• Korean Journal of Medicinal Crop Science
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• v.19 no.4
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• pp.217-226
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• 2011

The study was conducted to investigate candidate materials as anti-inflammation agent from plant resources. Activities of 33 plant parts extracts with the final concentration of 5${\mu}g/ml$ were evaluated on the several inflammation-related markers such as the release of proinflammatoty cytokine [tumor necrosis factor-alpha (TNF-${\alpha}$) & interleukin-6 (IL-6)], nitric oxide (NO), the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and inhibitor of nuclear factor kappa-B alpha ($I{\kappa}-B{\alpha}$) in lipopolysaccharide (LPS)-treated RAW 264.7 cells. The extracts in the final concentration of 10 ${\mu}g/ml$ were also screened on peroxynitrite (ONOO$^-$) scavenging activity. Eleven extracts selected from the screening assay were verified on the inhibition activity on peroxynitrite and total reactive species oxygen (ROS) in the several concentrations. As results, Alpinia officinarum Hance (rhizome), Inula britannica var. chinensis Regel (flower), Ulmus arvifolia Jacq (trunk peel) and Aster scaber Thunb. (aerial part) showed comparatively potent anti-inflammatory activities in vitro cells or chemical level systems, and then these four plant parts should be studied on the antiinflammatory mechanism by further studies.

• Journal of the Korean Wood Science and Technology
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• v.28 no.2
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• pp.66-74
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• 2000

Wood of black locust(Robinia pseudoacacia) and bark of poplar(Populus alba x glandulosa), ash(Fraxinus rhynchophylla) and elm(Ulmus davidiana var. japonica) trees were collected, extracted with acetone-$H_2O$(7:3. v/v), fractionated with hexane, chloroform, ethylacetate and $H_2O$. then freeze dried to get some dark brown powder for bioactive tests. Decay-resistant activity was tested using wood block specimens from the hardwood trees and expressed by weight loss rate. Black locust specimens indicated the best anti-decaying property and poplar blocks were the worst. Antimicrobial and antioxidant activities were also investigated against each wood or bark extractives. Antifungal and antibacterial activities did not indicate any significant differences among the tested fractions. In antioxidant activity. ${\alpha}$-tocopherol one of natural antioxidants. and BHT, one of synthetic antioxidants, were used as references to compare with the antioxidant activities of the extracted fractions. Ethylacetate fraction of ash bark indicated the highest activity besides BHT in this test and all fractions of black locust extractives also indicated higher activities compared with the other fractions.

• Journal of the Korean Wood Science and Technology
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• v.46 no.3
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• pp.241-252
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• 2018

It was estimated that the Imdang-dong site of Gyungsan was constructed in the 2nd to 4th century based on excavated layers and artifacts. This study was carried out to verify the result using the dendrochronological analysis of six wooden pillars excavated at the site. As a result, it was proven that 6 specimens were not cut at the same age because their tree-ring chronologies were not synchronized each other. And more, it was reconfirmed in wiggle matching dating as confirming two of them were dated to A.D. 94-135 and A.D. 224-289, respectively. It was coincided with the above-mentioned estimated age. In wood identification, most of them were identified as Hovenia dulcis Thunb., Tilia spp., Ulmus spp. which grow usually under cool environment. Based on the result, we could conclude that the climate at that time was cooler than the present.

• Integrative Medicine Research
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• v.3 no.2
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• pp.67-73
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• 2014

Background: The transcription factor signal transducer and activator of transcription 3 (Stat3)is constitutively activated in many human cancers. It promotes tumor cell proliferation,inhibits apoptosis, induces angiogenesis and metastasis, and suppresses antitumor hostimmune responses. Therefore, Stat3 has emerged as a promising molecular target for cancertherapies. In this study, we evaluated the Stat3-suppressive activity of 38 herbal medicinestraditionally used in Korea.Methods: Medicinal herb extracts in 70% ethanol were screened for their ability to suppressStat3 in the A549 human lung cancer cell line. A Stat3-responsive reporter assay system wasused to detect intracellular Stat3 activity in extract-treated cells, and Western blot analyseswere performed to measure the expression profiles of Stat3-regulated proteins.Results: Fifty percent of the 38 extracts possessed at least mild Stat3-suppressive activities(i.e., activity less than 75% of the vehicle control). Ethanol extracts of Bupleurum falcatumL., Taraxacum officinale Weber, Solanum nigrum L., Ulmus macrocarpa Hance, Euonymus alatusSieb., Artemisia capillaris Thunb., and Saururus chinensis (Lour.) Baill inhibited up to 75% of thevehicle control Stat3 activity level. A549 cells treated with these extracts also had reducedBcl-xL, Survivin, c-Myc, and Mcl-1 expression.Conclusion: Many medicinal herbs traditionally used in Korea contain Stat3 activity-suppressing substances. Because of the therapeutic impact of Stat3 inhibition, these resultscould be useful when developing novel cancer therapeutics from medicinal herbs.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.24 no.2
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• pp.85-102
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• 2021

