• 대한정형도수물리치료학회지
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• 제18권2호
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• pp.67-75
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• 2012

Background: Hemiplegic patients have the problems of the balance and weight shifting to the affected leg in walking. The aim of this study was to investigate the effect of unilateral stepping exercise combined with auditory feedback on balance and walking ability of the hemiplegic patients. Methods: Thirty hemiplegic patients were allocated in study group (n=15) or control group (n=15). General exercise and weight supporting exercise were conducted for the control group, and general exercises and unilateral stepping exercise combined with auditory feedback were conducted for the study group. Exercise were conducted three times a week for six weeks. Balance ability was measured by Berg Balance Scale (BBS), postural assessment scale for stroke (PASS), and performance-oriented mobility assessment (POMA). Walking ability was measured by time up and go test (TUG), 10m walk test (10mWT), and six minutes walk test (6MWT). Results: Balance and walking ability were significant increased in both group (p<.05). Balance and walking ability of the study group were more increased than that of the control group (p<.05). Conclusions: Unilateral stepping exercise combined with auditory feedback is more effective than weight supporting exercise to increase on balance and walking ability for the hemiplegic patients.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.579-589
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• 2020

Objective : No optimum genetic rat Huntington model both neuropathological using an adeno-associated virus (AAV-2) vector vector has been reported to date. We investigated whether direct infection of an AAV2 encoding a fragment of mutant huntingtin (AV2-82Q) into the rat striatum was useful for optimizing the Huntington rat model. Methods : We prepared ten unilateral models by injecting AAV2-82Q into the right striatum, as well as ten bilateral models. In each group, five rats were assigned to either the 2×10¹² genome copies (GC)/mL of AAV2-82Q (×1, low dose) or 2×10¹³ GC/mL of AAV2-82Q (×10, high dose) injection model. Ten unilateral and ten bilateral models injected with AAV-empty were also prepared as control groups. We performed cylinder and stepping tests 2, 4, 6, and 8 weeks after injection, tested EM48 positive mutant huntingtin aggregates. Results : The high dose of unilateral and bilateral AAV2-82Q model showed a greater decrease in performance on the stepping and cylinder tests. We also observed more prominent EM48-positive mutant huntingtin aggregates in the medium spiny neurons of the high dose of AAV2-82Q injected group. Conclusion : Based on the results from the present study, high dose of AAV2-82Q is the optimum titer for establishing a Huntington rat model. Delivery of high dose of human AAV2-82Q resulted in the manifestation of Huntington behaviors and optimum expression of the huntingtin protein in vivo.

• 디지털융복합연구
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• 제18권10호
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• pp.403-408
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• 2020

본 연구는 대학 원격강의의 질을 높이기 위한 연구의 발판이 되도록 현재 사용되는 대표적인 두 개의 화상 미팅서비스의 사용성 평가를 하는 것이다. 기능을 중심으로 분석하기 위해 카노모델(Kano)을 기반으로 한 질문지를 설계하여 반구조적 심층면담을 실시해 정성적인 접근을 꾀하였다. 두 서비스의 1차원적 기능인 화면공유 기능이 중요하게 여겨지고 있었고 매력적인 기능들은 비교적 다양한 방향성을 갖고 있었다. 꼭 있어야 할 기능인 카메라, 마이크의 경우 사용자에 따른 장비로 인해 질의 격차가 컸다. 대체할 타 플랫폼이 존재하는 업로드/다운로드 기능과 교육적 목적과 거리가 있는 예약하기, 전화걸기 기능들은 활용가치가 낮았다. 웹엑스는 전체적인 노후 된 UI가, 줌은 일방적인 음소거 기능이 원치 않는 기능으로 조사되었다. 그리고 이러한 결과를 분석해서 도출한 결론으로 개발 방향성을 다섯 가지로 제시하였다. 코로나-19에 따른 장기적인 교육 운영 방식을 고민해야 하는 상황에서 본 연구가 이러한 화상미팅 서비스가 교육용으로 개발되는 발판이 되도록 지속적인 연구로 이어져야 할 것이다.