• 한국분말재료학회지
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• 제30권4호
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• pp.310-317
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• 2023

Small-film-type ion sensors are garnering considerable interest in the fields of wearable healthcare and home-based monitoring systems. The performance of these sensors primarily relies on electrode capacitance, often employing nanocomposite materials composed of nano- and sub-micrometer particles. Traditional techniques for enhancing capacitance involve the creation of nanoparticles on film electrodes, which require cost-intensive and complex chemical synthesis processes, followed by additional coating optimization. In this study, we introduce a simple one-step electrochemical method for fabricating gold nanoparticles on a carbon nanotube (Au NP-CNT) electrode surface through cyclic voltammetry deposition. Furthermore, we assess the improvement in capacitance by distinguishing between the electrical double-layer capacitance and diffusion-controlled capacitance, thereby clarifying the principles underpinning the material design. The Au NP-CNT electrode maintains its stability and sensitivity for up to 50 d, signifying its potential for advanced ion sensing. Additionally, integration with a mobile wireless data system highlights the versatility of the sensor for health applications.

• Geomechanics and Engineering
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• 제31권2호
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• pp.197-208
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• 2022

Micropiles consisting of steel bars and grouts are commonly used in underpinning methods to reinforce supports or to suppress the subsidence of existing structures. Recently, applications in the field of geotechnical engineering have expanded. Despite the increasing use of micropiles are used, the PHC or steel pile formula is still applied for the settlement amount of micropiles. Compared with field test results, the amount of micropile subsidence obtained from the existing method may result in a very large error in the displacement of the micropile. Therefore, it is difficult to utilize micropiles effectively. Hence, to solve this problem, this study evaluated the behaviors and support characteristics of micropiles through field compression and tensile tests, and proposed a method for predicting the amounts of their subsidence. To confirm the appropriateness of the proposed method, field test results and the results obtained using the proposed method were compared. It was found that the settlement amounts of the micropiles as predicted through the existing method were significantly overestimated (error ≈ 50-80%) relative to the field test results, whereas the settlement errors of the piles predicted through the proposed method decreased (error ≈6-32%). Thus, it is possible to reduce the previously overestimated amount of settlement, and the modified method of this study allows more efficient design than the conventional method.

• BMB Reports
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• 제56권11호
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• pp.584-593
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• 2023

Hypoxia, a widespread occurrence observed in various malignant tumors, results from rapid tumor growth that outpaces the oxygen supply. Tumor hypoxia precipitates several effects on tumor biology; these include activating angiogenesis, intensifying invasiveness, enhancing the survival of tumor cells, suppressing anti-tumor immunity, and fostering resistance to therapy. Aligned with the findings that correlate CMGC kinases with the regulation of Hypoxia-Inducible Factor (HIF), a pivotal modulator, reports also indicate that hypoxia governs the activity of CMGC kinases, including DYRK1 kinases. Prolyl hydroxylation of DYRK1 kinases by PHD1 constitutes a novel mechanism of kinase maturation and activation. This modification "primes" DYRK1 kinases for subsequent tyrosine autophosphorylation, a vital step in their activation cascade. This mechanism adds a layer of intricacy to comprehending the regulation of CMGC kinases, and underscores the complex interplay between distinct post-translational modifications in harmonizing precise kinase activity. Overall, hypoxia assumes a substantial role in cancer progression, influencing diverse aspects of tumor biology that include angiogenesis, invasiveness, cell survival, and resistance to treatment. CMGC kinases are deeply entwined in its regulation. To fathom the molecular mechanisms underpinning hypoxia's impact on cancer cells, comprehending how hypoxia and prolyl hydroxylation govern the activity of CMGC kinases, including DYRK1 kinases, becomes imperative. This insight may pave the way for pioneering therapeutic approaches that target the hypoxic tumor microenvironment and its associated challenges.

