• Archives of Pharmacal Research
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• 제13권3호
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• pp.227-232
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• 1990

A Physiologically based pharmacokinetic model was used to describe the distribition and elimination of cefriazone in the rat. To validate the practical application of the model, the effect of cffeine on the model was also examined. The model consisted of eleven compartments representing the major sites for ceftriaxone distribution including carcass which served as a residual compartment. Elimination was represented by renal and hepatic (metabolic biliary )excretion with GI secretion and re-absorption. The drug concentrations in most of the tissues were simulated using flow limited equations while brain levels were simulated using membrane limited passive diffusion distribution. The experimental data were obtained by averaging the concentration of drug in the plasma and tissues of five rats after i. v. injection of cefriazone 100 mg/kg without and with caffeine 20 mg/kg. The data for the amount of ceftriazone excreted in urine and gut contents were used to apportion total body clearance. HPLC with UV detection was used for the assay with 0.1-0.2 $\mu$g/ml sensitivity. The great majority of drug concentrations with and without caffeine show reasonably good agreements to the simulation results within 20%. The effect of caffeine on renal and hepatic clearances was apparent with 18.8% and 18.6% increase in the model values, respectively.

• 천문학회보
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• 제43권2호
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• pp.52.2-52.2
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• 2018

The shape of a galaxy's spectral energy distribution ranging from ultraviolet (UV) to infrared (IR) wavelengths provides crucial information about the underlying stellar populations, metal contents, and star-formation history. Therefore, analysis of the SED is the main means through which astronomers study distant galaxies. However, interstellar dust absorbs and scatters UV and optical light, re-emitting the absorbed energy in the mid-IR and Far-IR. I present the updated 3D Monte-Carlo radaitive transfer code MoCafe to compute the radiative transfer of stellar, dust emission through a dusty medium. The code calculates the emission expected from dust not only in pure thermal equilibrium state but also in non-thermal equilibrium state. The stochastic heating of very small dust grains and/or PAHs is calculated by solving the transition probability matrix equation between different vibrational, internal energy states. The calculation of stochastic heating is computationally expensive. A pilot study of radiative transfer models of SEDs in clumpy (turbulent), galactic environments, which has been successfully used to understand the Calzetti attenuation curves in Seon & Draine (2016), is also presented.

• 천문학회지
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• 제41권2호
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• pp.23-37
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• 2008

The high-resolution optical region spectroscopic data of the symbiotic nova AG Peg secured with the Hamilton Echelle Spectrograph at the Lick Observatory, have been analyzed along with the International Ultraviolet Explorer UV archive data. We measure about 700 line intensities in the wavelengths of 3859 to $9230{\AA}$ and identify about 300 lines. We construct pure photoionization models that represent the observed lines and the physical condition for this symbiotic nova. The spectral energy distribution of the ionizing radiation is adopted from stellar model atmospheres. Based on photoionization models, we derive the elemental abundances; C & N appear to be similar to be smaller than the Galactic planetary nebular value while O is enhanced. Our result is compared with the Contini (1997, 2003) who analyzed the UV region spectral data with the shock + ionization model. The Fe abundance appears to be enhanced than that of normal planetary nebulae, which suggests that AG Peg may have formed in the Galactic disk. The models indicate that the temperature of the central star which excite the shell gas may have fluctuated to an unexpected extent during the years 1998 - 2002.

• 천문학논총
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• 제15권spc1호
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• pp.147-151
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• 2000

Symbiotic stars, believed to be binary systems of a mass-losing giant and a white dwarf with an emission nebula, are known to exhibit very broad wings around Hex that extend to $\~10^3km\;s^{-1}$. The wing formation mechanism is not a settled matter and recently Lee (2000) proposed that Raman scattering of Ly$\beta$ by neutral hydrogen is responsible for the broad H$\alpha$ wings. In this model, it is predicted that. the Hex wings will be polarized depending on the geometric and kinematic distribution of the scatterers relative to the UV emission region. In this paper, we investigate the polarization of Hex wings in symbiotic stars. Noting that many symbiotic stars possess bipolar nebular morphology, we assume that the distribution of neutral scatterers follows the similar pattern with a receding velocity of several tens of km $s^{-1}$ that mimics the expansion of the neutral envelope of the nebula. It is found that the red wing is more strongly polarized than the blue and main part and that the polarization direction is along the equatorial plane. We obtain a typical degree of polarization $\~10$ percent, however, it varies depending on the detailed distribution of H I scatterers We conclude that spectropolarimetry will provide very important information on the origin of the Hex wings.

