• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.265-278
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• 2016

In this study, an ascending capability experiment was performed with largemouth bass and bluegill, which are exotic fish species inhabiting (the freshwaters) in Korea. The experiment was performed by dividing the subject fish into four groups according to their size and at four flow rates for each group. The number of fish passing through a reference line was analyzed by recording videos, and their swimming and ascending capabilities were observed by the naked eye. The number of fish passing through the reference line did not include those returning downstream within five minutes due to the high flow rate. The flow rate used for the analysis was the mean of the flow rate values measured at the left bank, the right bank, and in the middle of the stream. The results showed that the number of exotic fish migrating upstream decreased as the flow rate increased, regardless of the species and size of the fish. The comparison between the fish species showed that the ascending capability of bass was higher than that of bluegill, but the difference was not significant when considering the difference in the size of the fish. In addition, the upper limit flow velocity allowing the ascending of the exotic fish species was 1.11 m/s, when considering the fish returning to the downstream after the upstream migration and experimental error. The results of the experiment may be used as fundamental data for the blocking of fish and the management of exotic fish species by means of a high flow rate current. Further experiments, verification, and monitoring may need to be conducted continuously to determine whether the fish are able to pass through the reference line at a high flow rate, when they attain a high or cruising velocity. Additionally, the reaction of the fish species should be investigated by considering the response to external forces as well as pressure differences due to the flow rate.

• Journal of Korea Soil Environment Society
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• v.1 no.1
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• pp.89-102
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• 1996

An integrated model is presented to describe underground flow and mass transport, using a multicomponent multiphase approach. The comprehensive governing equation is derived considering mass and force balances of chemical species over four phases(water, oil, air, and soil) in a schematic elementary volume. Compact and systemati notations of relevant variables and equations are introduced to facilitate the inclusion of complex migration and transformation processes, and variable spatial dimensions. The resulting nonlinear system is solved by a multidimensional finite element code. The developed code with dynamic array allocation, is sufficiently flexible to work across a wide spectrum of computers, including an IBM ES 9000/900 vector facility, SP2 cluster machine, Unix workstations and PCs, for one-, two and three-dimensional problems. To reduce the computation time and storage requirements, the system equations are decoupled and solved using a banded global matrix solver, with the vector and parallel processing on the IBM 9000. To avoide the numerical oscillations of the nonlinear problems in the case of convective dominant transport, the techniques of upstream weighting, mass lumping, and elementary-wise parameter evaluation are applied. The instability and convergence criteria of the nonlinear problems are studied for the one-dimensional analogue of FEM and FDM. Modeling capacity is presented in the simulation of three dimensional composite multiphase TCE migration. Comprehesive simulation feature of the code is presented in a companion paper of this issue for the specific groundwater or flow and contamination problems.

• Journal of the Korean Geographical Society
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• v.43 no.4
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• pp.466-476
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• 2008

Gurin Cave, 442 m long, is a lava tube developed on the northern slope of Mount Halla. Seventy-three meters of its lower reach became a river channel since Byeongmun River flowed into a window after roof collapse took place. The subterranean channel has a width of 447 cm and a height of 501 cm, respectively. Its banks show well-developed lava shelves of a typical lava tube, while its floor has sculpted forms which characterize a bed of a bedrock stream. The reach is likely to be collapsed and then has four collapsed windows since its roof has the densely developed testudinal joints and consists of thin lavas with a thickness of 30 to 60 cm. Before the subterranean channel appeared, a ground channel flowed over the cave and joined into a main channel of Byeongmun River at 653 m in altitude. However, the subterranean channel substituted the ground channel since a bed of the ground channel collapsed into the cave. The new channel, flowing through the cave, joined into a main channel at 660 m in altitude. As the drainage area of Byeongmun River expanded upstream the cave, the new channel changed into a main channel. Since floodwater flows down the ground channel as well as the subterranean channel, a distributary stream has temporarily appeared at the collapsed window. Lava tubes are likely to have an affect on the development of river system in Jeiu Island, in that the caves have constantly shown roof-fall.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.19 no.4
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• pp.61-79
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• 2016

