• Korean Journal of Biological Psychiatry
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• v.19 no.4
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• pp.172-178
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• 2012

Data from clinical studies are needed for psychiatrists to make quick and scientific decisions based on the best available evidence in clinical settings. Various methods of clinical studies are useful for clinicians to have reliable answers to unmet clinical needs. Although randomized controlled trials may provide high-quality information about major issues, well-designed, naturalistic and observational studies often give us unbiased explanation for real-world phenomena. Adequate selection of clinical variables and appropriate number of participants are key factors of well-designed clinical studies. Statistical methods can add an extra dimension to initial design of clinical studies. Given ethical issues in clinical studies on psychiatric disorders, special regards should be paid to participants' ability to provide informed consents. New strategies of clinical studies need to be developed to meet clinical needs and protect the rights and welfare of study participants.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.386-398
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• 2020

Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there are many mechanistic insights into the pathogenesis of tissue fibrosis, which facilitate the discovery of effective antifibrotic drugs. Moreover, many chronic diseases remain a significant clinical unmet need. For the past five years, many research works have undoubtedly addressed the functional dependency of ginsenosides in different types of fibrosis and the successful remission in various animal models treated with ginsenosides. Caveolin-1, interleukin, thrombospondin-1 (TSP-1), liver X receptors (LXRs), Nrf2, microRNA-27b, PPARδ-STAT3, liver kinase B1 (LKB1)-AMPK, and TGF-β1/Smads are potential therapy targeting using ginsenosides. Ginsenosides can play a targeting role and suppress chronic inflammatory response, collagen deposition, and epitheliale-mesenchymal transition (EMT), as well as myofibroblast activation to attenuate fibrosis. In this report, our aim was to focus on the therapeutic prospects of ginsenosides in fibrosis-related human diseases making use of results acquired from various animal models. These findings should provide important therapeutic clues and strategies for the exploration of new drugs for fibrosis treatment.

• Journal of Environmental Health Sciences
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• v.40 no.2
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• pp.157-170
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• 2014

Objectives: Agent Orange TCDD has been related to serious diseases among Korean veterans who were exposed to it. Decades after the end of the war, however, its effects are still being debated. The object of this study was to examine various unmet needs raised among Agent Orange exposed veterans and their families and to find grounds of a new welfare policy for providing alternative legislation. Methods: Literatures concerning Agent Orange, TCDD, the associated diseases, compensation for veterans and Supreme Court sentencing were searched using PubMed, ProQuest, press news and relevant homepages. Results: Agent Orange exposed veterans are eligible for various benefits from the government, including disability compensation for diseases associated with exposure. The Ministry of Patriots and Veterans Affairs has classified certain diseases into two categories, Agent Orange sequela diseases and sequela suspect diseases and has provided differential benefits based on separated laws. Big differences exist in benefits to veterans and their families between the two laws. The absence of definite standards to classify the Agent Orange associated diseases was confirmed by recent Supreme Court sentencing which ruled in favor of US manufacturers. Conclusion: It appears that the evidence for cause and effect of Agent Orange related diseases would never be perfect. The results suggest a need to change welfare principles from presumptive or indefinite disease basis to exposure experiences combined with integrated disability evaluation. We propose to extend eligibility by enacting a new law for Agent Orange exposed Korean veterans.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6339-6345
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• 2015

Background: Assessment of supportive care needs of cancer survivors and identifying factors affecting such needs is important for implementation of any supportive care programs. So, the aims of present study were to investigate the supportive care needs of Iranian cancer survivors and relationships with social support. Materials and Methods: In this descriptive-correlational study two hundred and fifty cancer survivors participated via convenient sampling methods. The Supportive Care Needs Survey (SCNS-SF34) and Multidimensional Scale of Perceived Social Support (MSPSS) were used for data collection. SPSS software was applied and univariate regression was used for examine relationships of supportive care needs with social support. Results: Participants demonstrated many unmet supportive care needs, especially in health system and information and psychological domains. In addition, participants reported that family members and significant others were their main source of support. Also, social support has a significant correlation with all domains of supportive care needs. Conclusions: There is an indispensable need for establishment of supportive care programs for Iranian cancer survivors. In addition, family members of family members of such survivors are an important resource to help develop such programs.

• Korean Journal of Adult Nursing
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• v.24 no.6
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• pp.627-634
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• 2012

Purpose: The purpose of this study was to identify registered nurses learning needs about physical assessment. Specifically, what are the perceived competency, frequency of skill use and the unmet training needs. Methods: The study was an exploratory survey study. The sample was 104 registered nurses. Data were collected through three instruments: The Perceived Competency in Physical Assessment Scale, the Frequency of Physical Assessment Scale, and the Training Needs of Physical Assessment Scale which incorporated 30 core Physical Assessment skills. Descriptive statistics, t-test, and Pearson's correlation coefficient were used to analyze the data. Results: Auscultation of heart and lung sounds and inspection of the spine were rated by the subjects as physical assessment skills they feel least competent and also were less frequently performed. The most competent area for physical assessment was neurological system. The respiratory and abdominal system was identified as two systems that more education would be needed. Nurses with less than one year of working experience reported needing more training. Nurses with more than five years of clinical work experience performed physical assessment more frequently than nurses with less than five year of work experience. The perceived competency was positively related to the frequency of physical assessment. Conclusion: Continuing education is necessary to further train registered nurses regarding physical assessment skills and the program needs to be focused on the area which nurses are less competent for and have high training need.

