• BMB Reports
• /
• v.36 no.1
• /
• pp.43-48
• /
• 2003

Understanding the process of carcinogenesis will involve both the accumulation of many scientific facts derived from molecular, biochemical, cellular, physiological, whole animal experiments and epidemiological studies, as well as from conceptual understanding as to how to order and integrate those facts. From decades of cancer research, a number of the "hallmarks of cancer" have been identified, as well as their attendant concepts, including oncogenes, tumor suppressor genes, cell cycle biochemistry, hypotheses of metastasis, angiogenesis, etc. While all these "hallmarks" are well known, two important concepts, with their associated scientific observations, have been generally ignored by many in the cancer research field. The objective of the short review is to highlight the concept of the role of human adult pluri-potent stem cells as "target cells" for the carcinogenic process and the concept of the role of gap junctional intercellular communication in the multi-stage, multi-mechanism process of carcinogenesis. With these two concepts, an attempt has been made to integrate the other well-known concepts, such as the multi-stage, multi-mechanisn or the "initiation/promotion/progression" hypothesis; the stem cell theory of carcinogenesis; the oncogene/tumor suppression theory and the mutation/epigenetic theories of carcinogenesis. This new "integrative" theory tries to explain the well-known "hallmarks" of cancers, including the observation that cancer cells lack either heterologous or homologous gap junctional intercellular communication whereas normal human adult stem cells do not have expressed or functional gap junctional intercellular communication. On the other hand, their normal differentiated, non-stem cell derivatives do express connexins and express gap junctional intercellular communication during their differentiation. Examination of the roles of chemical tumor promoters, oncogenes, connexin knock-out mice and roles of genetically-engineered tumor and normal cells with connexin and anti-sense connexin genes, respectively, seems to provide evidence which is consistent with the roles of both stem cells and gap junctional communication playing a major role in carcinogenesis. The integrative hypothesis provides new strategies for chemoprevention and chemotherapy which focuses on modulating connexin gene expression or gap junctional intercellular communication in the premalignant and malignant cells, respectively.

• Journal of the Korean Chemical Society
• /
• v.66 no.1
• /
• pp.42-49
• /
• 2022

Many elementary school teachers' lack of scientific knowledge reveal as several problems in teaching science. Thus, elementary school teachers need to improve their scientific knowledge, but there is the limit to improve the teachers' scientific knowledge through activities based on lecture that conducted in process of training and retraining them. Therefore, Improvement for training science teacher to improve scientific knowledge of elementary school teachers would be searched in this study. Depth interview was conducted toward three elementary school teachers, who had conducted action research, to improve content knowledge of material domain within teaching process and elementary school science. Based on result of the interview, difficulty and development that the three teachers were commonly experienced in process of conducting scientific inquiry in action research were analyzed. One of the difficulties of the inquiry were to figure out how the three teachers, who participated in the interview, understand specific concept, what they do not understand, and what they should study more to understand the concept. And there was a circumstance that the teachers did not know how to apply procedural knowledge, which learned explicitly in the process of setting plan for conducting research, into real context. Since there was difference between knowledge that they understand disjunctively and context that observed in real circumstance, they faced difficulty. However, the teachers conducted analysis of topic, planning research, conducting research, discussion of the result by themselves with those difficulties Thus, the teachers mentioned that not only content knowledge had been improved, but understanding of procedural knowledge, which is not intended to improve, had been also improved. Besides, they also mentioned that comprehensive understanding content knowledge, which they already understood, was also helpful. And the teachers suggest that if there were chance to discuss and examine the scientific practices by consisting of group with colleagues rather than conducting it individually it would more efficient studying. Considering their suggestion, direction of training elementary school teachers for improving their scientific knowledge should be improved in a way to understand science concepts based on direct research about context that is generated in circumstance of studying group of the teachers. Consequently, it would contribute to improvement of teaching science by combining teachers' practice and understanding.

