• 제목/요약/키워드: University of Oxford

검색결과 224건 처리시간 0.033초

Intracellular pH Regulation in Cardiac Myocytes

  • Lee, Chae-Hun;Vaughan-Jones, Richard D.
    • 한국생물물리학회:학술대회논문집
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    • 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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    • pp.24-25
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    • 1999
  • Intracellular pH(pH$_{i}$) regulation is very important to regulate the cellular functions of cardiac myocytes such as contractility, signal transduction, ion regulation, cell volume, and energy production etc. The resting pH$_{i}$ was maintained at about 7.07 and strictly regulated within the range of $\pm$0.1.(omitted)ted)

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PHILOS Plate Osteosynthesis in Metaphyseal Fractures of the Distal Humerus through an Anterolateral Approach

  • Park, Jung Ho;Kim, Jung Wook;Oh, Chi Hun;Choi, Keun Seok;Hong, Jae Young;Kim, Jae Gyoon
    • Clinics in Shoulder and Elbow
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    • 제18권3호
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    • pp.128-132
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    • 2015
  • Background: We described a surgical method for osteosynthesis and reported the resultant strength after application of a PHILOS plate through the anterolateral approach for the treatment of fractures of the distal humerus. Methods: Between February 2010 and March 2012, open reduction and internal fixation operations with the PHILOS plate for treatment of fracture of the distal humerus were performed on a total of nine patients (five men, four women). The mean age was 40.8 years (range, 24-50 years), and the average follow-up period was 9.1 months (range, 6-15 months). Clinical evaluations were performed 6 months after the operation. Clinical assessment included determination of the range of motion of the elbow, the Mayo and Oxford elbow scores, and any postoperative complications. Results: Fracture union was noted in all patients, with an average period of 12.4 weeks. The average Mayo elbow and Oxford elbow scores were 87.2 (of a total of 100) and 43.3 (of a total of 48), respectively. For the postoperative range of motion of the elbow, all patients showed complete recovery to the preoperative range of motion. No other conditions, such as neurolepsis, plate breakage, or rotational deformity, were observed. Conclusions: Open reduction and internal fixation of distal humerus fractures with a PHILOS plating system via anterolateral approach can be effective. A high rate of union with good outcomes can be assumed.

Determining Potential Link between Environmental and Clinical Isolates of Cryptococcus neoformans/Cryptococcus gattii Species Complexes Using Phenotypic and Genotypic Characterisation

  • Kenosi Kebabonye;Mosimanegape Jongman;Daniel Loeto;Sikhulile Moyo;Wonderful Choga;Ishmael Kasvosve
    • Mycobiology
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    • 제51권6호
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    • pp.452-462
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    • 2023
  • Opportunistic infections due to Cryptococcus neoformans and C. gattii species complexes continue to rise unabated among HIV/AIDS patients, despite improved antifungal therapies. Here, we collected a total of 20 environmental and 25 presumptive clinical cryptococcal isolates from cerebrospinal fluid (CSF) samples of 175 patients enrolled in an ongoing clinical trial Ambition 1 Project (Botswana-Harvard Partnership). Identity confirmation of the isolates was done using MALDI-TOF MS and PCR. We describe the diversity of the isolates by PCR fingerprinting and sequencing (Oxford Nanopore Technology) of the intergenic spacer region. Mating types of the isolates were determined by amplification of the MAT locus. We report an unusual prevalence of 42.1% of C. neoformans × C. deneoformans hybrids Serotype AD (n = 16), followed by 39.5% of C. neoformans Serotype A (n = 15), 5.3% of C. deneoformans, Serotype D (n = 2), 7.9% of C. gattii (n = 3), and 5.3% of C. tetragattii (n = 2) in 38 representative isolates that have been characterized. Mating type-specific PCR performed on 38 representative environmental and clinical isolates revealed that 16 (42.1%) were MATa/MAT𝛼 hybrids, 17 (44.7%) were MAT𝛼, and five (13.2%) possessed MATa mating type. We used conventional and NGS platforms to demonstrate a potential link between environmental and clinical isolates and lay a foundation to further describe mating patterns/history in Botswana.

