• Bulletin of the Korean Chemical Society
• /
• 제34권1호
• /
• pp.154-158
• /
• 2013

Development of dual functional liposome has been studied for cancer theragnostics. Therefore, we focused on ultrasound-sensitive liposomes with doxorubicin (DOX) and gadolinium (Gd) as a theragnostic carrier having a potential for cancer therapy and diagnosis. In this study, Gd(III)-DOTA-modified sonosensitive liposomes (GL) was developed using chemically synthesized Gd(III)-DOTA-DPPE lipid. Sonosensitivity of GL to 1 MHz ultrasound induced 25% of DOX release. The relaxivities ($r_1$) of GL were $7.33-10.34\;mM^{-1}s^{-1}$, which was higher than that of MR-bester$^{(R)}$. Intracellular delivery of DOX from GL by ultrasound irradiation was evaluated according to ultrasound intensity, resulting in increase of uptake of DOX released from ultrasound-triggered GLs compared to GL3 or Doxil$^{(R)}$ without ultrasound. Taken together, this study shows that the paramagnetic and sonosensitive liposomes, GL, is a novel and highly effective delivery system for drug with the potential for broad applications in human disease.

• 대한화학회지
• /
• 제54권5호
• /
• pp.582-588
• /
• 2010

Thiosemicarbazides의 cyclocondensation을 이용한 1,3,4-thiadiazoles, 1,3,4-triazoles과 1,3,4-oxadiazole계의 benzofuran의 합성을 좋은 수율로 합성하였다.

• The Journal of Korean Physical Therapy
• /
• 제15권1호
• /
• pp.9-25
• /
• 2003

The purpose of this study was to evaluate the effect of therapeutic ultrasound after muscle contusion injury by observed immunoreactivity of substance-P that plays an important role in pain transmission. Ultrasound irradiation(1MHz, 1W/$cm^{2}$ continuous mode, treatment time 5 min) was applied through water submersion technique to 1 limb daily by kept off 5cm from muscle belly of gastrocnemius. The result of this study were as follows. 1. The substance-P was expressed in lamina I and II of dorsal horn of spinal cord, also in lamina IV and around of central cannel of spinal cord. Experimental group was lower expressed than control group with the exception of 1 days. 2. The substance-P immunoreactivity was decreased for 5 days together in lumbar and sacral region of all groups, expecially experimental group was rapidly. These data suggest therapeutic ultrasound may stimulate pain relief by diminish of substance-P in dorsal horn of spinal cord.

• 환경위생공학
• /
• 제14권1호
• /
• pp.54-61
• /
• 1999

The industrial techniques of ultrasound have been used in the various fields, such as cleaning, medical surgery, emulsification, cell disruption etc. Especially the application of cell disruption was interested in the field of disinfection process in water by ultrasonic irradiation. It has been recognized that the ultrasounds are irradiated in aqueous solution, cavitation bubbles are generated and shock waves of high temperature and pressure are emitted as the bubbles are developed and finally broken, which function as a energy source to promote reaction efficiencies of various kinds of chemical reactions such as disinfection reaction in water. Therefore, this study was performed to apply the ultrasound for the disinfection method of infected drinking raw water and to discuss the limiting factors such as pH, sample volume and reaction temperature influenced on the removal efficiency of E. coli from experimental analysis of the results obtained in bench-scale plant. For the experiments to measure the influence of reaction parameters in the ultrasonic disinfection process, escalated reactivity of aqueous solutions was excellent when pH in aqueous solution was low, and sample volume was small. On the contrary, the reactivity of disinfection became elevated when reaction temperature was high. It was found that the rate constant of disinfection reaction was applied by Chick's law, reaction kinetics of Chick's law was irreversible and pseudo-first order at all the tested conditions.As a conclusion it appeared that the technology using ultrasonic irradiation can be applied to the treatment of disinfection in infected water which are difficult to be treated by conventional methods.

• Environmental Engineering Research
• /
• 제8권2호
• /
• pp.72-81
• /
• 2003

• 한국자기학회:학술대회 개요집
• /
• 한국자기학회 2003년도 하계학술연구발표회 및 한.일 공동심포지엄
• /
• pp.190-191
• /
• 2003

• 한국재료학회:학술대회논문집
• /
• 한국재료학회 2001년도 추계 학술발표강연 및 논문개요집
• /
• pp.56-56
• /
• 2001

• 한국세라믹학회:학술대회논문집
• /
• 한국세라믹학회 2003년도 추계총회 및 연구발표회 초록집
• /
• pp.113.2-113
• /
• 2003

• 폴리머
• /
• 제38권3호
• /
• pp.378-385
• /
• 2014

초음파를 이용한 수중 반응을 통하여 친수성 고분자인 poly(vinyl alcohol) (PVA)를 다중벽 탄소나노튜브 표면에 개질하였다. 초음파 인가 시 PVA는 라디칼을 지닌 상태로 절단되며 탄소나노튜브는 일반적으로 라디칼 스캐빈저 역할을 하므로 생성된 PVA 라디칼과 반응하여 PVA 사슬이 탄소나노튜브 표면에 그래프트 된다. PVA의 그래프트 반응을 조절하기 위하여 초음파 인가 조건을 300과 500 W로 선택하였으며, 인가 시간은 최대 50분으로 하였다. 탄소나노튜브 표면에 그래프트된 PVA는 FTIR, TGA, SEM, 및 TEM을 통하여 분석하였다. 또한 PVA로 개질된 탄소나노튜브의 분산안정성을 분석하였다. 그래프트된 PVA의 양은 초음파의 인가 출력과 인가 시간에 비례하여 증가하였으며, PVA로 개질된 탄소나노튜브는 물 속에서 매우 안정적인 분산성을 보였다. 이는 복잡한 화학반응 과정없이 초음파를 이용하면 탄소나노튜브를 고분자로 간단히 개질할 수 있음을 보여준다.

• Bulletin of the Korean Chemical Society
• /
• 제31권6호
• /
• pp.1589-1595
• /
• 2010

In order to effective degradation of organic dye both under visible light or ultrasonic irradiation, the MWCNTs (multiwalled carbon nanotube) deposited with Fe and $TiO_2$ were prepared by a modified sol-gel method. The Fe/$TiO_2$-MWCNT catalyst was characterized by surface area of BET, scanning electron microscope (SEM), Transmission Electron Microscope (TEM), X-ray diffraction (XRD), and energy dispersive X-ray (EDX) and ultraviolet-visible (UV-vis) spectroscopy. The low intensity visible light and low power ultrasound was as an irradiation source and the methylene blue (MB) was choose as the model organic dye. Then degradation experiments were carried out in present of undoped $TiO_2$, Fe/$TiO_2$ and Fe/$TiO_2$-MWCNT catalysts. Through the degradation of MB solution, the results showed the feasible and potential use of Fe/$TiO_2$-MWCNT catalyst under visible light and ultrasonic irradiation due to the enhanced formation of reactive radicals as well as the possible visible light and the increase of ultrasound-induced active surface area of the catalyst. After addition of $H_2O_2$, the MB degradation rates have been accelerated, especially with Fe/$TiO_2$-MWCNT catalyst, in case of that the photo-Fenton reaction occurred. The sonophotocatalysis was always faster than the respective individual processes due to the more formation of reactive radicals as well as the increase of the active surface area of Fe/$TiO_2$-MWCNT catalyst.