• Journal of the Korea Safety Management & Science
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• v.10 no.1
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• pp.167-174
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• 2008

본 연구는 공급자, 중간분배자 그리고 고객으로 구성된 2 단계 공급사슬에서 시간에 따라 일정률로 퇴화하는 퇴화성 제품을 취급하는 중간분배자의 경제적 재고모형을 분석하였다. 문제 분석을 위하여 공급자는 고객으로부터의 수요를 증대시키기 위한 수단으로 일정한 묶음 단위별로 일정한 양의 덤을 제공한다는 가정 하에 재고모형을 설계하였고, 모형 분석을 통하여 이익을 최대화하는 경제적 주문량 결정 방법을 제시하였다. 또한 예제를 통하여 제시된 해법을 적용하고, 그 타당성을 보였다.

• Journal of the Korean Ceramic Society
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• v.35 no.9
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• pp.958-968
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• 1998

Porous silica ceramics were prepared using DCCA(Drying Control Chemical Additives) Such as uncharged polymer(Polyethylene glycol) and protein (Lipase) under H2O/Low-grade TEOS=10 C2H5OH/Low-grade TEOS=1 HC1/Low=grade TEOS=0.01 After Plain which doesn't added DCCA and samples of 11 sorts which varied molecular weight of PEG(Mw=600, 1000, 2000) quantity of Lipase and concentration of wat-er were synthesized gellation time and thermal analysis were investigated. After heat-treated at 600, cry-stal structures analyses of SiO2 polymer and characteristics of pores were investigated. Gellation time was retarded about 2-6 times as compared with plain resulting in addition of DCCA and crystal structures ex-hibited amorphous state. Moreover as increase of water a short gellation time was obtained. The samples added PEG showed increase of specific surface areas up to 20-40% and had micropores while those of Lipase were decreased about 90% and showed broad pore size distribution.

• International Journal of Oral Biology
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• v.31 no.2
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• pp.67-72
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• 2006

Nitric oxide(NO) is a labile, uncharged, reactive radical that functions as a sensitive mediator of intercellular communication in diverse tissues. It has been reported that NO is produced by osteoblast and these results may suggest that NO is integrally involved in the regulation of osteoclast formation and osteoclast resorption activity by osteoblastic cells. We examined the effect of cytokines on NO release by mouse bone marrow cell. We also examined the effects of cytokines and sodium nitroprusside(SNP) on the formation of osteoclast-like cell from mouse bone marrow cells in culture. Cytokines stimulated NO production of mouse bone marrow cells, and N-nitro-L-arginine methyl ester, a specific inhibitor of NO synthase, suppressed the cytokine-induced NO production. SNP showed dual action in the generation of osteoclasts. The addition of $30{\mu}M$ SNP inhibited the formation of tartrate resistant acid phosphatase(TRAP)(+) multinucleated cell, whereas lower concentration($3{\mu}M$) of SNP enhanced it. Although the precise action of NO remains to be elucidated in detail, the action of NO in osteoclast generation in our studies seems to be associated, at least in part, with bone metabolism and bone pathophysiology.

• Explosives and Blasting
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• v.38 no.4
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• pp.16-25
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• 2020

Multi-setting smart-investigation of the ground and large uncharged hole boring (MSP) method to reduce the blast-induced vibration in a tunnel excavation is carried out over 50m of long-distance boring in a horizontal direction and thus has been accompanied by deviations in boring alignment because of the heavy and one-directional rotation of the rod. Therefore, the deviation has been adjusted through the boring machine's variable setting rely on the previous construction records and expert's experience. However, the geological characteristics, machine conditions, and inexperienced workers have caused significant deviation from the target alignment. The excessive deviation from the boring target may cause a delay in the construction schedule and economic losses. A deep learning-based prediction model has been developed to discover an ideal initial setting of the MSP machine. Dropout, early stopping, pre-training techniques have been employed to prevent overfitting in the training phase and, significantly improved the prediction results. These results showed the high possibility of developing the model to suggest the boring machine's optimum initial setting. We expect that optimized setting guidelines can be further developed through the continuous addition of the data and the additional consideration of the other factors.

• Restorative Dentistry and Endodontics
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• v.27 no.5
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• pp.543-551
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• 2002

Nitric oxide (NO) is a small molecule (mol. wt. 30 Da) and oxidative free radical. It is uncharged and can therefore diffuse freely within and between cells across membrane. Such characteristics make it a biologically important messenger in physiologic processes such as neurotransmission and the control of vascular tone. NO is also highly toxic and is known to acts as a mediator of cytotoxicity during host defense. NO is synthesized by nitric oxide synthase (NOS) through L-arginine/nitric oxide pathway which is a dioxygenation process. NO synthesis involves several participants, three co-substrates, five electrons, five co-factors and two prosthetic groups. Under normal condition, low levels of NO are synthesized by type I and III NOS for a short period of time and mediates many physiologic processes. Under condition of oxidant stress, high levels of NO are synthesized by type II NOS and inhibits a variety of metabolic processes and can also cause direct damage to DNA. Such interaction result in cytostasis, energy depletion and ultimately cell death. NO has the potential to interact with a variety of intercellular targets producing diverse array of metabolic effects. It is known that NO is involved in hemodynamic regulation, neurogenic inflammation, re-innervation, management of dentin hypersensitivity on teeth. Under basal condition of pulpal blood flow, NO provides constant vasodilator tone acting against sympathetic vasoconstriction. Substance P, a well known vasodilator, was reported to be mediated partly by NO, while calcitonin-gene related peptide has provided no evidence of its relation with NO. This review describes the roles of NO in dental pulp in addition to the known general roles of it.