Re-examination of Opisthorchis viverrini Infection in Northeast Thailand

  • Yeoh, Kheng-Wei;Promthet, Supannee;Sithithaworn, Paiboon;Kamsaard, Supot;Parkin, Donald Maxwell
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권8호
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    • pp.3413-3418
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    • 2015
  • Background: Liver fluke infection caused by the parasite Opisthorchis viverrini (O. viverrini), a human carcinogen, is endemic in north-eastern Thailand and remains a major health problem. Objectives: The objectives of the study were to (1) resurvey the prevalence of O. viverrini infection in a field site from the Khon Kaen Cohort Study (in newly recruited subjects as well as previous cohort subjects surveyed in 1992); (2) investigate how subjects' lifestyle habits and their exposure to health promotion initiatives influence changes in prevalence of O. viverrini infection. Materials and Methods: The prevalence of O. viverrini infection in the cohort subjects (as well as new subjects) was investigated using faecal egg counts. Information on demographic factors, lifestyle and awareness of health promotion initiatives were obtained through questionnaires. Results: O. viverrini infection rates in the same individuals of the cohort were lower in 2006 than in 1992. Also, by studying the period effect, the current 35-44 year olds had a 12.4% (95% CI 3.9% to 20.9%) lower prevalence of O. viverrini infection than the 35-44 year olds in 1992 (24.2% versus 11.8%). Lifestyle choices showed that smoking and alcohol consumption were associated with an increased chance of acquiring O. viverrini infection with adjusted odds ratios of 10.1 (95%CI 2.4-41.6) and 5.3 (95%CI 1.2-23.0), respectively. Conclusions: Our study has demonstrated that although the prevalence of O. viverrini infection over a 14-year period has decreased, unhealthy lifestyle was common with smoking and alcohol consumption being associated with increased chances of infection, emphasising the double burden of disease which developing countries are facing.

The first UV fundamental plane and evidence of star formation in early-type galaxies

  • Jeong, Hyun-Jin;Yi, Suk-Young;Bureau, Martin;Davies, Roger L.
    • 한국우주과학회:학술대회논문집(한국우주과학회보)
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    • 한국우주과학회 2009년도 한국우주과학회보 제18권2호
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    • pp.36.2-36.2
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    • 2009
  • We present GALEX (Galaxy Evolution Explorer) far (FUV) and near (NUV) ultraviolet imaging of 34 nearby early-type galaxies from the SAURON representative sample of 48 E/S0 galaxies, all of which have ground-based optical imaging from the MDM Observatory. The surface brightness profiles of nine galaxies (~26 per cent) show regions with blue UV-optical colours suggesting recent star formation. Five of these (~15 per cent) show blue integrated UV-optical colours that set them aside in the NUV integrated colour-magnitude relation. These are objects with either exceptionally intense and localised NUV fluxes or blue UV-optical colours throughout. They also have other properties confirming they have had recent star formation, in particular Hbeta absorption higher than expected for a quiescent population and a higher CO detection rate. This suggests that residual star formation is more common in early-type galaxies than we are used to believe. NUV-blue galaxies are generally drawn from the lower stellar velocity dispersion (sigma_e <200 km/s) and thus lower dynamical mass part of the sample. We have also constructed the first UV Fundamental Planes and show that NUV blue galaxies bias the slopes and increase the scatters. If they are eliminated the fits get closer to expectations from the virial theorem. Although our analysis is based on a limited sample, it seems that a dominant fraction of the tilt and scatter of the UV Fundamental Planes is due to the presence of young stars in preferentially low-mass early-type galaxies.

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Escape of LyC and Lyα Photons from Simulated Turbulent Clouds

  • 김태선
    • 천문학회보
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    • 제44권1호
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    • pp.73.2-73.2
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    • 2019
  • Understanding how ionizing radiation propagates from molecular clouds to the intergalactic space is the key to the study of reionization and the emergence of $Ly{\alpha}$ emission from galaxies. In this contribution, I will present our new efforts to better understand the escape of UV photons from turbulent clouds with different masses, star formation efficiencies, and spectral energy distributions using radiation-hydrodynamic simulations. I will also show predicted Lya profiles from turbulent clouds and discuss a few interesting differences identified when compared with the properties of the local green pea galaxies.

