• Journal of Korean Elementary Science Education
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• v.21 no.2
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• pp.201-212
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• 2002

This paper aims to find out how did elementary students understand scientific units in science textbooks. The subjects were 191 students of the 6th grade from 7 elementary schools in 3 different areas, consisting of 70 from 4 village schools of, 64 from 2 town schools of Gyeongnam province, and 57 from one city school in Ulsan Metro City. A test was developed based on the analysis of scientific units in the science textbooks and teacher's manuals constructed according to the 6th and 7th National Science Curriculum. The understanding of elementary students' on the scientific units(Temperature, Length, Weight, Volume, Speed, Plane Angle) were surveyed. The result are as follows: Regarding the temperature unit, the students generally well understand why to measure and how to read temperature, but had some problem in recording it, in confusion with the plane angle sign. As for the length unit, they obtained high scores in understanding the purpose of measuring length as well as recording and reading it. Which indicates that they are well aware of and use the unit appropriately. With respect to the weight unit, they got high scores in reading and recording weight, which means most students have no problem using the unit. However, it was found that they do not understand why to use the plate balance scale. The volume unit was one in which the students got relatively lower scores. They do not perceive the object of using a scale cylinder and confuse it with a device of length measurement. The unit of speed is the most difficult one for children's of science to understand, presumably, because it is an derived unit from two basic units. It is also assumed that the students got the highest score in the plane angle unit because they studied the unit immediately before the test. From the children's understanding of science units above the teacher's understanding and teaching methods presumed to play a major role for children to understand and use the science units properly.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.501-509
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• 2016

Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer cells by inducing apoptosis. Shikonin's biological activity was validated by observing cell viability, caspase 3 activity, reactive oxygen species (ROS) generation, and apoptotic marker expressions in AGS stomach cancer cells. The concentration range of shikonin was 35-250 nM with the incubation time of 6 h. Protein levels of Nrf2 and p53 were evaluated by western blotting and confirmed by real-time PCR. Our results revealed that shikonin induced the generation of ROS as well as caspase 3-dependent apoptosis. c-Jun-N-terminal kinases (JNK) activity was significantly elevated in shikonin-treated cells, thereby linking JNK to apoptosis. Furthermore, our results revealed that shikonin induced p53 expression but repressed Nrf2 expression. Moreover, our results suggested that there may be a co-regulation between p53 and Nrf2, in which transfection with siNrf2 induced the p53 expression. We demonstrated for the first time that shikonin activated cell apoptosis in AGS cells via caspase 3- and JNK-dependent pathways, as well as through the p53-Nrf2 mediated signal pathway. Our study validates in partly the contribution of shikonin as a new therapeutic approaches/agent for cancer chemotherapy.

• Design & Manufacturing
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• v.10 no.3
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• pp.14-19
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• 2016

Thermally or electrically conductive filler reinforced polymer composites are extensively being developed as the demand for light weight material increases rapidly in industiral applications need good conductivity such as heat sink of the electronics or light. Carbon or ceramic materials like graphite, carbon nanotube or boron nitride are typical conductive fillers with good thermal or electical conductivity. Using these conductive fillers, the polymer composites in the market show wide range of thermal conductivity from approximately 1 W/mK to 20 W/mK, which is quite enhanced considering the thermal conductivity lower than 0.5 W/mK for most polymeric materials. The practical use of these composites, however, is yet limited to specific applications because most composites are still not conductive enough or too difficult to process, too brittle, too expensive for higher conductivity. For practical use of conductive composite, the thermal conductivity required depending on the heat releasing mode are studied first for simplified unit cooling geometry to propose thermal conductivities of the composites for reasonable cooling performance comparing with the metal heat sink as a reference. Also, as a practical design for heat sink based on polymer composite, composite and metal sheet hybrid structures are investigated for LED lamp heat sink and audio amplication module housing to find that this hybrid structure can be a good solution considering all of the cooling performance, manufacturing, mechanical performance, cost and weight.

