• The Korean Journal of Pesticide Science
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• v.15 no.4
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• pp.374-382
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• 2011

We investigated the mutagenicity of methiozolin, newly developed herbicide, in vitro reverse mutation test using Salmonella typhimurium and Escherichia coli, chromosome aberration test using chinese hamster lung (CHL) cells and in vivo micronucleus test of mice. In the reverse mutation test, the methiozolin did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2uvrA with and without metabolic activation at $5,000{\mu}g$/plate. In the chromosome aberration test, the results showed no incidence of increased structural and numerical chromosome abberrations at any doses tested (80, 40, $20{\mu}g$/mL). In micronucleous test, the ratio of micronuclei was measured in polychromatic erythrocytes with treated methiozolin for ICR mice. No incidence of increased micronuclei were observed in polychromatic erythrocytes (1,500, 1,000, 500 mg/kg). Based on these results, we concluded that methiozolin has no mutagenic toxicity in vitro and in vivo systems.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.8
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• pp.960-964
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• 2007

This study was performed to examine the toxicity of Psoralea corylifolia L. by the single-dose oral toxicity tests in rat and bacterial reverse mutation assay. In single-dose oral toxicity tests, 5 mL ethanol extract of P. corylifolia L. were directly injected into 10 rats (5 males and 5 females) at a dosage of 2 g/kg. Death practice was not detected during breeding periods (14 days), and $LD_{50}$ was calculated over 2 g/kg. No difference were observed with control group in the growth rate and histological observations. In bacterial reverse mutation assay, his(-) Salmonella Typhimurium TA98, TA100, TA1535, TA1537 and trp(-) Escherichia coli WP2uvrA (pKM101) were used for assessing the toxicity of ethanol extracts of P. corylifolia L.. No significant difference in formation of the colonies and no dose-dependent increase was observed regardless of the addition of S9 mix. The results showed that ethanol extracts of P. corylifolia L. did not have single-dose oral toxicity and mutagenic toxicity.

• Environmental Mutagens and Carcinogens
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• v.21 no.1
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• pp.57-62
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• 2001

Bacterial reverse mutation assays were performed for 20 workplace chemicals in Korea, which were selected among workplace chemicals under the Korea Industrial Safety and Health Act (KISHA) with the occupational exposure levels (OELs). The assays were carried out by using the pre-incubation method ($37 ^{\circ}C$, 20 min) with and without metabolic activation using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and E. coli WP2uvrA. The chemicals were tested at 5 concentrations both in the preliminary and the second assays. Despite the cell toxicities, there were no chemical-induced mutagenicities with or without metabolic activation in any of 20 chemicals.

• Toxicological Research
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• v.29 no.3
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• pp.217-219
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• 2013

Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA). At the concentrations of 0, 62, 185, 556, 1667, and 5000 ${\mu}g$/plate, olmesartan cilexetil was negative in both Salmonella typhimurium and Escherichia coli regardless of presence or absence of metabolic activation system (S9 mix). These results demonstrate that olmesartan cilexetil does not induce bacterial reverse mutation.

• Toxicological Research
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• v.20 no.2
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• pp.153-158
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• 2004

To evaluate the genotoxicity of CJ-11555, an anti-cirrhotic agent, the reverse mutation test, chromosomal aberration test and in vivo micronucleus test in rats were performed. In the reverse mutation test, the treatment of CJ-11555 at doses of 33.3, 100, 333, 1000, 3330 and 5000 $\mu\textrm{g}$/plate with and without 89 did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli (E. call) WP2uvrA. In chromosomal aberration test, CJ-11555 did not induce structural a chromosomal aberration in Chinese hamster ovary (CHO) cells with and without metabolic activation at all doses. In micronucleus test, CJ-11555 did not induce any statistically significant increases in micronucleated polychromatic erythrocyte (MNPCE) at doses of 500, 1000, and 2000 mg/kg. These results suggest that CJ-11555 might not have a mutagenic potential under the conditions in this study.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.180-180
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• 2001

The mutagenic potency of a new antibiotics, IDC- 7181, was evaluated using the mutagenicity tests including Ames, chromosome aberration and micronucleus tests. In bacterial reversion assay, IDC-7181 did not show any mutagenic response in the absence or presence of S9 mixture with Salmonella typhimurium TA98, TAlOO, TA1535 and TA1537 and E. coli WP2uvrA-(100, 50, 25, 12.5 and 6.25 $\mu\textrm{g}$/plate).(omitted)

• Molecules and Cells
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• v.43 no.6
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• pp.509-516
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• 2020

To perceive fluctuations in light quality, quantity, and timing, higher plants have evolved diverse photoreceptors including UVR8 (a UV-B photoreceptor), cryptochromes, phototropins, and phytochromes (Phys). In contrast to plants, prokaryotic oxygen-evolving photosynthetic organisms, cyanobacteria, rely mostly on bilin-based photoreceptors, namely, cyanobacterial phytochromes (Cphs) and cyanobacteriochromes (CBCRs), which exhibit structural and functional differences compared with plant Phys. CBCRs comprise varying numbers of light sensing domains with diverse color-tuning mechanisms and signal transmission pathways, allowing cyanobacteria to respond to UV-A, visible, and far-red lights. Recent genomic surveys of filamentous cyanobacteria revealed novel CBCRs with broader chromophore-binding specificity and photocycle protochromicity. Furthermore, a novel Cph lineage has been identified that absorbs blue-violet/yellow-orange light. In this minireview, we briefly discuss the diversity in color sensing and signal transmission mechanisms of Cphs and CBCRs, along with their potential utility in the field of optogenetics.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.317-322
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• 2006

We have investigated the genotoxicity of 1,2,4-trimethylbenzene using Ames reverse mutation test. In Ames reverse mutation test, 1,2,4-trimethylbenzene treatment at the dose of 100, 50, 25, 12.5, $6.25{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 1,2,4-trimethylbenzene has no mutagenic potential under the rendition in this study.

• Proceedings of the KIEE Conference
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• 2003.07a
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• pp.268-270
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• 2003

This paper proposes a software design and hardware implementation of Intelligent Electronic Device(IED) for power transformer. The relaying algorithm is based on DFT. The protection functions implemented include RDR with a second harmonic restraint for magnetizing inrush, OCR, OCGR, OVR, and UVR etc. The main board of IED is based on the TMS32C32 Processor. The IED was tested with relaying signals obtained for EMTP simulation package.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.119-119
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• 2003

The objective of this study was to determine genotoxic potential of Sophora Japonica Linne Seed Extract(SE). The bacterial reverse mutation test set the treatment levels of SE at 0, 312.5, 625, 1250, 2500, 5000 $\mu\textrm{g}$/plate using Salmonella typhimurium strains (TA1535, TA1537, TA98, TA100) and Escherichia coli WP2uvrA(pKM101). (omitted)