• 제목/요약/키워드: University Hospital Medical Center

검색결과 7,431건 처리시간 0.032초

Factors Potentially Associated with Chemotherapy-induced Anemia in Patients with Solid Cancers

  • Cheng, Ke;Zhao, Feng;Gao, Feng;Dong, Hang;Men, Hai-Tao;Chen, Ye;Li, Long-Hao;Ge, Jun;Tang, Jie;Ding, Jing;Chen, Xin;Du, Yang;Luo, Wu-Xia;Liu, Ji-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권10호
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    • pp.5057-5061
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    • 2012

  • Purpose: Chemotherapy-induced anemia (CIA) is one of the most important causes of anemia in cancer patients. This study was conducted to describe the prevalence and characteristics of CIA in solid cancer patients in the Chinese population, and to explore the relationship of white blood cell (WBC) or platelet decrease with CIA. Methods: Data on age, gender, tumor diagnosis, anti-cancer treatment and blood cell analyses were available from 220 untreated non-anemic cancer patients who received at least 2 cycles of chemotherapy, and the data were analyzed to assess their relationship with CIA or its severity. Results: 139 patients (63.2%) presented anemia, most being Grade 1 or 2. Esophageal and lung cancers were associated with a high prevalence. G3/4 leucopenia and decrease of platelets were identified as independent risk factors for the occurrence of CIA. Moreover, G3/4 leucopenia, decrease of platelet and G3/4 thrombocytopenia were found to be also associated with the severity of CIA. Cisplatin-containing regimens were a main potential factor in causing CIA, although significant association was only found on univariate analysis. Conclusion: Anemia or decrease in hematoglobin are common in Chinese cancer patients receiving chemotherapy. Cisplatin-containing regimens might be an important factor influencing the occurrence of CIA. Our analysis firstly described some risk factors, such as decrease of platelets or WBCs, severity of leucopenia or thrombocytopenia, associated with the occurrence and severity of CIA.

  • https://doi.org/10.7314/APJCP.2012.13.10.5057 인용 PDF KSCI