• Journal of Gastric Cancer
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• v.19 no.4
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• pp.375-392
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• 2019

Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number of cases, the tumor is extremely resistant to these treatments and the patients are exposed to unnecessary toxicity and delayed surgical therapy. The current clinical trials evaluating the combination of preoperative systemic therapies with modern targeted and immunotherapeutic agents represent a unique opportunity for identifying predictive biomarkers of response to select patients that would benefit the most from these treatments. However, it is of utmost importance that these potential biomarkers are corroborated by extensive preclinical and translational research. The aim of this review article is to present the most promising biomarkers of response to classic chemotherapeutic, anti-HER2, antiangiogenic, and immunotherapeutic agents that can be potentially useful for personalized preoperative systemic therapies in gastric cancer patients.

• Korean Institute of Interior Design Journal
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• v.14 no.2 s.49
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• pp.112-119
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• 2005

This study attempts to suggest new directions of urban multi-family housing design in the recent era of information, in which the representation of publicity and privacy of the housing reflects new meanings and relationships of the current digital society. The study examines cases of Dutch multi-family housing and investigates the meanings and relationships of publicity and privacy in the building as well as unit design of the housings. Borneo-Sporenburg housing development is a good example that suggests new interpretation and design solution for low-rise, high-density multi-family housing. Thus, this study analyzes street patterns, facade design, and ways of housing unit combination in Borneo-Sporenburg housing and concludes as follows. First, public space in Borneo-Sporenburg housing, which was designed differently from hierarchical and centripetal organization of modern architecture, is divided into small units and spread into the inside, which provides high potential for personal control of space and personal programming of space by space choices. Second, street pattern and facade design of Borneo-Sporenburg housing provide visual publicity and privacy simultaneously as they maintain unity as a whole as well as articulate individual unit in many different ways and provide clues to neighboring. Streets as a public domain have self-controlled boundaries for residents and introduce voluntary use-programs for residents. Third, facades of the housing have no inter-mediate space or common space, and confront streets directly. Space in-between is composed inside the facade and extends into the streets by residents' own choices. Fourth, privacy and individuality of the housing is strengthened. Units of the housing have individual entrances, unique plan type and complicated combination of space that all together emphasize individuality of units, however they are not often notified from the outside.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.3
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• pp.22-29
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• 2015

In this study, we tested to develop and apply structural insulation performance improvement concrete to field, which had compressive strength in 24 MPa and thermal conductivity twice as much as normal concrete. After experiment about slump and air contents, combination product of Plain and calcined diatomite powder showed reduction of slump and air contents and combination product with micro foam cell admixture, we cannot find result of slump and air contents reduction. Unit weight of combination product with insulation performance improvement materials decreased more than that of Plain. In the test of compressive strength, compressive strength of insulation performance improvement concrete decreased more than that of Plain but was content with 24 MPa. thermal conductivity of insulation performance improvement concrete tended to decrease. Freezing and thawing resistance of insulation performance improvement concrete was similar to that of Plain. In carbonation resistance test, combination product with calcined diatomite powder showed the result which was similar to that of Plain. In carbonation resistance test, combination product with micro foam cell admixture showed a increase compared to that of Plain and length variation of combination product generally increased.

• ALGAE
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• v.18 no.2
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• pp.129-134
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• 2003

In order to examine the effects of deep seawater (mesopelagic water in the broad sense) on the growth of macroalgae, the growth and nutrient uptake (nitrate and phosphate) of Ulva sp. (Ulvophyceae, Chlorophyta) were investigated by cultivation in deep seawater (taken from 687 m depth at Yaizu, central Japan, in August 2001), surface seawater (taken from 24 m depth), and a combination of the two. Culture experiments were carried out in a continuous water supply system and an intermittent water supply system, in which aerated 500-mL flasks with 4 discs of Ulva sp. (cut sections of ca. 2 $cm_2$) were cultured at 20$^{\circ}C$ water temperature, 100 $\mu$mol photons $m^{-2}{\cdot}s^{-1}$ light intensity, and a 14:10 light:dark cycle. Nutrient uptake by Ulva sp. was high in all seawater media in both culture systems. The frond area, dry weight, chlorophyll a content, dry weight per unit area, and chlorophyll a content per unit area of Ulva sp. at the end of the experimental period were the highest in deep seawater and the lowest in surface seawater in both culture systems. These values, except for dry weight per unit area and chlorophyll a content per unit area, for each seawater media in the intermittent water supply system were higher than those in the continuous water supply system. We conclude that not only deep seawater as the culture medium but also the seawater supply system is important for effective cultivation of macroalgae.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.1
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• pp.1-7
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• 2016

In the dentistry field, an ultrasonic surgery unit is widely used in bone cutting and scaling to reduce operation time and minimize hemorrhage. The purpose of this study was to evaluate bone cutting and the effect of a specimen's temperature on the two-type ultrasonic surgery unit using a handpiece moving system(HMS). A HMS, which can cut the bone, was developed to perform the experimental procedure with precision of motion control. Bone specimens were prepared from a combination of epoxy-hardener and cortical bone of bovine leg. Through the bone-cutting experiment, the cutting depth was evaluated by not only scanning electron microscopy, but also Vernier calipers. Also, the temperature distribution was measured by a thermo-graphic camera. This study may be applied methodically in various experimental evaluations on a performance test by a HMS.