Phytosociological characteristics on Quercus acutissima forests distribution in Daechong-dam basin survey has been carried out using Z.-M. School's methodology and numerical-classification analyses. A total of 43 phytosociological relevés were sampled. Syntaxa were described as Oplismenus undulatifolius-Quercus acutissima community(typicum subcommunity, Phryma leptostachya var. asiatica subcommunity, Ulmus davidiana var. japonica subcommunity), Quercus acutissima community and Quercus variabilis-Quercus acutissima community (typicum subcommunity, Castanea crenata subcommunity). The above three plant communities were classified with species composition reflecting local environmental characteristics of mountain topographies, inclination degrees, and rock exposure rates. Conclusively, those communities were recognized as secondary vegetation affected by high intensity and frequency of human impacts as they inhabited in southward hill lands and low lying grounds in mountains adjacent to human settlements and arable lands. Quercus acutissima community was classified as rural type syntax based on their inlandward distribution and species composition differences from urban forests. Afforest process and natural succession were discussed in relation with habitat environmental elements of Quercus acutissima forest in the survey area.

• Journal of agriculture & life science
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• v.53 no.2
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• pp.65-75
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• 2019

Stem and root of elm trees have used as traditional medical materials, but there is little information on the distribution and resources of habitats. Korean native growing Ulmus spp. (U. davidiana var. Japonica, U. parvifolia, U. davidiana, and U. macrocarpa) genetic resources studied through The National Forest Inventory of Korea data and field survey. The distributions of U. davidiana var. japonica according to elevation distributed evenly. Both U. parvifolia and U. davidiana were inhabited mostly at less than 200 m of altitude. Each Ulmaceae species widely were distributed nationwide, but a dominant species was different depending on locals. It observed that Ulmaceae inhabits mainly in steep slopes of 31-45 degrees. Most of the habitats regenerated by natural seeding and the most abundant species were a codominant tree. Distribution of trees in U davidiana var. japonica was 7 m-13 m, and in young U. parvifolia and U. macrocarpa, more than 25% of young trees less than 7 m observed. The distribution of the diameter of breast height of the U. davidiana var. japonica was 46.4% for 11-20 cm, 52.6% for 11-20 cm in U. parvifolia. The average T/R ratio was 0.83, and the mean weight ratio of root bark was 62%. As the results of this study, the domestic Ulmaceae biomassare very small. It is difficult to harvest in that the habitat on the slope. Thus, it is too hard to develop functional materials using biomass at present. Therefore, it is necessary to develop technology for the selection and propagation of elite trees of Ulmaceae.

• Journal of the Korean Chemical Society
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• v.67 no.2
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• pp.120-128
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• 2023

Osteoporosis is a disease that causes the weakening of bone by increasing porosity, which often results in fractures. Osteoporosis treatment measures include the use of Bisphosphonates and estrogen. However, these treatments cannot be used in the long term as these treatments have adverse side effects. Therefore, there is a need to identify better and safer treatment options. For this, 63 plant extracts were screened and among them, six extracts showed high anti-osteoclastic activity with low cytotoxicity. Of these six extracts, three extracts, Cudrania tricuspidata (P371), Ulmus davidiana var. japonica (P401), and Torilis japonica (P411), showed more than 50 percent osteoclast inhibition. While the remaining, Stewartia pseudocamellia extracts I and II (P370, P397) and Cuscuta chinensis (P418), showed moderate or between 40-50 percent osteoclast inhibition. Among all the extracts, Torilis japonica (P411) showed the highest inhibitory action against osteoclast development. Torilis japonica (P411) primary components include Kaempferol, Quercetin, and Luteolin, all proven to inhibit osteoclastogenesis. Stewartia pseudocamellia extracts I and II (P370 and P397) showed moderate or 44% osteoclast inhibition. Stewartia pseudocamellia extract II (P397) enhanced the growth of RAW 264.7 cells by 19%. Torilis japonica (P411) and Stewartia pseudocamellia extract II (P397) suppressed the expression of osteoclast-specific genes in RANKL-induced osteoclastogenesis in RAW 246.7 cells. Torilis japonica (P411) extracts even increased osteoblast-specific RUNX2 gene expression. This results provide that six extracts could be used as a potential treatment option for osteoporosis disease with the extracts of Torilis japonica (P411) and Stewartia pseudocamellia (P397) as an ideal candidates. However, the combination of the extract with higher osteoclastic inhibition and less toxic effects with further analysis should be recommended.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.26 no.3
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• pp.29-42
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• 2023

