• 생약학회지
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• 제34권4호통권135호
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• pp.288-292
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• 2003

We compared the antitumor activity between hollow fiber assay and xenographic animal assay on thirty herbal plants. It is evaluated that the antitumor activity of above 30% is regarded as 'positive response', and its of below 30% is regarded as 'negative response'. The two herbal plants extracts (Ulmus davidiana Hedyotis diffusa) among thirty herbal plants show to be positive in xenographic animal assay and they were also correctly identified as positive by the hollow fiber assay. The correlation of the hollow fiber assay data with xenographic animal assay would suggest that hollow fiber assay presents a potentially unique tool to develop the herbal medicine for cancer.

• Applied Microscopy
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• 제22권1호
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• pp.70-78
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• 1992

Antibacterial effects of the water-soluble extract of Ulmus pumila L. on Staphylococcus aureus and Escherichia coli were studied by cylinder plate dilution method. The cells of S. aureus and E. coli treated with the extract were comparatively examined by scanning and transmission electron microscopies for their morphological features. The normal cells of S. aureus and E. coli showed thypical coccus and rod shapes, respectively, but the cells of S. aureus treated with the extract showed rough surface structures with many granular protrusions and were destroyed to form ghost cells by liberating their cytoplasmic components. E. coli cells treated with the extract were destoryed without enlarging in size and producing granules on their surfaces.

• The Korean Journal of Ecology
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• 제15권1호
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• pp.59-65
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• 1992

Pollen analysis to clear vegetational history of korea was carried out on the deposite taken from the pit of the miruksa site, south-western korea(36o00'18'N, 127o1'12'E, 10m in alt.). This area has been known as the cool temperate zone(southern zone) according to yim and kira(1975). But, now we can not found the original vegetation because the area has been disturbed severely and almost area changed to cultivated land.the area is one of the most developd area in early agricultural stage of korea. By the pollen diagram, three local pollen zones are distinguished in this site, bottom to surface, as following. is-Ⅰ :pinus-quercus zone (140∼120 cm, sample 1 and 2) is-Ⅱ :ulmus+zelkova zone(120∼84 cm, sample 3∼6) is-Ⅲ :pinus zone(84∼0 cm, sample 7 ∼13) is-Ⅰ is characterized by high values in frequences of pinus, the temperate conifer and quercus the cool temperate oak, and is-Ⅱ zone by the decrease of quercus and increase of ulmus and increase of ulman+zelkova as ravine forest elements, isⅢ zone is characterized by pinus, especially, based on data of sample no.9.

• Journal of the Korean Wood Science and Technology
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• 제9권3호
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• pp.1-6
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• 1981

This study examined the radial variations in element demensions of mongolian oak (Quercus mongolica.), elm (Ulmus japonica.), maackia(Maackia amurensis.), castor aralia (Kalopanax pictus.) from pith outwards. Disks were cut from the d.b.h.(above 1.2m) of each species and specimen for tangential pore diameters, fiber length, ray height and width were taken from 1-3rd, 5th, 10th, 15th.............40th ring number from pith. The tangential pore diameters in the earlywood increased rapidly near the pith and then maintained almost constant or very gradually increased diameters in about 20th-30th ring number from pith. In the latewood, tangential pore diameters gradually increased from pith to outwards though the increment is smaller than in early wood. Radial variations of ray height and width maintained almost constant, gradually increased or rapidly increased diameters and then maintained almost constant from pith to outwards. Patterns of radial variations in the fiber length were almost coincident with patterns of earlywood pore diameters, and of ray height or width in Ulmus japonica and Maackia amurensis.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.196.2-196.2
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• 2003

The Barks of Ulmus davidiana (Ulmaceae) have been used for the treatment of insecticide, anti-boil and anti-fungi in Korean traditional medicine. Four phenolic compounds were isolated from 80% Acetone extracts. The structures of these compounds were elucidated as (+)-catechin, (+)-catechin 7-O-${\beta}$-D-glucopyranoside, (+)-catechin 7-O-${\beta}$-D-xylopyranoside and procyanidin B-1. These phenolic compounds showed significant nitrogen monoxide(NO) production inhibitory activity in IFN-${\gamma}$, LPS stimulated RAW 264.7 cell and also showed significant antioxidative activity on DPPH radical. (omitted)

