• Applied Microscopy
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• 제32권2호
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• pp.91-105
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• 2002

포유동물의 콩팥에서 오줌 농축기전에 중요한 요소(urea)의 이동에 관여하는 요소운반체 (urea transporter, UT)에는 요세관에서 발현되는 요소운반체인 UT-A와 적혈구에서 발현되는 요소운반체인 UT-B가 있다. 최근 UT-A에는 UT-A1, UT-A2, UT-A3, UT-A4, UT-A5 등 5종류가 있음이 밝혀졌다. 이 연구에서는 콩팥내 요세관 세포에서 UT-A1, UT-A2 및 UT-A4를 표지하는 것으로 알려진 UT-A (L403)의 분포를 밝히고자 하였다. Sprague-Dawley계 흰쥐($200{\sim}250g$)의 콩팥을 대상으로 정상군, 탈수군(식수를 3일간 공급하지 않은 군) 및 수분과잉공급군(3%의 sucrose를 섞은 식수를 3일간 자유롭게 먹였다)의 3군으로 나누었다. 콩팥은 복대동맥을 통하여 2% paraformaldehyde-lysine-periodate (PLP) 또는 8% paraformaldehyde용액으로 10분간 관류 고정하였다. 콩팥조직절편은 UT-A에 대한 토끼 다클론항체를 이용하여 포매전면역염색법을 이용한 과산화효소법과 면역도금법을 시행한 후 광학 및 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 흰쥐 콩팥에서 UT-A1은 속수질집합관의 세포질에 산재하여 분포하고 있었으며, UT-A2는 짧은-헨레고리의 내림가는부분 말단 1/2 부분의 상피세포(I형 세포)와 속수질 초기부분에 있는 긴-헨레고리의 내림가는부분 상피세포(II형 세포)의 세포막에 분포하고 있었다. 속수질집합관내 UT-A1은 탈수군에서는 감소하였으며, 수분과잉공급군에서는 증가하였다. 짧은-헨레고리의 내림가는부분에 있는 UT-A2는 탈수군과 수분과잉공급군 모두에서 증가하되 수분과잉공급군에서 더 증가하였다. 긴-헨레고리의 내림가는부분 중 속수질 초기부분에서 발현되는 UT-A2의 면역반응성은 탈수군에서 현저히 증가하였으나, 수분과잉공급군에서는 정상군에서처럼 약하게 발현되었다. 이상의 연구 결과로 보아 흰쥐 콩팥에서 UT-A1은 속수질집합관의 세포질에 UT-A2는 짧은-헨레고리와 긴-헨레고리의 내림가는부분 상피세포의 세포막에 분포하고 있으며 서로 다른 기전에 의하여 조절되고 있는 것으로 생각된다.

• 대한물리의학회지
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• 제15권3호
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• pp.11-20
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• 2020

PURPOSE: Excessive activity of the upper trapezius (UT) muscle contributes to a rounded shoulder posture (RSP) through abnormal rotation of the scapula that weakens the lower trapezius (LT) and serratus anterior (SA) muscles. This study compared the effects of two arm-lifting exercises with and without the use of a Thera-band on the activities of LT, SA, and UT muscles, and the LT/UT and SA/UT activity ratio in subjects with a rounded shoulder posture. METHODS: Sixteen subjects with RSP participated in this study. All subjects performed arm-lifting (AL), diagonal arm-lifting (DAL), arm lifting with isometric adduction (ALIA), and diagonal arm-lifting with isometric adduction (DALIA) exercises. The surface electromyography data, LT, SA, UT, and the LT/UT and SA/UT activity ratios were measured. A paired t-test was used to compare the differences between two arm-lifting exercises and two arm lifting with isometric adduction exercises. RESULTS: In ALIA and DALIA exercises, the UT muscle activity decreased significantly, whereas the LT/UT, SA/UT activity ratio increased significantly. The activity of SA muscle increased significantly more with DALIA than that with DAL. CONCLUSION: Arm-lifting exercises using a Thera-band can be implemented as an effective way to reduce the UT overactivity and increase the SA activity and LT/UT, SA/UT activity ratio in subjects with RSP.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.295-303
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• 2019

A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted drug-induced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http://ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.