As the destruction of habitats due to recent development continues, there is also increasing interest in endangered species. Mankyua chejuense is a vulnerable species that is sensitive to changes in population and habitat, and it has recently been upgraded from Endangered Species II to Endangered Species I, requiring significant management efforts. So in this study, we analyzed the potential habitats of Mankyua chejuense using MaxEnt(Maximum Entropy) modeling. We developed three models: one that considered only environmental characteristics, one that considered artificial factors, and one that reflected the habitat of dominant tree species in the overstory. Based on previous studies, we incorporated environmental and human influence factors for the habitats of Mankyua chejuense into spatial information, and we also used the habitat distribution models of dominant tree species, including Ulmus parvifolia, Maclura tricuspidata, and Ligustrum obtusifolium, that have been previously identified as major overstory species of Mankyua chejuense. Our analysis revealed that rock exposure, elevation, slope, forest type, building density, and soil type were the main factors determining the potential habitat of Mankyua chejuense. Differences among the three models were observed in the edges of the habitats due to human influence factors, and results varied depending on the similarity of the habitats of Mankyua chejuense and the dominant tree species in the overstory. The potential habitats of Mankyua chejuense presented in this study include areas where the species could potentially inhabit in addition to existing habitats. Therefore, these results can be used for the conservation and management planning of Mankyua chejuense.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.34-34
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• 2021

과거 식물상에 대한 정보가 없었던 경기도 양주시 장흥면에 위치한 장군봉(425.0 m)의 식물상을 2020년 4월부터 10월까지 총 3회에 걸쳐 조사하였다. 본 조사에서 확인된 조사지 내 관속식물은 양치식물 8과 10속 9종 1변종 10분류군, 나자식물 3과 4속 6종 6분류군, 쌍자엽식물 62과 144속 198종 7아종 16변종 2품종 223분류군, 단자엽식물 6과 29속 38종 1아종 5변종 1픔종 45분류군으로 총 284분류군을 확인할 수 있었다. 장군봉 일대의 특산식물은 은사시나무 (Populus tomentiglandulosa T.B.Lee), 키버들 (Salix koriyanagi Kimura), 병꽃나무 (Weigela subsessilis (Nakai) L.H.Bailey), 백운산원추리 (Hemerocallis hakuunensis Nakai)의 4분류군이 분포하고 있었고 산림청에서 지정한 희귀식물로는 취약종 (VU) 등급의 주목 (Taxus cuspidata Siebold & Zucc.) 1분류군이 확인되었다. 느릅나무 (Ulmus davidiana var. japonica (Rehder) Nakai)를 포함하여 I등급 10종, 함박꽃나무 (Magnolia sieboldii K.Koch) 등 II등급 4종, 병조희풀 (Clematis heracleifolia DC.) 등 III등급 8종, IV등급에 해당하는 바위말발도리 (Deutzia grandiflora var. baroniana Diels) 등 총 25종이 식물구계학적특정종에 속했다. 침입외래식물은 미국자리공 (Phytolacca americana L.), 유럽점나도나물 (Cerastium glomeratum Thuill.), 청비름 (Amaranthus viridis L.) 등 20분류군을 확인할 수 있었고, 생태계교란야생식물인 환삼덩굴 (Humulus japonicus Sieboid & Zucc.), 돼지풀 (Ambrosia artemisiifolia L.), 단풍잎돼지풀 (Ambrosia trifida L.), 미국쑥부쟁이 (Aster pilosus Willd.)의 4분류군이 확인되었다.

• Herbal Formula Science
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• v.31 no.4
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• pp.315-325
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• 2023

Objectives : Recently, research has been actively conducted on the efficacy of complexes based on oriental medicine prescriptions for improving immune activity and allergies. In this study, In this study, we aimed to examine the effect of Angelica gigas Nakai and Corni fructus extract (AC), medicinal herbs, among candidate drugs derived through preliminary experiments with various components of oriental medicine prescriptions for allergies, on allergies in RBL-2H3 cells. Methods : We evaluated the effect of the ethanol extract of Ulmus on the allergic inflammatory response in anti-DNP-IgE activated DNP-HSA in RBL-2H3 cells. Cell toxicity was determined by WST-1 assay and the markers of degranulation such as beta-hexosaminidase, histamine, TNF-α and IL-6 production of inflammatory mediators and FcεRI-mediated expression. Results : The results showed that treatment with AC extract (20, 40 and 80㎍/㎖) noncytotoxic levels and significantly inhibited the release of β-hexosaminidase, histamine and the production of TNF-α and IL-6 in RBL-2H3 by the antigen stimulation. Conclusions : These results indicate that AC extract exhibits anti-allergic activity through inhibition of degranulation and inhibition of inflammatory mediators and cytokine release. These findings suggest that AC extract may have potential as a prophylactic and therapeutic agent for the treatment of various allergic diseases.