• Journal of Yeungnam Medical Science
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• 제16권2호
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• pp.376-379
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• 1999

저자들은 전자궁적축술과 요실금 수술후 요도폐색이 발생한 43세의 여자 환자에서 장기간의 간헐적 자가도뇨법과 약물요법으로 치료되지 않아, 외요도구 상방을 통한 요도 박리술을 시행하여 좋은 결과를 볼 수 있었다. 저자들의 견해로는 과거에 부인과 수술과 동반해서 시행하거나 혹은 복측으로 치골후방으로 접근하여 시행한 요실금수술이나 요도하부 슬링수술등의 방법으로 인해 요도 폐색이 발생시 외요도구 상방을 통한 요도박리술이 바람직할 것으로 사료된다.

• Animal cells and systems
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• 제14권4호
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• pp.237-244
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• 2010

Stress urinary incontinence (SUI) is a common condition that primarily affects women. Here, we investigate the effects of human adipose-derived stem cells (ADSCs) in a rodent model of SUI. Female Sprague-Dawley rats at 7 weeks of age were randomly divided into three groups (n=8 per group): sham-operation, SUI-induction by transabdominal urethrolysis, and SUI-induction followed by transplantation of human ADSCs into the urethra. The abdominal leak point pressure at 8 weeks after the operation was markedly decreased by transabdominal urethrolysis, confirming successful induction of SUI. Interestingly, transplantation of human ADSCs into the urethra significantly blunted the decrease of abdominal leak point pressure in SUI-induced rats. Accordingly, we observed expression of ${\alpha}$-smooth muscle actin in a significant proportion of transplanted ADSCs, indicating differentiation of ADSCs into smooth muscle cells in the urethra. Moreover, the SUI-induced elevations of c-Fos immunoreactivities in the pontine micturition center (PMC) and in the ventrolateral periaqueductal gray (vlPAG) were clearly suppressed by transplantation of human ADSCs. These results imply that human ADSCs can be an effective therapeutic modality to ameliorate the symptoms of SUI.