• Corrosion Science and Technology
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• 제11권4호
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• pp.129-134
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• 2012

UT(Ultrasonic Test), one of the non-destructive tests, is the most common thickness measurement method for evaluating the wear rate in NPPs(Nuclear Power Plants). UT is used widely because it is easy and safe for use. However some amount of error inevitably occurs in attempting to measure the thickness. The error, that could make the thickness data thicker or thinner, may affect estimation of wear rate in pipes. NPPs are composed of a lot of pipes and components. Some of them are tested to check the current status during RFO(Re-Fueling Outage). Reliability analysis of UT is essential for evaluating pipe wear rate and establishing the long-term management plan in NPPs. This paper reviewed the cause of error occurrence and presented the UT data reliability analysis method. Also, this paper shows the application result of reliability analysis to the UT data acquired in NPPs.

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
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• pp.71-71
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• 2006

• 한국컴퓨터정보학회논문지
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• 제15권10호
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• pp.173-182
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• 2010

최근 우리사회는 예측이 불가능한 재난발생의 양상이 다변화 하고 있다. 그러므로 안전문제에 대한 부정적인 인식이 나타나면서, UT를 활용한 우리 일상의 재난 대응체계를 준비하자는 해결방안이 부각되고 있다. 따라서 본 논문에서는 u-Gov의 응용서비스로 재난 대응체계를 위해 UT를 응용한 예측 프로토타입을 제시하였다. 그리고 UT를 응용한 정책과제로, e-Gov와 u-Gov의 차별성을 비교분석하여, e-Gov의 한계를 극복하는 방안으로 u-Gov의 개선안과 예측 프로토타입 구현시 예상되는 문제의 개선점도 제시하였다.

• 한국전문물리치료학회지
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• 제21권2호
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• pp.67-73
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• 2014

The aim of this study was to compare the activity of the upper trapezius (UT) and serratus anterior (SA) and ratio of UT to SA during shoulder elevations. Ten subjects with UT pain (UTP) and 13 subjects without UTP participated in this study. Subjects with a UTP of over five in a pain intensity visual analogue scale (0-10 ㎝) for more than 2 months and latent myofascial trigger points (MTrPs) in the UT muscle were included in the UTP group. Electromyography (EMG) data of UT and SA at 1st and 10th elevations were analyzed. Two-way repeated analyses of variance were used to compare the EMG activity of UT and SA and the ratio of UT to SA during shoulder elevations between groups with and without UTP. There was a significant increase in UT/SA ratio in the group with UTP compared to the group without UTP (p=.01). The activity of UT and SA measured at the 10th elevation was significantly greater than that in the first elevation (p<.05). The activity of SA was significantly greater in the group without UTP than the group with UTP (p=.03). However, there was no significant difference between groups with and without UTP in terms of UT activity (p=.28). These results indicate that UTP may have relevance to the increased muscle activity ratio of UT to SA during shoulder elevations.

• 한국전문물리치료학회지
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• 제24권1호
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• pp.86-96
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• 2017

