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Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis

  • HYUN‑KYUNG LEE;TAYABA ISMAIL;CHOWON KIM;YOUNI KIM;JEEN‑WOO PARK;OH‑SHIN KWON;BEOM‑SIK KANG;DONG‑SEOK LEE;TAEJOON KWON;TAE JOO PARK;HYUN‑SHIK LEE
    • International Journal of Molecular Medicine
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    • v.43 no.2
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    • pp.1105-1113
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    • 2019

  • Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono- and di-methylated ninth lysine of histone 3 and belongs to the Jumonji domain-containing group of demethylases. Kdm3a serves roles during various biological and pathophysiological processes, including spermatogenesis and metabolism, determination of sex, androgen receptor-mediated transcription and embryonic carcinoma cell differentiation. In the present study, physiological functions of Kdm3a were evaluated during embryogenesis of Xenopus laevis. Spatiotemporal expression pattern indicated that kdm3a exhibited its expression from early embryonic stages until tadpole stage, however considerable increase of kdm3a expression was observed during the neurula stage of Xenopus development. Depleting kdm3a using kdm3a antisense morpholino oligonucleotides induced anomalies, including head deformities, small-sized eyes and abnormal pigmentation. Whole-mount in situ hybridization results demonstrated that kdm3a knockdown was associated with defects in neural crest migration. Further, quantitative polymerase chain reaction revealed abnormal expression of neural markers in kdm3a morphants. RNA sequencing of kdm3a morphants indicated that kdm3a was implicated in mesoderm formation, cell adhesion and metabolic processes of embryonic development. In conclusion, the results of the present study indicated that Kdm3a may serve a role in neural development during Xenopus embryogenesis and may be targeted for treatment of developmental disorders. Further investigation is required to elucidate the molecular mechanism underlying the regulation of neural development by Kdm3a.

  • https://doi.org/10.3892/ijmm.2018.4024 인용

Transport of space charge between sub-pixels in AC-plasma cell discharge

  • Lee, S.B.;Park, E.Y.;Han, Y.G.;Moon, M.W.;Oh, P.Y.;Song, K.B.;Lee, H.J.;Son, C.G.;Jeong, S.H.;Yoo, N.L.;Hong, Y.J.;Jeong, S.J.;Kim, J.H.;Park, S.O.;Choi, E.H.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.929-931
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    • 2006

  • In this experiment, we have investigated that the transported space charge between sub-pixels in AC-plasma cell discharge. The test pulse 30 V, $5{\mu}s$ was applied to the address electrodes of neighbor cells of discharge occurred cells. And we have measured the transported space charge between sub-pixels in accordance with the various last sustain pulse widths t(time gap between the rising edges of sustain and test pulses) of 0.2 to $3{\mu}s$. It was observed that the peak value of transported space charge has been shown to be 21.5pC at $1.0{\mu}s$. And the IR peak value have been occured after $0.51{\mu}s$ with respect to sustain voltage.

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Influence of Sustain Voltage on Wall Charge and Wall Voltage Characteristics in AC-PDPs

  • Kim, T.Y.;Cho, T.S.;Kim, S.S.;Cho, D.S.;Kim, J.G.;Ahn, J.C.;Jung, Y.H.;Lim, J.Y.;Jung, J.M.;Ko, J.J.;Kim, D.I.;Lee, C.W.;Seo, Y.;Cho, G.S.;Choi, E.H.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2000.01a
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    • pp.119-120
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    • 2000

  • Influences of sustain voltage on wall charges and wall voltages are experimentally investigated in surface AC plasma display panels(AC-PDPs), in which electrode gap and width are $80\;{\mu}m$ and $270\;{\mu}m$, respectively. The filling gas is Ne-Xe gas mixture, and total pressures 300 Torr. Also it is found that the more amount of Xe mixing ratio makes the less wall charge and voltage for sustain voltage ranged from 140 V to 222 V. The response time has been delayed by adding a small amount of Xe to Ne in comparison with that without Xe. It is also found that the wall charge and voltage are reduced by adding a small amount of Xe to Ne in comparison with those without Xe.

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