• The Korean Journal of Applied Statistics
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• v.25 no.2
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• pp.293-300
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• 2012

When Binomial data are obtained, logit and logit mixed models are commonly used for small area estimation. Those models are known to have good statistical properties through the use of unit level information; however, data should be obtained as area level in order to use area level information such as spatial correlation or auto-correlation. In this research, we suggested a new small area estimator obtained through the combination of unit level information with area level information.

• The Journal of Korea Robotics Society
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• v.5 no.4
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• pp.294-301
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• 2010

In order to produce a convenient robot for the aged and the lower limb disabled, it is needed for the research detecting implicit walking intention and controlling robot by a user's intention. In this study, we developed sensor module system to control the walking- assist robot using FSR sensor and tilt sensor, and analyzed the signals being acquired from two sensors. The sensor module system consisted of the assist device control unit, communication unit by wire/wireless, information collection unit, information operation unit, and information processing PC which handles integrated processing of assist device control. The FSR sensors attached user's the palm and the soles of foot are sensing force/pressure signals from these areas and are used for detecting the walking intention and states. The tilt sensor acquires roll and pitch signal from area of vertebrae lumbales and reflects the pose of the upper limb. We could recognize the more detailed user's walking intention such as 'start walking', 'start of right or left foot forward', and 'stop walking' by the combination of FSR and tilt signals can recognize.

• Journal of the Korean housing association
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• v.17 no.3
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• pp.99-109
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• 2006

The purpose of this study was to analyze the characteristic of each view in an apartment unit in terms of the quality. This study was accomplished by two research methods; the field survey on 181 apartment complexes in Daegu, and the preference evaluation on 24 cases sampled in the sense of its location, i.e. inside or outside of a complex. In the field survey, view targets were categorized into various items such as a building, a road, a mountain, a tree, another apartment, the sky, and so on, and the characteristics of the distance from a viewer to view targets and view of the level in an apartment were analyzed. In the preference evaluation, 24 cases, each one has one of the follows; the natural view, the artificial view, and the combined view of the both, were chosen and those were evaluated by 167 interviewees. As a result, the conclusions from the study were drawn as follows; 1) The view, the combination of buildings, roads, mountains, trees, apartments, and the sky, is usually seen in an apartment unit. 2) The type of view target is more significant to a person than its location. 3) The natural and combined view are preferred to the artificial one. 4) In the case of the same outside view, a person likes the open view more than the somewhat covered one.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6151-6154
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• 2014

A growing body of literature is evidence that identifying subtypes of high-risk human papillomavirus (HR-HPV) has impacted on various steps of cervical cancer prevention.Thus, it is mandatory to determine the background prevalence and distribution of HPV subtypes for designing and implementing area-specific management. The present study was conducted to evaluate prevalence and distribution of HPV subtypes among women aged 30-70 years living in Lampang, an area with a high incidence of cervical cancer, through use of a mobile screening unit. Of 2,000 women recruited in this study, 108 (5.40%, 95%CI: 4.45-6.48) were found to have HR-HPV infection. Risk was significantly correlated with age and number of partners. Singly or in combination, the most common genotype was HPV 52 (17.6%), followed by HPV 16 (14.81%), HPV 58 (13.89%), HPV 33 (11.11%), HPV 51 (11.11%), and HPV 56 (9.26%). HPV 18 was found in only 5.6% of cases. Together, HPV 16/18 were noted in approximately 20.4% of cases. Eighteen(16.67%) women were positive with multiple subtypes of HR-HPV. Co-infection most frequently involved HPV 16 or HPV 58. These findings have obvious implications for vaccine policy.

• Journal of the Semiconductor & Display Technology
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• v.11 no.2
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• pp.59-62
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• 2012

This test method covers a procedure for measuring particle removal characteristic of equipment fan filter unit(EFFU) installed inside of semiconductor process equipments, FPD manufacturing equipments and so on. Since EFFU is a combination of air filter and the assembly of fan, motor and frame, the integrity of these parts is very important for the performance of EFFU. So a conventional particle removal test method for air filters is not suitable for EFFU particle removal performance. This test method defines an evaluation method for EFFU which is installed inside an enclosed space to remove particles that are generated inside process equipment. The particle removal performance of EFFUs is usually depending on the performance of filter media and air flow rate. To understand a performance of an EFFU, the filter media characteristic, air flow rate and the integrity of EFFU parts should be considered simultaneously. This test method is intended to demonstrate the system performance of an EFFU and successfully evaluated EFFU performance characteristics.