• Journal of The Korean Association For Science Education
• /
• v.20 no.1
• /
• pp.155-165
• /
• 2000

The purpose of this study was to find out the degree of science problem solving by the information processing types and cognitive styles of 235 6th grade students. The results of this study were as follows. First, as the students got higher scores in the two types of information processing, they could solve more science achievement items and creative problem solving items correctly. And as the students got higher scores in simultaneous information processing test, they could solve more scientific concept understanding items. Secondly, as the students were more field-independent, they could solve more science achievement items and creative problem solving items. And especially in solving scientific concept understanding items, much higher field-independence was required. Finally, there was a significant difference on the distributions of cognitive styles by the information processing types. As the students got higher scores in the two types of information processing, their cognitive style tended to be more field-independent.

• Journal of The Korean Association For Science Education
• /
• v.23 no.2
• /
• pp.176-188
• /
• 2003

Self-induction is an important concept in the field of electromagnetism, which is dealt with in all the high school physics textbooks. According to the results of the survey on self-induction, most of general high school students and even science high school students have overgeneralized concepts that high self-induced emf. are produced whenever the switch is turned off in the circuit containing inductors. The reasons of this overgeneralization on self-induction could be explained through the analysis of current high school physics II textbooks. Main reasons can be attributed to the fact that, by depending on their intuitive ideas, students try to vaguely explain the concept, based on lighting up of Ne tube in the special circuit. This study found out qualitative method to have students effectively understand self-induction based on quantitative interpretation to gain scientific understanding on self-induction.

• Archives of design research
• /
• v.3 no.1
• /
• pp.83-93
• /
• 1990

The constant evolution of society, culture and scientific technology, coupled with changes in life style and behavioral patterns, has led mankind to peroeive diverse needs for space. Particularly, the rapid structural change in the field of marketing has entailed changes in techinques for construction and presentation of space for an improved marketing environment. To satisfy such new, diverse needs for space, interior designers will have to redefine the "mankind and environmen( concept and examine their design methodology anew. The question of how to design available space for a certain purpose will remain a daunting task for designers in the future, as it has been in the past. In the pursuit of convenience and conformity to mankind's surroundings, every nation has, in common with other nations, basic design elements, design skills and other factors. In designing camercial space in a particular region, it is essential, however, to have a proper understanding of the social economic and cultural context indigenous to that region, as well as the impact on environmental and ecological change and marketing strategy. This study discusses design metholdology for the comming camercial space on the basis of the space concept and current status in Korea, with major emphasis on Korea's regional characteristics.

• Journal of the Korean Chemical Society
• /
• v.61 no.4
• /
• pp.211-217
• /
• 2017

The purpose of this study was to examine UK students' use of multimodal representations in science. Students were asked to explain their understandings of the scientific concept and presentation of the multimodal representations in a science Assessing Pupils' Progress (APP) task. Participants of this study were fifty-four Year 7 students taught by the same teacher. Students from one class (27 students) were assigned to the experimental group, and then they received instruction encouraging the using of multimodal representations as evidences to support students' claims. One class (27 students) was assigned to the control group and they received instruction with traditional teaching methods. Both groups performed an APP task for assessment. The samples of APP assessments produced by students both from the experimental and control groups were analyzed using an analysis framework of multimodal representations, embeddedness in evidence and understanding of scientific concepts. Data analysis indicated that the students in the experimental group performed better than that of the control group on embeddedness of multimodal representations in the APP task. In addition, there was a significant difference between the two groups in the evaluation of understand of the scientific concepts.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.17 no.1
• /
• pp.25-31
• /
• 2012

The frequency and abundance of jellyfish, presumably related with climate change, fisheries overexploitation, marine pollution including land reclamation and dyke construction, are increasing worldwide. This feature has attracted interest and concerns from general public and public officials, and government is seeking how the damages could be prevented or reduced down. Korean government, having recent huge blooms of jellyfish, engaged in reducing and/or countermeasuring jellyfish damages. Korean research themes include ecology and physiology of blooming jellyfish species, understanding of the blooming mechanism, and focus on the eradication of blooming jellyfish, without governmental integrative management plan. EU is undertaking scientific projects focused on understanding of the mechanism and control of jellyfish blooms, and establishment of an integrative management. In USA, government has established the code on jellyfish management for conserving and protecting the fish and shellfish resources and one of its department is specially assigned to monitor jellyfish appearance, undertake research, and prepare management plan. Japan also assigned a department and research institute for jellyfish research. Their main interest is to predict jellyfish drifting and mass bloom. Compared to Korea, USA, EU and Japan emphasize integrative management that includes ecological understanding, public education and outreaches, communication and control, if possible, of jellyfish blooms, based on scientific data. We suggest then, 1) establishment of an integrative scientific system consisting of policy and scientific experts to prepare inter-ministrial integrative management plan to effectively combat jellyfish blooms and to maximize the scientific result; 2) concept change from harmful to exploitable marine animal in policy making and research; and 3) active education and information service for people. We expect that these suggestions can be useful for jellyfish management and policy making on another harmful marine organisms.