• Microbiology and Biotechnology Letters
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• v.33 no.2
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• pp.90-95
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• 2005

An Actinomycetes producing an anti-VRSA (vancomycin-resistant Staphylococcus aureus) substance was isolated from soil. The cultural, morphological, physiological and phylogenetic analyses of an isolated strain were investigated for identification. Cultural characteristics based on ISP (International Streptomyces Project) were as follows: white aerial mycelium, yellow reverse side, and good growth on various medium. Also, the isolate did not produce the soluble pigment. Morphological characteristics were showed cylindrical spore chain and smooth spore surface by SEM (Scanning Electron Microscope). Physiological characteristics were showed LL-type by DAP isomer analysis and detected glycine, glutamic acid and alanine. A phylogenetic analysis of the 16S rDNA provided a clue that the isolated strain was actually a member of the genus Streptomyces, because the determined sequence exhibited a higher homology with Streptomyces echinatus. The isolate was identified to be a genus of Streptomyces sp.. The optimal culture conditions for the maximum production of anti-VRSA substance by Streptomyces sp. were attained in a culture medium composed of $2.0\%$ (w/v) glucose, and $0.4\%$ (w/v) yeast extract. The anti-VRSA substance was highly produced after 5 days of culture. Optimal pH and temperature conditions for the production of anti-VRSA substance were pH 7.0 and $28^{\circ}C$, respectively.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.936-936
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• 2006

Bulk amorphous materials have been intensively studied to apply for various advanced industry fields due to their high mechanical, chemical and electrical properties. These materials have been produced by several techniques such as mechanical alloying, melt spinning and gas atomization, etc. Among them, the atomization is the most potential technique for commercialization due to high cooling rate during solidification of the melt and mass productivity. However, the amorphous powders still have some limitations because of their low ductility and toughness. Therefore, intensive efforts have to be carried out to increase the ductility and toughness. In this study, the Ni-based amorphous powder was produced by the gas atomization process. And in order to increase the ductile toughness, ductile Cu phase was coated on the Ni amorphous powder by spray drying process. The characteristics of the as-synthesis powders have been examined and briefly mentioned. The master alloy with $Ni_{57}Zr_{20}Ti_{16}Si_2Sn_3$ was prepared by vacuum induction melting furnace with graphite crucible and mold. The atomization was conducted at $1450^{\circ}C$ under the vacuum of $10^{-2}$ torr. The gas pressure during atomization was varied from 35 to 50 bars. After making the Ni amorphous powders, the spray drying was processed to produce the Cu -coated Ni amorphous composite powder. The amorphous powder and Cu nitrate solution were mixed together with a small amount of binder and then it was sprayed at temperature of $130^{\circ}C$ and rotating speed of 15,000 R.P.M.

• BMB Reports
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• v.49 no.1
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• pp.51-56
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• 2016

Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine protein kinase that is known to mediate cancer cell death. Here, we show that B-cell lymphoma 2 (Bcl-2), an anti-apoptotic protein, is regulated by GSK-3β and that GSK-3β-mediated regulation of Bcl-2 is crucial for mitochondrial-dependent cell death in paclitaxel-stimulated cells. We demonstrate that MCF7 GSK-3β siRNA cells are more sensitive to cell death than MCF7 GFP control cells and that in the absence of GSK-3β, Bcl-2 levels are reduced, a result enhanced by paclitaxel. Paclitaxel-induced JNK (c-Jun N-terminal kinase) activation is critical for Bcl-2 modulation. In the absence of GSK-3β, Bcl-2 was unstable in an ubiquitination-dependent manner in both basal- and paclitaxel-treated cells. Furthermore, we demonstrate that GSK-3β-mediated regulation of Bcl-2 influences cytochrome C release and mitochondrial membrane potential. Taken together, our data suggest that GSK-3β-dependent regulation of Bcl-2 is crucial for mitochondria-dependent cell death in paclitaxel-mediated breast cancer therapy. [BMB Reports 2016; 49(1): 51-56]

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1241-1246
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• 2009

