• 제목/요약/키워드: Urea receptor

검색결과 44건 처리시간 0.021초

Synthesis and Anion Recognition of Cholic Acid-based Tripodal Receptor: A Chloride Selective Anion Receptor

  • Kim, Ki-Soo;Cho, Nam-Ju;Kim, Hong-Seok
    • Bulletin of the Korean Chemical Society
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    • 제27권5호
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    • pp.739-743
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    • 2006

  • Synthesis of cholic acid-based tripodal receptor (1) and its high chloride ion affinity in comparison with that of chenodeoxycholic acid (2) and lithocholic acid-based receptor (3) was achieved. Anion binding affinities of the receptors were evaluated $by\;^1H$ NMR and ITC titrations. Tripodal receptor 1 showed a selective affinity for $CI ^-$ over $Br ^-$, $I^-$, $H_2 PO _4\;^-$, and $CH _3 CO_2\;^-$. The selectivity of 1 for $CI ^-$ is about 3 times that of $Br ^-$, and 17 times that for $H_2 PO_4\;^-$.

  • https://doi.org/10.5012/bkcs.2006.27.5.739 인용 PDF KSCI

Sulfonylurea 유도체들의 구조분석 : Acetohexamide와 Tolazamide (Conformational Analysis of Sulfonylureas : Acetohexamide and Tolazamide)

  • 정우태;강기롱;이성희
    • 약학회지
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    • 제39권3호
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    • pp.329-336
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    • 1995

  • Conformational free energy calculations using an empirical potential function and a hydration shell model(program CONBIO) were carried out on hypoglycemic agent acetohexamide and tolazamide in the unhydrated and hydrated states. The initial geometry of sulfonylureas was obtained from X-ray crystallographieal data and homologous molecular fragments. In both states, the feasible conformations were obtained from the calculations of conformational energy, conformational entropy, and hydration free energy by varying all the torsion angles of the molecules. From the calculation results, it is known that the conformations] entropy is the major contribution to stabflize the low-free-energy conformations of two sulfonylureas in both states. But, in hydrated state, the hydration does not directly affect each conformations. The intramolecular hydrogen bonding of sulfonylurea hydrogen and 7-membered nitrogen appeared to the conformations of tolazamide in both states. It is thought that the hydrogen bonding decrease steric hindrance on the receptor binding direction. The substitution of alicyclic or N-heterocyclic ring than that of carbons chain of urea moiety may be properly interaction between sulfonylureas and the putative pancreatic receptor.

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