Background: Scapular dyskinesis is characterized by altered scapular position and motion. Specifically, excess activation of the Upper trapezius (UT) combined with decreased Lower trapezius (LT) and Serratus anterior (SA) have been observed. The Standard push-up plus exercise (SPP) is considered as a therapeutic exercise for increasing SA activity and maintaining the scapular kinematics. In addition, Using the Sling surface can lead to higher muscle activity. However, the advantage of an unstable surface has been uncertatin. Objects: To compare the activation of the UT, LT, and lower serratus anterior (LSA) muscles during various push-up plus exercises with and without sling in subjects with scapular dyskinesis. Methods: Total 18 male subjects with scapular dyskinesis were recruited. The UT, LT, and LSA electromyographic activities and the UT/LSA and UT/LT EMG activity ratios were measured during three push-up plus exercises with and without sling. Two-way repeated of analysis of variance was used to determine the statistical significance. Results: The UT activity was significantly lower in all postures without sling than that with sling. In addition, the LSA activity was significantly greater without than with sling, and significantly large in SPP, Low back supported push-up plus (LSPP), and Quadruped push-up plus. Additionally, the UT/LSA and UT/LT activity ratios were lower in SPP and LSPP without sling than with the other four push-up plus exercises. Conclusion: The push-up plus without sling were considered to decrease UT and increase LSA activity compared with exercises with sling. Furthermore, SPP without sling seems to be a more effective exercise for increasing LSA activity and lowering the UT/LSA and UT/LT activity ratios in scapular dyskinesis subjects.

• 한국전문물리치료학회지
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• 제22권4호
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• pp.17-26
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• 2015

The purpose of this study was to investigate the effects of visual electromyography (EMG) biofeedback on the EMG activity of the lower trapezius (LT), serratus anterior (SA), and upper trapezius (UT) muscles, the LT/UT and SA/UT EMG activity ratios, and the scapular upward rotation angle during scapular posterior tilting exercise (SPTE). Twenty-four subjects with round-shoulder posture participated in this study. The EMG activities of the LT, SA, and UT were collected during SPTE both without and with visual EMG biofeedback. The scapular upward rotation angle was measured at the baseline, after SPTE without visual EMG biofeedback, and after SPTE with visual EMG biofeedback. The LT, SA, and UT EMG activities, and the LT/UT and SA/UT EMG activity ratios were analyzed by paired t-test. The scapular upward rotation angle was statistically analyzed using one-way repeated analysis of variance. If a significant difference was found, a Bonferroni correction was performed (p=.05/3=.017). The EMG activities of LT and SA significantly increased, and the EMG activity of UT significantly decreased during SPTE with visual EMG biofeedback compared to SPTE without visual EMG biofeedback (p<.05). In addition, the LT/UT and SA/UT EMG activity ratios significantly increased during SPTE with visual EMG biofeedback compared to SPTE without visual EMG biofeedback (p<.05). Significant increases were found in the scapular upward rotation angle after SPTE without and with visual EMG biofeedback compared to baseline (p<.017), and no significant differences were observed in the scapular upward rotation angle between SPTE without and with visual EMG biofeedback. In conclusion, SPTE using visual EMG biofeedback may be an effective method for increasing LT and SA activities while reducing UT activity.

• 한국전문물리치료학회지
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• 제29권2호
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• pp.165-170
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• 2022

Background: The serratus anterior (SA) muscle prevents scapular winging (SW) by stabilizing the medial border of the scapula during arm movement. The upper trapezius (UT) and lower trapezius (LT) muscles may compensate for the weak SA muscle in individuals with SW during shoulder flexion. However, there is no study to examine whether compensation by UT and LT occurs in individuals with SW. Objects: This study compared the muscle activities of UT, LT, and SA as well as the SA/UT activity ratio between individuals with and without SW during shoulder flexion with load. Methods: This study recruited 27 participants with SW (n = 14) and without SW (n = 13). Electromyography data of the SA, UT, and LT muscles and SA/UT activity ratio were recorded and analyzed during shoulder flexion with 25% load of the maximal shoulder flexion force. Independent t-test was used to compare the UT, LT, and SA muscle activities and SA/UT ratio between the groups with and without SW; statistical significance was set at α of 0.05. Results: SA activity was significantly lesser in the group with SW than in the group without SW. However, there were no significant differences in the UT and LT activities and SA/UT activity ratio between the two groups. Conclusion: The SA activity was lesser in the group with SW than in the group without SW with 25% load of the maximal shoulder flexion force, but there was no compensatory muscle activity of the UT and LT observed. Therefore, further studies are warranted to clarify the compensatory strategy of scapular stabilization in individuals with SW during shoulder flexion under other heavy load conditions.