• Journal of the Korean Society of Clothing and Textiles
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• v.37 no.3
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• pp.306-319
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• 2013

This study explores various issues of appearance management behavior for plus-size women in Korea with a focus on clothing. In-depth interviews and focused group interviews were conducted with 24 plus-size women. The interviews were recorded and the transcripts were analyzed based on grounded theory. Discomfort was the main phenomenon involving the experience of plus-size women related to appearance management. Psychological as well as physiological/physical discomfort, unmet needs (regarding clothing) and inconvenient shopping experiences were frequently mentioned. Causal conditions for discomfort were obesity, social stigma, and an underdeveloped clothing market for plus-size consumers. Interviewees developed strategies to cope with discomfort (suppressing clothing need, loss of interest in clothing, diversion from clothing needs, sole focus on physical comfort, dress-up and increase in shopping channels, and change in shopping patterns) that depended on contextual conditions (such as duration of obesity and attitudes of people) close to the interviewees. The discomfort of interviewees decreased or continued depending on if they became ambivalent about their obese condition, lost weight, or utilized plus-size specialty stores.

• Korean Journal of Health Education and Promotion
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• v.32 no.5
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• pp.17-31
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• 2015

Objectives: This paper aims to identify the health related behaviors patterns and its associated factors among marriage immigrant women in Korea, and discusses their application to health promotion strategies. Methods: The study participants were 7,591 immigrant wives in Gyeonggi province who participated in health examinations conducted by the Korea Association of Health Promotion in 2011-2013. The participants completed self-administered questionnaires on sociodemographics, psychological characteristics, health status and health care factors, and health related behaviors. Results: A 3-latent-class model of health behaviors was identified related to 'lack of physical activity', 'abnormal diet', and 'not experienced medical check-up': 'high risk class', 'middle risk class', and 'low risk class'. Most of the participants belong to 'middle risk class'. Country of origin, age, length of stay, number of children, work status, health insurance status, and unmet health care needs were associated with problematic health behaviors in middle risk health behavior class. Conclusions: Health promotion and intervention programs for marriage immigrant women and their family members need to consider the health behavior patterns of physical inactivity, abnormal diet and no medical check-up and develop multiple behavior intervention with pre-existing program modification.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.5
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• pp.253-263
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• 2021

This research aims to increase the tourism destination competitiveness for the city of Malang. This research uses the extended criteria of Resource-based View (RBV): VRIOLU (Valuable, Rare, Inimitable, Organization, Large Market, Unmet Need) to analyze tourism destination competitiveness for the city of Malang. A qualitative approach with a case study research design is adopted in this research. Data was collected using data triangulation, such as an in-depth interview with the informants, direct observation in the form of field notes, and picture documentation. The data was analyzed manually by the researchers using thematic analysis. In this research, VRIOLU, the extended criteria of RBV is proven that it can be used as a tool to analyze tourism destination competitiveness by giving the researchers a framework to get the answers from the informants to achieve the research aim. Suggestions to improve the tourism destination competitiveness for the city of Malang include: (1) Actively promoting the added value that can be given by the city of Malang to the visitors; (2) Forming a tourism board to manage the city of Malang as a tourism destination in a holistic manner; (3) Creating synergistic promotion between the stakeholders of tourism operator and governments.

• Journal of Labour Economics
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• v.43 no.4
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• pp.117-141
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• 2020

The paper focuses on the question of whether and how the labor underutilization indicator supplements the unemployment rate. The research is based on the differences in the labor market behavior among three groups of the not-employed; the unemployed, potential labor force and the rest of outside the labor force. The annual transition rate among the labor market states shows that the potential labor force has the explicit unmet need for employment different from the rest of the outside the labor force. The multinomial logit regression controlling the effects of individual characteristics rejects the hypothesis that the potential labor forces are behaviorally identical to the unemployed. The evidence shows that the two indices should be interpreted distinctively.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.165-175
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• 2021

Background: Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here, we present the first characterized and validated model of open wound pain. Methods: Unilateral full-skin excisional punch biopsy wounds on rat hind paws were evaluated for evoked pain using withdrawal responses to mechanical and thermal stimulation, and spontaneous pain was measured using hind paw weight distribution and guarding behavior. Evaluations were done before wounding (baseline) and 2-96 hours post-wounding. The model was validated by testing the effects of buprenorphine and carprofen. Results: Pain responses to all tests increased within 2 hours post-wounding and were sustained for at least 4 days. Buprenorphine caused a reversal of all four pain responses at 1 and 4 hours post-treatment compared to 0.9% saline (P < 0.001). Carprofen decreased the pain response to thermal stimulation at 1 (P ≤ 0.049) and 4 hours (P < 0.011) post-treatment compared to 0.9% saline, but not to mechanical stimulation. Conclusions: This is the first well-characterized and validated model of pain from open wounds and will allow study of the pathophysiology of pain in open wounds and the development of wound-specific analgesics.