This study aims at examining the structural and managemental problems of the existing fishways which affect the migrations of fishes, and at suggesting alternatives to improve the fishways' efficiency. The study focuses on the fishways constructed in the diversion weirs in the lower reaches of 41 rivers(2 national rivers and 39 rural rivers) in the eastern coast of Korea. Most of water-using facilities in Korean rivers are diversion weirs, and fishways are established as subsidiary facilities of most of the weirs. Among the 58 or so fishways examined in this study, only a few are doing their proper function, and most of them need improvement. This study aims at strengthening those fishways function and increasing their economic efficiency and migration efficiency. Based on the results of this study, the followings are suggested. In case the fishway sticks out downstream from the apron, a subsidiary fishway diverging from the main is suggested to attract fish. The entrance to the subsidiary should head below the raised part of the apron and a pool should be constructed in the connecting part with the main. To attract fish and let the upstream migrators rest for a while, an entrance pool should be constructed in the fishway. Most of the examined fishways have low side walls, which allow the upstreamers to jump out of the fishway. Those side walls are suggested to be raised above the jumping height of target fishes. The exit parts of most fishways are too shallow, or have no grass to protect the fish from the birds. Protective facilities are suggested to keep the birds from entering the fishway. By the time Ice-harbor type and Vertical-slot type fishways are scientifically proved to be defective, the fishway should not diverge from the standard design.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8539-8548
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• 2014

Mitogen-activated protein kinase (MAPK) is an important signaling pathway in living beings in response to extracellular stimuli. There are 5 main subgroups manipulating by a set of sequential actions: ERK(ERK1/ERK2), c-Jun N(JNK/SAPK), p38 MAPK($p38{\alpha}$, $p38{\beta}$, $p38{\gamma}$ and $p38{\delta}$), and ERK3/ERK4/ERK5. When stimulated, factors of upstream or downstream change, and by interacting with each other, these groups have long been recognized to be related to multiple biologic processes such as cell proliferation, differentiation, death, migration, invasion and inflammation. However, once abnormally activated, cancer may occur. Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1. Among them, alteration of the RAS-RAF-MEK-ERK-MAPK(RAS-MAPK) pathway has frequently been reported in human cancer as a result of abnormal activation of receptor tyrosine kinases or gain-of-function mutations in genes. The reported roles of MAPK signaling in apoptotic cell death are controversial, so that further in-depth investigations are needed to address these controversies. Based on an extensive analysis of published data, the goal of this review is to provide an overview on recent studies about the mechanism of MAP kinases, and how it generates certain tumors, as well as related treatments.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1957-1962
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• 2012

Bladder cancer is a common malignancy worldwide. Despite the increased use of cisplatin-based combination therapy, the outcomes for patients with advanced disease remain poor. Recently, altered activation of the PI3K/Akt/mTOR pathway has been associated with reduced patient survival and advanced stage of bladder cancer, making its upstream or downstream components attractive targets for therapeutic intervention. In the present study, we showed that treatment with DTCM-glutaramide, a piperidine that targets PDK1, results in reduced proliferation, diminished cell migration and G1 arrest in 5637 and T24 bladder carcinoma cells. Conversely, no apoptosis, necrosis or autophagy were detected after treatment, suggesting that reduced cell numbers in vitro are a result of diminished proliferation rather than cell death. Furthermore previous exposure to 10 ${\mu}g/ml$ DTCM-glutarimide sensitized both cell lines to ionizing radiation. Although more studies are needed to corroborate our findings, our results indicate that PDK1 may be useful as a therapeutic target to prevent progression and abnormal tissue dissemination of urothelial carcinomas.

• Journal of The Korean Society of Agricultural Engineers
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• v.59 no.1
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• pp.97-107
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• 2017

In this study, the validity and applicability of the multipurpose fishway which has been constructed for the upstream migration of fish at Chuksan river in Uljin is assessed and analyzed by a commercial software. The upper slab types of fishway in this investigation are reinforced concrete slab (S1 type) and reinforced concrete slab with steel plate (S2 type). The three different sizes of subway passage ($0.8m{\times}0.1m$, $0.8m{\times}0.2m$, $0.8 m{\times}0.3m$) and velocities (0.6 m/s, 1.2 m/s, 1.8 m/s) of Chuksan fishway was investigated and compared for the Chuksan in government design code. The analysis showed that the maximum stress and bending moment of S1 type decreased 1~21 % and 12~27 % compared to the Chuksan in government design code, respectively. Also, the maximum stress of and bending moment of S2 type decreased 11~32 % and 27~39 %. From the numerical analysis, it was found that the S2 type was greatly effective and the subway passage size of $0.8m{\times}0.2m$ was most safe. This result can be utilized to be the basic data for design of the Multipurpose fishway.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.33-33
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• 2019