It has been suggested that Tae-Eum peoples are prone to obesity. Although extensive clinical observations have shown this tendency in Sasang Constitutional Medicine (SCM), no scientific hypothesis has been proposed to delineate its mechanism. According to SCM theory, Tae-Eum peoples have a hypoactive lung system and a hyperactive liver system. In this paper we propose a new hypothesis explaining the tendency of obesity in Tae-Eum people in the viewpoint of cell physiology. The hypoactive lung system might imply an attenuated 'respiration' at the cell/subcell level, namely mitochondrial oxygen consumption. Because a functional weakness in mitochondria energy metabolism indicates intrinsic hypo-activity in the consumption (or production) of metabolic energy, we deduced that the tendency can easily induce body weight gain via an increase in anabolism. This relation is also introduced in the graph of cellular metabolic power against body weight. To test this hypothesis, we analyzed the clinical data with 863 subjects. Statistical analysis of the data showed that Tae-Eum peoples had relatively a lower cellular metabolic power, and that the percentage of peoples with BMI>25 was significantly higher than that of the other constitutional types.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.17 no.1
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• pp.27-43
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• 2014

The purpose of this research is to assess potential area of mountainous wetland by GIS and AHP (Analytic Hierarchy Process). Mountainous wetland is topographically located at high altitude, so it's difficult to approach for researchers. And, it's difficult to investigate systematically because of the insufficient information of mountainous wetland. Therefore, it's necessary to study on potential area of mountainous wetland for systematic and efficient investigation. This research selected slope, wetting index, land-cover map and soil map as assessment items indicating environmental characteristics of mountainous wetland and established them by GIS DB. And, spatial value of mountainous wetland for each assessment item was drawn by existing investigation data and overlap analysis of mountainous wetland. Based on the numerical results of each assessment item, a survey was conducted and relative importance for each assessment item was decided by AHP. As the result, slope was the highest as 0.550 and ground coverage was the lowest as 0.083. The subject of this research was Yangsan-si and Ulsan of Gyeongnam and an analysis was conducted for mountainous wetland in those research areas. As the result, all of wetland was distributed in the range of potential area. And, field survey and literature search were conducted for the point that the distribution of mountainous wetland is expected. As the result, mountainous wetland was distributed. Therefore, mountainous wetland should be excavated through the results of this research and it should be helpful for effective investigation as providing information necessary to the following studies on mountainous wetland.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.6
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• pp.3963-3972
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• 2015

This study was conducted to evaluate the effects of simulation integrated with problem based learning in terms of critical thinking, problem solving, learning motivation according to Myers-Briggs type indicator(MBTI) personality type in advanced nursing course students. This study was a non-equivalent control posttest only design. Students were all enrolled in advanced nursing course which included 1) 6 weeks problem based learning 2) 5 weeks simulation integrated with PBL and debriefing. Total 19 students' data were collected and analyzed on SPSS win 21.0. The results showed students who have out patients working experience were significantly higher learning motivation(${\chi}^2=9.85$, p=.044), no experienced simulation were significantly higher critical thinking(${\chi}^2=4.44$, p=.035) and as temperament of MBTI, NT types were significantly higher on critical thinking(${\chi}^2=8.53$, p=.036). Students show various personality types and it might be impact on attitudes of learning and the results. Thus we need to understand their diversity and consider it to apply teaching methods on nursing education.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.6
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• pp.141-150
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• 2021

In order to assess the impact of climate change on irrigation reservoirs, climate exposure (EI), sensitivity (SI), and potential impact (PI) were evaluated for 1,651 reservoirs nationwide. Climate exposure and sensitivity by each reservoir were calculated using data collected from 2011 to 2020 for seven proxy variables (e.g. annual rainfall) and six proxy variables (e.g. irrigation days), respectively. The potential impact was calculated as the weighted sum of climate exposure and sensitivity, and was classified into four levels: 'Low (PI<0.4)', 'Medium (PI<0.6)', 'High (PI<0.8)', and 'Critical (PI≥0.8)'. The result showed that both the climate exposure index and the sensitivity index were on average high in Daegu and Gyeongbuk with high temperature and low rainfall. About 79.8% of irrigation reservoirs in Daegu, Gyeongbuk, and Ulsan with high climate exposure and sensitivity resulted in a 'High' level of potential impact. On the contrary, 64.5% of the study reservoirs in Gyeongnam and Gangwon showed 'Low' in potential impact. In further studies, it is required to reorganize the proxy variables and the weights in accordance with practical alternatives for improving adaptive capacity to drought, and it is expected to contribute to establishing a framework for vulnerability assessment of an irrigation reservoir.