• Journal of Information Processing Systems
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• 제20권2호
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• pp.273-283
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• 2024

The digital domain has witnessed unprecedented growth, reshaping the way we interact, work, and even perceive reality. The internet has evolved into a vast ecosystem of interconnected virtual worlds, giving birth to the concept of the Metaverse. The Metaverse, often envisioned as a collective virtual shared space, is created by the convergence of virtually enhanced physical reality and interactive digital spaces. Within this Metaverse space, the concept of ownership, identity, and authenticity takes on new dimensions, necessitating innovative solutions to safeguard individual rights. The digital transformation through Metaverse has also brought forth challenges, especially in copyright protection. As the lines between the virtual and physical blur, the traditional notions of ownership and rights are being tested. The Metaverse, with its multitude of user-generated content, poses unique challenges. The primary objective of this research is multifaceted. Firstly, there's a pressing need to understand the strategies employed by non-fungible token (NFT) marketplaces within the Metaverse to strengthen security and prevent copyright violations. As these platforms become centers for digital transactions, ensuring the authenticity and security of each trade becomes paramount. Secondly, the study aims to delve deep into the foundational technologies underpinning NFTs, from the workings of blockchain to the mechanics of smart contracts, to understand how they collectively ensure copyright protection. Thus, in this paper, we propose a quantum based NFT solution that can secure Metaverse and copyright contents in an advanced manner.

• Journal of Ginseng Research
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• 제48권3호
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• pp.286-297
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• 2024

Brain plasticity refers to the brain's ability to modify its structure, accompanied by its functional changes. It is influenced by learning, experiences, and dietary factors, even in later life. Accumulated researches have indicated that ginseng may protect the brain and enhance its function in pathological conditions. There is a compelling need for a more comprehensive understanding of ginseng's role in the physiological condition because many individuals without specific diseases seek to improve their health by incorporating ginseng into their routines. This review aims to deepen our understanding of how ginseng affects brain plasticity of people undergoing normal aging process. We provided a summary of studies that reported the impact of ginseng on brain plasticity and related factors in human clinical studies. Furthermore, we explored researches focused on the molecular mechanisms underpinning the influence of ginseng on brain plasticity and factors contributing to brain plasticity. Evidences indicate that ginseng has the potential to enhance brain plasticity in the context of normal aging by mediating both central and peripheral systems, thereby expecting to improve age-related declines in brain function. Moreover, given modern western diet can damage neuroplasticity in the long term, ginseng can be a beneficial supplement for better brain health.

• 산경연구논집
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• 제15권5호
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• pp.39-46
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• 2024

Purpose: This study seeks to address the following research questions: (1) What are the fundamental principles of sports psychology that can be applied to business leadership? (2) How can these principles enhance business leadership effectiveness? As a result, the study may evaluate the necessity and benefits of incorporating sports psychology principles into business leadership practices. Research design, data and methodology: The data collection process in this study involved a systematic Literature review approach, following the prior literature analysis guidelines by numerous past studies. This methodical approach to selecting articles can be useful in synthesizing existing literature and can be referred to as Literature review and selection. Results: The literature analysis has indicated that there is much support for assumptions underpinning business leadership modules, which can be enhanced by applying sports psychology. This topic discusses the traits of self-positivity and mental toughness, goal perspective and interpersonal relationships within a team, and visualization in a sporting organization that can be implemented in business management to support organizational performance. Conclusions: All in all, it can be concluded that organizations must consider adopting Sports Psychology principles into their Leadership Development Programs. Psychological skills development training that includes mental toughness, goal setting, team cohesion,

• IMMUNE NETWORK
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• 제21권2호
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• pp.12.1-12.17
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• 2021

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the emergence of SARS-CoV-2 in the human population in late 2019, it has spread on an unprecedented scale worldwide leading to the first coronavirus pandemic. SARS-CoV-2 infection results in a wide range of clinical manifestations from asymptomatic to fatal cases. Although intensive research has been undertaken to increase understanding of the complex biology of SARS-CoV-2 infection, the detailed mechanisms underpinning the severe pathogenesis and interactions between the virus and the host immune response are not well understood. Thus, the development of appropriate animal models that recapitulate human clinical manifestations and immune responses against SARS-CoV-2 is crucial. Although many animal models are currently available for the study of SARS-CoV-2 infection, each has distinct advantages and disadvantages, and some models show variable results between and within species. Thus, we aim to discuss the different animal models, including mice, hamsters, ferrets, and non-human primates, employed for SARS-CoV-2 infection studies and outline their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis. Moreover, a significant advantage of these animal models is that they can be tailored, providing unique options specific to the scientific goals of each researcher.

