• Journal of Preventive Medicine and Public Health
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• 제27권4호
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• pp.735-745
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• 1994

The incidence data (1991. 7. 1$\sim$1992. 6. 30) from the Implementation Study of Seoul Cancer Registry (ISSCR) were evaluated in terms of its completeness and validity. Two indicators for the completeness, Mortality/Incidence ratio (M/I ratio) and Age-specific Incidence Curve, showed fairy good registration throughout the age-sex specific strata, except the strata aged over 75 years old. The strata had very high M/I ratio (over 100%) and decreasing pattern of incidence, which suggested incomplete registration of cancer in this group. The active surveillance by a ISSCR staff improved the registration rate especially among elderlies. From the site specific M/I ratio, we found that liver cancer had oddly high M/I ratio. Since this high M/I ratio of liver cancer appears consistently in other reliable cancer registries, it is more like to be due to the high fatality of it rather than incomplete registration. The validity of the incidence data was assessed by three indicators; Histological Verification (HV%), Primary Site Unknown (PSU%), and Age Unknown (Age UNK%). The average HV% were 77% for men and 85% for women, which were slightly lower than those of other reliable cancer registries. This low HV% might be due to the considerable size of relative frequency of liver cancer in Korea, regarding the fact that the diagnosis of liver cancer is made mostly by non-biopsical radiologic methods (CT, Ultrasono, Angiography, MRI etc.). The level of PSU% and Age UNK% were in acceptable range, but not low enough, especially in terms of Age UNK%. Although ISSCR data had acceptable quality in general, it is needed to have more hospitals participate in the registry surveillance, to make registery data merged with death certificate data regulary, and educate the registration stans to be more competent and dedicated.

• Journal of Preventive Medicine and Public Health
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• 제39권3호
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• pp.255-262
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• 2006

Objectives: This study is conducted to identify the cancer incidence in Gwangju during the 5-year period from 1998 to 2002 and to assess the completeness and validity of the cancer registry data during this time period. Methods: All cases that had a diagnosis of invasive cancer (ICD-10 sites C00-C97) during the study period were retrieved from the records of the Gwangju Cancer Registry (GCR), which theoretically includes all the cancer cases in Gwangju. All the cases during the study period were analyzed by gender, age group and cancer sites. The completeness (mortality/incidence ratio and age-specific incidence curve) and validity (histologic verification, primary site unknown, age unknown and death certificate only) of the cancer registry in Gwangju were analyzed by gender, age group and cancer sites for the 5-year period. Results: The overall cancer incidence was higher in the males than in the females (age-standardized incidence rates (ASR) 299.8 and 172.4 per 100,000, respectively). In males, the most common cancer was stomach (ASR: 65.8), followed by liver (ASR: 50.5), bronchus and lung (ASR: 50.5), colo-rectum (ASR: 26.7), oesophagus (ASR: 10.6), and bladder (ASR: 10.3) in descending order. In females, the most common cancer was stomach (ASR: 26.8), followed by thyroid (ASR: 20.7), breast (ASR: 20.4), cervix uteri (ASR: 14.3), bronchus and lung (ASR: 13.0), liver (ASR: 10.7) and colo-rectum (ASR: 17.2) in descending order. The overall quality (completeness and validity) of the cancer registry was at the in 'good' level. Conclusions: These results will be useful in the overall context of planning and evaluating of cancer control activities in Gwangju.

• 대한한의학회지
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• 제21권4호
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• pp.159-173
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• 2000

Objectives : First, to restore reliability of oriental prescriptions that are effective against incurable diseases, Second, in the short term, to secure the validity of traditional remedies with the help of accumulated data and in the long term, develop new therapeutic methods and prescriptions in order to broaden its aspect in the field of medicine. Third, to maintain predominance on oriental therapeutic methods and put it into practical use based upon the results obtained by this paper. Methods : In the primary sub-thesis(herbalogical analytic methods applied on unknown oriental prescriptions), models of analytic method and in gathering information that could be put into practice are being revised In the secondary sub-thesis(method in gathering and analysing in dealing with oriental prescription), several statistical approaches and analysis on data that has been gathered are being revised. In the tertiary sub-thesis(research on legal guarantee of the offerer rights), an alternative scheme that covers the limitations of the legislative content in dealing with offerer rights is being revised Results : This research has revealed several problems, including those which were foreseen, in proceeding with the project. The prospect of the involvement of the medical personnel engaging in the field of oriental medicine was remarkably bright. Given the condition that the project will proceed as it follows, unknown oriental prescriptions and remedies which have been particularly ignored will eventually play an important role in clinical practice. Conclusions : It is clear to everyone that these oriental remedies will remain ignored by the public unless they gain popularity. Strict verifications on these oriental remedies are definitely needed in order to overcome this limitation. Finally, it should provide a momentum in the field of medicine in gaining popularity to the public.

