urination and hematuria. CBC, serum chemistry profile, urinalysis and urine culture were performed. Malignant cells were found in the urine sediment. Thoracic and abdominal radiography, retrograde positive-contrast cystography, retrograde double-contrast cystography, excretory urography, ultrasonography were performed. On the retrograde positive-contrast cystography examination, irregular filling defects were present on the left side of the cranial part of the bladder. Partial cystectomy performed and then medical therapy was conducted. On histopathological examinations, the lesion was confirmed as a transitional cell carcinoma of the urinary bladder.

• 한국임상수의학회지
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• 제27권4호
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• pp.386-391
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• 2010

This retrospective study was performed in 40 cases of canine crystalluria and urinary tract symptoms. Breed, age, sex, diet history and common clinical signs were investigated for patient information. CBC, serum chemistry, urinalysis, urine culture, urine sediment and urinary stone analysis were undertaken for clinicopathological diagnosis. Crystalluria and urinary tract symptoms occurred from 6 months till 14 years in this clinical investigation and the average age was 4.68 years. It had taken an average 7.4 weeks to correct crystalluria and urinary tract symptoms treated by supportive therapy and dietary management. In conclusion, regular clinical pathologic examination, treatment and diet management should be needed to prevent the formation of urolithiasis and urinary tract diseases in dogs with crystalluria and urinary tract symptoms.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.412-422
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• 2002

The use of biochemical markers of bone turnover may be particular interest in the investigation of bone disorders with osteoporosis. Serum osteocalcin(OC), total alkaline phosphatase and procollagen C, reflecting bone formation, and urinary pyridinium cross-links excretion, reflecting bone reabsorption have been measured in hyperthyroidism, postmenopause women, after testosterone supplementation, androgen, testosterone and estrogen deficiency, bone mineral density degree, age duration. Bone marks which is reflect to metabolic bone disorders are biochemical indices method to measure enzyme activity about bone formation, bone absorption and bone components in blood or urine. Bone metabolism biochemical marks are correlated with osteophorotic agents and also represent significantly different between bone mineral density and bone biochemical marks. Therefore if we develope and use bone metabolism marks which have higher sensitivity and specificity in bone formation and bone absorption, I think that these bone biochemical marks can have utility in the clinical application to predict osteoporosis risk group, bone loss, bone fracture and response degree to treatment of osteoporosis risk groups.

• 대한한방부인과학회지
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• 제29권3호
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• pp.100-109
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• 2016

Objectives: Hematuria can occur frequently for various reasons, but there are so many patients who suffered from unexplained hematuria. This study aims to report the clinical effect of Korean medicine on unexplained hematuria with chronic pelvic pain.Methods: The patient received Korean medicine therapies such as herbal medication, acupuncture, moxibustion, cupping therapy, and Korean medicine steam therapy (about 20 days).Results: Urine occult blood and urine micro red blood cell of the patient were noticeably reduced during the treatment. The clinical symptoms about chronic pelvic pain were also improved.Conclusions: This case shows that Korean medicine is effective on unexplained hematuria with chronic pelvic pain.

• Journal of Chest Surgery
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• 제15권1호
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• pp.40-45
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• 1982

A Clinical study was carried out to observe changes in concentration of serum and urinary potassium during and after open-heart surgery under extracorporeal circulation with Heart-Lung-Machine. The patients studied in the present work included eight cases of congenital heart anomalies and seven cases of acquired valvular diseases of the heart. Blood and urine samples were collected at intervals of 30 minutes during open-heart surgery and at intervals of 8 hours until 48 hours after the operation to determine concentration of serum and urinary potassium. 1.While the concentration of urinary potassium was not changed during the operation, the concentration of urinary potassium was rapidly increased after the operation. Eight hours after the operation, the concentration of urinary potassium was increased to the highest value of 86.97±43.96 mEq/L and was gradually decreased thereafter. The concentration of urinary potassium, however, still remained elevated even 48 hours after the operation, the concentration being greater than preoperative state by 19.90 mEq/L. 2.The concentration of urinary potassium after the operation was higher in the group who went through 90 minutes of extracorporeal circulation [$108.71{\pm}94.71mEq/L$] than in the group who went through 60 minutes of extracorporeal circulation [$86.58{\pm}50.87mEq/L$]. The Increased level of urinary potas-sium observed In the group who went through 90 minutes of extracorporeal circulation continued for longer period of time as compared with that in the group who went through 60 minutes of extracorporeal circulation. 3.The increased level of urinary potassium was observed in the both groups of patients with or without diuretics plus digitalis therapy. However, the increased level of urinary potassium appeared to con-tinue for longer period of time in the group of patients receiving diuretics plus digitalis therapy prior to the operation than in the group of patients receiving no diuretics plus digitalis therapy.