• Journal of the Optical Society of Korea
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• 제20권6호
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• pp.799-806
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• 2016

We present a polarization-dependent prism array film for controlling the viewing angle distribution of liquid crystal (LC) display panels without loss of light efficiency. On a directional backlight unit, our polarization-dependent prism array film, made into a stacked bilayer with a well-aligned liquid crystalline reactive mesogen (RM) layer on the UV-imprinted prism structure, can continuously control the light refraction function of the prism array by electrically switching incident polarization states of a polarization-controlling layer prepared by a twisted nematic LC mode. The viewing angle control properties of the polarization-dependent prism array film are analyzed under different prism angle and refractive index conditions of the RM layer. A simple analytic model is also presented to describe the intermediate viewing angle distributions with continuously varying applied voltages and incident polarization states.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5225-5231
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• 2015

Background: One of the most prevalent cancers in whole world is skin cancer and its prevalence is growing. The present research sought to estimate relative risk of morbidity and mortality due to skin cancer. Materials and Methods: In this cross-sectional study. The required data were gathered from the registered cancer reports of Cancer Control Office in the Center for Non Communicable Disease of the Iranian Ministry of Health (MOH). The data were extracted at province level in the time span of 2008-10. WINBUGS software was used to analyze the data and to identify high risk regions. ArcGIS10 was utilized to map the distribution of skin cancer and to demonstrate high risk provinces by using classic and fully Bayesian models taking into account spatial correlations of adjacent regions separately for men and women. Results: Relative risk of morbidity for women in Yazd and for men in Kurdistan and relative risk of mortality for women in Bushehr and for men in Kohgiluyeh were found to be the highest. Bayesian model due to regarding adjacent regions correlation, have precise estimation in comparing to classical model. More frequent epidemiological studies to enact skin cancer prevention programs. Conclusions: High risk regions in Iran include central and highland regions. Therefore it is suggested that health decision makers enact public education, using anti UV creams and sunglasses for those parts as a short preventing program.

• Journal of Astronomy and Space Sciences
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• 제15권1호
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• pp.91-100
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• 1998

자외선 영역에서 색지수와 유효온도의 상관관계를 구하기 위한 pilot project 로 25개의 표준상태에 대하여 유효온도와 색지수를 산출하였다. 유효온도는 자외선 영역의 IUE 저분산 스펙트럼의 에너지 분포 곡선을 Kurucx 모델과 비교하여 산출하였고, 자외선 색지수는 IUE 저분산 스펙트럼의 플럭스를 $300{\AA}$ 단위로 적분하여 등급으로 환산하여 산출하였다. 자외선 영역으 상관관계는 가시관선 영역의 상관관계와 유사한 형태로 나타났다.

• 천문학회보
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• 제35권1호
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• pp.69.2-69.2
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• 2010

The far-ultraviolet (FUV) H2 and C IV emission images and spectra of Orion Eridanus Superbubble (OES) is hereby presented. The OES seems to consists of multiple phase through the detection of highly-ionized gas and pervasive neutral hydrogen. The former is traced by hot gas while the latter is traced by cold medium. A spectral image made with H2 fluorescent emission shows that the spatial distribution of hydrogen molecule is well correlated with the dust map. The model spectra was taken from a photodissociation region (PDR) radiation code which find a best suitable parameter such as hydrogen density, gas temperature and incident uv intensity of the radiation field. C IV emission is caused by intermediate temperature ISM about 10^4.5 K~10^6 K. Therefore we could get more clear evidence to reveal the structure of OES. Feature of spectra for the each sub region is also presented and discussed. The data were obtained with the Far-Ultraviolet Imaging Spectrograph (FIMS) and the whole data handling were followed by previous FIMS analysis.

• Environmental Analysis Health and Toxicology
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• 제11권1_2호
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• pp.1-10
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• 1996

A decrease in stratospheric ozone probably caused by chloroflurocarbons (CFCs) emissions, has been observed large parts of-the globe. It is generally accepted that if ozone levels in the stratosphere are depleted, greater amounts of shortwave ultraviolet radiationB (UVB) will reach the earth's surface, resulting in increased incidence of nonmelanoma skin cancer. In this study, we evaluated several mathematical models, such as a power and an exponential model, and a geometric model considering the surface area of a human body part and ages for the prediction of Skin cancer incidence caused by exposure to the UVB radiation. These models basically estimated the risk of skin cancer based on those measurements of the local ozone in stratosphere and UVB. Both were measured at a part of Seoul with a Dobson ozone spectrometer and Robertson-Berger UV Biometer for 1995. As a result, we calculated the point estimation applying a biological amplification factor (BAF), UVB radiation and other factors. We used a Monte-Carlo simulation technique with assumption on the distribution of each considered factor. The sensitivity analysis of model by there components conducted using Gaussian sensitivity method. The annual integral of UVB radiation was 2275 MED (minimal erythema dose)/yr. Also, an estimate of the annual amount of UVB reaching the earth's surface at a korea's latitude and altitude was 3328 MED/yr. The values of the radiation amplification factor (RAF) were ranged from 0.9 to 1.5 in Seoul. To give the effective factors required to model the prediction of skin cancer incidence caused by exposure to the UVB radiation in Korea, we studied the pros and cons of above mentioned models with the application of those parameters measured in Seoul, Korea.

• The Korean Journal of Physiology and Pharmacology
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• 제8권1호
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• pp.65-67
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• 2004

Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was $21.9\;and\;53.9\;{\mu}g{\cdot}min/ml$ after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was $91.8{\pm}16.6\;min$ and $78.7{\pm}11.9\;min$ in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.