• 보존과학회지
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• 제32권4호
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• pp.449-457
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• 2016

2013년 인천 영흥도선에서 출수된 도기병은 해양생물과 주변 물질들이 단단하게 굳어져 표면 전체를 덮고 있던 상태였다. 표면과 구연부의 이물질을 물리적, 화학적인 방법으로 제거하니 표면에 파도무늬가 나타났으며 내부에서 황갈색 투명한 고체물질도 확인되었다. 이 논문은 도기병의 보존처리 과정과 내부 물질을 확인하는 분석과정을 설명했다. 도기병은 이물질 제거, 탈염, 복원 등의 순서로 보존처리를 진행했고, 없어진 구연부를 복원하여 원래 형태를 더 잘 이해할 수 있게 했다. 또한 내용물의 성분을 확인하기 위해 문헌을 토대로 통일신라(8~9세기)에 유통 가능했던 재료들을 푸리에변환 적외분광분석(FT-IR)과 가스크로마토그래피-질량분석기(GC-MS)로 비교분석하였다. 분석 결과 FT-IR과 GC-MS 모두 황칠과의 유사성을 확인하였다. 보존처리 후에 드러난 도기병의 파도무늬와 분석결과 확인된 황칠과의 유사성을 통해 영흥도선은 통일신라시대에 황칠을 싣고 가다가 난파된 선박임을 추측해볼 수 있다.

• 정보보호학회논문지
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• 제22권3호
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• pp.667-677
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• 2012

악성코드 유포자들은 웹 어플리케이션 취약점 공격을 이용해 주로 악성코드를 유포한다. 이러한 공격들은 주로 악성링크를 통해 이루어지며, 이를 탐지하고 분석하는 연구가 활발히 이루어지고 있다. 하지만, 현재의 악성링크 탐지 시스템은 대부분 시그니처 기반이어서 난독화 된 악성링크는 탐지가 거의 불가능하고 알려진 취약점은 백신을 통해 공격을 사전에 방지 할 수 있지만 알려지지 않은 취약점 공격은 사전 방지가 불가능한 실정이다. 이러한 한계점을 극복하기 위해 기존의 시그니처 기반 탐지 방법을 지양하고 행위기반 탐지 시스템에 관한 연구가 이루어지고 있다. 하지만 현재 개발된 탐지 시스템은 현실적으로 제약사항이 많아 실제로 활용하기에는 한계가 있다. 본 논문에서는 이와 같은 한계를 극복하고 탐지 효율을 높일 수 있는 새로운 웹 브라우저 기반 악성행위 탐지 시스템인 WMDS (Web-browser based Malicious behavior Detection System)를 소개 하고자 한다.

• Tuberculosis and Respiratory Diseases
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• 제47권1호
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• pp.103-110
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• 1999

저자 등은 폐색전증이 확인된 환자에서 지속적인 경구 warfarin 항응고 치료에도 불구하고 색전에 의한 호흡곤란 증상이 악화하여 시행한 색전제거술 후 혈전에서 원발 미상의 미분화 편평 상피 세포암이 확인된 1예를 경험하여 보고하는 바이다.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.208-218
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• 2021

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH. Methods: The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated. Results: Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1-83 years), and the median follow-up duration was 8.5 months (range, 0-204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×10⁹/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH. Conclusion: Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.363-368
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• 2014

Determination of the cause of malignant pleural effusions is important for treatment and management, especially in cases of unknown primaries. There are limited biomarkers available for prediction of the cause of malignant pleural effusion in clinical practice. Hence, we evaluated pleural levels of five tumor biomarkers (CEA, AFP, CA125, CA153 and CA199) in predicting the cause of malignant pleural effusion in a retrospective study. Kruskal-Wallis or Mann-Whitney U tests were carried out to compare levels of tumor markers in pleural effusion among different forms of neoplasia - lung squamous cell carcinoma, adenocarcinoma, or small cell carcinoma, mesothelioma, breast cancer, lymphoma/leukemia and miscellaneous. Receiver operator characteristic analysis was performed to evaluate sensitivity and specificity of biomarkers. The Kruskal-Wallis test showed significant differences in levels of pleural effusion CEA (P<0.01), AFP (P<0.01), CA153 (P<0.01) and CA199 (P<0.01), but not CA125 (P>0.05), among the seven groups. Receiver operator characteristic analysis showed that, compared with other four tumor markers, CA153 was the best biomarker in diagnosing malignant pleural effusions of lung adenocarcinoma (area under curve (AUC): 0.838 (95%confidence interval: 0.787, 0.888); cut-off value: 10.2U/ml; sensitivity: 73.2% (64.4-80.8)%, specificity: 85.2% (77.8-90.8)%), lung squamous cell carcinoma (AUC: 0.716 (0.652, 0.780); cut-off value: 14.2U/ml; sensitivity: 57.6% (50.7-64.3)%, specificity: 91.2% (76.3-98.0)%), and small-cell lung cancer (AUC: 0.812 (0.740, 0.884); cut-off value: 9.7U/ml; sensitivity: 61.5% (55.0-67.8)%, specificity: 94.1% (71.2-99.0)%); CEA was the best biomarker in diagnosing MPEs of mesothelioma (AUC: 0.726 (0.593, 0.858); cut-off value: 1.43ng/ml; sensitivity: 83.7% (78.3-88.2)%, specificity: 61.1% (35.8-82.6)%) and lymphoma/leukemia (AUC: 0.923 (0.872, 0.974); cut-off value: 1.71ng/ml; sensitivity: 82.8% (77.4-87.3)%, specificity: 92.3% (63.9-98.7)%). Thus CA153 and CEA appear to be good biomarkers in diagnosing different causes of malignant pleural effusion. Our findings implied that the two tumor markers may improve the diagnosis and treatment for effusions of unknown primaries.