The AKT signaling pathway is a highly regulated cell signaling system that forms a network with other cell signaling pathways. Hence, the AKT signaling pathway mediates several important cellular functions that include cell survival, proliferation, cell migration, and et cetera. Irregularities that led overactive AKT signaling have been linked to many diseases such as cancer and metabolic-associated diseases. Hence, modulating the overactive AKT signaling pathway via inhibitor is a tantalizing prospect for treatment of cancer and metabolic-associated diseases. Two inhibitors of the AKT signaling pathway will be presented in this symposium: 1) Bisleuconothine A (BisA), a bisindole alkaloid that inhibit autophagy and 2) Ceramicine B (CerB), a limonoid that inhibit adipogenesis. The first topic is on a bisindole alkaloid, BisA and its mechanism in inducing autophagosome formation in lung cancer cell line, A549.(1) Since most autophagy inducing agents generally induce apoptosis, we found that BisA does not induce apoptosis even in high dose. BisA up-regulation of LC3 lipidation is achieved through mTOR inactivation. The phosphorylation of PRAS40, a mTOR repressor was suppressed by BisA. This observation suggested that BisA inactivates mTOR via suppression of PRAS40 phosphorylation. Interestingly, the phosphorylation of AKT, an upstream regulator of PRAS40 phosphorylation was also down-regulated by BisA. These findings suggested that Bis-A induces autophagosomes formation by interfering with the AKT-mTOR signaling pathway. The second topic is on CerB and its mechanism in inhibiting adipogenesis in preadipocytes cell line, MC3T3-G2/PA6.(2,3) CerB inhibits the phosphorylation of protein kinase B (AKT) at the Thr308 position but not the Ser473. Consequently, the phosphorylation of FOXO3 which is located downstream of AKT is also inhibited. Considering that FOXO3 is an important regulator of PPARγ which is a key factor in adipogenesis, CerB may inhibit adipogenesis via the AKT-FOXO3 signaling pathway. Taken together, both BisA and CerB highlighted the potential of AKT signaling pathway modulation as an approach to induce autophagy and inhibit the formation of fat cells, respectively.

• Journal of Environmental Science International
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• v.31 no.10
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• pp.861-868
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• 2022

The Namdae stream in Gangneung-si is one of the rivers where salmon stock is mainly maintained by natural spawning rather than artificial seedlings. There are structures including weir, and fish distribution and movement characteristics can be different by these structures. In this study, we investigated the distribution and behavioral characteristics of salmon by sighting survey within 12 km immediately upstream of the river mouth between October 2021 and February 2022. As a result, salmon distributed within 9 km from rivermouth. There were more salmon in the lower reaches of Doosan weir than in the upper reaches of that. The main spawning ground for salmon was between 7-9 km from rivermouth and around the lower part of Doosan weir. Salmon behaved for spawning in the gravel-bed area and undercut slope of the mainstream, such as mating, digging the riverbed, and competition among males. Salmon moved more slowly in the gravel-bed area than sand-bed area. Doosan weir hinders the spawning migration of salmon by frequent flow changes and terraced fishway. This study provides primary information to understand the ecological changes of salmon by environmental changes in the Namdae stream.

• Journal of Korea Water Resources Association
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• v.37 no.7
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• pp.541-552
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• 2004

In this paper, ascending functions of the pool-and-weir fishway which has been established for the upstream migration of migratory fish at Jamsil Weir in the lower part of the Han River was assessed by applying tile Existing Fishway Measurement Method, and measures to improve these functions were suggested. The primary fish which ascended the fishway during the period of measurement was Erythroculter erythropterus Basilewsky, greater than 29cm in the body length. A total of 361 individual fish were collected with traps established at the exit of the fishway The maximum ascending capacity for the fish was 2.53${\times}$10^{-3}$ fish/hr/g. The fishway of Jamsil Weir does not satisfy the various fish species inhabiting in the river. Especially, small fishes of lower swimming ability may not ascend the fishway because the difference in water levels between upper and lower pools in the fishway was too large at the exit and there was too much discharge flowing into the fishway. This fishway does not have a roll in the ascending function for other species except Erythroculter erythropterus Basilewsky and Hemibarbus labeo Pallas, for which swimming ability is great. In order to improve the ascending function of the fishway, the structures of the fishway need to be changed so that various species in the river can easily ascend and the fishway function be taken into consideration in operation of the gates of the weir. Additional construction of fishways on both sides of the lower flow channel are needed to correct a decline in the fishway effectiveness due to continuous flow over the fixed part of the weir.