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한국 남동지역 상류 하천에서의 낙엽 분해기작과 shredder 분포 유형 (Leaf Litter Processing and Patterns of Shredder Distribution in Headwater Steams in Southeastern Korea)

  • Kim Hyun-woo;Gea-Jae Joo;Jong-hoon Choi
    • The Korean Journal of Ecology
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    • 제19권6호
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    • pp.529-541
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    • 1996
  • During the period of December 1992 (winter-spring) and from February 1995 (winter-spring), the leaf processing rates of oak (Quercus serrata) and tulip (Liriodendron tulipifera) tree was investigated in the headwater streams in southeastern part of Korea in conjunction with the distribution pattern of macroinvertebrate fauna. Using two types of bags ($10\times30cm$ with 5 g of dry leaves; open bag with holes, closed bag without holes), decomposition rates of oak and tulip tree by shredder and/or microbiota at a reatively undisturbed 2nd-order stream were compared, Regardless of leaf type, leaves in the open bage decomposed slightly faster than those in the closed bags. In the 1992 experiment, osk leaves decomposed much slower than tulip leaves (after 138 degree days, osk : closed, 0.006% loss/day ; open, 0.008 ; tulip: closed, 0.021 ; open, 0.023; n=2). The of the first experiment using oak leaves in 1995 were similar to those of the first experiment (after 151 degree days, oak: closed, 0.005% loss / day; open, 0.006; n=6). Over 50% of invertebrates from 122 leaf pack samples collected from 12 streams during the winter period of 1994 were identified as shredders (shredder, 56.2; collector, 32.7; scraper, 8.65; predator, 2.45%). Among shredders, Gammarus sp. and Tipula sp. were dominant species in terms of number and biomass (8.2 ind./g, 1.0 ind./g AFDW of leaves). Among many physico-chemical parameters, the width of stream channel was found to be the most influential factor in the distribution of Gammarus and Tipula (Gammarus: r=-0.34, P<0.001;Tipula:r=0.40, P<0.001). Considering the fact that oak is one the dominant riparian vegetation in the southeastern part of korea, the patterns of oak processing and shredder distribution shown in theis study may well represent some of the important characteristics of headwater steams in southeastern Korea.

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The internal UV-line-strength relations of early-type galaxies

  • 정현진;이석영
    • 천문학회보
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    • 제36권2호
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    • pp.66.2-66.2
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    • 2011
  • The unexpected rising flux of early-type galaxies at decreasing ultraviolet (UV) wavelengths is a long-standing mystery. One important observational constraint is the correlation between UV-optical colours and Mg2 line strengths found by Burstein et al. (1988). The simplest interpretation of this phenomenon is that the UV strength is related to the Mg line-strength. Under this assumption, we expect galaxies with larger Mg gradients to have larger UV colour gradients. By combining UV imaging from GALEX, optical imaging from MDM and SAURON integral-field spectroscopy, we investigate the spatially-resolved relationships between UV colours and stellar population properties of 34 early-type galaxies from the SAURON survey sample. We find that galaxies with old stellar populations show tight correlations between the FUV colours (FUV-V and FUV-NUV) and the Mg b index, $H{\beta}$ index and metallicity [Z/H]. We have also derived logarithmic internal radial colour, measured line strength and derived stellar population gradients for each galaxy and again found a strong dependence of the FUV-V and FUV-NUV colour gradients on both the Mg b line-strength and the metallicity gradients. In particular, global gradients of Mg b and [Z/H] with respect to the UV colour across galaxies are consistent with their local gradients within galaxies, suggesting that the global correlations also hold locally. From a simple model based on multi-band colour fits of UV upturn and UV-weak galaxies, we have identified a plausible range of parameters that reproduces the observed radial colour profiles. In these models, the centers of elliptical galaxies, where the UV flux is strong, are enhanced in metals by roughly 60% compared to UV-weak regions.

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