• 대한한방부인과학회지
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• 제23권3호
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• pp.184-191
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• 2010

Purpose: Examine changes in the aspect and state of patient with infertility who admitted to Korean oriental hospital. Look at the changes in last 8 years and seek how oriental medicine can approach to infertility patients who admitted to Korean oriental hospital in last 8 years. Methods: Total of 7434 new patients with infertility who admitted to Gynecology of Oriental Hospital, $\bigcirc\bigcirc$ University Medical Center, from October 2002 to December 2009 was compared to infertility patients based on bottom collected data in this study, total of 1061 infertility patients were targeted for this study. Results: 1.There is no distinct increases in age between women who admitted to oriental medicine and patient's average age, it has shown constantly increasing trend in their age though. However, the average age of infertility patients have shown significant increasing range than average age of all infertility patients. 2. After analysis the result of infertility patient's rate of overall patients, the rate of infertility patients are remaining the same or slowing down in 2005, as the starting year(Table 2). The significant relationship was found in diagnosis and treatment of gynecology(Table 4~5) for infertility patients. In 2005 as the starting year, as patients who admitted to oriental hospital after diagnosed or treated at gynecology are increasing, the rate of infertility patients of overall patients admitted to hospital is slowing down, which is decreasing. 3. There is increasing number of patient diagnosed with "unknown cause" who admitted to Gynecology of Oriental Hospital after year of 2005. 4. The increasing number of patient diagnosed with "unknown cause" who admitted to oriental hospital has a tendency to be important factor in infertility treatment of oriental medicine. Conclusion: Unknown causes of infertility patients who admitted to oriental hospital will continuously increase as senses of society, economic, and social climate change.

• Journal of Korean Neurosurgical Society
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• 제30권11호
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• pp.1340-1344
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• 2001

뇌로 전이한 악성 섬유성 조직구종 1례를 문헌 고찰과 함께 보고하고자 한다. 환자는 62세 남자로 다발성 전이성 뇌종양 의증하에 개두술 및 종양 제거술을 시행받았다. 술전 검사상 두개강외 원발 부위를 의심할만한 병변은 발견하지 못하였다. 수술과 전뇌 방사선 치료후 6개월째에 성장하는 우측 견부 종양이 발견되어 적출술을 시행하였다. 뇌와 견부 조직 표본에서 악성 섬유성 조직 세포종에 부합되는 일치된 병리 소견을 보였으나 GFAP-양성 세포들은 뇌병변의 조직 표본에서만 발견되었다. 이후에 발생한 척추 등의 골격계 전이성 병변에 대하여서는 고식적 방사선 치료를 행하였다. 최초 진단 후 12개월째 우측 견부 종양이 재발하여 항암 화학 치료 중이다. 이 증례에서 특이한 점은 원발 부위 발견전 전이성 뇌종양이 진단된 것인데, 악성 섬유성 조직구종으로부터 뇌로 전이한 경우가 드물거니와 특히 원발부위가 확인되기 전에 뇌로 전이한 병변이 먼저 발견된 경우는 보고된 바가 없다. 또 하나의 중요한 소견은 GFAP 발현이 뇌병변에서만 나타나며 원발부위인 견부 종양에서는 관찰되지 않은 점이다. 원발성 두개강내 악성 섬유성 조직구종에서 GFAP-양성 세포의 존재는 중요한 조직학적 특성의 하나로 알려져 있으나, 본 증례의 소견은 원발성 두개강내 악성 섬유성 조직구종에 존재하는 GFAP-양성 세포들도 악성 섬유성 조직구종에 의해 이차적으로 생성된 비종양성 성상 세포들이라는 가설을 뒷받침하고 있다.