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2019년도 정기학술대회 발표논문집
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• pp.208-208
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• 2019

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.239.2-239.2
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• 2000

• 한국식품과학회지
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• 제37권3호
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• pp.479-483
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• 2005

느릅나무 에탄올 추출물의 각 용매 분획물에 대한 항산화활성과 L-glutamate에 의하여 유도된 PC 12세포에 대한 세포 독성 및 세포 내 활성산소종(ROS)을 측정하였다. 느릅나무 수피의 에틸아세테이트 및 부탄올 분획과 근피의 에틸아세테이트 분획층은 흰쥐 뇌조직에서 $FeSO_{4}-H_{2}O_{2}$로 유도한 산화적 스트레스를 유의하게 억제하였으며 강한 fire radical 소거능을 나타내었다. 또한 glutamate에 의하여 PC 12 세포의 생존율이 억제되었고 세포내 ROS가 증가하였으며 이러한 ROS의 증가는 근피의 에틸아세테이트 및 부탄올 획분에 의하여 억제되었다. 따라서 느릅나무 근피의 에틸아세테이트 및 부탄올 획분은 PC 12 세포에서 glutamate로 유도된 세포내 ROS를 억제함으로써 세포의 독성을 보호한 것으로 사료되었다.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.86-95
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• 2011

Objectives : Ulmus davidiana (UD) has been widely used in Korean herbal medicines used for treatment of acute and chronic inflammatory diseases, such as rhinitis, asthma, and abscess. In this study, To investigated the protective effect of UD on type 1 allergic response, we determined whether UD inhibits early and late allergic response. Methods : The effect of UD was analyzed by ELISA and RT-PCR in RBL-2H3 cells. Levels of ${\beta}$ -hexosaminidase, interleukin (IL)-4 and TNF-${\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISAs). mRNA levels of COX-2 and T-helper type 2(Th2) cytokines were analyzed with RT-PCR. Results : We found that UD suppressed ${\beta}$-hexosaminidase release in RBL-2H3 not only by the PMA plus A23187 stimulation, but also by the IgE-DNP-HSA stimulation at the antigen-antibody binding stage and antibody-receptor binding stage. UD also significantly inhibited COX2 level, along with reduced Th2 cytokine levels, such as IL-3, IL-4, IL-5, IL-13, GM-CSF, and TNF-${\alpha}$ in RBL-2H3. Conclusions : Our results indicate that UD protects against type 1 allergic response and exerts an anti-inflammatory effect through the inhibition of degranulation and expression of COX2 and Th2 cytokines.

• KSBB Journal
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• 제16권6호
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• pp.554-561
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• 2001

본 연구에서는 느릅나무 뿌리껍질에서 분리한 신규 균주인 Enterobacter sp. SSYL(KCTC 0687BP)을 사용하여 세포밖 당화합물(exopolysaccharide, EPS)을 생산하여, EPS의 면역활성에 의한 항암효과를 실험적으로 제시하였다. EPS는 총당함량이 43.0% 내지 70.8%였으며, 총산성당 함량은 7.1% 내지 11.4%, 총단백질 함량은 19.3% 내지 20.6%로, 분자량은 100,000에서 1,000,000 Da의 당단백질임을 알 수 있었다. EPS의 당구성성분을 보면 glucuronic acid (46.7%), fucose(10.8%), fructose (0.2%), glucose(29.9%), galactose(11.0%)이었고, 이외 미지의 성분이 1.3% 정도였다. EPS의 면역활성 검정에 따르면 EPS는 면역세포의 증식을 자극하는 mitogen역할을 하며, 특히 T 세포에 의한 면역증강효과를 나타내었다. B16 흑색종 이식마우스를 이용한 생체내 면역활성에 의한 항암효과를 관찰한 결과 유의성 있는 항암효과를 나타내었으며, 천연물인 유근피 추출 단백다당체의 결과(3 mg/kg에서 약 140%의 생존연장효과를 보임)와 비교해 볼 때 1/10의 농도인 0.3mg/kg에서 약 138.1%의 비슷한 항암효과를 나타내었다.