• Journal of The Korean Association For Science Education
• /
• v.24 no.3
• /
• pp.646-658
• /
• 2004

In this study, the effects of feedback types in self-assessment on the students' science concept understanding and science-related attitudes were investigated. Student's perceptions towards the self-assessment and the feedback provided were also examined. Ten classes from a middle school were chosen. Five of those classes were assigned to the comparative group that any type of feedback was not provided and the other five classes were assigned to the experimental group which feedback was provided. The experimental group was further divided into three groups for implement of three types of feedback. Experimental group A was given feedback in the form of written comments and experimental group B was provided feedback through correct-wrong response to the students answer. Experimental group C was provided oral feedback to the whole class. The tests of science-related attitudes were administered before and after the instruction period. The science concepts understanding test was done only after the instruction. There were significant differences between the experimental group and comparative group in understanding of scientific concepts. The enhancement of science-related attitudes was also significantly higher for the experimental group. There were significant differences between the experimental groups in science-related attitudes. However, there were no significant differences in understanding of scientific concepts in relation to the types of feedback in experiment groups. Interviews with the students of the experimental groups showed that students had positive attitudes towards self-assessment and the types of feedback. And they regarded self-assessment and feedback as helping them understand the science concepts. In conclusion, it was acknowledged that providing feedback in self-assessment showed considerably positive influences on the improvement of the understanding of scientific concepts and science-related attitudes.

• Journal of Fisheries and Marine Sciences Education
• /
• v.25 no.4
• /
• pp.878-890
• /
• 2013

The purpose of this study is to apply the PEOE class model that can enhance students' scientific creative problem-solving ability and self-directed learning ability in the middle school science subject and analyze the effects of it on students' long- and short-term retention, scientific creative problem-solving ability, and self-directed learning characteristics. And the paper has gained the following results: First, according to the result of analysis through the pre-test, post-test, and delay test to examine the effects of PEOE-based class on learners' long- and short-term retention, it is found to be statistically significant in the significant level of .05. In other words, the class using PEOE influences learners' short-term retention significantly, but it is even more effective in transmitting the concept that students acquire into their long-term memory. Second, according to the result of analysis through the pre-test and post-test to examine the effects of PEOE-based class on learners' scientific creative problem-solving ability, it is found to be statistically significant in the significant level of .05 in general. However, 'elaboration' and 'originality', the subfactors of scientific creative problem-solving ability, do not indicate significant effects. Third, according to the result of analysis through the pre-test and post-test to examine the effects of PEOE-based class on learners' self-directed learning characteristics, it is found to be statistically significant in the significant level of .05 as a whole. However, 'openness' and 'future-oriented self-understanding', the subfactors of self-directed learning characteristics, do not exert significant effects. Based on the above study results, it can be concluded that PEOE-based class is more effective for learners' academic achievement in science, scientific creative problem-solving ability, and self-directed learning characteristics than lecture-method instruction regarding the middle school science unit of 'The Properties of Air and Weather Change'.

• Journal of The Korean Association For Science Education
• /
• v.33 no.6
• /
• pp.1103-1118
• /
• 2013

In this research, we analysed definitions and examples of conductor and electrolysis concept in middle school science textbooks. We also surveyed 9 senior pre-service teachers' understanding of the concept definitions and appropriate examples. From the analysis of the textbooks, we found that the possibility of misunderstanding of learners is high because of the broad definition concept and narrow list of examples. After confirming the differences among pre-service teachers' understanding of the subject through questionnaires and interviews, they also debated for a need to an agreement on scientific concepts. The pre-service teachers recognized the meaning of social constructivism and the need for an agreement process in teaching science concepts.