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Multi-Institutional Database System for The Aid of Improvement in Radiotherapy Results

  • Ishibashi, Masatoshi;Harauchi, Hajime;Kou, Hiroko;Kumazaki, Yu;Shimizu, Keiji;Harano, Masako;Numasaki, Hodaka;Yoshioka, Munenori;Inamura, Kiyonari
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.126-128
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    • 2002

  • A learning system was built into an on-line, multi-institutional radiotherapy database, where the treatment history records and the results in each institution were integrated, each radiotherapy planning was supported, and it led to the improvement in treatment results.

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OXIDATIVE DAMAGE, DNA REPAIR AND SIGNAL TRANSDUCTION IN CHEMICAL TERATOGENESIS.

  • Peter G Wells;Yadvinder Bhuller;Connie S Chen;Jeffrey T Henderson;Winnie Jeng;Sonja Kasapinovic;Julia C Kennedy;Rebecca R Laposa;Christopher J Nicol;Toufan Parman;Michael J Wiley;Louise M Winn;Andrea W Wong
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.44-64
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    • 2002

  • Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics (phenytoin, thalidomide, benzo[a]pyrene) to free radical intermediates that initiate reactive oxygen species (ROS) formation, which oxidatively damage cellular macromolecules and/or alter signal transduction.(omitted)

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Clinicopathological Features in Bilateral Breast Cancer

  • Baykara, Meltem;Ozturk, Selcuk Cemil;Buyukberber, Suleyman;Helvaci, Kaan;Ozdemir, Nuriye;Alkis, Necati;Berk, Veli;Koca, Dogan;Coskun, Ugur;Oksuzoglu, Berna;Uncu, Dogan;Arpaci, Erkan;Ustaalioglu, Basak Oven;Demirci, Umut;Kucukoner, Mehmet;Dogu, Gamze Gokoz;Alici, Suleyman;Akman, Tulay;Ozkan, Metin;Aslan, Ulku Yalcintas;Durnali, Ayse Gok;Benekli, Mustafa
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4571-4575
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    • 2012

  • Introduction and Purpose: The frequency of bilateral breast cancer is 1.4-11.0% among all breast cancers. It can present as synchronous (SC) or metachronous (MC). Data regarding clinical course of bilateral breast cancer are scarce. In this study, we therefore evaluated demographic, pathological and clinical characteristics, treatments and responses in bilateral breast cancer cases; making distinctions between metachronous-synchronous and comparing with historic one-sided data for the same parameters. Materials and Methods: One hundred fifty bilateral breast cancer cases from ten different centers between 2000 and 2011 were retrospectively scanned. Age of the cases, family history, menopausal status, pathological features, pathological stages, neoadjuvant, surgery, adjuvant and palliative chemotherapy/radiotherapy were examined in the context of the first and second occurrence and discussed with reference to the literature. Results: Metachronous and synchronous groups showed similar age, menopausal status, tumor type, HER2/neu expression; the family history tumor grade, tumor stage, ER-negativity rate, local and distant metastases rates, surgery, adjuvant chemotherapy application rates were identified as significantly different. Palliative chemotherapy response rate was greater in the metachronous group but median PFS rates did not differ between the groups. Conclusion: Although bilateral breast cancer is not frequent, MC breast cancer is different from SC breast cancer by having more advanced grade, stage, less ER expression, more frequent rates of local relapse and distant metastasis and better response to chemotherapy in case of relapse/metastasis.

  • https://doi.org/10.7314/APJCP.2012.13.9.4571 인용 PDF KSCI