• Molecules and Cells
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• 제46권11호
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• pp.710-724
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• 2023

The plant defense responses to microbial infection are tightly regulated and integrated with the developmental program for optimal resources allocation. Notably, the defense-associated hormone salicylic acid (SA) acts as a promoter of flowering while several plant pathogens actively target the flowering signaling pathway to promote their virulence or dissemination. Ralstonia pseudosolanacearum inject tens of effectors in the host cells that collectively promote bacterial proliferation in plant tissues. Here, we characterized the function of the broadly conserved R. pseudosolanacearum effector RipL, through heterologous expression in Arabidopsis thaliana. RipL-expressing transgenic lines presented a delayed flowering, which correlated with a low expression of flowering regulator genes. Delayed flowering was also observed in Nicotiana benthamiana plants transiently expressing RipL. In parallel, RipL promoted plant susceptibility to virulent strains of Pseudomonas syringae in the effector-expressing lines or when delivered by the type III secretion system. Unexpectedly, SA accumulation and SA-dependent immune signaling were not significantly affected by RipL expression. Rather, the RNA-seq analysis of infected RipL-expressing lines revealed that the overall amplitude of the transcriptional response was dampened, suggesting that RipL could promote plant susceptibility in an SA-independent manner. Further elucidation of the molecular mechanisms underpinning RipL effect on flowering and immunity may reveal novel effector functions in host cells.

• 복식문화연구
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• 제32권1호
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• pp.38-57
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• 2024

This study utilizes social big data to investigate the factors influencing the awareness, attitude, and behavior toward vegan fashion consumption among global and Korean consumers. Social media posts containing the keyword "vegan fashion" were gathered, and meaningful discourse patterns were identified using semantic network analysis and sentiment analysis. The study revealed that diverse factors guide the purchase of vegan fashion products within global consumer groups, while among Korean consumers, the predominant discourse involved the concepts of veganism and ethics, indicating a heightened awareness of vegan fashion. The research then delved into the factors underpinning awareness (comprehension of animal exploitation, environmental concerns, and alternative materials), attitudes (both positive and negative), and behaviors (exploration, rejection, advocacy, purchase decisions, recommendations, utilization, and disposal). Global consumers placed great significance on product-related information, whereas Korean consumers prioritized ethical integrity and reasonable pricing. In addition, environmental issues stemming from synthetic fibers emerged as a significant factor influencing the awareness, attitude, and behavior regarding vegan fashion consumption. Further, this study confirmed the potential presence of cultural disparities influencing overall awareness, attitude, and behavior concerning the acceptance of vegan fashion, and offers insights into vegan fashion marketing strategies tailored to specific cultures, aiming to provide vegan fashion companies and brands with a deeper understanding of their consumer base.

• 한국비블리아학회지
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• 제29권2호
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• pp.109-126
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• 2018

공공도서관에서 공중에게 도서관서비스를 제공하는 사서는 감정노동의 종사자라 할 수 있다. 그리고 공공도서관 사서의 감정노동은 종사자의 감정과 조직에서 요구하는 감정 간의 차이로 인하여 지각하게 되는 스트레스를 구성하게 되어, 조직몰입이나 직무만족 등의 조직유효성에 영향을 미치게 된다. 이에 본 연구는 공공도서관 사서의 감정노동이 직무몰입과 직무만족에 미치는 영향에 대해서 살펴보고자 한다. 이를 위하여 문헌조사를 통한 공공도서관 사서와 감정노동과의 개념적 배경을 바탕으로, 공공도서관 사서의 조직몰입과 조직만족 대한 이론적 근거를 마련하였다. 그리고 본 연구는 수도권소재 33개 공공도서관에 근무하는 238명의 사서를 대상으로 설문조사를 실시하여, 조사된 설문내용은 SPSS20 통계패키지를 이용한 통계분석으로 처리하여 각 변인간의 관계를 분석하였다. 그리고 이러한 분석결과를 바탕으로 공공도서관 사서의 감정노동이 공공도서관 사서의 조직몰입과 조직만족에 미치는 영향에 대한 토론을 전개하였다.